Case Report: A Rare Association of Diffuse Thyroid Lipomatosis with Amyloid Deposition

We report a case of a 46-year-old man with 1-year history of progressive goiter enlargement with compressive symptoms. Imaging studies revealed multiple coalescent nodules. The patient underwent surgery, and the microscopic appearance revealed a diffuse infiltration of thyroid stroma by mature adipose tissue with associated amyloid deposition. A final diagnosis of diffuse lipomatosis of the thyroid gland was established. This patient represents one of the few reported cases of diffuse lipomatosis with coexisting deposition of amyloid protein of the thyroid gland and contributes to the better understanding of this extremely rare condition.Eur Thyroid J 2021;10:528 –532

Source: European Thyroid Journal - September 7, 2021 Category: Endocrinology Source Type: research