Calcitonin Levels in Thyroid Disease Are Not Affected by Autoimmune Thyroiditis or Differentiated Thyroid Carcinoma
Conclusions: AIT and DTC seem not to affect serum CT levels in patients with thyroid nodules. Therefore, hypercalcitoninemia, in these patients, should be submitted to the same diagnostic workup than patients without AIT or DTC.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - October 12, 2020 Category: Endocrinology Source Type: research

Efficacy of a Salt Iodization Program on Iodine Status and Intakes in Schoolchildren of S ão Miguel Island, Azores, Portugal
Conclusion: Five years after the implementation of the government salt iodization program, the mUIC increased from 70.9 to 106.7 μg/L. This study confirms the efficacy of the adopted measures in schoolchildren population.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - October 9, 2020 Category: Endocrinology Source Type: research

Disappearance of Anti-Thyroid Autoantibodies following Thymectomy in Patients with Myasthenia Gravis
Conclusions: Our findings suggest a role of the thymus in the maintenance of humoral thyroid autoimmunity.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - October 6, 2020 Category: Endocrinology Source Type: research

Sex-Specific Differences in Outcomes Following Thyroidectomy: A Population-Based Cohort Study
Conclusions: Male patients undergoing thyroidectomy have higher 30-day hospital readmission and ICU admission rates. Following surgery, male patients revealed higher rates of neck hematoma, while hypocalcemia was more frequent among female patients.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - September 30, 2020 Category: Endocrinology Source Type: research

Prevalence and Treatment Outcomes of Marine-Lenhart Syndrome in Japan
Conclusions: The prevalence of MLS among patients with Graves ’ disease was 0.26% in Japan. RAI therapy induces hypothyroidism more frequently than in those with AFTNs probably because RAI is taken up in the surrounding Graves’ tissues.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - September 30, 2020 Category: Endocrinology Source Type: research

Long-Term Outcome of Lobectomy for Thyroid Cancer
Conclusion: The outcome of thyroid cancer treated by lobectomy is very good, particularly for cancer ≤40 mm. A prolonged follow-up is required due to the risk of late recurrence.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - September 29, 2020 Category: Endocrinology Source Type: research

Cardiac Troponin Is Elevated in Patients with Thyrotoxicosis and Decreases as Thyroid Function Improves and Brain Natriuretic Peptide Levels Decrease
Conclusions: In thyrotoxicosis, the myocardial biomarker hsTnI is elevated in about 20% of patients; hsTnI levels decrease as thyroid function improves and BNP decreases.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - September 28, 2020 Category: Endocrinology Source Type: research

Proposal for Standardization of Primary and Secondary Outcomes in Patients with Active, Moderate-to-Severe Graves ’ Orbitopathy
Standardization of treatment outcomes in randomized clinical trials (RCTs) for active, moderate-to-severe Graves ’ orbitopathy (GO) is needed to make results of different RCTs comparable and to draw sound conclusions on the efficacy of a given treatment. Both subjective patient-reported outcome (PRO) and objective clinician-reported outcome (CRO) are important in this regard. In this paper, it is proposed th at primary PRO should be the evaluation of treatment-related changes in the quality of life by the use of a validated and disease-specific questionnaire (GO-QoL). The proposed primary CRO is a revised composite i...
Source: European Thyroid Journal - September 21, 2020 Category: Endocrinology Source Type: research

Reproducibility and Interobserver Agreement of Different Thyroid Imaging and Reporting Data Systems (TIRADS)
Conclusion: Despite the wide variability in the description of single ultrasonographic features, both Kw-TIRADS and EU-TIRADS may be a useful diagnostic tool in clinical practice.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - September 17, 2020 Category: Endocrinology Source Type: research

High Prevalence and Conservative Management of Acute Cholecystitis during Lenvatinib for Advanced Thyroid Cancer
Conclusions: In patients with RAI-R DTC treated with LEN, a high prevalence of AC in the first months of treatment was documented. Mainly due to the low specificity of symptoms such as anorexia, nausea, and vomiting, this AE is likely to be frequently misdiagnosed. The onset of the disease was associated to the weight loss observed during the first months of treatment and contributes to further decrease in body weight. Therefore, particularly during the first months of treatment, or at any time of huge reduction of body weight, monitoring of γGT and US is crucial for prompt diagnosis and treatment. Conservative medic...
Source: European Thyroid Journal - September 16, 2020 Category: Endocrinology Source Type: research

Benefits and Limitations of TKIs in Patients with Medullary Thyroid Cancer: A Systematic Review and Meta-Analysis
Conclusion: Treatment with TKIs in MTC patients with progressive disease is associated with a moderate therapeutic benefit, with achievement of either disease stability or partial response in 73%. The toxicity of these drugs is not negligible, but it is, nonetheless, manageable.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - September 11, 2020 Category: Endocrinology Source Type: research

Twentieth EUGOGO Anniversary Symposium
Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - September 8, 2020 Category: Endocrinology Source Type: research

High Prevalence of Hearing Impairment in Primary Congenital Hypothyroidism
Conclusions: Our findings indicate a high prevalence of HI among patients with CH, predominantly of the conductive type. HI was not associated with the etiology of CH or with delayed initiation of LT4 therapy. Audiometry is recommended for children diagnosed with CH and repeat monitoring may be warranted to identify acquired HI and to prevent long-term sequelae of undiagnosed deafness.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - September 3, 2020 Category: Endocrinology Source Type: research

Glycosylation of Anti-Thyroglobulin IgG1 and IgG4 Subclasses in Thyroid Diseases
Conclusion: Our study describes different distributions of TgAb IgG1 glycosylation in various thyroid diseases. The aberrantly increased glycosylation levels of TgAb IgG1 observed in HT, PTC, and PTC-T might be indicative of immune disorders and participate in the pathogenesis of these diseases.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - August 27, 2020 Category: Endocrinology Source Type: research

Medullary Thyroid Cancer Patient ’s Assessment of Quality of Life Tools: Results from the QaLM Study
Conclusions: MTC patients regardless of their performance status, disease aetiology and disease burden did not express a preference for any one particular questionnaire suggesting any of the tools studied could be utilized in this patient cohort. The least preferred questionnaire being a gastrointestinal NET specific tool suggests that diarrhoea was not a significant symptom and concern for the population studied.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - August 23, 2020 Category: Endocrinology Source Type: research

Macro-TSH: A Diagnostic Challenge
Conclusion: The patient harboured macro-TSH, which is a rare condition. The complex binding of TSH to other plasma proteins, most often immunoglobulins, results in elevated plasma TSH. However, the biologically active fraction of TSH is normal, reflected by clinical and biochemical euthyroidism.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - August 21, 2020 Category: Endocrinology Source Type: research

Usefulness of Color Doppler Ultrasonography in the Risk Stratification of Thyroid Nodules
Conclusions: Color Doppler study of thyroid nodules does not improve the risk stratification ability of the ACR TI-RADS US classification system.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - August 19, 2020 Category: Endocrinology Source Type: research

Multinational Survey of Treatment Practices of Clinicians Managing Subclinical Hypothyroidism in Older People in 2019
Conclusion: The majority of clinicians are aware of guidelines regarding management of SCH in older individuals. However, a considerable proportion of clinicians would still treat an older person with non-specific symptoms and mild SCH. These guidelines need to be disseminated more widely and more research is required to understand barriers to adherence to international recommendations.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - August 19, 2020 Category: Endocrinology Source Type: research

Dose-Dependent Influence of Antithyroid Drugs on the Difference in Free Thyroxine Levels between Mothers with Graves ’ Hyperthyroidism and Their Neonates
Conclusions: We found a dose-dependent influence of ATDs on the difference in serum FT4 levels between mothers with Graves ’ hyperthyroidism and their neonates. Further studies to evaluate the optimal target FT4 and FT3 levels for the mother and neonate during pregnancy may improve the outcome of pregnant women with Graves’ hyperthyroidism.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - August 19, 2020 Category: Endocrinology Source Type: research

Novel Approaches for Immunosuppression in Graves ’ Hyperthyroidism and Associated Orbitopathy
Background: Both Graves ’ hyperthyroidism (GH) and Graves’ orbitopathy (GO) are associated with significant adverse health consequences. All conventional treatment options have limitations regarding efficacy and safety. Most importantly, they do not specifically address the underlying immunological mechanisms. We aim t o review the latest development of treatment approaches in these two closely related disorders.Summary: Immunotherapies of GH have recently demonstrated clinical efficacy in preliminary studies. They include ATX-GD-59, an antigen-specific immunotherapy which restores immune tolerance to the thyro...
Source: European Thyroid Journal - August 10, 2020 Category: Endocrinology Source Type: research

Adherence to Active Surveillance and Clinical Outcomes in Patients with Indeterminate Thyroid Nodules Not Referred for Thyroidectomy
Conclusions: Most patients with initially unoperated B3/B4 nodules adhere, at least partially, to active surveillance. For B3 nodules, subsequent thyroidectomy and thyroid cancer detection are rare events, and patients may be safely managed without using molecular markers. Thyroid cancer is diagnosed in most B4 patients who undergo thyroidectomy in our institution.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - August 6, 2020 Category: Endocrinology Source Type: research

Analyzing the Role of DICER1 Germline Variations in Papillary Thyroid Carcinoma
We report 1 new germline possibly pathogenic variant, besides 15 others already been identified in ClinVar. We found that the DICER1-positive PTC group more frequently includes PTC variants, namely the oncocytic, follicular, and aggressive (hobnail variant of PTC) variants. A previous association of DICER1 had been demonstrated, mainly with the follicular variant of PTC and follicular thyroid carcinomas. Tumours harbouring germline DICER1 mutations were more frequently “bilateral” and “encapsulated.” The frequent association of DICER1 germline variants with other mutations associated with thyroid ca...
Source: European Thyroid Journal - August 6, 2020 Category: Endocrinology Source Type: research

Congenital Hypothyroidism due to a Low Level of Maternal Thyrotropin Receptor-Blocking Antibodies
Conclusion: We report herein a case of transient congenital hypothyroidism with a normal neonatal TRAbs level. In case of maternal TBAbs, similar activity of maternal TBAbs must be expected in the neonate, independently of the neonatal level of TRAbs.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - August 5, 2020 Category: Endocrinology Source Type: research

Recommendations on Surveillance for Differentiated Thyroid Carcinoma in Children with PTEN Hamartoma Tumor Syndrome
Conclusions: Children with PHTS are at increased risk for developing DTC, with 4 years being the youngest age reported at presentation and FTC being overrepresented. DTC in pediatric PHTS patients does not seem to be more aggressive than sporadic DTC.Recommendations: Surveillance for DTC in pediatric PHTS patients seems justified, as early diagnosis may decrease morbidity. Consensus within the study team was reached to recommend surveillance from the age of 10 years onwards, since at that age the incidence of DTC seems to reach 5%. Surveillance for DTC should consist of yearly neck palpation and triennial thyroid ultrasoun...
Source: European Thyroid Journal - July 28, 2020 Category: Endocrinology Source Type: research

A Novel Long-Term Graves ’ Disease Animal Model Confirmed by Functional Thyrotropin Receptor Antibodies
Conclusions: TBAb/TSAb were highly prevalent in Ad-TSHR-immunized mice, thus confirming the successful establishment of a novel, long-term murine model for GD. All TBAb- and TSAb-positive Ad-TSHR-immunized mice were TBII-positive. Thus, the binding immunoassay did not differentiate between TSHR-Ab functionality.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - July 23, 2020 Category: Endocrinology Source Type: research

Teprotumumab Treatment for Thyroid-Associated Ophthalmopathy
Background: Thyroid-associated ophthalmopathy (TAO), an autoimmune process affecting the tissues surrounding the eye, most commonly develops in individuals with Graves ’ disease. It is disfiguring, can cause vision loss, and dramatically lessens the quality of life in patients. There has been an absence of approved medical therapies for TAO with proven effectiveness and safety in multicenter, placebo-controlled, and adequately powered clinical trials.Summary: The following is a brief overview of the rationale for developing a monoclonal antibody inhibitor of the insulin-like growth factor-I receptor into a treatment ...
Source: European Thyroid Journal - July 13, 2020 Category: Endocrinology Source Type: research

Quality of Life during Treatment with Lenvatinib for Thyroid Cancer: The Patients ’ Perspective beyond the Medical Evaluation
Conclusion: RAI-R TC patients reported a general increase in prevalence and interference on daily activities of symptomatic AEs during therapy with LEN. Self-perceived QoL initially decreased during therapy. However, our data suggest that QoL could be restored after 12 months; this trend might partly reflect the impact of therapy optimisation.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - July 13, 2020 Category: Endocrinology Source Type: research

Effect of Thyroid Hormones on Adipose Tissue Flexibility
The recruitment and activation of energy-consuming brown adipocytes is currently considered as potential therapeutic approach to combat obesity. Thyroid hormones (TH) significantly contribute to full thermogenic capacity of brown adipocytes. A number of recent studies suggest that TH also induce the recruitment of brown adipocytes in white adipose depots, a process known as browning. In this review, we will summarize underlying mechanisms by which TH mediate brown adipose tissue activity and white adipose tissue browning. Furthermore, we will discuss the relevance of TH-induced white adipose tissue browning for thermoregul...
Source: European Thyroid Journal - July 9, 2020 Category: Endocrinology Source Type: research

Thyroid Hormones within the Normal Range and Cardiac Function in the General Population: The EPIPorto Study
Conclusions: Thyroid function within the reference range was associated with heart rate, blood pressure, cardiac structure, and function. Increasing thyroid function (lower TSH, higher FT4, or higher FT3) was associated with a higher heart rate, a lower diastolic blood pressure, and larger LV volumes. LV wall thickness and ejection fraction had a U-shaped association with thyroid hormones.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - July 8, 2020 Category: Endocrinology Source Type: research

The Protein Translocation Defect of MCT8 < sup > L291R < /sup > Is Rescued by Sodium Phenylbutyrate
Conclusion: NaPB is not only suitable for the treatment of mutations leading to misfolding and protein degradation, but also for a mutant wrongly sorted inside a cell which is otherwise functional.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - July 8, 2020 Category: Endocrinology Source Type: research

Predictive Factors for Changes in Quality of Life after Steroid Treatment for Active Moderate-to-Severe Graves ’ Orbitopathy: A Prospective Trial
Conclusions: Predictive factors for GO-QoL differed not only between the 2 subscales but also before and after the first treatment of GO.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - July 2, 2020 Category: Endocrinology Source Type: research

Therapeutic Equivalence of a New Preparation of Liquid Levothyroxine with Tablets in Patients with Overt Primary Hypothyroidism
Conclusions: In hypothyroid patients, the new liquid LT4 preparation (T4 ® drops) is therapeutically equivalent to the tablet form (T4® tablets).Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - June 23, 2020 Category: Endocrinology Source Type: research

Placing Thermal Ablation for Benign Thyroid Nodules into Context
Eur Thyroid J 2020;9:169 –171 (Source: European Thyroid Journal)
Source: European Thyroid Journal - June 15, 2020 Category: Endocrinology Source Type: research

Importance of Imaging Procedures in the Evaluation of Methotrexate-Associated Lymphoproliferative Disorder of the Thyroid Gland: A Case Study
Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - June 11, 2020 Category: Endocrinology Source Type: research

Oral Levothyroxine is an Effective Option for Myxedema Coma: A Single-Centre Experience
Conclusion: Oral LT4 is an effective treatment option for myxedema coma when intravenous LT4 is unavailable.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - June 11, 2020 Category: Endocrinology Source Type: research

2020 European Thyroid Association Clinical Practice Guideline for the Use of Image-Guided Ablation in Benign Thyroid Nodules
Standard therapeutic approaches for benign thyroid lesions that warrant intervention are surgery for cold and either surgery or radioiodine for autonomously functioning thyroid nodules (AFTN). Image-guided thermal ablation (TA) procedures are increasingly proposed as therapy options for selected clinical conditions. Due to mounting scientific evidence and widening availability, ETA considered it appropriate to develop guidelines for the use of TA in adult patients. TA procedures are well tolerated, but a dedicated training of the operators is required and information on possible complications needs to be shared with the pa...
Source: European Thyroid Journal - June 8, 2020 Category: Endocrinology Source Type: research

Palliative Electrochemotherapy Treatment of Cutaneous Metastases in a Patient with Advanced Thyroid Papillary Carcinoma
Advanced papillary thyroid carcinoma (PTC) with cutaneous metastases may cause pain, ulceration, and bleeding. Electrochemotherapy (ECT) is a minimally invasive treatment of tumors located in the skin and subcutaneous tissue. The electric pulses potentiate the toxicity of cytostatic agents entering the tumor cell. It is highly effective especially to relieve pain and improve the quality of life. The adverse events are local and transient. A case of progressive metastatic PTC who developed bleeding cutaneous metastases treated with ECT is described.Eur Thyroid J 2020;9:221 –224 (Source: European Thyroid Journal)
Source: European Thyroid Journal - June 5, 2020 Category: Endocrinology Source Type: research

New Impact for the Journal
Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - July 5, 2019 Category: Endocrinology Source Type: research

2019 European Thyroid Association Guidelines on the Management of Thyroid Dysfunction following Immune Reconstitution Therapy
Thyroid dysfunction (TD) frequently occurs as an autoimmune complication of immune reconstitution therapy (IRT), especially in individuals with multiple sclerosis treated with alemtuzumab, a pan-lymphocyte depleting drug with subsequent recovery of immune cell numbers. Less frequently, TD is triggered by highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV), or patients undergoing bone-marrow/hematopoietic-stem-cell transplantation (BMT/HSCT). In both alemtuzumab-induced TD and HIV/HAART patients, the commonest disorder is Graves ’ disease (GD), followed by hypothyr...
Source: European Thyroid Journal - July 4, 2019 Category: Endocrinology Source Type: research

Risk of Thyroid Cancer in 1,504 Patients Referred for Thyroid Surgery with Assumed Benign Histology
Conclusions: The risk of malignancy of 7.6% and 6.8% was high, considering that patients with malignant FNA, suspicious FNA, or clinical findings indicating malignancy were excluded, and 2.2% of these malignancies were stages T2 –4. In cases with solitary solid tumour on ultrasound, the risk of malignancy should not be ignored, even with benign FNA.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - June 26, 2019 Category: Endocrinology Source Type: research

Performance of ATA Risk Stratification Systems, Response to Therapy, and Outcome in an Indian Cohort of Differentiated Thyroid Carcinoma Patients: A Retrospective Study
Conclusion: This study found that both ATA RSS-2009 and ATA RTR-2015 are reliable in predicting outcome in DTC patients after initial treatment. However, the response to initial therapy at 1 year predicted outcome more accurately than the initial risk status.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - June 26, 2019 Category: Endocrinology Source Type: research

A Case of Unilateral Dermopathy Possibly Related to Graves ’ Disease
Discussion: The observation of a patient with a monolateral dermopathy somehow reports to the Kriss ’ hypothesis, especially in view of the patient’s habit of sleeping on the same side as dermopathy was present. Of course, this does not represent a proof that the Kriss’ hypothesis is correct, but it carries an element in favour of it. The fact that GO was bilateral is somehow against it, but does not exclude this possibility.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - June 11, 2019 Category: Endocrinology Source Type: research

Orbital Radioiodine Uptake on Scintigraphy in a Patient with Thyroid Cancer
Discussion: Ocular and orbital metastases from thyroid cancer, as well as some non-neoplastic disorders or contamination, are possible causes for131I uptake in the orbital region in scintigraphy. Conjunctival inclusion cyst is a condition associated with incidental131I uptake that had not been reported before and should be ruled out as a non-metastatic cause of orbital radioiodine uptake in patients with PTC.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - May 23, 2019 Category: Endocrinology Source Type: research

The Colorful Diversity of Thyroid Hormone Metabolites
Since the discovery of L-thyroxine, the main secretory product of the thyroid gland, and its major metabolite T3, which exerts the majority of thyroid hormone action via ligand-dependent modulation of the function of T3 receptors in nuclei, mitochondria, and other subcellular compartments, various other T4-derived endogenous metabolites have been identified in blood and tissues of humans, animals, and early protochordates. This review addresses major historical milestones and experimental findings resulting in the discovery of the key enzymes of thyroid hormone metabolism, the three selenoprotein deiodinases, as well as th...
Source: European Thyroid Journal - May 21, 2019 Category: Endocrinology Source Type: research

In Memoriam – Prof. Dr. Georg Hennemann, Internist (1932–2018)
Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - May 17, 2019 Category: Endocrinology Source Type: research

Prevalence of Undiagnosed Hypothyroidism in Europe: A Systematic Review and Meta-Analysis
Conclusions: The current evidence suggests that a considerable proportion of the European population has hypothyroidism, particularly subclinical hypothyroidism, which is undiagnosed. This issue deserves further investigation because of possible deleterious consequences for public health.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - May 17, 2019 Category: Endocrinology Source Type: research

Sex-Dependent Association between Weight Change and Thyroid Dysfunction: Population-Level Analysis Using the Korean National Health and Nutrition Examination Survey
Conclusions: This study highlights the necessity of performing thyroid function testing in women who complain of weight loss, but such testing may be less vital in women with weight gain or men with any changes in weight.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - May 14, 2019 Category: Endocrinology Source Type: research

The Role of Calcitonin in Predicting the Extent of Surgery in Medullary Thyroid Carcinoma: A Nationwide Population-Based Study in Norway
Conclusions: Basal calcitonin cannot predict the need for prophylactic lateral lymph node dissection in patients with MTC. Further prospective, randomized studies are warranted.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - May 5, 2019 Category: Endocrinology Source Type: research

The Use of the Iodine-Rich Drug Amiodarone in the Rapid Preoperative Preparation for Thyroidectomy because of Persistent Hyperthyroidism
Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - April 15, 2019 Category: Endocrinology Source Type: research

CA19-9 as a Predictor of Worse Clinical Outcome in Medullary Thyroid Carcinoma
Conclusion: CA19-9 might have a role as a prognostic factor in addition to calcitonin and carcinoembryonic antigen in metastatic MTC.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - April 3, 2019 Category: Endocrinology Source Type: research