Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence
CONCLUSIONS: Aging-associated impairment of vascular repair is partly determined by the vasoprotective enzyme CSE.PMID:37800327 | DOI:10.1161/CIRCRESAHA.123.323084 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - October 6, 2023 Category: Genetics & Stem Cells Authors: Jiong Hu Matthias S Leisegang Mario Looso Maria-Kyriaki Drekolia Janina Wittig Janina Mettner Christina Karantanou Anastasia Kyselova Gabrjela Dumbovic Xiaoming Li Yuanyuan Li Stefan Guenther David John Mauro Siragusa Sven Zukunft James Oo Ilka Wittig Sus Source Type: research
α-ketoglutarate-dependent KDM6 histone demethylases regulate Interferon Stimulated Gene expression in Lupus
CONCLUSION: Our study suggests chronic IFNα exposure alters epigenetic regulation of ISG expression in SLE monocytes via changes in immunometabolism, a mechanism reflecting trained immunity to type I IFN. Importantly, it opens the possibility that targeting histone modifying enzymes such as KDM6A/B may reduce IFN responses in SLE.PMID:37800478 | DOI:10.1002/art.42724 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - October 6, 2023 Category: Genetics & Stem Cells Authors: Erica N Montano Moumita Bose Lihong Huo Gantsetseg Tumurkhuu Gabriela De Los Santos Brianna Simental Aleksandr B Stotland Janet Wei C Noel Bairey Merz Jo Suda Gislaine Martins Sarfaraz Lalani Kate Lawrenson Yizhou Wang Sarah Parker Swamy Venuturupalli Mar Source Type: research
The non-ribosomal peptide synthetase-independent siderophore (NIS) rhizobactin produced by < em > Caballeronia mineralivorans < /em > PML1(12) confers the ability to weather minerals
This study provides the first demonstration of the synthesis of a NIS in the genus Caballeronia and its involvement in mineral weathering. Our conclusions reinforce the idea that strain PML1(12) is particularly well adapted to nutrient-poor environments. IMPORTANCE This work deciphers the molecular and genetic bases used by strain PML1(12) of Caballeronia mineralivorans to mobilize iron and weather minerals. Through the combination of bioinformatics, chemical, and phylogenetic analyses, we characterized the siderophore produced by strain PML1(12) and the related genes. This siderophore was identified as rhizobactin and cla...
Source: Genomics Proteomics ... - October 6, 2023 Category: Genetics & Stem Cells Authors: Cintia Blanco Nouche C édric Paris Tiphaine Dhalleine Philippe Oger Marie-Pierre Turpault St éphane Uroz Source Type: research
Emerging Trends in Big Data Analysis in Computational Biology and Bioinformatics in Health Informatics: A Case Study on Epilepsy and Seizures
This study might provide insight into the workings of the disease and shows the importance of continued research into epilepsy and other conditions that can trigger seizure activity.PMID:37803114 | DOI:10.1007/978-1-0716-3461-5_6 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - October 6, 2023 Category: Genetics & Stem Cells Authors: Usha Chouhan Rakesh Kumar Sahu Shaifali Bhatt Sonu Kurmi Jyoti Kant Choudhari Source Type: research
Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence
CONCLUSIONS: Aging-associated impairment of vascular repair is partly determined by the vasoprotective enzyme CSE.PMID:37800327 | DOI:10.1161/CIRCRESAHA.123.323084 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - October 6, 2023 Category: Genetics & Stem Cells Authors: Jiong Hu Matthias S Leisegang Mario Looso Maria-Kyriaki Drekolia Janina Wittig Janina Mettner Christina Karantanou Anastasia Kyselova Gabrjela Dumbovic Xiaoming Li Yuanyuan Li Stefan Guenther David John Mauro Siragusa Sven Zukunft James Oo Ilka Wittig Sus Source Type: research
Plasma proteomic associations with genetics and health in the UK Biobank
We present comprehensive protein quantitative trait locus (pQTL) mapping of 2,923 proteins that identifies 14,287 primary genetic associations, of which 81% are previously undescribed, alongside ancestry-specific pQTL mapping in non-European individuals. The study provides an updated characterization of the genetic architecture of the plasma proteome, contextualized with projected pQTL discovery rates as sample sizes and proteomic assay coverages increase over time. We offer extensive insights into trans pQTLs across multiple biological domains, highlight genetic influences on ligand-receptor interactions and pathway pertu...
Source: Genomics Proteomics ... - October 4, 2023 Category: Genetics & Stem Cells Authors: Benjamin B Sun Joshua Chiou Matthew Traylor Christian Benner Yi-Hsiang Hsu Tom G Richardson Praveen Surendran Anubha Mahajan Chloe Robins Steven G Vasquez-Grinnell Liping Hou Erika M Kvikstad Oliver S Burren Jonathan Davitte Kyle L Ferber Christopher E Gi Source Type: research
Proteomic profiling identifies novel inflammation-related plasma proteins associated with ischemic stroke outcome
CONCLUSIONS: We identified candidate blood-based protein biomarkers for post-stroke functional outcome involved in, e.g., NLRP3 inflammasome regulation and signaling pathways, such as TNF, JAK/STAT, MAPK, and NF-κB. These proteins warrant further study for stroke outcome prediction as well as investigations into the putative causal role for stroke outcome.PMID:37794467 | DOI:10.1186/s12974-023-02912-9 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - October 4, 2023 Category: Genetics & Stem Cells Authors: Annelie Angerfors Cecilia Br ännmark Cecilia Lagging Kara Tai Robert M ånsby Svedberg Bj örn Andersson Christina Jern Tara M Stanne Source Type: research
Rethinking underutilized cereal crops: pan-omics integration and green system biology
Planta. 2023 Sep 30;258(5):91. doi: 10.1007/s00425-023-04242-9.ABSTRACTDue to harsh lifestyle changes, in the present era, nutritional security is needed along with food security so it is necessary to include underutilized cereal crops (UCCs) in our daily diet to counteract the rising danger of human metabolic illness. We can attain both the goal of zero hunger and nutritional security by developing improved UCCs using advanced pan-omics (genomics, transcriptomics, proteomics, metabolomics, nutrigenomics, phenomics and ionomics) practices. Plant sciences research progressed profoundly since the last few decades with the in...
Source: Genomics Proteomics ... - September 30, 2023 Category: Genetics & Stem Cells Authors: Mohammed Saba Rahim Vinita Sharma None Pragati Yadav Afsana Parveen Adarsh Kumar Joy Roy Vinay Kumar Source Type: research
Rethinking underutilized cereal crops: pan-omics integration and green system biology
Planta. 2023 Sep 30;258(5):91. doi: 10.1007/s00425-023-04242-9.ABSTRACTDue to harsh lifestyle changes, in the present era, nutritional security is needed along with food security so it is necessary to include underutilized cereal crops (UCCs) in our daily diet to counteract the rising danger of human metabolic illness. We can attain both the goal of zero hunger and nutritional security by developing improved UCCs using advanced pan-omics (genomics, transcriptomics, proteomics, metabolomics, nutrigenomics, phenomics and ionomics) practices. Plant sciences research progressed profoundly since the last few decades with the in...
Source: Genomics Proteomics ... - September 30, 2023 Category: Genetics & Stem Cells Authors: Mohammed Saba Rahim Vinita Sharma None Pragati Yadav Afsana Parveen Adarsh Kumar Joy Roy Vinay Kumar Source Type: research
Rethinking underutilized cereal crops: pan-omics integration and green system biology
Planta. 2023 Sep 30;258(5):91. doi: 10.1007/s00425-023-04242-9.ABSTRACTDue to harsh lifestyle changes, in the present era, nutritional security is needed along with food security so it is necessary to include underutilized cereal crops (UCCs) in our daily diet to counteract the rising danger of human metabolic illness. We can attain both the goal of zero hunger and nutritional security by developing improved UCCs using advanced pan-omics (genomics, transcriptomics, proteomics, metabolomics, nutrigenomics, phenomics and ionomics) practices. Plant sciences research progressed profoundly since the last few decades with the in...
Source: Genomics Proteomics ... - September 30, 2023 Category: Genetics & Stem Cells Authors: Mohammed Saba Rahim Vinita Sharma None Pragati Yadav Afsana Parveen Adarsh Kumar Joy Roy Vinay Kumar Source Type: research
Rethinking underutilized cereal crops: pan-omics integration and green system biology
Planta. 2023 Sep 30;258(5):91. doi: 10.1007/s00425-023-04242-9.ABSTRACTDue to harsh lifestyle changes, in the present era, nutritional security is needed along with food security so it is necessary to include underutilized cereal crops (UCCs) in our daily diet to counteract the rising danger of human metabolic illness. We can attain both the goal of zero hunger and nutritional security by developing improved UCCs using advanced pan-omics (genomics, transcriptomics, proteomics, metabolomics, nutrigenomics, phenomics and ionomics) practices. Plant sciences research progressed profoundly since the last few decades with the in...
Source: Genomics Proteomics ... - September 30, 2023 Category: Genetics & Stem Cells Authors: Mohammed Saba Rahim Vinita Sharma None Pragati Yadav Afsana Parveen Adarsh Kumar Joy Roy Vinay Kumar Source Type: research
Aptamer-Based Proteomics Measuring Preoperative Cerebrospinal Fluid Protein Alterations Associated with Postoperative Delirium
Biomolecules. 2023 Sep 15;13(9):1395. doi: 10.3390/biom13091395.ABSTRACTDelirium is a common postoperative complication among older patients with many adverse outcomes. Due to a lack of validated biomarkers, prediction and monitoring of delirium by biological testing is not currently feasible. Circulating proteins in cerebrospinal fluid (CSF) may reflect biological processes causing delirium. Our goal was to discover and investigate candidate protein biomarkers in preoperative CSF that were associated with the development of postoperative delirium in older surgical patients. We employed a nested case-control study design c...
Source: Genomics Proteomics ... - September 28, 2023 Category: Genetics & Stem Cells Authors: Simon T Dillon Sarinnapha M Vasunilashorn Hasan H Otu Long Ngo Tamara Fong Xuesong Gu Michele Cavallari Alexandra Touroutoglou Mouhsin Shafi Sharon K Inouye Zhongcong Xie Edward R Marcantonio Towia A Libermann Source Type: research
Improvements in Gut Microbiome Composition Predict the Clinical Efficacy of a Novel Synbiotics Formula in Children with Mild to Moderate Atopic Dermatitis
Microorganisms. 2023 Aug 28;11(9):2175. doi: 10.3390/microorganisms11092175.ABSTRACTAtopic dermatitis (AD) is a common chronic inflammatory skin disease with a significant association with various type-2 inflammation-related comorbidities. Ongoing research suggests the crucial involvement of gut microbiome, especially in childhood onset AD, and hence, probiotics have emerged as a potential non-steroid-based therapeutics option to complement existing AD management plans. In order to delineate the impact of probiotics in the gut microbiome of pediatric AD patients from southern China, targeted 16S rRNA sequencing and thoroug...
Source: Genomics Proteomics ... - September 28, 2023 Category: Genetics & Stem Cells Authors: Chi Tung Choy Pui Ling Kella Siu Junwei Zhou Chi Ho Wong Yuk Wai Lee Ho Wang Chan Joseph Chi Ching Tsui Claudia Jun Yi Lo Steven King Fan Loo Stephen Kwok Wing Tsui Source Type: research
Aptamer-Based Proteomics Measuring Preoperative Cerebrospinal Fluid Protein Alterations Associated with Postoperative Delirium
Biomolecules. 2023 Sep 15;13(9):1395. doi: 10.3390/biom13091395.ABSTRACTDelirium is a common postoperative complication among older patients with many adverse outcomes. Due to a lack of validated biomarkers, prediction and monitoring of delirium by biological testing is not currently feasible. Circulating proteins in cerebrospinal fluid (CSF) may reflect biological processes causing delirium. Our goal was to discover and investigate candidate protein biomarkers in preoperative CSF that were associated with the development of postoperative delirium in older surgical patients. We employed a nested case-control study design c...
Source: Genomics Proteomics ... - September 28, 2023 Category: Genetics & Stem Cells Authors: Simon T Dillon Sarinnapha M Vasunilashorn Hasan H Otu Long Ngo Tamara Fong Xuesong Gu Michele Cavallari Alexandra Touroutoglou Mouhsin Shafi Sharon K Inouye Zhongcong Xie Edward R Marcantonio Towia A Libermann Source Type: research
Improvements in Gut Microbiome Composition Predict the Clinical Efficacy of a Novel Synbiotics Formula in Children with Mild to Moderate Atopic Dermatitis
Microorganisms. 2023 Aug 28;11(9):2175. doi: 10.3390/microorganisms11092175.ABSTRACTAtopic dermatitis (AD) is a common chronic inflammatory skin disease with a significant association with various type-2 inflammation-related comorbidities. Ongoing research suggests the crucial involvement of gut microbiome, especially in childhood onset AD, and hence, probiotics have emerged as a potential non-steroid-based therapeutics option to complement existing AD management plans. In order to delineate the impact of probiotics in the gut microbiome of pediatric AD patients from southern China, targeted 16S rRNA sequencing and thoroug...
Source: Genomics Proteomics ... - September 28, 2023 Category: Genetics & Stem Cells Authors: Chi Tung Choy Pui Ling Kella Siu Junwei Zhou Chi Ho Wong Yuk Wai Lee Ho Wang Chan Joseph Chi Ching Tsui Claudia Jun Yi Lo Steven King Fan Loo Stephen Kwok Wing Tsui Source Type: research
