Cardiac Thyroid Hormone Metabolism and Heart Failure
The heart is a principal target of thyroid hormone, and a reduction of cardiac thyroid hormone signaling is thought to play a role in pathological ventricular remodeling and the development of heart failure. Studies in various rodent models of heart disease have identified increased activity of cardiac type III deiodinase as a possible cause of diminished levels and action of thyroid hormone. Recent data indicate novel mechanisms underlying the induction of this thyroid hormone-degrading enzyme in the heart as well as post-transcriptional regulation of its expression by microRNAs. In addition, the relevance of diminished t...
Source: European Thyroid Journal - April 25, 2017 Category: Endocrinology Source Type: research
Hypothyroid Patients Encoding Combined MCT10 and DIO2 Gene Polymorphisms May Prefer L-T3 + L-T4 Combination Treatment – Data Using a Blind, Randomized, Clinical Study
Conclusion: The present study indicates that the combination of polymorphisms inDIO2 (rs225014) andMCT10 (rs17606253) enhances hypothyroid patients ’ preference for L-T4 + L-T3 replacement therapy. In the future, combination therapy may be restricted or may be even recommended to individuals harbouring certain polymorphisms.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - April 25, 2017 Category: Endocrinology Source Type: research
Prolonged Duration of Surgery Predicts Postoperative Hypoparathyroidism among Patients Undergoing Total Thyroidectomy in a Tertiary Referral Centre
Conclusions: Transient and permanent hypoparathyroidism is common among patients undergoing total thyroidectomy in a tertiary referral centre. A duration of surgery #x3e;120 min constitutes an independent risk factor due to the risk of ischaemic damage. Regain of function of devascularized parathyroid glands must be expected to last at least 1 year postoperatively. Furthermore, the recovery of autotransplanted parathyroid glands should not be evaluated within 1 –3 months after surgery.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - April 25, 2017 Category: Endocrinology Source Type: research
Thyroid Autoimmunity and Thyroid Cancer: Review Focused on Cytological Studies
The association between Hashimoto thyroiditis (HT) and papillary thyroid carcinoma (PTC) has been originally suggested by retrospective pathological studies and has recently been re-evaluated and proposed on the basis of several fine-needle aspiration cytology (FNAC) studies. In FNAC studies, the association between HT and PTC is based on the comparison of anti-thyroid autoantibodies (ATA) (anti-thyroperoxidase [TPOAb] and anti-thyroglobulin [TgAb]), thyroid function (TSH), and cytology with histology of thyroid nodules and lymphocytic thyroid infiltration (LTI) of operated thyroid glands. Most of the pathological studies ...
Source: European Thyroid Journal - April 25, 2017 Category: Endocrinology Source Type: research
Tremelimumab-Induced Graves Hyperthyroidism
We report a case of tremelimumab-induced Graves hyperthyroidism in a 55-year-old man who was diagnosed with metastatic melanoma after 8 years of tremelimumab therapy. He had no personal or family history of thyroid or autoimmune diseases. His biochemical profile was in keeping with Graves disease, with raised serum free thyroid hormones, suppressed thyroid-stimulating hormone concentration, and raised thyrotropin receptor antibody level. He was treated with carbimazole as part of the block and replace therapy, without complications. Tremelimumab therapy was temporarily discontinued and recommenced when he was rendered bioc...
Source: European Thyroid Journal - April 19, 2017 Category: Endocrinology Source Type: research
Radioiodine Ablation following Thyroidectomy for Differentiated Thyroid Cancer: Literature Review of Utility, Dose, and Toxicity
Management recommendations for differentiated thyroid cancer are evolving. Total thyroidectomy is the backbone of curative-intent therapy, with radioiodine ablation (RAI) of the thyroid remnant routinely performed, in order to facilitate serologic surveillance and reduce recurrence risk. Several single-institution series have identified patient subsets for whom recurrence risk is sufficiently low that RAI may not be indicated. Further, the appropriate dose of RAI specific to variable clinicopathologic presentations remains poorly defined. While recent randomized trials demonstrated equivalent thyroid remnant ablation rates...
Source: European Thyroid Journal - April 19, 2017 Category: Endocrinology Source Type: research
TPOAb and Thyroid Function Are Not Associated with Breast Cancer Outcome: Evidence from a Large-Scale Study Using Data from the Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001)
Conclusions: No evidence for a prognostic role of TPOAb and/or thyroid function in moderate-to-high-risk early breast cancer was found in the largest and longest observational study to date.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - April 19, 2017 Category: Endocrinology Source Type: research
Serum miRNAs as Biomarkers for the Diagnosis and Prognosis of Thyroid Cancer: A Comprehensive Review of the Literature
Conclusions: Given that most common methods for the screening of thyroid cancer cannot detect the disease in its early stages, identifying miRNAs that are released in the bloodstream during the gradual progression of the disease is considered a key method in the early diagnosis of thyroid cancers.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - April 19, 2017 Category: Endocrinology Source Type: research
Lymph Node Metastases in Papillary and Medullary Thyroid Carcinoma Are Independent of Intratumoral Lymphatic Vessel Density
Background: Blood and lymph vessel invasion are well-recognized markers of tumor aggressiveness, as these are the routes that lead to metastases. Thyroid tumors, depending on the histological variant, tend to have distinctive biological behaviors and use different vascular routes to metastasize, yet the mechanisms underlying the metastatic process are still poorly understood.Objectives: The aim of this study was to assess how the lymph vessel density (LVD) in different histological types of thyroid tumors, and in their surrounding tissue, correlate with the presence of lymph node metastases (LNM) and tumor pathological fea...
Source: European Thyroid Journal - March 16, 2017 Category: Endocrinology Source Type: research
Nodular Thyroid Disease and Thyroid Cancer in the Era of Precision Medicine
We present here a commentary on some of the current challenges faced by endocrinologists in the field of thyroid nodules and cancer, and illustrate how precision medicine may improve their diagnostic and therapeutic capabilities in the future.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - March 2, 2017 Category: Endocrinology Source Type: research
Selenium in the Treatment of Thyroid Diseases
Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - February 28, 2017 Category: Endocrinology Source Type: research
Successful Pretreatment Using Plasma Exchange before Thyroidectomy in a Patient with Amiodarone-Induced Thyrotoxicosis
Conclusion: TPE is successful in rapidly restoring a clinical and biochemical euthyroid state, and may be used to decrease the perioperative risks associated with thyroidectomy in patients with life-threatening thyrotoxicosis or in cases refractory to medical treatment.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - February 17, 2017 Category: Endocrinology Source Type: research
The European Thyroid Journal Reaches Its Sixth Year of Publication with Honours
Eur Thyroid J 2017;6:1-2 (Source: European Thyroid Journal)
Source: European Thyroid Journal - February 8, 2017 Category: Endocrinology Source Type: research
The < b > < i > European Thyroid Journal < /i > < /b > Reaches Its Sixth Year of Publication with Honours
Eur Thyroid J 2017;6:1-2 (Source: European Thyroid Journal)
Source: European Thyroid Journal - February 7, 2017 Category: Endocrinology Source Type: research
A Novel Mutation in the TBG Gene Producing Partial Thyroxine-Binding Globulin Deficiency (Glencoe) Identified in 2 Families
Conclusions: We report a novel mutation in theTBG gene in 2 unrelated families that produces a molecule with reduced affinity for T4 resulting in low serum T4. However, the physical properties of the mutant molecule remained unaltered as determined by isoelectric focusing.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - February 2, 2017 Category: Endocrinology Source Type: research
