ROS-induced ribosome impairment underlies ZAK α-mediated metabolic decline in obesity and aging
Science. 2023 Dec 8;382(6675):eadf3208. doi: 10.1126/science.adf3208. Epub 2023 Dec 8.ABSTRACTThe ribotoxic stress response (RSR) is a signaling pathway in which the p38- and c-Jun N-terminal kinase (JNK)-activating mitogen-activated protein kinase kinase kinase (MAP3K) ZAKα senses stalling and/or collision of ribosomes. Here, we show that reactive oxygen species (ROS)-generating agents trigger ribosomal impairment and ZAKα activation. Conversely, zebrafish larvae deficient for ZAKα are protected from ROS-induced pathology. Livers of mice fed a ROS-generating diet exhibit ZAKα-activating changes in ribosomal elongation...
Source: Genomics Proteomics ... - December 7, 2023 Category: Genetics & Stem Cells Authors: Goda Snieckute Laura Ryder Anna Constance Vind Zhenzhen Wu Frederic Schr øder Arendrup Mark Stoneley S ébastien Chamois Ana Martinez-Val Marion Leleu Ren é Dreos Alexander Russell David Michael Gay Aitana Victoria Genzor Beatrice So-Yun Choi Astrid Lin Source Type: research
Genomic analysis reveals novel allergens of Blomia tropicalis
Allergol Int. 2023 Dec 6:S1323-8930(23)00116-8. doi: 10.1016/j.alit.2023.11.004. Online ahead of print.NO ABSTRACTPMID:38061933 | DOI:10.1016/j.alit.2023.11.004 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - December 7, 2023 Category: Genetics & Stem Cells Authors: Qing Xiong Xiaoyu Liu Angel Tsz-Yau Wan Nat Malainual Xiaojun Xiao Hui Cao Man-Fung Tang Judy Kin-Wing Ng Soo-Kyung Shin Yang Yie Sio Mingqiang Wang Baoqing Sun Ting-Fan Leung Fook Tim Chew Anchalee Tungtrongchitr Stephen Kwok-Wing Tsui Source Type: research
Comparative genomics and proteomics analysis of phages infecting multi-drug resistant Escherichia coli O177 isolated from cattle faeces
Sci Rep. 2023 Dec 5;13(1):21426. doi: 10.1038/s41598-023-48788-w.ABSTRACTThe increasing prevalence of antimicrobial-resistant (AMR) pathogens has become a major global health concern. To address this challenge, innovative strategies such as bacteriophage therapy must be optimised. Genomic characterisation is a crucial step in identifying suitable phage candidates for combating AMR pathogens. The aim of this study was to characterise seven phages that infect the Escherichia coli O177 strain using a whole genome sequencing. The analysis of genome sequences revealed that these phages had linear dsDNA, with genome sizes spanni...
Source: Genomics Proteomics ... - December 5, 2023 Category: Genetics & Stem Cells Authors: Peter Kotsoana Montso Andrew M Kropinski Fortunate Mokoena Rian Ewald Pierneef Victor Mlambo Collins Njie Ateba Source Type: research
Comparative genomics and proteomics analysis of phages infecting multi-drug resistant Escherichia coli O177 isolated from cattle faeces
Sci Rep. 2023 Dec 5;13(1):21426. doi: 10.1038/s41598-023-48788-w.ABSTRACTThe increasing prevalence of antimicrobial-resistant (AMR) pathogens has become a major global health concern. To address this challenge, innovative strategies such as bacteriophage therapy must be optimised. Genomic characterisation is a crucial step in identifying suitable phage candidates for combating AMR pathogens. The aim of this study was to characterise seven phages that infect the Escherichia coli O177 strain using a whole genome sequencing. The analysis of genome sequences revealed that these phages had linear dsDNA, with genome sizes spanni...
Source: Genomics Proteomics ... - December 5, 2023 Category: Genetics & Stem Cells Authors: Peter Kotsoana Montso Andrew M Kropinski Fortunate Mokoena Rian Ewald Pierneef Victor Mlambo Collins Njie Ateba Source Type: research
Phosphoglycerate-kinase-1 Is a Potential Prognostic Biomarker in HNSCC and Correlates With Immune Cell Infiltration
CONCLUSION: The current study reports that PGK1 expression was increased in HNSCC and that high PGK1 expression was closely associated with poor prognosis and immune cell infiltration, which could serve as a promising independent prognostic biomarker and potential immunotherapeutic target for HNSCC.PMID:38035710 | PMC:PMC10687726 | DOI:10.21873/cgp.20419 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 30, 2023 Category: Genetics & Stem Cells Authors: Ping Wang Yue-Yue Wang Yang-Long Xu Chun-Yu Zhang Kun Wang Qian Wang Source Type: research
Phosphoglycerate-kinase-1 Is a Potential Prognostic Biomarker in HNSCC and Correlates With Immune Cell Infiltration
CONCLUSION: The current study reports that PGK1 expression was increased in HNSCC and that high PGK1 expression was closely associated with poor prognosis and immune cell infiltration, which could serve as a promising independent prognostic biomarker and potential immunotherapeutic target for HNSCC.PMID:38035710 | PMC:PMC10687726 | DOI:10.21873/cgp.20419 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 30, 2023 Category: Genetics & Stem Cells Authors: Ping Wang Yue-Yue Wang Yang-Long Xu Chun-Yu Zhang Kun Wang Qian Wang Source Type: research
Phosphoglycerate-kinase-1 Is a Potential Prognostic Biomarker in HNSCC and Correlates With Immune Cell Infiltration
CONCLUSION: The current study reports that PGK1 expression was increased in HNSCC and that high PGK1 expression was closely associated with poor prognosis and immune cell infiltration, which could serve as a promising independent prognostic biomarker and potential immunotherapeutic target for HNSCC.PMID:38035710 | PMC:PMC10687726 | DOI:10.21873/cgp.20419 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 30, 2023 Category: Genetics & Stem Cells Authors: Ping Wang Yue-Yue Wang Yang-Long Xu Chun-Yu Zhang Kun Wang Qian Wang Source Type: research
Phosphoglycerate-kinase-1 Is a Potential Prognostic Biomarker in HNSCC and Correlates With Immune Cell Infiltration
CONCLUSION: The current study reports that PGK1 expression was increased in HNSCC and that high PGK1 expression was closely associated with poor prognosis and immune cell infiltration, which could serve as a promising independent prognostic biomarker and potential immunotherapeutic target for HNSCC.PMID:38035710 | PMC:PMC10687726 | DOI:10.21873/cgp.20419 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - November 30, 2023 Category: Genetics & Stem Cells Authors: Ping Wang Yue-Yue Wang Yang-Long Xu Chun-Yu Zhang Kun Wang Qian Wang Source Type: research
OmicsSuite: a customized and pipelined suite for analysis and visualization of multi-omics big data
Hortic Res. 2023 Sep 28;10(11):uhad195. doi: 10.1093/hr/uhad195. eCollection 2023 Nov.ABSTRACTWith the advancements in high-throughput sequencing technologies such as Illumina, PacBio, and 10X Genomics platforms, and gas/liquid chromatography-mass spectrometry, large volumes of biological data in multiple formats can now be obtained through multi-omics analysis. Bioinformatics is constantly evolving and seeking breakthroughs to solve multi-omics problems; however, it is challenging for most experimental biologists to analyse data using command-line interfaces, coding, and scripting. Based on experience with multi-omics, we...
Source: Genomics Proteomics ... - November 29, 2023 Category: Genetics & Stem Cells Authors: Ben-Ben Miao Wei Dong Yi-Xin Gu Zhao-Fang Han Xuan Luo Cai-Huan Ke Wei-Wei You Source Type: research
OmicsSuite: a customized and pipelined suite for analysis and visualization of multi-omics big data
Hortic Res. 2023 Sep 28;10(11):uhad195. doi: 10.1093/hr/uhad195. eCollection 2023 Nov.ABSTRACTWith the advancements in high-throughput sequencing technologies such as Illumina, PacBio, and 10X Genomics platforms, and gas/liquid chromatography-mass spectrometry, large volumes of biological data in multiple formats can now be obtained through multi-omics analysis. Bioinformatics is constantly evolving and seeking breakthroughs to solve multi-omics problems; however, it is challenging for most experimental biologists to analyse data using command-line interfaces, coding, and scripting. Based on experience with multi-omics, we...
Source: Genomics Proteomics ... - November 29, 2023 Category: Genetics & Stem Cells Authors: Ben-Ben Miao Wei Dong Yi-Xin Gu Zhao-Fang Han Xuan Luo Cai-Huan Ke Wei-Wei You Source Type: research
Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia
CONCLUSIONS/INTERPRETATION: The present study provides a model of defective counterregulation in a mouse model of type 2 diabetes. It shows that repeated hypoglycaemic episodes induce multiple defects affecting all hypothalamic cell types and their interactions, indicative of impaired neuronal network signalling and dysegulated hypoglycaemia sensing, and displaying features of neurodegenerative diseases. It also shows that repeated hypoglycaemia leads to specific molecular adaptation in the hypothalamus when compared with the cortex.DATA AVAILABILITY: The transcriptomic dataset is available via the GEO ( http://www.ncbi.nl...
Source: Genomics Proteomics ... - November 28, 2023 Category: Genetics & Stem Cells Authors: Judit Castillo-Armengol Flavia Marzetta Ana Rodriguez Sanchez-Archidona Christian Fledelius Mark Evans Alison McNeilly Rory J McCrimmon Mark Ibberson Bernard Thorens Source Type: research
Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia
CONCLUSIONS/INTERPRETATION: The present study provides a model of defective counterregulation in a mouse model of type 2 diabetes. It shows that repeated hypoglycaemic episodes induce multiple defects affecting all hypothalamic cell types and their interactions, indicative of impaired neuronal network signalling and dysegulated hypoglycaemia sensing, and displaying features of neurodegenerative diseases. It also shows that repeated hypoglycaemia leads to specific molecular adaptation in the hypothalamus when compared with the cortex.DATA AVAILABILITY: The transcriptomic dataset is available via the GEO ( http://www.ncbi.nl...
Source: Genomics Proteomics ... - November 28, 2023 Category: Genetics & Stem Cells Authors: Judit Castillo-Armengol Flavia Marzetta Ana Rodriguez Sanchez-Archidona Christian Fledelius Mark Evans Alison McNeilly Rory J McCrimmon Mark Ibberson Bernard Thorens Source Type: research
CCR8 as a Therapeutic Novel Target: Omics-Integrated Comprehensive Analysis for Systematically Prioritizing Indications
In this study, we conducted an extensive bioinformatics analysis integrating genomics, proteomics, and transcriptomics data to establish CCR8 as a promising anti-cancer drug target. Our approach encompassed data collection from diverse knowledge resources, gene function analysis, differential gene expression profiling, immune cell infiltration assessment, and strategic prioritization of target indications. Our findings revealed strong correlations between CCR8 and specific cancers, notably Breast Invasive Carcinoma (BRCA), Colon Adenocarcinoma (COAD), Head and Neck Squamous Cell Carcinoma (HNSC), Rectum adenocarcinoma (REA...
Source: Genomics Proteomics ... - November 25, 2023 Category: Genetics & Stem Cells Authors: Nari Kim Mi-Hyun Kim Junhee Pyo Soo-Min Lee Ji-Sung Jang Do-Wan Lee Kyung Won Kim Source Type: research
CCR8 as a Therapeutic Novel Target: Omics-Integrated Comprehensive Analysis for Systematically Prioritizing Indications
In this study, we conducted an extensive bioinformatics analysis integrating genomics, proteomics, and transcriptomics data to establish CCR8 as a promising anti-cancer drug target. Our approach encompassed data collection from diverse knowledge resources, gene function analysis, differential gene expression profiling, immune cell infiltration assessment, and strategic prioritization of target indications. Our findings revealed strong correlations between CCR8 and specific cancers, notably Breast Invasive Carcinoma (BRCA), Colon Adenocarcinoma (COAD), Head and Neck Squamous Cell Carcinoma (HNSC), Rectum adenocarcinoma (REA...
Source: Genomics Proteomics ... - November 25, 2023 Category: Genetics & Stem Cells Authors: Nari Kim Mi-Hyun Kim Junhee Pyo Soo-Min Lee Ji-Sung Jang Do-Wan Lee Kyung Won Kim Source Type: research
CCR8 as a Therapeutic Novel Target: Omics-Integrated Comprehensive Analysis for Systematically Prioritizing Indications
In this study, we conducted an extensive bioinformatics analysis integrating genomics, proteomics, and transcriptomics data to establish CCR8 as a promising anti-cancer drug target. Our approach encompassed data collection from diverse knowledge resources, gene function analysis, differential gene expression profiling, immune cell infiltration assessment, and strategic prioritization of target indications. Our findings revealed strong correlations between CCR8 and specific cancers, notably Breast Invasive Carcinoma (BRCA), Colon Adenocarcinoma (COAD), Head and Neck Squamous Cell Carcinoma (HNSC), Rectum adenocarcinoma (REA...
Source: Genomics Proteomics ... - November 25, 2023 Category: Genetics & Stem Cells Authors: Nari Kim Mi-Hyun Kim Junhee Pyo Soo-Min Lee Ji-Sung Jang Do-Wan Lee Kyung Won Kim Source Type: research
