Metabolic Changes after Radioiodine Correction of Grade 1 and Grade 2 Subclinical Hyperthyroidism
Conclusions: After correction of eSCH, increases in BMI and LDL levels were observed only in patients with grade 2 eSCH. Pretreatment serum TSH was the main independent factor associated with BMI changes after radioiodine treatment.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - January 25, 2021 Category: Endocrinology Source Type: research
2021 European Thyroid Association Guideline on Thyroid Disorders prior to and during Assisted Reproduction
Severe thyroid dysfunction may lead to menstrual disorders and subfertility. Fertility problems may persist even after restoring normal thyroid function, and then an assisted reproductive technology (ART) may be a solution. Prior to an ART treatment, ovarian stimulation is performed, leading to high oestradiol levels, which may lead to hypothyroidism in women with thyroid autoimmunity (TAI), necessitating levothyroxine (LT4) supplements before pregnancy. Moreover, women with the polycystic ovarian syndrome and idiopathic subfertility have a higher prevalence of TAI. Women with hypothyroidism treated with LT4 prior to ART s...
Source: European Thyroid Journal - January 21, 2021 Category: Endocrinology Source Type: research
Erratum
Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - December 17, 2020 Category: Endocrinology Source Type: research
Preliminary Pages
Eur Thyroid J 2020;9(suppl 1):I –IV (Source: European Thyroid Journal)
Source: European Thyroid Journal - December 15, 2020 Category: Endocrinology Source Type: research
Long-Term Outcomes of Tamoxifen Citrate Therapy and Histo- and Immunopathological Properties in Riedel Thyroiditis
Conclusion: Even though RT is suggested to be a member of IgG4-RD, serologic or histological evidence of IgG4 elevation or positivity is only useful for diagnosis and follow-up of RT. The diagnosis should be based on clinical and radiological evidence and confirmed by histopathology. GCs are effective for initial treatment, and TMX is a successful and safe therapeutic option for long-term maintenance therapy.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - December 8, 2020 Category: Endocrinology Source Type: research
Body Weight Changes in Hyperthyroidism: Timing and Possible Explanations during a One Year Repeated Measurement Study
Conclusion: In this study, treatment of hyperthyroidism was associated with marked increase in body weight in the patients. This increase correlated to a decrease in REE and only to a negligible extent to changes in energy efficiency and not at all to changes in physical activity level of daily living.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - December 2, 2020 Category: Endocrinology Source Type: research
Natural Course of the American Thyroid Association Response to Therapy Statuses (Dynamic Risk Stratification) in Differentiated Thyroid Cancer
Conclusions: The response to therapy at the initial evaluation is predictive of the long-term outcome. Most patients with the indeterminate response and some in the biochemically incomplete statuses spontaneously regress to an excellent status. Mortality and progression of DTC occur mostly in the structurally incomplete status.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - December 1, 2020 Category: Endocrinology Source Type: research
Ultrasound-Based Indications for Thyroid Fine-Needle Aspiration: Outcome of a TIRADS-Based Approach versus Operators ’ Expertise
Conclusions: Recommendations for FNA based on the investigators ’ US expertise demonstrated a better sensitivity for thyroid cancer in the 2 best prognostic groups, while TIRADS methodology showed superior specificity over the full prognostic range of cancers. Thus, personal experience provided more accurate diagnoses of malignancy, missing a lower number of s mall thyroid cancers, but the TIRADS approach resulted in a similar accuracy for the diagnosis of potentially aggressive lesions while sparing a relevant number of FNAs. Until it is not clearly stated what the goal of the US evaluation is, that is to diagnose all o...
Source: European Thyroid Journal - November 25, 2020 Category: Endocrinology Source Type: research
Investigating the Sources of Heterogeneity in Systematic Review of Recurrence Rate after Hemithyroidectomy for Low-Risk Well-Differentiated Thyroid Cancer
Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - November 25, 2020 Category: Endocrinology Source Type: research
Primary Squamous Cell Carcinoma of the Thyroid with Severe Tracheal Invasion: A Case Report
Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - November 25, 2020 Category: Endocrinology Source Type: research
Modulating TSH Receptor Signaling for Therapeutic Benefit
Autoimmune thyroid-stimulating antibodies are activating the thyrotropin receptor (TSHR) in both the thyroid and the eye, but different molecular mechanisms are induced in both organs, leading to Graves ’ disease (GD) and Graves’ orbitopathy (GO), respectively. Therapy with anti-thyroid drugs to reduce hyperthyroidism (GD) by suppressing the biosynthesis of thyroid hormones has only an indirect effect on GO, since it does not causally address pathogenic TSHR activation itself. GO is thus very d ifficult to treat. The activated TSHR but also the cross-interacting insulin-like growth factor 1 receptor (IGF-1R) contribute...
Source: European Thyroid Journal - November 23, 2020 Category: Endocrinology Source Type: research
Oxidative Stress in Graves Disease and Graves Orbitopathy
Oxidative stress is involved in the pathogenesis of Graves hyperthyroidism (GH) and Graves orbitopathy (GO) and an antioxidant approach has been proposed for both. In GH, a disbalance of the cell redox state is associated with thyroid hyperfunction and antithyroid medications may reduce oxidative stress. Tissue hypoxia participates in the pathogenesis of GO, and oxygen free radicals are involved in the typical changes of orbital tissues as reported by in vitro and clinical studies. Antioxidant agents, especially selenium, have been proposed as a therapeutic option for GH and GO. A clinical study regarding the use of seleni...
Source: European Thyroid Journal - November 20, 2020 Category: Endocrinology Source Type: research
Thyroidectomy in Pediatric Patients with Graves ’ Disease: A Systematic Review of Postoperative Morbidity
Conclusion: The results of this systematic review suggest that thyroidectomy is a safe treatment option for pediatric GD patients. The minority of patients will experience transient and benign morbidities, with hypocalcemia being the most common transient postoperative morbidity. Permanent postoperative morbidities are relatively rare.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - November 17, 2020 Category: Endocrinology Source Type: research
The Growth Kinetics of Collision Nodal Metastasis from Medullary and Papillary Thyroid Carcinomas: A Case Report
We report a 27-year-old male patient who had collision nodal metastases from PTC and sporadic MTC in the central compartment. This was treated with total thyroidectomy and central neck dissection. The collision nodal metastasis persisted and presented with a single sonographically enlarging central compartmental lymph node postoperatively. The volume of the collision nodal metastasis increased from 226 to 507 mm3 over the first 8 months, from 507 to 572 mm3 over the next 6 months, and from 572 to 762 mm3 over the next 31 months. The calcitonin and carcinoembryonic antigen (CEA) fluctuated in the first 19 months followed by...
Source: European Thyroid Journal - November 10, 2020 Category: Endocrinology Source Type: research
Microbiome and Graves ’ Orbitopathy
Background: Studies from animal models of autoimmunity have highlighted the potential importance of microorganisms and their metabolic products in shaping the immune system.Summary: This review provides an introduction to the current state-of-the-art in microbiome research both from the perspective of “what is known” and of methodologies for its investigation. It then summarises the evidence for a role for the microbiome in the pathogenesis of Graves’ disease and Graves’ orbitopathy with reference to animal models and studies in human cohorts, from both published and ongoing sources.Key Message: Microbiome research...
Source: European Thyroid Journal - November 5, 2020 Category: Endocrinology Source Type: research
