Microbiome and Graves ’ Orbitopathy

Background: Studies from animal models of autoimmunity have highlighted the potential importance of microorganisms and their metabolic products in shaping the immune system.Summary: This review provides an introduction to the current state-of-the-art in microbiome research both from the perspective of “what is known” and of methodologies for its investigation. It then summarises the evidence for a role for the microbiome in the pathogenesis of Graves’ disease and Graves’ orbitopathy with reference to animal models and studies in human cohorts, from both published and ongoing sources.Key Message: Microbiome research is in its infancy but has already provided novel insights into disease pathogenesis across the spectrum from cancer to mental health and autoimmunity.Eur Thyroid J
Source: European Thyroid Journal - Category: Endocrinology Source Type: research