Integrated multi-omics analyses and genome-wide association studies reveal prime candidate genes of metabolic and vegetative growth variation in canola
Plant J. 2023 Nov 15. doi: 10.1111/tpj.16524. Online ahead of print.ABSTRACTGenome-wide association studies (GWAS) identified thousands of genetic loci associated with complex plant traits, including many traits of agronomical importance. However, functional interpretation of GWAS results remains challenging because of large candidate regions due to linkage disequilibrium. High-throughput omics technologies, such as genomics, transcriptomics, proteomics and metabolomics open new avenues for integrative systems biological analyses and help to nominate systems information supported (prime) candidate genes. In the present stu...
Source: Genomics Proteomics ... - November 15, 2023 Category: Genetics & Stem Cells Authors: Dominic Knoch Rhonda C Meyer Marc C Heuermann David Riewe Fritz F Peleke J ędrzej Szymański Amine Abbadi Rod J Snowdon Thomas Altmann Source Type: research
Compartment-specific protein interactions in beryllium lung disease
ERJ Open Res. 2023 Nov 13;9(6):00138-2023. doi: 10.1183/23120541.00138-2023. eCollection 2023 Nov.ABSTRACTThe study provides insights into proteins that may be relevant in BeS and CBD. It provides a framework to investigate the global changes in lung compartment-specific inflammatory cells to better understand the potential interplay of proteins in CBD. https://bit.ly/3PLNTXC.PMID:37965231 | PMC:PMC10641575 | DOI:10.1183/23120541.00138-2023 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 15, 2023 Category: Genetics & Stem Cells Authors: Li Li Brian Vestal Margaret M Mroz Sucai Liu Kristyn MacPhail Tim J Griffin Ivana V Yang Lisa A Maier Maneesh Bhargava Source Type: research
Integrated multi-omics analyses and genome-wide association studies reveal prime candidate genes of metabolic and vegetative growth variation in canola
Plant J. 2023 Nov 15. doi: 10.1111/tpj.16524. Online ahead of print.ABSTRACTGenome-wide association studies (GWAS) identified thousands of genetic loci associated with complex plant traits, including many traits of agronomical importance. However, functional interpretation of GWAS results remains challenging because of large candidate regions due to linkage disequilibrium. High-throughput omics technologies, such as genomics, transcriptomics, proteomics and metabolomics open new avenues for integrative systems biological analyses and help to nominate systems information supported (prime) candidate genes. In the present stu...
Source: Genomics Proteomics ... - November 15, 2023 Category: Genetics & Stem Cells Authors: Dominic Knoch Rhonda C Meyer Marc C Heuermann David Riewe Fritz F Peleke J ędrzej Szymański Amine Abbadi Rod J Snowdon Thomas Altmann Source Type: research
Compartment-specific protein interactions in beryllium lung disease
ERJ Open Res. 2023 Nov 13;9(6):00138-2023. doi: 10.1183/23120541.00138-2023. eCollection 2023 Nov.ABSTRACTThe study provides insights into proteins that may be relevant in BeS and CBD. It provides a framework to investigate the global changes in lung compartment-specific inflammatory cells to better understand the potential interplay of proteins in CBD. https://bit.ly/3PLNTXC.PMID:37965231 | PMC:PMC10641575 | DOI:10.1183/23120541.00138-2023 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 15, 2023 Category: Genetics & Stem Cells Authors: Li Li Brian Vestal Margaret M Mroz Sucai Liu Kristyn MacPhail Tim J Griffin Ivana V Yang Lisa A Maier Maneesh Bhargava Source Type: research
Integrated multi-omics analyses and genome-wide association studies reveal prime candidate genes of metabolic and vegetative growth variation in canola
Plant J. 2023 Nov 15. doi: 10.1111/tpj.16524. Online ahead of print.ABSTRACTGenome-wide association studies (GWAS) identified thousands of genetic loci associated with complex plant traits, including many traits of agronomical importance. However, functional interpretation of GWAS results remains challenging because of large candidate regions due to linkage disequilibrium. High-throughput omics technologies, such as genomics, transcriptomics, proteomics and metabolomics open new avenues for integrative systems biological analyses and help to nominate systems information supported (prime) candidate genes. In the present stu...
Source: Genomics Proteomics ... - November 15, 2023 Category: Genetics & Stem Cells Authors: Dominic Knoch Rhonda C Meyer Marc C Heuermann David Riewe Fritz F Peleke J ędrzej Szymański Amine Abbadi Rod J Snowdon Thomas Altmann Source Type: research
Compartment-specific protein interactions in beryllium lung disease
ERJ Open Res. 2023 Nov 13;9(6):00138-2023. doi: 10.1183/23120541.00138-2023. eCollection 2023 Nov.ABSTRACTThe study provides insights into proteins that may be relevant in BeS and CBD. It provides a framework to investigate the global changes in lung compartment-specific inflammatory cells to better understand the potential interplay of proteins in CBD. https://bit.ly/3PLNTXC.PMID:37965231 | PMC:PMC10641575 | DOI:10.1183/23120541.00138-2023 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 15, 2023 Category: Genetics & Stem Cells Authors: Li Li Brian Vestal Margaret M Mroz Sucai Liu Kristyn MacPhail Tim J Griffin Ivana V Yang Lisa A Maier Maneesh Bhargava Source Type: research
Amnion responses to intrauterine inflammation and effects of inhibition of TNF signaling in preterm Rhesus macaque
iScience. 2023 Oct 6;26(11):108118. doi: 10.1016/j.isci.2023.108118. eCollection 2023 Nov 17.ABSTRACTIntrauterine infection/inflammation (IUI) is a frequent complication of pregnancy leading to preterm labor and fetal inflammation. How inflammation is modulated at the maternal-fetal interface is unresolved. We compared transcriptomics of amnion (a fetal tissue in contact with amniotic fluid) in a preterm Rhesus macaque model of IUI induced by lipopolysaccharide with human cohorts of chorioamnionitis. Bulk RNA sequencing (RNA-seq) amnion transcriptomic profiles were remarkably similar in both Rhesus and human subjects and r...
Source: Genomics Proteomics ... - November 13, 2023 Category: Genetics & Stem Cells Authors: Pietro Presicce Monica Cappelletti Marco Morselli Feiyang Ma Paranthaman Senthamaraikannan Giulia Protti Brian B Nadel Laila Aryan Mansoureh Eghbali Lukasz Salwinski Neema Pithia Emily De Franco Lisa A Miller Matteo Pellegrini Alan H Jobe Claire A Chougne Source Type: research
Amnion responses to intrauterine inflammation and effects of inhibition of TNF signaling in preterm Rhesus macaque
iScience. 2023 Oct 6;26(11):108118. doi: 10.1016/j.isci.2023.108118. eCollection 2023 Nov 17.ABSTRACTIntrauterine infection/inflammation (IUI) is a frequent complication of pregnancy leading to preterm labor and fetal inflammation. How inflammation is modulated at the maternal-fetal interface is unresolved. We compared transcriptomics of amnion (a fetal tissue in contact with amniotic fluid) in a preterm Rhesus macaque model of IUI induced by lipopolysaccharide with human cohorts of chorioamnionitis. Bulk RNA sequencing (RNA-seq) amnion transcriptomic profiles were remarkably similar in both Rhesus and human subjects and r...
Source: Genomics Proteomics ... - November 13, 2023 Category: Genetics & Stem Cells Authors: Pietro Presicce Monica Cappelletti Marco Morselli Feiyang Ma Paranthaman Senthamaraikannan Giulia Protti Brian B Nadel Laila Aryan Mansoureh Eghbali Lukasz Salwinski Neema Pithia Emily De Franco Lisa A Miller Matteo Pellegrini Alan H Jobe Claire A Chougne Source Type: research
Integrated Immunopeptidomic and Proteomic Analysis of COVID-19 lung biopsies
DISCUSSION: Our findings emphasize the significant role of macrophage-mediated immunity in the development of severe lung disease in COVID-19 patients.PMID:37942334 | PMC:PMC10628763 | DOI:10.3389/fimmu.2023.1269335 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 9, 2023 Category: Genetics & Stem Cells Authors: Shanye Yin Susan Klaeger Vipheaviny A Chea Isabel P Carulli Suzanna Rachimi Katharine E Black Michael Filbin Lida P Hariri Rachel S Knipe Robert F Padera Jonathan D Stevens William J Lane Steven A Carr Catherine J Wu Edy Yong Kim Derin B Keskin Source Type: research
From Microcosm to Macrocosm: The -Omics, Multiomics, and Sportomics Approaches in Exercise and Sports
This article explores the progressive integration of -omics methods, including genomics, metabolomics, and proteomics, into sports research, highlighting the development of the concept of "sportomics." We discuss how sportomics can be used to comprehend the multilevel metabolism during exercise in real-life conditions faced by athletes, enabling potential personalized interventions to improve performance and recovery and reduce injuries, all with a minimally invasive approach and reduced time. Sportomics may also support highly personalized investigations, including the implementation of n-of-1 clinical trials and the cura...
Source: Genomics Proteomics ... - November 9, 2023 Category: Genetics & Stem Cells Authors: Renan Muniz-Santos Alexandre Magno-Fran ça Igor Jurisica L C Cameron Source Type: research
MAF amplification licenses ER α through epigenetic remodelling to drive breast cancer metastasis
Nat Cell Biol. 2023 Nov 9. doi: 10.1038/s41556-023-01281-y. Online ahead of print.ABSTRACTMAF amplification increases the risk of breast cancer (BCa) metastasis through mechanisms that are still poorly understood yet have important clinical implications. Oestrogen-receptor-positive (ER+) BCa requires oestrogen for both growth and metastasis, albeit by ill-known mechanisms. Here we integrate proteomics, transcriptomics, epigenomics, chromatin accessibility and functional assays from human and syngeneic mouse BCa models to show that MAF directly interacts with oestrogen receptor alpha (ERα), thereby promoting a unique chrom...
Source: Genomics Proteomics ... - November 9, 2023 Category: Genetics & Stem Cells Authors: Alicia Llorente Mar ía Teresa Blasco Irene Espuny Marc Guiu Cecilia Ballar é Enrique Blanco Adri à Caballé Anna Bellmunt Fernando Salvador Andrea Morales Marc Nu ñez Guillem Loren Francesca Imbastari Marta Fidalgo Cristina Figueras-Puig Patrizia Gibl Source Type: research
Integrated Immunopeptidomic and Proteomic Analysis of COVID-19 lung biopsies
DISCUSSION: Our findings emphasize the significant role of macrophage-mediated immunity in the development of severe lung disease in COVID-19 patients.PMID:37942334 | PMC:PMC10628763 | DOI:10.3389/fimmu.2023.1269335 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 9, 2023 Category: Genetics & Stem Cells Authors: Shanye Yin Susan Klaeger Vipheaviny A Chea Isabel P Carulli Suzanna Rachimi Katharine E Black Michael Filbin Lida P Hariri Rachel S Knipe Robert F Padera Jonathan D Stevens William J Lane Steven A Carr Catherine J Wu Edy Yong Kim Derin B Keskin Source Type: research
From Microcosm to Macrocosm: The -Omics, Multiomics, and Sportomics Approaches in Exercise and Sports
This article explores the progressive integration of -omics methods, including genomics, metabolomics, and proteomics, into sports research, highlighting the development of the concept of "sportomics." We discuss how sportomics can be used to comprehend the multilevel metabolism during exercise in real-life conditions faced by athletes, enabling potential personalized interventions to improve performance and recovery and reduce injuries, all with a minimally invasive approach and reduced time. Sportomics may also support highly personalized investigations, including the implementation of n-of-1 clinical trials and the cura...
Source: Genomics Proteomics ... - November 9, 2023 Category: Genetics & Stem Cells Authors: Renan Muniz-Santos Alexandre Magno-Fran ça Igor Jurisica L C Cameron Source Type: research
MAF amplification licenses ER α through epigenetic remodelling to drive breast cancer metastasis
Nat Cell Biol. 2023 Nov 9. doi: 10.1038/s41556-023-01281-y. Online ahead of print.ABSTRACTMAF amplification increases the risk of breast cancer (BCa) metastasis through mechanisms that are still poorly understood yet have important clinical implications. Oestrogen-receptor-positive (ER+) BCa requires oestrogen for both growth and metastasis, albeit by ill-known mechanisms. Here we integrate proteomics, transcriptomics, epigenomics, chromatin accessibility and functional assays from human and syngeneic mouse BCa models to show that MAF directly interacts with oestrogen receptor alpha (ERα), thereby promoting a unique chrom...
Source: Genomics Proteomics ... - November 9, 2023 Category: Genetics & Stem Cells Authors: Alicia Llorente Mar ía Teresa Blasco Irene Espuny Marc Guiu Cecilia Ballar é Enrique Blanco Adri à Caballé Anna Bellmunt Fernando Salvador Andrea Morales Marc Nu ñez Guillem Loren Francesca Imbastari Marta Fidalgo Cristina Figueras-Puig Patrizia Gibl Source Type: research
Integrated Immunopeptidomic and Proteomic Analysis of COVID-19 lung biopsies
DISCUSSION: Our findings emphasize the significant role of macrophage-mediated immunity in the development of severe lung disease in COVID-19 patients.PMID:37942334 | PMC:PMC10628763 | DOI:10.3389/fimmu.2023.1269335 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 9, 2023 Category: Genetics & Stem Cells Authors: Shanye Yin Susan Klaeger Vipheaviny A Chea Isabel P Carulli Suzanna Rachimi Katharine E Black Michael Filbin Lida P Hariri Rachel S Knipe Robert F Padera Jonathan D Stevens William J Lane Steven A Carr Catherine J Wu Edy Yong Kim Derin B Keskin Source Type: research
