Plasma proteins and persistent post-surgical pelvic pain among adolescents and young adults with endometriosis
CONCLUSION: Using an aptamer-based proteomics platform, we identified plasma proteins and pathways associated with worsening or persistent pelvic pain post-surgical treatment of endometriosis among adolescents and young adults that may aid in risk stratification of individuals with endometriosis.PMID:38462144 | DOI:10.1016/j.ajog.2024.03.005 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - March 10, 2024 Category: Genetics & Stem Cells Authors: Naoko Sasamoto Long Ngo Allison F Vitonis Simon T Dillon Pooja Prasad Marc R Laufer Sawsan As-Sanie Andrew Schrepf Stacey A Missmer Towia A Libermann Kathryn L Terry Source Type: research
Exploration of potential immune mechanisms in cervical dystonia
CONCLUSIONS: Altogether, the association of CD with multiple different blood-based immune measures point to abnormalities in cell-mediated immunity that may play a pathogenic role for a subgroup of individuals with CD.PMID:38462403 | DOI:10.1016/j.parkreldis.2024.106036 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - March 10, 2024 Category: Genetics & Stem Cells Authors: Laura M Scorr Gamze Kilic-Berkmen Diane J Sutcliffe Ashok R Dinasarapu J Lucas McKay Pritha Bagchi Michael D Powell Jeremy M Boss Nezih Cereb Marian Little Loren Gragert John Hanfelt Andrew McKeon William Tyor H A Jinnah Source Type: research
Plasma proteins and persistent post-surgical pelvic pain among adolescents and young adults with endometriosis
CONCLUSION: Using an aptamer-based proteomics platform, we identified plasma proteins and pathways associated with worsening or persistent pelvic pain post-surgical treatment of endometriosis among adolescents and young adults that may aid in risk stratification of individuals with endometriosis.PMID:38462144 | DOI:10.1016/j.ajog.2024.03.005 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - March 10, 2024 Category: Genetics & Stem Cells Authors: Naoko Sasamoto Long Ngo Allison F Vitonis Simon T Dillon Pooja Prasad Marc R Laufer Sawsan As-Sanie Andrew Schrepf Stacey A Missmer Towia A Libermann Kathryn L Terry Source Type: research
Exploration of potential immune mechanisms in cervical dystonia
CONCLUSIONS: Altogether, the association of CD with multiple different blood-based immune measures point to abnormalities in cell-mediated immunity that may play a pathogenic role for a subgroup of individuals with CD.PMID:38462403 | DOI:10.1016/j.parkreldis.2024.106036 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - March 10, 2024 Category: Genetics & Stem Cells Authors: Laura M Scorr Gamze Kilic-Berkmen Diane J Sutcliffe Ashok R Dinasarapu J Lucas McKay Pritha Bagchi Michael D Powell Jeremy M Boss Nezih Cereb Marian Little Loren Gragert John Hanfelt Andrew McKeon William Tyor H A Jinnah Source Type: research
Tutorial on survival modeling with applications to omics data
We present a general workflow for survival analysis that is applicable to high-dimensional omics data as inputs when identifying survival-associated features and validating survival models. In particular, we focus on the commonly used Cox-type penalized regressions and hierarchical Bayesian models for feature selection in survival analysis, which are are especially useful for high-dimensional data, but the framework is applicable more generally.AVAILABILITY AND IMPLEMENTATION: A step-by-step R tutorial using The Cancer Genome Atlas survival and omics data for the execution and evaluation of survival models has been made av...
Source: Genomics Proteomics ... - March 6, 2024 Category: Genetics & Stem Cells Authors: Zhi Zhao John Zobolas Manuela Zucknick Tero Aittokallio Source Type: research
Uncovering the secrets of resistance: An introduction to computational methods in infectious disease research
In conclusion, we emphasize the value of computational methods in understanding and combating AMR. Integration of experimental and computational approaches can expedite the discovery of innovative antimicrobial treatments and mitigate the threat posed by AMR.PMID:38448135 | DOI:10.1016/bs.apcsb.2023.11.004 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - March 6, 2024 Category: Genetics & Stem Cells Authors: Aditya K Padhi Shweata Maurya Source Type: research
Tutorial on survival modeling with applications to omics data
We present a general workflow for survival analysis that is applicable to high-dimensional omics data as inputs when identifying survival-associated features and validating survival models. In particular, we focus on the commonly used Cox-type penalized regressions and hierarchical Bayesian models for feature selection in survival analysis, which are are especially useful for high-dimensional data, but the framework is applicable more generally.AVAILABILITY AND IMPLEMENTATION: A step-by-step R tutorial using The Cancer Genome Atlas survival and omics data for the execution and evaluation of survival models has been made av...
Source: Genomics Proteomics ... - March 6, 2024 Category: Genetics & Stem Cells Authors: Zhi Zhao John Zobolas Manuela Zucknick Tero Aittokallio Source Type: research
Uncovering the secrets of resistance: An introduction to computational methods in infectious disease research
In conclusion, we emphasize the value of computational methods in understanding and combating AMR. Integration of experimental and computational approaches can expedite the discovery of innovative antimicrobial treatments and mitigate the threat posed by AMR.PMID:38448135 | DOI:10.1016/bs.apcsb.2023.11.004 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - March 6, 2024 Category: Genetics & Stem Cells Authors: Aditya K Padhi Shweata Maurya Source Type: research
Tutorial on survival modeling with applications to omics data
We present a general workflow for survival analysis that is applicable to high-dimensional omics data as inputs when identifying survival-associated features and validating survival models. In particular, we focus on the commonly used Cox-type penalized regressions and hierarchical Bayesian models for feature selection in survival analysis, which are are especially useful for high-dimensional data, but the framework is applicable more generally.AVAILABILITY AND IMPLEMENTATION: A step-by-step R tutorial using The Cancer Genome Atlas survival and omics data for the execution and evaluation of survival models has been made av...
Source: Genomics Proteomics ... - March 6, 2024 Category: Genetics & Stem Cells Authors: Zhi Zhao John Zobolas Manuela Zucknick Tero Aittokallio Source Type: research
Uncovering the secrets of resistance: An introduction to computational methods in infectious disease research
In conclusion, we emphasize the value of computational methods in understanding and combating AMR. Integration of experimental and computational approaches can expedite the discovery of innovative antimicrobial treatments and mitigate the threat posed by AMR.PMID:38448135 | DOI:10.1016/bs.apcsb.2023.11.004 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - March 6, 2024 Category: Genetics & Stem Cells Authors: Aditya K Padhi Shweata Maurya Source Type: research
Tutorial on survival modeling with applications to omics data
We present a general workflow for survival analysis that is applicable to high-dimensional omics data as inputs when identifying survival-associated features and validating survival models. In particular, we focus on the commonly used Cox-type penalized regressions and hierarchical Bayesian models for feature selection in survival analysis, which are are especially useful for high-dimensional data, but the framework is applicable more generally.AVAILABILITY AND IMPLEMENTATION: A step-by-step R tutorial using The Cancer Genome Atlas survival and omics data for the execution and evaluation of survival models has been made av...
Source: Genomics Proteomics ... - March 6, 2024 Category: Genetics & Stem Cells Authors: Zhi Zhao John Zobolas Manuela Zucknick Tero Aittokallio Source Type: research
CUL4A Ubiquitin Ligase Is an Independent Predictor of Overall Survival in Pancreatic Adenocarcinoma
CONCLUSION: Our findings implicate CUL4A, CDT1, CDC6 and MCM7 in PDAC progression and identify CUL4A as an independent prognostic factor for this disease.PMID:38423594 | PMC:PMC10905276 | DOI:10.21873/cgp.20438 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - February 29, 2024 Category: Genetics & Stem Cells Authors: Panagiotis Tavlas Sofia Nikou Christina Geramoutsou Pinelopi Bosgana Spyridon Champeris Tsaniras Maria Melachrinou Ioannis Maroulis Vasiliki Bravou Source Type: research
Impact of Tumor Grade Distribution on Genetic Alterations in Clear Cell Renal Cell Carcinoma and Prostate Cancer
CONCLUSION: Our results suggest the importance of selecting the maximum distribution of higher tumor grade areas to obtain results on the precise gene alterations for genomics-focused treatments.PMID:38423595 | PMC:PMC10905277 | DOI:10.21873/cgp.20441 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - February 29, 2024 Category: Genetics & Stem Cells Authors: Kosuke Mizutani Seiji Sugiyama Koji Kameyama Shingo Kamei Shigeaki Yokoi Akemi Morikawa Makoto Takeuchi Kensaku Seike Toru Yamada Hidetoshi Ehara Seiya Sawada Kouseki Hirade Hirohito Furuta Kengo Matsunaga Tetsuya Yamada Ippei Sakamoto Yasutaka Kato Hiros Source Type: research
Non-homologous End-joining Genotype, mRNA Expression, and DNA Repair Capacity in Childhood Acute Lymphocytic Leukemia
CONCLUSION: Our study identified significant associations between XRCC4 rs3734091, rs28360071, XRCC5 rs828907, and XRCC6 rs5751129 genotypes and childhood ALL. Notably, lower transcriptional expression and reduced precise NHEJ repair capacity were observed in patients carrying the C allele of XRCC6 rs5751129. Further investigations are required to gain deeper insights into childhood ALL development.PMID:38423600 | PMC:PMC10905275 | DOI:10.21873/cgp.20436 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - February 29, 2024 Category: Genetics & Stem Cells Authors: Chao-Chun Chen Wen-Shin Chang Jen-Sheng Pei Chien-Chung Kuo Chung-Hsing Wang Yun-Chi Wang Pei-Chen Hsu Jie-Long He Jian Gu DA-Tian Bau Chia-Wen Tsai Source Type: research
CUL4A Ubiquitin Ligase Is an Independent Predictor of Overall Survival in Pancreatic Adenocarcinoma
CONCLUSION: Our findings implicate CUL4A, CDT1, CDC6 and MCM7 in PDAC progression and identify CUL4A as an independent prognostic factor for this disease.PMID:38423594 | PMC:PMC10905276 | DOI:10.21873/cgp.20438 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - February 29, 2024 Category: Genetics & Stem Cells Authors: Panagiotis Tavlas Sofia Nikou Christina Geramoutsou Pinelopi Bosgana Spyridon Champeris Tsaniras Maria Melachrinou Ioannis Maroulis Vasiliki Bravou Source Type: research
