Immunoglobulin G4-Related Thyroid Diseases
Immunoglobulin G4-related disease (IgG4-RD) is a new disease category involving many organ systems, including the endocrine system in general and the thyroid in particular. Since an initial association was made between hypothyroidism and autoimmune (IgG4-related) pancreatitis, more forms of IgG4-related thyroid disease (IgG4-RTD) have been recognized. Four subcategories of IgG4-RTD have so far been identified: Riedel thyroiditis (RT), fibrosing variant of Hashimoto thyroiditis (FVHT), IgG4-related Hashimoto thyroiditis, and Graves disease with elevated IgG4 levels. Although a male predominance is seen for IgG4-RD in genera...
Source: European Thyroid Journal - December 2, 2016 Category: Endocrinology Source Type: research
Immunohistochemical Expression of Estrogen Receptor- α and Progesterone Receptor in Patients with Papillary Thyroid Cancer
Conclusions: The present study confirmed recent data indicating that ER- α and PR expression is a common finding in thyroid tumor tissue. However, in contrast to previous reports, we observed an association between ER-α expression and a more favorable outcome in PTC patients.Eur Thyroid J 2016;5:224-230 (Source: European Thyroid Journal)
Source: European Thyroid Journal - November 23, 2016 Category: Endocrinology Source Type: research
Pseudomalabsorption of Levothyroxine: A Challenge for the Endocrinologist in the Treatment of Hypothyroidism
Conclusions: Non-compliance with medical therapy should be considered in patients with treatment-refractory hypothyroidism. Supervised once weekly levothyroxine treatment is a safe and well-tolerated treatment option, obviating the need for parenteral administration of the drug. Apart from the medical treatment, there is also a need for psychiatric evaluation and care.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - November 23, 2016 Category: Endocrinology Source Type: research
Pre-Operative Lugol's Iodine Treatment in the Management of Patients Undergoing Thyroidectomy for Graves' Disease: A Review of the Literature
Conclusion: Having undertaken an extensive literature review, we are of the opinion that the evidence on which the American Thyroid Association's guidance on the use of preoperative Lugol's iodine is based is tenuous. There appears to be little in the way of sound clinical evidence that post-operative outcomes are any different following a course of Lugol's iodine. Given the lack of robust clinical evidence regarding the clinical need for iodine solution in the pre-operative period, it appears clear that a larger, prospective, randomised controlled trial of all relevant outcomes - clinical and scientific - is required to a...
Source: European Thyroid Journal - November 22, 2016 Category: Endocrinology Source Type: research
An Invitation to Join the Consortium on Thyroid and Pregnancy
Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - November 16, 2016 Category: Endocrinology Source Type: research
Thirty-Five Years of Thyroid Cancer Experience in a Paediatric Population: Incidence Trends in Lithuania between 1980 and 2014
The objectives of this study were to analyse the prevalence and incidence trends over 3 decades and clinical features of TC in the paediatric population in Lithuania.Methods: We reviewed all TC cases diagnosed in children aged less than 18 years during the period 1980-2014 using medical records from 3 main hospitals in Lithuania where such TC cases are managed.Results: During the 35-year period (1980-2014) there were 57 cases (45 females) of TC in children in Lithuania. The mean age at the time of diagnosis was 14.51 ± 0.52 years. The crude incidence rate of TC ranged from 0 to 0.93 cases per 100,000 children per year and...
Source: European Thyroid Journal - November 8, 2016 Category: Endocrinology Source Type: research
Association between Serum Thyroid-Stimulating Hormone Levels and Visceral Adipose Tissue: A Population-Based Study in Northeast Germany
Conclusions: No association between TSH and VAT was observed. Other biomarkers such as leptin may play a role in the relationship between thyroid function and metabolic risk.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - November 7, 2016 Category: Endocrinology Source Type: research
Medullary Thyroid Carcinoma - Distinction towards Neuroectodermal Tumours: Reply to the Letter by Paschou and Vryonidou
Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - November 1, 2016 Category: Endocrinology Source Type: research
Trends and Predictors of Chemotherapy Use among Thyroid Cancer Patients in the National Cancer Database (2004-2013)
Conclusions: Overall, chemotherapy use among MTCs increased marginally following the FDA's approval of MKIs in 2011, although their use remains very low. MKIs were infrequently used in metastatic DTCs in 2013. Future studies examining patterns of chemotherapy in thyroid cancer patients are warranted.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - October 20, 2016 Category: Endocrinology Source Type: research
Can the American Thyroid Association Risk of Recurrence Predict Radioiodine Refractory Disease in Differentiated Thyroid Cancer?
Conclusion: The TNM and ATA staging systems show no significant difference in predicting the development of RRD. RRD is less likely in stage I, II and low-risk patients. There is no correlation between the level or rate of Tg rise and a positive18F-FDG PET/CT scan.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - October 20, 2016 Category: Endocrinology Source Type: research
Origin of Thyroid C Cells: Clinical Interpretation
Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - October 19, 2016 Category: Endocrinology Source Type: research
Van Wyk-Grumbach Syndrome with Kocher-Debr é-Sémélaigne Syndrome: Case Report of a Rare Association
Conclusions: VWGS and KDSS are rare presentations of juvenile hypothyroidism, and their association is even rarer. Early diagnosis and prompt replacement therapy can avoid unnecessary investigations and surgical interventions.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - October 3, 2016 Category: Endocrinology Source Type: research
Patients with Multifocal Macroscopic Papillary Thyroid Carcinoma Have a Low Risk of Recurrence at Early Follow-Up after Total Thyroidectomy and Radioactive Iodine Treatment
Conclusions: Patients presenting with multifocal macroscopic papillary thyroid cancer without bulky nodal involvement or gross extrathyroidal extension have a low risk of thyroid cancer recurrence.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - October 3, 2016 Category: Endocrinology Source Type: research
Pregnant Greek Women May Have a Higher Prevalence of Iodine Deficiency than the General Greek Population
Background: Adequate dietary iodine consumption, predicted via the urinary iodine concentration (UIC), is necessary for normal thyroid function and for the neurodevelopment of fetuses and neonates. The general population of Greece is considered to be iodine sufficient, but our preliminary findings suggest that Greek pregnant women are at risk of iodine deficiency.Objective: Our aim was to estimate the thyroid function and UIC in a representative population of pregnant Greek women.Methods: UIC and thyroid function were assessed in 1,118 women from 19 representative areas of the country.Results: The median UIC was found to b...
Source: European Thyroid Journal - September 27, 2016 Category: Endocrinology Source Type: research
Minimizing the Health Effects of the Nuclear Accident in Fukushima on Thyroids
Results of the Screening of Thyroids: Because of the March 2011 nuclear accident in Fukushima, Japan, the Fukushima Prefecture initiated a thyroid ultrasound examination program. The first cycle of examinations on all children (more than 300,000) of the Fukushima Prefecture identified 116 patients as having malignant or suspected malignant thyroid nodules, and in the second cycle 59 new cases were identified. According to the available data, the thyroid cancers found by the screening are unlikely to be due to radiation, but the possibility cannot be excluded.Urgent Measures: The current thyroid ultrasound examination progr...
Source: European Thyroid Journal - September 22, 2016 Category: Endocrinology Source Type: research
