Screening for Circulating Inflammatory Proteins Does Not Reveal Plasma Biomarkers of Constant Tinnitus
DISCUSSION: Our results did not identify significant associations of the selected inflammatory proteins with constant tinnitus. Future studies examining longitudinal relations among those with more severe tinnitus and using more recent expanded proteomics platforms and sampling of cerebrospinal fluid could increase the likelihood of identifying relevant molecular biomarkers.PMID:38079022 | DOI:10.1007/s10162-023-00920-3 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - December 11, 2023 Category: Genetics & Stem Cells Authors: Christopher R Cederroth Mun-Gwan Hong Maxim B Freydin Niklas K Edvall Natalia Trpchevska Carlotta Jarach Winfried Schlee Jochen M Schwenk Jose-Antonio Lopez-Escamez Silvano Gallus Barbara Canlon Jan Bulla Frances M K Williams Source Type: research
Simulation-predicted and -explained inheritance model of pathogenicity confirmed by transgenic mice models
In this study, using molecular dynamics (MD) simulations, we showed that detached inner-wall N-terminal "plugs" aggregated to reduce the channel ion flow in a highly prevalent V37I variant in humans. To examine the predictive ability of the computational platform, an artificial mutant, V37M, of which the effect was previously unknown in hearing loss, was created. Microsecond simulations showed that homo-hexameric V37M Cx26 hemichannels had an abnormal affinity between the inner edge and N-termini to block the narrower side of the cone-shaped Cx26, while the most stable hetero-hexameric channels did not. From the perspectiv...
Source: Genomics Proteomics ... - December 11, 2023 Category: Genetics & Stem Cells Authors: Cheng-Yu Tsai Ying-Chang Lu Yen-Hui Chan Navaneethan Radhakrishnan Yuan-Yu Chang Shu-Wha Lin Tien-Chen Liu Chuan-Jen Hsu Pei-Lung Chen Lee-Wei Yang Chen-Chi Wu Source Type: research
Screening for Circulating Inflammatory Proteins Does Not Reveal Plasma Biomarkers of Constant Tinnitus
DISCUSSION: Our results did not identify significant associations of the selected inflammatory proteins with constant tinnitus. Future studies examining longitudinal relations among those with more severe tinnitus and using more recent expanded proteomics platforms and sampling of cerebrospinal fluid could increase the likelihood of identifying relevant molecular biomarkers.PMID:38079022 | DOI:10.1007/s10162-023-00920-3 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - December 11, 2023 Category: Genetics & Stem Cells Authors: Christopher R Cederroth Mun-Gwan Hong Maxim B Freydin Niklas K Edvall Natalia Trpchevska Carlotta Jarach Winfried Schlee Jochen M Schwenk Jose-Antonio Lopez-Escamez Silvano Gallus Barbara Canlon Jan Bulla Frances M K Williams Source Type: research
ROS-induced ribosome impairment underlies ZAK α-mediated metabolic decline in obesity and aging
Science. 2023 Dec 8;382(6675):eadf3208. doi: 10.1126/science.adf3208. Epub 2023 Dec 8.ABSTRACTThe ribotoxic stress response (RSR) is a signaling pathway in which the p38- and c-Jun N-terminal kinase (JNK)-activating mitogen-activated protein kinase kinase kinase (MAP3K) ZAKα senses stalling and/or collision of ribosomes. Here, we show that reactive oxygen species (ROS)-generating agents trigger ribosomal impairment and ZAKα activation. Conversely, zebrafish larvae deficient for ZAKα are protected from ROS-induced pathology. Livers of mice fed a ROS-generating diet exhibit ZAKα-activating changes in ribosomal elongation...
Source: Genomics Proteomics ... - December 7, 2023 Category: Genetics & Stem Cells Authors: Goda Snieckute Laura Ryder Anna Constance Vind Zhenzhen Wu Frederic Schr øder Arendrup Mark Stoneley S ébastien Chamois Ana Martinez-Val Marion Leleu Ren é Dreos Alexander Russell David Michael Gay Aitana Victoria Genzor Beatrice So-Yun Choi Astrid Lin Source Type: research
Genomic analysis reveals novel allergens of Blomia tropicalis
Allergol Int. 2023 Dec 6:S1323-8930(23)00116-8. doi: 10.1016/j.alit.2023.11.004. Online ahead of print.NO ABSTRACTPMID:38061933 | DOI:10.1016/j.alit.2023.11.004 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - December 7, 2023 Category: Genetics & Stem Cells Authors: Qing Xiong Xiaoyu Liu Angel Tsz-Yau Wan Nat Malainual Xiaojun Xiao Hui Cao Man-Fung Tang Judy Kin-Wing Ng Soo-Kyung Shin Yang Yie Sio Mingqiang Wang Baoqing Sun Ting-Fan Leung Fook Tim Chew Anchalee Tungtrongchitr Stephen Kwok-Wing Tsui Source Type: research
ROS-induced ribosome impairment underlies ZAK α-mediated metabolic decline in obesity and aging
Science. 2023 Dec 8;382(6675):eadf3208. doi: 10.1126/science.adf3208. Epub 2023 Dec 8.ABSTRACTThe ribotoxic stress response (RSR) is a signaling pathway in which the p38- and c-Jun N-terminal kinase (JNK)-activating mitogen-activated protein kinase kinase kinase (MAP3K) ZAKα senses stalling and/or collision of ribosomes. Here, we show that reactive oxygen species (ROS)-generating agents trigger ribosomal impairment and ZAKα activation. Conversely, zebrafish larvae deficient for ZAKα are protected from ROS-induced pathology. Livers of mice fed a ROS-generating diet exhibit ZAKα-activating changes in ribosomal elongation...
Source: Genomics Proteomics ... - December 7, 2023 Category: Genetics & Stem Cells Authors: Goda Snieckute Laura Ryder Anna Constance Vind Zhenzhen Wu Frederic Schr øder Arendrup Mark Stoneley S ébastien Chamois Ana Martinez-Val Marion Leleu Ren é Dreos Alexander Russell David Michael Gay Aitana Victoria Genzor Beatrice So-Yun Choi Astrid Lin Source Type: research
Genomic analysis reveals novel allergens of Blomia tropicalis
Allergol Int. 2023 Dec 6:S1323-8930(23)00116-8. doi: 10.1016/j.alit.2023.11.004. Online ahead of print.NO ABSTRACTPMID:38061933 | DOI:10.1016/j.alit.2023.11.004 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - December 7, 2023 Category: Genetics & Stem Cells Authors: Qing Xiong Xiaoyu Liu Angel Tsz-Yau Wan Nat Malainual Xiaojun Xiao Hui Cao Man-Fung Tang Judy Kin-Wing Ng Soo-Kyung Shin Yang Yie Sio Mingqiang Wang Baoqing Sun Ting-Fan Leung Fook Tim Chew Anchalee Tungtrongchitr Stephen Kwok-Wing Tsui Source Type: research
ROS-induced ribosome impairment underlies ZAK α-mediated metabolic decline in obesity and aging
Science. 2023 Dec 8;382(6675):eadf3208. doi: 10.1126/science.adf3208. Epub 2023 Dec 8.ABSTRACTThe ribotoxic stress response (RSR) is a signaling pathway in which the p38- and c-Jun N-terminal kinase (JNK)-activating mitogen-activated protein kinase kinase kinase (MAP3K) ZAKα senses stalling and/or collision of ribosomes. Here, we show that reactive oxygen species (ROS)-generating agents trigger ribosomal impairment and ZAKα activation. Conversely, zebrafish larvae deficient for ZAKα are protected from ROS-induced pathology. Livers of mice fed a ROS-generating diet exhibit ZAKα-activating changes in ribosomal elongation...
Source: Genomics Proteomics ... - December 7, 2023 Category: Genetics & Stem Cells Authors: Goda Snieckute Laura Ryder Anna Constance Vind Zhenzhen Wu Frederic Schr øder Arendrup Mark Stoneley S ébastien Chamois Ana Martinez-Val Marion Leleu Ren é Dreos Alexander Russell David Michael Gay Aitana Victoria Genzor Beatrice So-Yun Choi Astrid Lin Source Type: research
Genomic analysis reveals novel allergens of Blomia tropicalis
Allergol Int. 2023 Dec 6:S1323-8930(23)00116-8. doi: 10.1016/j.alit.2023.11.004. Online ahead of print.NO ABSTRACTPMID:38061933 | DOI:10.1016/j.alit.2023.11.004 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - December 7, 2023 Category: Genetics & Stem Cells Authors: Qing Xiong Xiaoyu Liu Angel Tsz-Yau Wan Nat Malainual Xiaojun Xiao Hui Cao Man-Fung Tang Judy Kin-Wing Ng Soo-Kyung Shin Yang Yie Sio Mingqiang Wang Baoqing Sun Ting-Fan Leung Fook Tim Chew Anchalee Tungtrongchitr Stephen Kwok-Wing Tsui Source Type: research
ROS-induced ribosome impairment underlies ZAK α-mediated metabolic decline in obesity and aging
Science. 2023 Dec 8;382(6675):eadf3208. doi: 10.1126/science.adf3208. Epub 2023 Dec 8.ABSTRACTThe ribotoxic stress response (RSR) is a signaling pathway in which the p38- and c-Jun N-terminal kinase (JNK)-activating mitogen-activated protein kinase kinase kinase (MAP3K) ZAKα senses stalling and/or collision of ribosomes. Here, we show that reactive oxygen species (ROS)-generating agents trigger ribosomal impairment and ZAKα activation. Conversely, zebrafish larvae deficient for ZAKα are protected from ROS-induced pathology. Livers of mice fed a ROS-generating diet exhibit ZAKα-activating changes in ribosomal elongation...
Source: Genomics Proteomics ... - December 7, 2023 Category: Genetics & Stem Cells Authors: Goda Snieckute Laura Ryder Anna Constance Vind Zhenzhen Wu Frederic Schr øder Arendrup Mark Stoneley S ébastien Chamois Ana Martinez-Val Marion Leleu Ren é Dreos Alexander Russell David Michael Gay Aitana Victoria Genzor Beatrice So-Yun Choi Astrid Lin Source Type: research
Genomic analysis reveals novel allergens of Blomia tropicalis
Allergol Int. 2023 Dec 6:S1323-8930(23)00116-8. doi: 10.1016/j.alit.2023.11.004. Online ahead of print.NO ABSTRACTPMID:38061933 | DOI:10.1016/j.alit.2023.11.004 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - December 7, 2023 Category: Genetics & Stem Cells Authors: Qing Xiong Xiaoyu Liu Angel Tsz-Yau Wan Nat Malainual Xiaojun Xiao Hui Cao Man-Fung Tang Judy Kin-Wing Ng Soo-Kyung Shin Yang Yie Sio Mingqiang Wang Baoqing Sun Ting-Fan Leung Fook Tim Chew Anchalee Tungtrongchitr Stephen Kwok-Wing Tsui Source Type: research
Comparative genomics and proteomics analysis of phages infecting multi-drug resistant Escherichia coli O177 isolated from cattle faeces
Sci Rep. 2023 Dec 5;13(1):21426. doi: 10.1038/s41598-023-48788-w.ABSTRACTThe increasing prevalence of antimicrobial-resistant (AMR) pathogens has become a major global health concern. To address this challenge, innovative strategies such as bacteriophage therapy must be optimised. Genomic characterisation is a crucial step in identifying suitable phage candidates for combating AMR pathogens. The aim of this study was to characterise seven phages that infect the Escherichia coli O177 strain using a whole genome sequencing. The analysis of genome sequences revealed that these phages had linear dsDNA, with genome sizes spanni...
Source: Genomics Proteomics ... - December 5, 2023 Category: Genetics & Stem Cells Authors: Peter Kotsoana Montso Andrew M Kropinski Fortunate Mokoena Rian Ewald Pierneef Victor Mlambo Collins Njie Ateba Source Type: research
Comparative genomics and proteomics analysis of phages infecting multi-drug resistant Escherichia coli O177 isolated from cattle faeces
Sci Rep. 2023 Dec 5;13(1):21426. doi: 10.1038/s41598-023-48788-w.ABSTRACTThe increasing prevalence of antimicrobial-resistant (AMR) pathogens has become a major global health concern. To address this challenge, innovative strategies such as bacteriophage therapy must be optimised. Genomic characterisation is a crucial step in identifying suitable phage candidates for combating AMR pathogens. The aim of this study was to characterise seven phages that infect the Escherichia coli O177 strain using a whole genome sequencing. The analysis of genome sequences revealed that these phages had linear dsDNA, with genome sizes spanni...
Source: Genomics Proteomics ... - December 5, 2023 Category: Genetics & Stem Cells Authors: Peter Kotsoana Montso Andrew M Kropinski Fortunate Mokoena Rian Ewald Pierneef Victor Mlambo Collins Njie Ateba Source Type: research
Phosphoglycerate-kinase-1 Is a Potential Prognostic Biomarker in HNSCC and Correlates With Immune Cell Infiltration
CONCLUSION: The current study reports that PGK1 expression was increased in HNSCC and that high PGK1 expression was closely associated with poor prognosis and immune cell infiltration, which could serve as a promising independent prognostic biomarker and potential immunotherapeutic target for HNSCC.PMID:38035710 | PMC:PMC10687726 | DOI:10.21873/cgp.20419 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 30, 2023 Category: Genetics & Stem Cells Authors: Ping Wang Yue-Yue Wang Yang-Long Xu Chun-Yu Zhang Kun Wang Qian Wang Source Type: research
Phosphoglycerate-kinase-1 Is a Potential Prognostic Biomarker in HNSCC and Correlates With Immune Cell Infiltration
CONCLUSION: The current study reports that PGK1 expression was increased in HNSCC and that high PGK1 expression was closely associated with poor prognosis and immune cell infiltration, which could serve as a promising independent prognostic biomarker and potential immunotherapeutic target for HNSCC.PMID:38035710 | PMC:PMC10687726 | DOI:10.21873/cgp.20419 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 30, 2023 Category: Genetics & Stem Cells Authors: Ping Wang Yue-Yue Wang Yang-Long Xu Chun-Yu Zhang Kun Wang Qian Wang Source Type: research
