Inhibition of carbonic anhydrase using aspirin is a novel method to block schistosomiasis infection of the parasitic trematode, Schistosoma mansoni, in the intermediate snail host, Biomphalaria glabrata
In this study, we investigated the role of CA inhibition in B. glabrata snails exposed to S. mansoni miracidia. We analyzed the expression of the B. glabrata CA encoding transcript in juvenile susceptible and resistant snails, with and without exposure to S. mansoni. Our results showed that the expression of the CA mRNA encoding transcript was upregulated during early and prolonged infection in susceptible snails (BBO2), but not in the resistant BS-90 stock. Notably, sodium salicylate, a form of aspirin, inhibited the expression of CA, post-exposure, to the parasite. Increasing research between parasites and cancer has sho...
Source: Experimental Parasitology - September 11, 2023 Category: Parasitology Authors: Simone Parn Gabriela Lewis Matty Knight Source Type: research
Biochemical characterization of a novel sphingomyelinase-like protein from the Rhipicephalus microplus tick
Exp Parasitol. 2023 Sep 9:108616. doi: 10.1016/j.exppara.2023.108616. Online ahead of print.ABSTRACTSphingomyelinase D is a toxin present in venomous spiders and bacteria and is associated with infection symptoms in patients affected by spider bites. It was observed that in Ixodes scapularis ticks, sphingomyelinase-like protein secreted in saliva can modulate the host immune response, affecting the transmission of flavivirus to the host via exosomes. In this work, a sphingomyelinase D-like protein (RmSMase) from R. microplus, a tick responsible for economic losses and a vector of pathogens for cattle, was investigated. The...
Source: Experimental Parasitology - September 11, 2023 Category: Parasitology Authors: Fernando A A Silva Gabriel C A Costa Lu ís F Parizi Itabajara da Silva Vaz Junior Aparecida S Tanaka Source Type: research
Inhibition of carbonic anhydrase using aspirin is a novel method to block schistosomiasis infection of the parasitic trematode, Schistosoma mansoni, in the intermediate snail host, Biomphalaria glabrata
In this study, we investigated the role of CA inhibition in B. glabrata snails exposed to S. mansoni miracidia. We analyzed the expression of the B. glabrata CA encoding transcript in juvenile susceptible and resistant snails, with and without exposure to S. mansoni. Our results showed that the expression of the CA mRNA encoding transcript was upregulated during early and prolonged infection in susceptible snails (BBO2), but not in the resistant BS-90 stock. Notably, sodium salicylate, a form of aspirin, inhibited the expression of CA, post-exposure, to the parasite. Increasing research between parasites and cancer has sho...
Source: Experimental Parasitology - September 11, 2023 Category: Parasitology Authors: Simone Parn Gabriela Lewis Matty Knight Source Type: research
Biochemical characterization of a novel sphingomyelinase-like protein from the Rhipicephalus microplus tick
Exp Parasitol. 2023 Sep 9:108616. doi: 10.1016/j.exppara.2023.108616. Online ahead of print.ABSTRACTSphingomyelinase D is a toxin present in venomous spiders and bacteria and is associated with infection symptoms in patients affected by spider bites. It was observed that in Ixodes scapularis ticks, sphingomyelinase-like protein secreted in saliva can modulate the host immune response, affecting the transmission of flavivirus to the host via exosomes. In this work, a sphingomyelinase D-like protein (RmSMase) from R. microplus, a tick responsible for economic losses and a vector of pathogens for cattle, was investigated. The...
Source: Experimental Parasitology - September 11, 2023 Category: Parasitology Authors: Fernando A A Silva Gabriel C A Costa Lu ís F Parizi Itabajara da Silva Vaz Junior Aparecida S Tanaka Source Type: research
Inhibition of carbonic anhydrase using aspirin is a novel method to block schistosomiasis infection of the parasitic trematode, Schistosoma mansoni, in the intermediate snail host, Biomphalaria glabrata
In this study, we investigated the role of CA inhibition in B. glabrata snails exposed to S. mansoni miracidia. We analyzed the expression of the B. glabrata CA encoding transcript in juvenile susceptible and resistant snails, with and without exposure to S. mansoni. Our results showed that the expression of the CA mRNA encoding transcript was upregulated during early and prolonged infection in susceptible snails (BBO2), but not in the resistant BS-90 stock. Notably, sodium salicylate, a form of aspirin, inhibited the expression of CA, post-exposure, to the parasite. Increasing research between parasites and cancer has sho...
Source: Experimental Parasitology - September 11, 2023 Category: Parasitology Authors: Simone Parn Gabriela Lewis Matty Knight Source Type: research
Biochemical characterization of a novel sphingomyelinase-like protein from the Rhipicephalus microplus tick
Exp Parasitol. 2023 Sep 9:108616. doi: 10.1016/j.exppara.2023.108616. Online ahead of print.ABSTRACTSphingomyelinase D is a toxin present in venomous spiders and bacteria and is associated with infection symptoms in patients affected by spider bites. It was observed that in Ixodes scapularis ticks, sphingomyelinase-like protein secreted in saliva can modulate the host immune response, affecting the transmission of flavivirus to the host via exosomes. In this work, a sphingomyelinase D-like protein (RmSMase) from R. microplus, a tick responsible for economic losses and a vector of pathogens for cattle, was investigated. The...
Source: Experimental Parasitology - September 11, 2023 Category: Parasitology Authors: Fernando A A Silva Gabriel C A Costa Lu ís F Parizi Itabajara da Silva Vaz Junior Aparecida S Tanaka Source Type: research
Changes in oxygen delivery during experimental models of cerebral malaria
Exp Parasitol. 2023 Sep 4:108608. doi: 10.1016/j.exppara.2023.108608. Online ahead of print.ABSTRACTCerebral malaria (CM) is a severe manifestation of malaria that commonly occurs in children and is hallmarked by neurologic symptoms and significant Plasmodium falciparum parasitemia. It is currently hypothesized that cerebral hypoperfusion from impaired microvascular oxygen transport secondary to parasitic occlusion of the microvasculature is responsible for cerebral ischemia and thus disease severity. Animal models to study CM, are known as experimental cerebral malaria (ECM), and include the C57BL/6J infected with Plasmod...
Source: Experimental Parasitology - September 6, 2023 Category: Parasitology Authors: Vinay P Jani Alexander T Williams Leonardo Carvalho Pedro Cabrales Source Type: research
Changes in oxygen delivery during experimental models of cerebral malaria
Exp Parasitol. 2023 Sep 4:108608. doi: 10.1016/j.exppara.2023.108608. Online ahead of print.ABSTRACTCerebral malaria (CM) is a severe manifestation of malaria that commonly occurs in children and is hallmarked by neurologic symptoms and significant Plasmodium falciparum parasitemia. It is currently hypothesized that cerebral hypoperfusion from impaired microvascular oxygen transport secondary to parasitic occlusion of the microvasculature is responsible for cerebral ischemia and thus disease severity. Animal models to study CM, are known as experimental cerebral malaria (ECM), and include the C57BL/6J infected with Plasmod...
Source: Experimental Parasitology - September 6, 2023 Category: Parasitology Authors: Vinay P Jani Alexander T Williams Leonardo Carvalho Pedro Cabrales Source Type: research
Changes in oxygen delivery during experimental models of cerebral malaria
Exp Parasitol. 2023 Sep 4:108608. doi: 10.1016/j.exppara.2023.108608. Online ahead of print.ABSTRACTCerebral malaria (CM) is a severe manifestation of malaria that commonly occurs in children and is hallmarked by neurologic symptoms and significant Plasmodium falciparum parasitemia. It is currently hypothesized that cerebral hypoperfusion from impaired microvascular oxygen transport secondary to parasitic occlusion of the microvasculature is responsible for cerebral ischemia and thus disease severity. Animal models to study CM, are known as experimental cerebral malaria (ECM), and include the C57BL/6J infected with Plasmod...
Source: Experimental Parasitology - September 6, 2023 Category: Parasitology Authors: Vinay P Jani Alexander T Williams Leonardo Carvalho Pedro Cabrales Source Type: research
Changes in oxygen delivery during experimental models of cerebral malaria
Exp Parasitol. 2023 Sep 4:108608. doi: 10.1016/j.exppara.2023.108608. Online ahead of print.ABSTRACTCerebral malaria (CM) is a severe manifestation of malaria that commonly occurs in children and is hallmarked by neurologic symptoms and significant Plasmodium falciparum parasitemia. It is currently hypothesized that cerebral hypoperfusion from impaired microvascular oxygen transport secondary to parasitic occlusion of the microvasculature is responsible for cerebral ischemia and thus disease severity. Animal models to study CM, are known as experimental cerebral malaria (ECM), and include the C57BL/6J infected with Plasmod...
Source: Experimental Parasitology - September 6, 2023 Category: Parasitology Authors: Vinay P Jani Alexander T Williams Leonardo Carvalho Pedro Cabrales Source Type: research
Anti-leishmanial, immunomodulatory and additive potential effect of Piperine on Leishmania major: The in silico and in vitro study of Piperine and its combination
CONCLUSIONS: The superior effectiveness of combination therapy on L. major warrants further investigations on the clinical potential of this combination in the treatment of leishmaniasis.PMID:37666407 | DOI:10.1016/j.exppara.2023.108607 (Source: Experimental Parasitology)
Source: Experimental Parasitology - September 4, 2023 Category: Parasitology Authors: Fatemeh Sharifi Neda Mohamadi Ali Afgar Razieh Tavakoli Oliaee Source Type: research
Increased susceptibility to encephalitozoonosis associated with mixed Th1/Th2 profile and M1/M2 profile in mice immunosuppressed with cyclophosphamide
Exp Parasitol. 2023 Sep 2:108606. doi: 10.1016/j.exppara.2023.108606. Online ahead of print.ABSTRACTEncephalitozoon cuniculi is a unicellular, spore-forming, obligate intracellular eukaryote belonging to the phylum Microsporidia. It is known to infect mainly immunocompromised and immunocompetent mammals, including humans. The parasite-host relationship has been evaluated using both in vitro cell culturing and animal models. For example, Balb/c and C57BL/6 mouse strains have been used interchangeably, although the latter has been considered more susceptible due to the higher fungal load observed after infection. In the pres...
Source: Experimental Parasitology - September 4, 2023 Category: Parasitology Authors: Amanda Miyuki Hidifira Anuska Marcelino Alvares-Saraiva Elizabeth Christina Perez Diva Denelle Spadacci-Morena Ronalda Silva de Araujo Maria Anete Lallo Source Type: research
Anti-leishmanial, immunomodulatory and additive potential effect of Piperine on Leishmania major: The in silico and in vitro study of Piperine and its combination
CONCLUSIONS: The superior effectiveness of combination therapy on L. major warrants further investigations on the clinical potential of this combination in the treatment of leishmaniasis.PMID:37666407 | DOI:10.1016/j.exppara.2023.108607 (Source: Experimental Parasitology)
Source: Experimental Parasitology - September 4, 2023 Category: Parasitology Authors: Fatemeh Sharifi Neda Mohamadi Ali Afgar Razieh Tavakoli Oliaee Source Type: research
Increased susceptibility to encephalitozoonosis associated with mixed Th1/Th2 profile and M1/M2 profile in mice immunosuppressed with cyclophosphamide
Exp Parasitol. 2023 Sep 2:108606. doi: 10.1016/j.exppara.2023.108606. Online ahead of print.ABSTRACTEncephalitozoon cuniculi is a unicellular, spore-forming, obligate intracellular eukaryote belonging to the phylum Microsporidia. It is known to infect mainly immunocompromised and immunocompetent mammals, including humans. The parasite-host relationship has been evaluated using both in vitro cell culturing and animal models. For example, Balb/c and C57BL/6 mouse strains have been used interchangeably, although the latter has been considered more susceptible due to the higher fungal load observed after infection. In the pres...
Source: Experimental Parasitology - September 4, 2023 Category: Parasitology Authors: Amanda Miyuki Hidifira Anuska Marcelino Alvares-Saraiva Elizabeth Christina Perez Diva Denelle Spadacci-Morena Ronalda Silva de Araujo Maria Anete Lallo Source Type: research
Anti-leishmanial, immunomodulatory and additive potential effect of Piperine on Leishmania major: The in silico and in vitro study of Piperine and its combination
CONCLUSIONS: The superior effectiveness of combination therapy on L. major warrants further investigations on the clinical potential of this combination in the treatment of leishmaniasis.PMID:37666407 | DOI:10.1016/j.exppara.2023.108607 (Source: Experimental Parasitology)
Source: Experimental Parasitology - September 4, 2023 Category: Parasitology Authors: Fatemeh Sharifi Neda Mohamadi Ali Afgar Razieh Tavakoli Oliaee Source Type: research
