Remote Ischemic Conditioning: A Potential Treatment for Chronic Cerebral Hypoperfusion
Background: Chronic cerebral hypoperfusion (CCH) is a clinical syndrome, which is characterized by significantly decreased cerebral blood flow (CBF). CCH is a common consequence of cerebrovascular and cardiovascular diseases and the elderly. CCH results in a series of pathological damages, increasing cell death, autophagy dysfunction, amyloid β (Aβ) peptide accumulation, blood-brain barrier (BBB) disruption, and endothelial damage, which are found in CCH models. In addition, CCH is a prominent risk factor of cognitive impairment, such as vascular dementia, and CCH contributes to the occurrence and development of Alzheime...
Source: European Neurology - February 1, 2022 Category: Neurology Source Type: research
Effectiveness of Calcitonin Gene-Related Peptide Receptor Antagonists for Migraine Treatment: A Meta-Analysis
Conclusions: CGRP receptor antagonists are effective for acute migraine treatment and are expected to be used clinically as emerging therapeutic agents.Eur Neurol (Source: European Neurology)
Source: European Neurology - January 31, 2022 Category: Neurology Source Type: research
The Novel microRNA Rno-miR-686-3p Is Associated with the Ischaemic Penumbra
Conclusion: rno-miR-686-3p is a novel miRNA associated with the ischaemic penumbra that is implicated in transcriptional regulation and modulation of the Wnt and cAMP signalling pathways. Furthermore, it may serve as a possible new biomarker with potential value for detecting the existence of the penumbra.Eur Neurol (Source: European Neurology)
Source: European Neurology - January 31, 2022 Category: Neurology Source Type: research
125 years of European Neurology
Eur Neurol (Source: European Neurology)
Source: European Neurology - January 27, 2022 Category: Neurology Source Type: research
Affection of Cranial Nerves in COVID-19 Patients Should Prompt Suspicion of Guillain-Barre Syndrome
Eur Neurol (Source: European Neurology)
Source: European Neurology - January 21, 2022 Category: Neurology Source Type: research
Susceptibility-Weighted MRI and Microbleeds in Mild Traumatic Brain Injury: Prediction of Posttraumatic Complaints?
Background: Only in 7 –15% of patients with mild traumatic brain injury (mTBI), traumatic CT-abnormalities are found. Nevertheless, 40% of mTBI patients suffer from posttraumatic complaints not resolving after 6 months. We discuss the ability of susceptibility-weighted imaging (SWI), sensitive for microbleeds, to detec t more subtle brain abnormalities.Summary: After a search on PubMed, we selected 15 studies on SWI in adult mTBI patients; 11 studies on 3T MRI, and 4 studies on 1.5T MRI. All 1.5T studies showed that, compared to T2, gradient echo, diffusion-weighted imaging, or fluid-attenuated inversion recovery sequenc...
Source: European Neurology - January 17, 2022 Category: Neurology Source Type: research
The Involvement of miRNAs in Pituitary Adenomas Pathogenesis and the Clinical Implications
Pituitary adenomas (PAs) account for the top three primary intracranial tumors in terms of total incidence rate. PAs can cause severe endocrine disorders and even malignant features, such as invasion, metastasis, and recurrence. Therefore, the early diagnosis and accurate prognosis would be greatly beneficial for clinical treatment of PAs. MicroRNAs (miRNAs) are small, protein-noncoding RNAs that regulate gene expression posttranscriptionally. They regulate essential physiological processes, including proliferation, growth, and apoptosis, and also they involve in the invasion and metastasis of malignant tumors. At the tiss...
Source: European Neurology - January 14, 2022 Category: Neurology Source Type: research
Uncovering of Key Pathways and miRNAs for Intracranial Aneurysm Based on Weighted Gene Co-Expression Network Analysis
Conclusion: Hub miRNAs and key signaling pathways were identified by bioinformatics analysis. This evidence lays the foundation for understanding the underlying molecular mechanisms of IA and provided potential therapeutic targets for the treatment of this disease.Eur Neurol (Source: European Neurology)
Source: European Neurology - January 14, 2022 Category: Neurology Source Type: research
From Discipline to Quality of Care: How Neurologists Can Learn from Decisions of Disciplinary Tribunals
Conclusion: Medical disciplinary cases in the field of neurology are usually about diagnosis- and treatment-related aspects. Recordkeeping, interpretation of neuroimaging, and involvement of several consultants frequently play a role in a complaint being upheld. It is important that specialties evaluate disciplinary decisions on a structural and continuous basis.Eur Neurol (Source: European Neurology)
Source: European Neurology - January 11, 2022 Category: Neurology Source Type: research
Do Patient/Doctor Benefits from Telephone/Electronic Contacts Exceed Those of Face-To-Face Visits?
Eur Neurol (Source: European Neurology)
Source: European Neurology - December 30, 2021 Category: Neurology Source Type: research
Identification of Novel Biomarkers in Platelets for Diagnosing Parkinson ’s Disease
Conclusion: Our findings demonstratedWASH5P,MALAT1,EEF1A1, andCTSS may be promising biomarkers in PD, which may contribute to improving the effectiveness and accuracy of diagnosis for PD in the future.Eur Neurol (Source: European Neurology)
Source: European Neurology - December 7, 2021 Category: Neurology Source Type: research
Efficacy of Intra-Arterial Thrombolysis for Acute Central Retinal Artery Occlusion: A Meta-Analysis
Conclusion: Our meta-analysis of available published data supports IAT to be an alternative treatment option for CRAO patients within 6 h from symptom onset.Eur Neurol (Source: European Neurology)
Source: European Neurology - November 30, 2021 Category: Neurology Source Type: research
Mechanical Thrombectomy with or without Intravenous Thrombolysis in Acute Ischemic Stroke: A Meta-Analysis for Randomized Controlled Trials
Conclusion: In this meta-analysis including 7 RCTs, MT had comparable consequences to bridging treatment in efficacy and safety outcomes for patients with ischemic stroke caused by the occlusion of proximal anterior circulation, irrespective of geographical location. These findings support the adoption of dMT in acute ischemic stroke treatments and have higher cost-effectiveness in global applications.Eur Neurol (Source: European Neurology)
Source: European Neurology - November 24, 2021 Category: Neurology Source Type: research
Shell Shock: The Response of UK Neurology
The neurological and psychological manifestations of trauma, confinement, and terror became apparent throughout Europe as soldiers were evacuated from the trenches of the Western Front. The response in the UK evolved as a result of the experience of medical staff embedded with the troops in base hospitals and the philosophy of those treating returned soldiers in specialist establishment. There were widely disparate approaches to the management encompassing simple supportive care, a psychanalytic approach and radical electric shock therapy. The latter was partially driven by the Queen Square experience in the UK but was als...
Source: European Neurology - November 17, 2021 Category: Neurology Source Type: research
Design and Validation of an Expanded Disability Status Scale Model in Multiple Sclerosis
Conclusions: MS disability measured through EDSS is an age-dependent magnitude that is partly conditioned by SC and GCL. Further studies assessing paraclinical disability predictors are needed.Eur Neurol (Source: European Neurology)
Source: European Neurology - November 17, 2021 Category: Neurology Source Type: research
