Biological evaluation of 1,3-benzodioxole acids points to 3,4-(methylenedioxy) cinnamic acid as a potential larvicide against Aedes aegypti (Diptera: Culicidae)
Exp Parasitol. 2023 Dec 1:108657. doi: 10.1016/j.exppara.2023.108657. Online ahead of print.ABSTRACTAedes aegypti serves as the primary vector for viruses like dengue, Chikungunya, Zika, and yellow fever, posing a significant public health challenge in Brazil. Given the absence of approved vaccines for these diseases, effective mosquito control becomes paramount in preventing outbreaks. However, currently available chemical insecticides face issues related to toxicity and the emergence of resistance, necessitating the exploration of new active compounds. Drawing inspiration from natural products, we identified the 1,3-benz...
Source: Experimental Parasitology - December 3, 2023 Category: Parasitology Authors: Mariza Severina de Lima Silva Marcilene Souza da Silva R ômulo Carlos Dantas da Cruz Bruno de Oliveira Veras Ivone Antonia de Souza Rafael Matos Ximenes Thiago Mendon ça de Aquino Alexandre Jos é da Silva Góes Source Type: research
Biological evaluation of 1,3-benzodioxole acids points to 3,4-(methylenedioxy) cinnamic acid as a potential larvicide against Aedes aegypti (Diptera: Culicidae)
Exp Parasitol. 2023 Dec 1:108657. doi: 10.1016/j.exppara.2023.108657. Online ahead of print.ABSTRACTAedes aegypti serves as the primary vector for viruses like dengue, Chikungunya, Zika, and yellow fever, posing a significant public health challenge in Brazil. Given the absence of approved vaccines for these diseases, effective mosquito control becomes paramount in preventing outbreaks. However, currently available chemical insecticides face issues related to toxicity and the emergence of resistance, necessitating the exploration of new active compounds. Drawing inspiration from natural products, we identified the 1,3-benz...
Source: Experimental Parasitology - December 3, 2023 Category: Parasitology Authors: Mariza Severina de Lima Silva Marcilene Souza da Silva R ômulo Carlos Dantas da Cruz Bruno de Oliveira Veras Ivone Antonia de Souza Rafael Matos Ximenes Thiago Mendon ça de Aquino Alexandre Jos é da Silva Góes Source Type: research
Biological evaluation of 1,3-benzodioxole acids points to 3,4-(methylenedioxy) cinnamic acid as a potential larvicide against Aedes aegypti (Diptera: Culicidae)
Exp Parasitol. 2023 Dec 1:108657. doi: 10.1016/j.exppara.2023.108657. Online ahead of print.ABSTRACTAedes aegypti serves as the primary vector for viruses like dengue, Chikungunya, Zika, and yellow fever, posing a significant public health challenge in Brazil. Given the absence of approved vaccines for these diseases, effective mosquito control becomes paramount in preventing outbreaks. However, currently available chemical insecticides face issues related to toxicity and the emergence of resistance, necessitating the exploration of new active compounds. Drawing inspiration from natural products, we identified the 1,3-benz...
Source: Experimental Parasitology - December 3, 2023 Category: Parasitology Authors: Mariza Severina de Lima Silva Marcilene Souza da Silva R ômulo Carlos Dantas da Cruz Bruno de Oliveira Veras Ivone Antonia de Souza Rafael Matos Ximenes Thiago Mendon ça de Aquino Alexandre Jos é da Silva Góes Source Type: research
Biological evaluation of 1,3-benzodioxole acids points to 3,4-(methylenedioxy) cinnamic acid as a potential larvicide against Aedes aegypti (Diptera: Culicidae)
Exp Parasitol. 2023 Dec 1:108657. doi: 10.1016/j.exppara.2023.108657. Online ahead of print.ABSTRACTAedes aegypti serves as the primary vector for viruses like dengue, Chikungunya, Zika, and yellow fever, posing a significant public health challenge in Brazil. Given the absence of approved vaccines for these diseases, effective mosquito control becomes paramount in preventing outbreaks. However, currently available chemical insecticides face issues related to toxicity and the emergence of resistance, necessitating the exploration of new active compounds. Drawing inspiration from natural products, we identified the 1,3-benz...
Source: Experimental Parasitology - December 3, 2023 Category: Parasitology Authors: Mariza Severina de Lima Silva Marcilene Souza da Silva R ômulo Carlos Dantas da Cruz Bruno de Oliveira Veras Ivone Antonia de Souza Rafael Matos Ximenes Thiago Mendon ça de Aquino Alexandre Jos é da Silva Góes Source Type: research
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice
Exp Parasitol. 2023 Nov 18;255:108655. doi: 10.1016/j.exppara.2023.108655. Online ahead of print.ABSTRACTIn previous studies, the artemisinin derivatives artemisone, its pro-drug artemiside and the bumped-kinase inhibitor BKI-1748 were effective against T. gondii via different modes of action. This suggests that they may act synergistically resulting in improved efficacies in vitro and in vivo. To test this hypothesis, the compounds were applied alone and in combination to T. gondii infected human fibroblast host cells in order to determine their inhibition constants and effects on cellular ultrastructure. In addition, the...
Source: Experimental Parasitology - November 19, 2023 Category: Parasitology Authors: Carling Schlange Joachim M üller Dennis Imhof Kai Pascal Alexander H änggeli Ghalia Boubaker Luis-Miguel Ortega-Mora Ho Ning Wong Richard K Haynes Wesley C Van Voorhis Andrew Hemphill Source Type: research
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice
Exp Parasitol. 2023 Nov 18;255:108655. doi: 10.1016/j.exppara.2023.108655. Online ahead of print.ABSTRACTIn previous studies, the artemisinin derivatives artemisone, its pro-drug artemiside and the bumped-kinase inhibitor BKI-1748 were effective against T. gondii via different modes of action. This suggests that they may act synergistically resulting in improved efficacies in vitro and in vivo. To test this hypothesis, the compounds were applied alone and in combination to T. gondii infected human fibroblast host cells in order to determine their inhibition constants and effects on cellular ultrastructure. In addition, the...
Source: Experimental Parasitology - November 19, 2023 Category: Parasitology Authors: Carling Schlange Joachim M üller Dennis Imhof Kai Pascal Alexander H änggeli Ghalia Boubaker Luis-Miguel Ortega-Mora Ho Ning Wong Richard K Haynes Wesley C Van Voorhis Andrew Hemphill Source Type: research
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice
Exp Parasitol. 2023 Nov 18;255:108655. doi: 10.1016/j.exppara.2023.108655. Online ahead of print.ABSTRACTIn previous studies, the artemisinin derivatives artemisone, its pro-drug artemiside and the bumped-kinase inhibitor BKI-1748 were effective against T. gondii via different modes of action. This suggests that they may act synergistically resulting in improved efficacies in vitro and in vivo. To test this hypothesis, the compounds were applied alone and in combination to T. gondii infected human fibroblast host cells in order to determine their inhibition constants and effects on cellular ultrastructure. In addition, the...
Source: Experimental Parasitology - November 19, 2023 Category: Parasitology Authors: Carling Schlange Joachim M üller Dennis Imhof Kai Pascal Alexander H änggeli Ghalia Boubaker Luis-Miguel Ortega-Mora Ho Ning Wong Richard K Haynes Wesley C Van Voorhis Andrew Hemphill Source Type: research
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice
Exp Parasitol. 2023 Nov 17:108655. doi: 10.1016/j.exppara.2023.108655. Online ahead of print.ABSTRACTIn previous studies, the artemisinin derivatives artemisone, its pro-drug artemiside and the bumped-kinase inhibitor BKI-1748 were effective against T. gondii via different modes of action. This suggests that they may act synergistically resulting in improved efficacies in vitro and in vivo. To test this hypothesis, the compounds were applied alone and in combination to T. gondii infected human fibroblast host cells in order to determine their inhibition constants and effects on cellular ultrastructure. In addition, the eff...
Source: Experimental Parasitology - November 19, 2023 Category: Parasitology Authors: Carling Schlange Joachim M üller Dennis Imhof Kai Pascal Alexander H änggeli Ghalia Boubaker Luis-Miguel Ortega-Mora Ho Ning Wong Richard K Haynes Wesley C Van Voorhis Andrew Hemphill Source Type: research
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice
Exp Parasitol. 2023 Nov 17:108655. doi: 10.1016/j.exppara.2023.108655. Online ahead of print.ABSTRACTIn previous studies, the artemisinin derivatives artemisone, its pro-drug artemiside and the bumped-kinase inhibitor BKI-1748 were effective against T. gondii via different modes of action. This suggests that they may act synergistically resulting in improved efficacies in vitro and in vivo. To test this hypothesis, the compounds were applied alone and in combination to T. gondii infected human fibroblast host cells in order to determine their inhibition constants and effects on cellular ultrastructure. In addition, the eff...
Source: Experimental Parasitology - November 19, 2023 Category: Parasitology Authors: Carling Schlange Joachim M üller Dennis Imhof Kai Pascal Alexander H änggeli Ghalia Boubaker Luis-Miguel Ortega-Mora Ho Ning Wong Richard K Haynes Wesley C Van Voorhis Andrew Hemphill Source Type: research
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice
Exp Parasitol. 2023 Nov 17:108655. doi: 10.1016/j.exppara.2023.108655. Online ahead of print.ABSTRACTIn previous studies, the artemisinin derivatives artemisone, its pro-drug artemiside and the bumped-kinase inhibitor BKI-1748 were effective against T. gondii via different modes of action. This suggests that they may act synergistically resulting in improved efficacies in vitro and in vivo. To test this hypothesis, the compounds were applied alone and in combination to T. gondii infected human fibroblast host cells in order to determine their inhibition constants and effects on cellular ultrastructure. In addition, the eff...
Source: Experimental Parasitology - November 19, 2023 Category: Parasitology Authors: Carling Schlange Joachim M üller Dennis Imhof Kai Pascal Alexander H änggeli Ghalia Boubaker Luis-Miguel Ortega-Mora Ho Ning Wong Richard K Haynes Wesley C Van Voorhis Andrew Hemphill Source Type: research
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice
Exp Parasitol. 2023 Nov 17:108655. doi: 10.1016/j.exppara.2023.108655. Online ahead of print.ABSTRACTIn previous studies, the artemisinin derivatives artemisone, its pro-drug artemiside and the bumped-kinase inhibitor BKI-1748 were effective against T. gondii via different modes of action. This suggests that they may act synergistically resulting in improved efficacies in vitro and in vivo. To test this hypothesis, the compounds were applied alone and in combination to T. gondii infected human fibroblast host cells in order to determine their inhibition constants and effects on cellular ultrastructure. In addition, the eff...
Source: Experimental Parasitology - November 19, 2023 Category: Parasitology Authors: Carling Schlange Joachim M üller Dennis Imhof Kai Pascal Alexander H änggeli Ghalia Boubaker Luis-Miguel Ortega-Mora Ho Ning Wong Richard K Haynes Wesley C Van Voorhis Andrew Hemphill Source Type: research
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice
Exp Parasitol. 2023 Nov 17:108655. doi: 10.1016/j.exppara.2023.108655. Online ahead of print.ABSTRACTIn previous studies, the artemisinin derivatives artemisone, its pro-drug artemiside and the bumped-kinase inhibitor BKI-1748 were effective against T. gondii via different modes of action. This suggests that they may act synergistically resulting in improved efficacies in vitro and in vivo. To test this hypothesis, the compounds were applied alone and in combination to T. gondii infected human fibroblast host cells in order to determine their inhibition constants and effects on cellular ultrastructure. In addition, the eff...
Source: Experimental Parasitology - November 19, 2023 Category: Parasitology Authors: Carling Schlange Joachim M üller Dennis Imhof Kai Pascal Alexander H änggeli Ghalia Boubaker Luis-Miguel Ortega-Mora Ho Ning Wong Richard K Haynes Wesley C Van Voorhis Andrew Hemphill Source Type: research
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice
Exp Parasitol. 2023 Nov 17:108655. doi: 10.1016/j.exppara.2023.108655. Online ahead of print.ABSTRACTIn previous studies, the artemisinin derivatives artemisone, its pro-drug artemiside and the bumped-kinase inhibitor BKI-1748 were effective against T. gondii via different modes of action. This suggests that they may act synergistically resulting in improved efficacies in vitro and in vivo. To test this hypothesis, the compounds were applied alone and in combination to T. gondii infected human fibroblast host cells in order to determine their inhibition constants and effects on cellular ultrastructure. In addition, the eff...
Source: Experimental Parasitology - November 19, 2023 Category: Parasitology Authors: Carling Schlange Joachim M üller Dennis Imhof Kai Pascal Alexander H änggeli Ghalia Boubaker Luis-Miguel Ortega-Mora Ho Ning Wong Richard K Haynes Wesley C Van Voorhis Andrew Hemphill Source Type: research
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice
Exp Parasitol. 2023 Nov 17:108655. doi: 10.1016/j.exppara.2023.108655. Online ahead of print.ABSTRACTIn previous studies, the artemisinin derivatives artemisone, its pro-drug artemiside and the bumped-kinase inhibitor BKI-1748 were effective against T. gondii via different modes of action. This suggests that they may act synergistically resulting in improved efficacies in vitro and in vivo. To test this hypothesis, the compounds were applied alone and in combination to T. gondii infected human fibroblast host cells in order to determine their inhibition constants and effects on cellular ultrastructure. In addition, the eff...
Source: Experimental Parasitology - November 19, 2023 Category: Parasitology Authors: Carling Schlange Joachim M üller Dennis Imhof Kai Pascal Alexander H änggeli Ghalia Boubaker Luis-Miguel Ortega-Mora Ho Ning Wong Richard K Haynes Wesley C Van Voorhis Andrew Hemphill Source Type: research
Development and evaluation of the in vitro schistosomicidal activity of solid dispersions based on 2-(-5-bromo-1-H-indole-3-yl-methylene)-N-(naphthalene-1-ylhydrazine-carbothiamide
Exp Parasitol. 2023 Nov 14:108626. doi: 10.1016/j.exppara.2023.108626. Online ahead of print.ABSTRACTAmong all the neglected diseases, schistosomiasis is considered the second most important parasitic infection after malaria. Praziquantel is the most widely used drug for this disease, but its exclusive use may result in the development of drug-resistant schistosomiasis. To increase the control of the disease, new drugs have been developed as alternative treatments, among them 2-(-5-bromo-1-h-indole-3-yl-methylene)-N-(naphthalene-1-ylhydrazine-carbothiamide (LQIT/LT-50), which showed promising schistosomicidal activity in n...
Source: Experimental Parasitology - November 16, 2023 Category: Parasitology Authors: Th âmara Carollyne de Luna Rocha Maria Joanellys Dos Santos Lima J éfferson Luan Nunes do Nascimento Jamerson Ferreira de Oliveira Emerson de Oliveira Silva Victor Hugo Barbosa Dos Santos Andr é de Lima Aires Victor de Albuquerque Wanderley Sales Talit Source Type: research
