From Microcosm to Macrocosm: The -Omics, Multiomics, and Sportomics Approaches in Exercise and Sports
This article explores the progressive integration of -omics methods, including genomics, metabolomics, and proteomics, into sports research, highlighting the development of the concept of "sportomics." We discuss how sportomics can be used to comprehend the multilevel metabolism during exercise in real-life conditions faced by athletes, enabling potential personalized interventions to improve performance and recovery and reduce injuries, all with a minimally invasive approach and reduced time. Sportomics may also support highly personalized investigations, including the implementation of n-of-1 clinical trials and the cura...
Source: Genomics Proteomics ... - November 9, 2023 Category: Genetics & Stem Cells Authors: Renan Muniz-Santos Alexandre Magno-Fran ça Igor Jurisica L C Cameron Source Type: research
MAF amplification licenses ER α through epigenetic remodelling to drive breast cancer metastasis
Nat Cell Biol. 2023 Nov 9. doi: 10.1038/s41556-023-01281-y. Online ahead of print.ABSTRACTMAF amplification increases the risk of breast cancer (BCa) metastasis through mechanisms that are still poorly understood yet have important clinical implications. Oestrogen-receptor-positive (ER+) BCa requires oestrogen for both growth and metastasis, albeit by ill-known mechanisms. Here we integrate proteomics, transcriptomics, epigenomics, chromatin accessibility and functional assays from human and syngeneic mouse BCa models to show that MAF directly interacts with oestrogen receptor alpha (ERα), thereby promoting a unique chrom...
Source: Genomics Proteomics ... - November 9, 2023 Category: Genetics & Stem Cells Authors: Alicia Llorente Mar ía Teresa Blasco Irene Espuny Marc Guiu Cecilia Ballar é Enrique Blanco Adri à Caballé Anna Bellmunt Fernando Salvador Andrea Morales Marc Nu ñez Guillem Loren Francesca Imbastari Marta Fidalgo Cristina Figueras-Puig Patrizia Gibl Source Type: research
Integrated Immunopeptidomic and Proteomic Analysis of COVID-19 lung biopsies
DISCUSSION: Our findings emphasize the significant role of macrophage-mediated immunity in the development of severe lung disease in COVID-19 patients.PMID:37942334 | PMC:PMC10628763 | DOI:10.3389/fimmu.2023.1269335 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 9, 2023 Category: Genetics & Stem Cells Authors: Shanye Yin Susan Klaeger Vipheaviny A Chea Isabel P Carulli Suzanna Rachimi Katharine E Black Michael Filbin Lida P Hariri Rachel S Knipe Robert F Padera Jonathan D Stevens William J Lane Steven A Carr Catherine J Wu Edy Yong Kim Derin B Keskin Source Type: research
From Microcosm to Macrocosm: The -Omics, Multiomics, and Sportomics Approaches in Exercise and Sports
This article explores the progressive integration of -omics methods, including genomics, metabolomics, and proteomics, into sports research, highlighting the development of the concept of "sportomics." We discuss how sportomics can be used to comprehend the multilevel metabolism during exercise in real-life conditions faced by athletes, enabling potential personalized interventions to improve performance and recovery and reduce injuries, all with a minimally invasive approach and reduced time. Sportomics may also support highly personalized investigations, including the implementation of n-of-1 clinical trials and the cura...
Source: Genomics Proteomics ... - November 9, 2023 Category: Genetics & Stem Cells Authors: Renan Muniz-Santos Alexandre Magno-Fran ça Igor Jurisica L C Cameron Source Type: research
Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging
Nat Commun. 2023 Nov 3;14(1):7034. doi: 10.1038/s41467-023-42822-1.ABSTRACTAβ peptides derived from the amyloid precursor protein (APP) have been strongly implicated in the pathogenesis of Alzheimer's disease. However, the normal function of APP and the importance of that role in neurodegenerative disease is less clear. We recover the Drosophila ortholog of APP, Appl, in an unbiased forward genetic screen for neurodegeneration mutants. We perform comprehensive single cell transcriptional and proteomic studies of Appl mutant flies to investigate Appl function in the aging brain. We find an unexpected role for Appl in contr...
Source: Genomics Proteomics ... - November 4, 2023 Category: Genetics & Stem Cells Authors: Vanitha Nithianandam Hassan Bukhari Matthew J Leventhal Rachel A Battaglia Xianjun Dong Ernest Fraenkel Mel B Feany Source Type: research
Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging
Nat Commun. 2023 Nov 3;14(1):7034. doi: 10.1038/s41467-023-42822-1.ABSTRACTAβ peptides derived from the amyloid precursor protein (APP) have been strongly implicated in the pathogenesis of Alzheimer's disease. However, the normal function of APP and the importance of that role in neurodegenerative disease is less clear. We recover the Drosophila ortholog of APP, Appl, in an unbiased forward genetic screen for neurodegeneration mutants. We perform comprehensive single cell transcriptional and proteomic studies of Appl mutant flies to investigate Appl function in the aging brain. We find an unexpected role for Appl in contr...
Source: Genomics Proteomics ... - November 4, 2023 Category: Genetics & Stem Cells Authors: Vanitha Nithianandam Hassan Bukhari Matthew J Leventhal Rachel A Battaglia Xianjun Dong Ernest Fraenkel Mel B Feany Source Type: research
Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging
Nat Commun. 2023 Nov 3;14(1):7034. doi: 10.1038/s41467-023-42822-1.ABSTRACTAβ peptides derived from the amyloid precursor protein (APP) have been strongly implicated in the pathogenesis of Alzheimer's disease. However, the normal function of APP and the importance of that role in neurodegenerative disease is less clear. We recover the Drosophila ortholog of APP, Appl, in an unbiased forward genetic screen for neurodegeneration mutants. We perform comprehensive single cell transcriptional and proteomic studies of Appl mutant flies to investigate Appl function in the aging brain. We find an unexpected role for Appl in contr...
Source: Genomics Proteomics ... - November 4, 2023 Category: Genetics & Stem Cells Authors: Vanitha Nithianandam Hassan Bukhari Matthew J Leventhal Rachel A Battaglia Xianjun Dong Ernest Fraenkel Mel B Feany Source Type: research
A Historic Retrospective on the Early Bioinformatics Research in China
Genomics Proteomics Bioinformatics. 2023 Nov 1:S1672-0229(23)00118-3. doi: 10.1016/j.gpb.2023.10.006. Online ahead of print.NO ABSTRACTPMID:37923291 | DOI:10.1016/j.gpb.2023.10.006 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 3, 2023 Category: Genetics & Stem Cells Authors: Runsheng Chen Source Type: research
Capturing heart valve development with Gene Ontology
Discussion: To address the needs of the heart valve research community this project has provided GO annotations to describe the specific roles of key proteins involved in heart valve development. The breadth of GO annotations created by this project will benefit many of those seeking to interpret a wide range of cardiovascular genomic, transcriptomic, proteomic and metabolomic datasets.PMID:37915827 | PMC:PMC10616796 | DOI:10.3389/fgene.2023.1251902 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 2, 2023 Category: Genetics & Stem Cells Authors: Saadullah H Ahmed Alexander T Deng Rachael P Huntley Nancy H Campbell Ruth C Lovering Source Type: research
Capturing heart valve development with Gene Ontology
Discussion: To address the needs of the heart valve research community this project has provided GO annotations to describe the specific roles of key proteins involved in heart valve development. The breadth of GO annotations created by this project will benefit many of those seeking to interpret a wide range of cardiovascular genomic, transcriptomic, proteomic and metabolomic datasets.PMID:37915827 | PMC:PMC10616796 | DOI:10.3389/fgene.2023.1251902 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 2, 2023 Category: Genetics & Stem Cells Authors: Saadullah H Ahmed Alexander T Deng Rachael P Huntley Nancy H Campbell Ruth C Lovering Source Type: research
Capturing heart valve development with Gene Ontology
Discussion: To address the needs of the heart valve research community this project has provided GO annotations to describe the specific roles of key proteins involved in heart valve development. The breadth of GO annotations created by this project will benefit many of those seeking to interpret a wide range of cardiovascular genomic, transcriptomic, proteomic and metabolomic datasets.PMID:37915827 | PMC:PMC10616796 | DOI:10.3389/fgene.2023.1251902 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 2, 2023 Category: Genetics & Stem Cells Authors: Saadullah H Ahmed Alexander T Deng Rachael P Huntley Nancy H Campbell Ruth C Lovering Source Type: research
Capturing heart valve development with Gene Ontology
Discussion: To address the needs of the heart valve research community this project has provided GO annotations to describe the specific roles of key proteins involved in heart valve development. The breadth of GO annotations created by this project will benefit many of those seeking to interpret a wide range of cardiovascular genomic, transcriptomic, proteomic and metabolomic datasets.PMID:37915827 | PMC:PMC10616796 | DOI:10.3389/fgene.2023.1251902 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 2, 2023 Category: Genetics & Stem Cells Authors: Saadullah H Ahmed Alexander T Deng Rachael P Huntley Nancy H Campbell Ruth C Lovering Source Type: research
A novel proteomic-based model for predicting colorectal cancer with Schistosoma japonicum co-infection by integrated bioinformatics analysis and machine learning
This study also provides new clues for the mechanism research of S. japonicum infection and CRC.PMID:37904220 | PMC:PMC10614356 | DOI:10.1186/s12920-023-01711-8 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - October 31, 2023 Category: Genetics & Stem Cells Authors: Shan Li Xuguang Sun Ting Li Yanqing Shi Binjie Xu Yuyong Deng Sifan Wang Source Type: research
The Rising Role of Omics and Meta-Omics in Table Olive Research
Foods. 2023 Oct 15;12(20):3783. doi: 10.3390/foods12203783.ABSTRACTTable olives are often the result of fermentation, a process where microorganisms transform raw materials into the final product. The microbial community can significantly impact the organoleptic characteristics and safety of table olives, and it is influenced by various factors, including the processing methods. Traditional culture-dependent techniques capture only a fraction of table olives' intricate microbiota, prompting a shift toward culture-independent methods to address this knowledge gap. This review explores recent advances in table olive research...
Source: Genomics Proteomics ... - October 28, 2023 Category: Genetics & Stem Cells Authors: Anastasios Tsoungos Violeta Pemaj Aleksandra Slavko John Kapolos Marina Papadelli Konstantinos Papadimitriou Source Type: research
The Dynamics of Nerve Degeneration and Regeneration in a Healthy Milieu and in Diabetes
Int J Mol Sci. 2023 Oct 16;24(20):15241. doi: 10.3390/ijms242015241.ABSTRACTAppropriate animal models, mimicking conditions of both health and disease, are needed to understand not only the biology and the physiology of neurons and other cells under normal conditions but also under stress conditions, like nerve injuries and neuropathy. In such conditions, understanding how genes and different factors are activated through the well-orchestrated programs in neurons and other related cells is crucial. Knowledge about key players associated with nerve regeneration intended for axonal outgrowth, migration of Schwann cells with ...
Source: Genomics Proteomics ... - October 28, 2023 Category: Genetics & Stem Cells Authors: Lars B Dahlin Source Type: research
