Trends in Diagnostics, Surgical Treatment, and Prognostic Factors for Outcomes in Medullary Thyroid Carcinoma in Norway: A Nationwide Population-Based Study
Conclusions: Preoperative diagnostics have improved over time with increased therapeutic control. A low ratio of metastatic and dissected lymph nodes predicts better outcomes in patients with metastatic lymph nodes.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - November 8, 2018 Category: Endocrinology Source Type: research
TRH Neurons and Thyroid Hormone Coordinate the Hypothalamic Response to Cold
Thyroid hormone (TH) plays a key role in regulating body temperature in mammals. Cold exposure stimulates the hypothalamus-pituitary-thyroid (HPT) axis at the hypothalamic level by activating hypophysiotropic thyrotropin-releasing hormone (TRH)-producing neurons, ultimately resulting in increased plasma TH concentrations. Importantly, the local TH metabolism within various cold-responsive organs enables tissue-specific action of TH on heat production and adaption to cold independently of the circulating TH levels. In addition to these neuroendocrine effects, TRH neurons in the hypothalamus also have neural connections with...
Source: European Thyroid Journal - October 31, 2018 Category: Endocrinology Source Type: research
The Impact of Esophageal Compression on Goiter Symptoms before and after Thyroid Surgery
Conclusions: In patients with goiter, thyroidectomy leads to substantial improvements in esophageal anatomy, as assessed by MRI, and this correlates with improved swallowing symptoms. This information is valuable in qualifying the dialogue with goiter patients, before deciding on the mode of therapy. Clinicaltrials.gov (NCT03072654).Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - October 17, 2018 Category: Endocrinology Source Type: research
A Case of Oculocutaneous Albinism in a Patient with Hashimoto ’s Thyroiditis
Discussion: In the majority of cases, OCA in Caucasians is caused by mutations in the tyrosinase gene. The tyrosinase peptide is normally expressed on the surface of melanocytes, although recent studies have shown its presence in thyroid follicular epithelial cells of patients with Hashimoto ’s thyroiditis. Therefore, although the mechanism is unclear, the present case report may suggest a pathogenetic link between OCA and Hashimoto’s thyroiditis.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - October 16, 2018 Category: Endocrinology Source Type: research
Differentiated Thyroid Cancer: How Do Current Practice Guidelines Affect Management?
Conclusions: Management of DTC at our institution closely adheres to contemporary clinical practice guidelines. The finding of more aggressive management in those requiring a personalised decision-making approach highlights the requirement for improved risk stratification in this cohort to ratio nalise management strategies.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - October 5, 2018 Category: Endocrinology Source Type: research
European Thyroid Association (ETA) and Thyroid Federation International (TFI) Joint Position Statement on the Interchangeability of Levothyroxine Products in EU Countries
Several European countries have seen major health issues after a switch from one levothyroxine brand to another, as well as following the introduction of several levothyroxine formulation changes. While the relationship between these health issues and brand or formulation changes merits further investigation, the current position statement on behalf of both health-care providers and patients summarizes recent events in several European countries and provides a number of recommendations to limit the burden for patients, so as to prevent increased health-care consumption and health-care expenses in this context.Eur Thyroid J...
Source: European Thyroid Journal - October 5, 2018 Category: Endocrinology Source Type: research
The Impact of Zoledronic Acid and Radioactive Iodine Therapy on Morbi-Mortality of Patients with Bone Metastases of Thyroid Cancer Derived from Follicular Cells
Conclusion: ZA can successfully diminish the chance of having new SRE and possibly affect OS in DTC patients with bone metastases. The positive impact of RAI adjuvant treatment on OS is directly associated with RAI uptake.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - October 5, 2018 Category: Endocrinology Source Type: research
Hypofractionated Radiotherapy for Anaplastic Thyroid Carcinoma: 15 Years of Experience in a Single Institution
Conclusions: Multivariate analysis showed that an EQD2≥50 Gy resulted in better OS, and hypofractionated radiotherapy decreased the rate of mortality from local recurrence.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - October 5, 2018 Category: Endocrinology Source Type: research
Association between Thyroid-Stimulating Hormone Levels and Non-Alcoholic Fatty Liver Disease Is Not Independent from Metabolic Syndrome Criteria
Conclusions: Although the TSH variability within the reference range is associated with NAFLD in univariable models, once adjusted for metabolic syndrome factors no significant association is noted.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - September 2, 2018 Category: Endocrinology Source Type: research
Poorly Differentiated Thyroid Carcinoma Patients with Detectable Thyroglobulin Levels after Initial Treatment Show an Increase in Mortality and Disease Recurrence
Conclusions: Our results suggest that detectable Tg levels after surgery and RAI in a subset of PDTC patients appear to predict a higher rate of death and recurrence.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - August 21, 2018 Category: Endocrinology Source Type: research
41st Annual Meeting of the European Thyroid Association
Eur Thyroid J 2018;7(suppl 1):I –IV (Source: European Thyroid Journal)
Source: European Thyroid Journal - August 16, 2018 Category: Endocrinology Source Type: research
Anti VEGF-TKI Treatment and New Renal Adverse Events Not Reported in Phase III Trials
In conclusion, these 2 c ases argue for increased awareness for the possibility of renal failure as a consequence of anti-VEFG treatment. Predisposing conditions like known mild chronic renal insufficiency with only mild proteinuria and with atherosclerosis or precipitating co-medications like zoledronate infusion need to b e accounted for to prevent these severe AEs.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - August 16, 2018 Category: Endocrinology Source Type: research
How Do We Improve the Impact of Iodine Deficiency Disorders Prevention in Europe and Beyond?
Conclusions: EUthyroid has taken steps towards achieving a euthyroid Europe. Our challenge is to inspire a greater sense of urgency in both policymakers and the wider public to address this remediable deficit caused by IDD.Eur Thyroid J 2018;7:1 –8 (Source: European Thyroid Journal)
Source: European Thyroid Journal - July 31, 2018 Category: Endocrinology Source Type: research
A 2018 Italian and Romanian Survey on Subclinical Hypothyroidism in Pregnancy
Conclusions: Respondents globally appeared well informed about the management of thyroid autoimmunity and subclinical hypothyroidism in pregnancy. A more aggressive attitude in implementing iodine supplementation would be desirable. Most endocrinologists were convinced about an evident association between mild thyroid impairment and adverse outcomes in pregnancy, thus using a TSH value of 2.5 mIU/L as the threshold for diagnosing hypothyroidism and starting levothyroxine in pregnant women.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - July 26, 2018 Category: Endocrinology Source Type: research
2018 European Thyroid Association Guideline for the Management of Graves ’ Hyperthyroidism
Graves ’ disease (GD) is a systemic autoimmune disorder characterized by the infiltration of thyroid antigen-specific T cells into thyroid-stimulating hormone receptor (TSH-R)-expressing tissues. Stimulatory autoantibodies (Ab) in GD activate the TSH-R leading to thyroid hyperplasia and unregulated thyro id hormone production and secretion. Diagnosis of GD is straightforward in a patient with biochemically confirmed thyrotoxicosis, positive TSH-R-Ab, a hypervascular and hypoechoic thyroid gland (ultrasound), and associated orbitopathy. In GD, measurement of TSH-R-Ab is recommended for an accurate di agnosis/differential ...
Source: European Thyroid Journal - July 25, 2018 Category: Endocrinology Source Type: research
