Classical Clinical and Neuroimaging Findings in SMART (Stroke-Like Migraine Attacks after Radiation Therapy) Syndrome
Eur Neurol (Source: European Neurology)
Source: European Neurology - August 31, 2020 Category: Neurology Source Type: research
Progressive Multiple Sclerosis Transcriptome Deconvolution Indicates Increased M2 Macrophages in Inactive Lesions
Accumulating evidence suggests M2 macrophages contribute to tissue reparation and limit inflammation in multiple sclerosis (MS). However, most studies have focused on murine models without substantial support through human MS observations. The present study aimed to quantify the relative abundances of M2 macrophages in different lesion types excised from human MS patients. CIBERSORTx, an established RNA deconvolution algorithm, was applied on bulk RNA-sequencing data developed from 98 lesions from 10 progressive MS patients and 5 neuropathological control donors. A validated gene signature matrix for 22 human hematopoietic...
Source: European Neurology - August 28, 2020 Category: Neurology Source Type: research
Accelerated MR Evaluation of Patients with Suspected Large Arterial Vessel Occlusion: Diagnostic Performances of the FLAIR Vessel Hyperintensities
Conclusion: We found that FVH demonstrated excellent diagnostic performances for the identification of LVO and its level with good to excellent reproducibility. This MRI radio marker of occlusion provides additional arguments and may speed-up the detection of potential candidates for MT.Eur Neurol (Source: European Neurology)
Source: European Neurology - August 12, 2020 Category: Neurology Source Type: research
Egocentric and Allocentric Spatial Cognition in Amnestic Mild Cognitive Impairment and Early Alzheimer ’s Disease
Conclusion: Allocentric spatial cognition is selectively impaired in aMCI patients, while an egocentric spatial cognition is additionally impaired in AD patients.Eur Neurol (Source: European Neurology)
Source: European Neurology - August 12, 2020 Category: Neurology Source Type: research
HyperCKemia in Guillain-Barr é Syndrome
The aim of the present study was to investigate the frequency and clinical features of Guillain-Barr é syndrome (GBS) with hyperCKemia. We retrospectively identified 139 patients with GBS at 2 teaching hospitals in South Korea. We excluded patients with Miller-Fisher syndrome (n = 19), acute bulbar palsy (n = 3), and those whose serum creatine kinase (CK) levels were not measured (n = 45). Twelve of 72 patients (16.7%) had transient hyperCKemia, defined as serum CK ≥300 IU/L. The frequency of male sex and non-demyelinating electrodiagnostic features were higher in patients with hyperCKemia than those without. Transient ...
Source: European Neurology - August 12, 2020 Category: Neurology Source Type: research
Feasibility of a Cognitive Training Game in Parkinson ’s Disease: The Randomized Parkin’Play Study
Cognitive training (CT) shows modest positive effects on cognitive function in patients with Parkinson ’s disease (PD). Gamification may enhance adherence to traditional CT, but this has not been studied yet. Here, we investigated the feasibility of a gamified CT. We performed a randomized controlled trial including PD patients with mild cognitive impairment. Participants were randomly allocated to a 12-week home-based gamified CT intervention or waiting-list control group. Assessments were performed at baseline and at weeks 12 and 24. Forty-one patients were included (21 intervention and 20 waiting-list controls). Sixty...
Source: European Neurology - August 5, 2020 Category: Neurology Source Type: research
Cerebral Cavernous Malformations, Developmental Venous Anomaly, and Its Coexistence: A Review
Conclusion: Individual CCM or DVA lesions have a benign course; however, when they coexist in the same individual, the hemorrhagic risk is increased, which prompts for rapid diagnosis and treatment.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 30, 2020 Category: Neurology Source Type: research
Babinski, Bektherev, Cerletti, Head, and Hitzig: European Neurologists Nominated for the Nobel Prize 1901 –1950
Conclusion: Nobel Prize nominations constitute a lens through which credit and recognition around major contributions in neurology during the 20th century can be examined. They are unique sources that enable the reconstruction of both research trends in the field and the reputation of individual neurologists.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 30, 2020 Category: Neurology Source Type: research
Factors Influencing Health-Related Quality of Life of Patients with Multiple Sclerosis and Their Caregivers
Conclusion: Appropriate intervention should be directed particularly at older patients and caregivers who have faced the disease for longer time and at patients without any partner. Supporting the emotional and social well-being and mitigating the burden caused by symptoms of the patients as well as caregivers can improve the QoL of both groups.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 28, 2020 Category: Neurology Source Type: research
Headache and Osmophobia in Gas Station Workers Exposed to Gasoline Odor
Conclusions: Gas station workers diagnosed with migraine or TTH may experience osmophobia and headache triggered by the odor of gasoline.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 28, 2020 Category: Neurology Source Type: research
Ceasing Antiquated Conceptions: A Telling of the Early and Evolving History of Epilepsy
The wordepilepsy is derived from the Greek wordepilambanein, meaning “to seize.” This term came to embody the disease as early descriptions characterized seizures as events in which the faculties of the mind and body were “seized” from the individual. This notion of seizing the mind and body’s faculties has in essence remained a constant throughout the evol ution of epilepsy. The theories elucidating the significance of the event, however, have surely shifted with the times, reflecting an elegant battle among magic, science, and theology. Subsequent advents in clinical observation, diagnostic evaluation, and ther...
Source: European Neurology - July 27, 2020 Category: Neurology Source Type: research
Evaluation of Clinical Features and Stroke Etiology in Patients with Bilateral Middle Cerebellar Peduncle Infarction
Conclusion: BMCPI is a rare cerebrovascular disease characterized by vertigo, ataxia, and dysarthria, which may also be accompanied by a hearing deficit or clinical signs of brainstem damage. BMCPI may be associated with hypoperfusion secondary to occlusive disease of the bilateral VA or proximal basilar artery.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 24, 2020 Category: Neurology Source Type: research
Mild Encephalitis/Encephalopathy with a Reversible Isolated Splenial Lesion (MERS) in Adult Patients: A Small Case Series
Conclusion: In our study, the clinical features identified in all affected patients were mostly identical, which consisted of relatively mild CNS manifestations with a promising prognostic status.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 22, 2020 Category: Neurology Source Type: research
Loss of GFAP and Vimentin Does Not Affect Peri-Infarct Depolarizations after Focal Cerebral Ischemia
In conclusion, the 4-wavelength OIS system allows acquisition of high temporal-spatial resolution color images for analyzing temporal-spatial characteristics of PIDs in detail. GFAP and Vim in astrocytes are not involved in PIDs after MCAO in mice.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 21, 2020 Category: Neurology Source Type: research
Mesenchymal Stem Cells: A Potential Therapeutic Strategy for Neurodegenerative Diseases
Neurodegenerative disease is a kind of chronic, progressive nervous system disease characterized by neuron degeneration or apoptosis. Current treatments cannot prevent the development of the disease. Possible alternative treatments include cell therapy, especially with the use of mesenchymal stem cells (MSCs). MSCs are pluripotent stem cells with capacities for self-renewal and multidirectional differentiation. MSCs may serve as a reliable source of neural cells for potential cell replacement therapy or regenerative medicine treatment. Here, we summarized the therapeutic mechanisms of MSCs and how they can contribute to th...
Source: European Neurology - July 20, 2020 Category: Neurology Source Type: research
