Early Experiences in Switching between Monoclonal Antibodies in Patients with Nonresponsive Migraine in Spain: A Case Series
Monoclonal antibodies targeting the calcitonin gene-related peptide have been introduced into the therapeutic arsenal of migraine prophylaxis. Clinical trials report similar efficacy between them, and there is no evidence of switching to another one after failure. We aim to describe our experience in switching from erenumab to galcanezumab after therapeutic failure. We retrospectively reviewed 30 migraine patients who received monoclonal antibodies, with 15 of them switched after failure to achieve reduction in migraine days per month ≥30%. A ≥30% reduction in migraine days per month compared to baseline was observed i...
Source: European Neurology - September 10, 2021 Category: Neurology Source Type: research
Investigating the Association between Wake-Up Stroke and Obstructive Sleep Apnea: A Meta-Analysis
Conclusion: WUS patients have severer SDB problems compared to NWUS patients suggesting that respiratory events during sleep might be underlying the induction of WUS. Besides, the induction of WUS was significantly associated with men rather than women. Therefore, early diagnosis and management of potential WUS patients should benefit from the detection of SDB status and respiratory effects.Eur Neurol (Source: European Neurology)
Source: European Neurology - September 9, 2021 Category: Neurology Source Type: research
In Memoriam of Prof. Henri M. Duvernoy (1931 –2021)
Eur Neurol (Source: European Neurology)
Source: European Neurology - August 31, 2021 Category: Neurology Source Type: research
Retinal Neurovascular Structural Changes in Optical Coherence Tomography and the Relationship between These Changes and White Matter Hyperintensities in Patients with Migraine
Conclusions: Retinal neural and vascular structures might be affected in migraine sufferers, including those in subgroups. Rebound vasodilation may cause alterations in CL thickness during a migraine attack. Factors other than hypoperfusion may contribute to the pathophysiology responsible for the formation of WMH.Eur Neurol (Source: European Neurology)
Source: European Neurology - August 30, 2021 Category: Neurology Source Type: research
A pilot study of the ticagrelor role in ischemic stroke secondary prevention
Conclusion: Ticagrelor was noninferior to aspirin regarding safety profile. Compared with aspirin, ticagrelor had a better clinical outcome based on NIHSS and mRS in first-ever acute ischemic stroke patients who received it within 9 h from symptom onset, leading to a shorter hospital stay.Eur Neurol (Source: European Neurology)
Source: European Neurology - August 30, 2021 Category: Neurology Source Type: research
Function of Astrocytes in Neuroprotection and Repair after Ischemic Stroke
Background: Astrocytes are the most numerous cell types within the central nervous system, and many efforts have been put into determining the exact role of astrocytes in neuroprotection and repair after ischemic stroke. Although numerous studies have been done in recent years, there is still no thorough understanding of the exact function of astrocytes in the whole course of the stroke.Summary: According to the recent literature, there are many structures and factors that play important roles in the process of ischemic stroke, among which blood-brain barrier, various growth factors, gap junctions, AQP4, and glial scars ha...
Source: European Neurology - August 27, 2021 Category: Neurology Source Type: research
Cerebrovascular Accident and SARS-CoV-19 (COVID-19): A Systematic Review
Discussion: The data suggest SARS-CoV-2 is a risk factor for developing stroke, particularly in patients with hypertension and diabetes. Furthermore, the younger average age of stroke in patients with SARS-CoV-2, particularly those patients with zero identifiable preexisting conditions, creates high suspicion that SARS-CoV-2 is an independent risk factor for development of stroke; however, this cannot yet be proven without comparable control population. The data suggest the risk of developing CVA in the setting of COVID-19 infection is not dependent upon severity of illness. Continued studies must be done to understand the...
Source: European Neurology - August 5, 2021 Category: Neurology Source Type: research
The Impact of the COVID-19 Lockdown on the Quality of Life in Chronic Neurological Diseases: The Results of a COVQoL-CND Study
Conclusions: The results of the COVQoL-CND study showed that lockdown causes posttraumatic stress and deterioration in the QoL in CND.Eur Neurol (Source: European Neurology)
Source: European Neurology - August 3, 2021 Category: Neurology Source Type: research
The Role of Apolipoprotein E ε4 in Early and Late Mild Cognitive Impairment
Conclusions: AnAPOEε4 allele is associated with increased CSF tau and worse cognition in both EMCI and LMCI, and this association may be mediated by Aβ. We conclude thatAPOEε4 may be an important mediator of tau pathology and cognition in the early stages of AD.Eur Neurol (Source: European Neurology)
Source: European Neurology - August 2, 2021 Category: Neurology Source Type: research
CXCL13 Levels Indicate Treatment Responsiveness to Fingolimod in MS Patients
Eur Neurol (Source: European Neurology)
Source: European Neurology - August 2, 2021 Category: Neurology Source Type: research
Association between Vitamin D and Risk of Stroke: A PRISMA-Compliant Systematic Review and Meta-Analysis
Conclusions: Our analysis indicated that lower circulating level of vitamin D was associated with an elevated risk of stroke, but extra supplement of vitamin D failed to show benefit in decreasing the risk of stroke. Further research and study are also needed to show the role of vitamin D in relation to stroke.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 29, 2021 Category: Neurology Source Type: research
Total Cerebral Small Vessel Disease Score and Anthropometric Indices: A Population-Based Study in Older Adults of Amerindian Ancestry
A total of 590 older adults of Amerindian ancestry living in rural Ecuador received anthropometric measurements and a brain magnetic resonance imaging to estimate the total cerebral small vessel disease (cSVD) score. A fully adjusted ordinal logistic regression model, with categories of the total cSVD score as the dependent variable, disclosed significant associations between the waist circumference, the waist-to-hip, and the waist-to-height ratios – but not the body mass index (BMI) – and the cSVD burden. Indices of abdominal obesity may better correlate with severity of cSVD than the BMI in Amerindians. Phenotypic ch...
Source: European Neurology - July 27, 2021 Category: Neurology Source Type: research
Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging for the Analysis of Microvascular Permeability in Peritumor Brain Edema of Fibrous Meningiomas
Conclusion: DCE-magnetic resonance imaging ·Meningioma·Blood vessel MRI can be used to quantify the microvascular permeability of PTBE in patients with meningioma.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 27, 2021 Category: Neurology Source Type: research
Reallocation of Carotid Surgery Activity with the Support of Telemedicine in a COVID-Free Clinic during COVID-19 Pandemic
The aim of this study is to report the reallocation of carotid surgery activity with the support of telemedicine in a COVID-free clinic during COVID-19 pandemic. Patients with symptomatic carotid stenosis or asymptomatic vulnerable plaques were reallocated to a COVID-free private clinic which began to cooperate with the National Health System during the emergency. Quick training of staff nurses was performed. Surgeons moved to the COVID-19 free clinic. Remote cerebral monitoring was performed with the support of telemedicine. Twenty-four patients underwent standard carotid endarterectomy with eversion technique. Five patie...
Source: European Neurology - July 23, 2021 Category: Neurology Source Type: research
Cognitive Impairment in Multiple System Atrophy Is Related to White Matter Damage Detected by the T1-Weighted/T2-Weighted Ratio
Conclusion: The sT1w/T2w ratio is sensitive to degenerative changes in the white matter that is associated with cognitive ability in MSA patients.Eur Neurol (Source: European Neurology)
Source: European Neurology - July 20, 2021 Category: Neurology Source Type: research
