Dissociative Language Representation in a Patient with Schizencephaly
Eur Neurol (Source: European Neurology)
Source: European Neurology - October 8, 2020 Category: Neurology Source Type: research
The Genetics Analysis of Molecular Pathogenesis for Alzheimer & apos;s Disease
Conclusions: The pathogenesis of AD at molecular levels may link to cell membrane structures and signal transduction; hence, a list of 20 genes, includingLRRTM1 andRASAL1,potentially are important for the discovery of treatment target or molecular marker of AD.Eur Neurol (Source: European Neurology)
Source: European Neurology - October 7, 2020 Category: Neurology Source Type: research
John Cunningham Virus Status, Seroconversion Rate, and the Risk of Progressive Multifocal Leukoencephalopathy in Polish John Cunningham Virus-Seronegative Patients with Relapsing-Remitting Multiple Sclerosis
Conclusions: NAT therapy in JCV-seronegative RRMS patients is safe and results in the absence of PML cases. In Poland, JCV seroconversion rate is similar to that observed in other European countries.Eur Neurol (Source: European Neurology)
Source: European Neurology - October 7, 2020 Category: Neurology Source Type: research
Validation of the Simplified Modified Rankin Scale Questionnaire
Conclusion: Our results show good validity of the postal smRSq, answered by the patients, compared with the mRS carried out face-to-face at 6 months after a stroke. This result could help trialists in the future simplify study design and make multicentre trials and quality registers with a large number of patients more feasible and time-saving.Eur Neurol (Source: European Neurology)
Source: European Neurology - October 7, 2020 Category: Neurology Source Type: research
“Stat Rosa Pristina Nomine, Nomina Nuda Tenemus”: The Many Syndromes, Diseases, and Anatomic Structures Bearing Jean-Martin Charcot’s Name
The sheer magnitude of Jean-Martin Charcot ’s contributions to neurology, pathology, psychiatry, and internal medicine has allowed for the common usage of eponyms bearing the master’s name in recognition of his work. However, these are so numerous that confusion has naturally arisen concerning the exact nature of each eponym, allowing fo r different specialists to refer to completely different ailments or symptoms, while using the very same expression. Previous compilations of his eponyms were often incomplete. Therefore, the authors aimed to bring some clarification into the nature and origin of each known eponym with...
Source: European Neurology - October 5, 2020 Category: Neurology Source Type: research
Effectiveness, Safety, and Health-Related Quality of Life of Chronic Migraine Patients Treated with Onabotulinum Toxin A
Conclusion: This study confirms that BoNT-A treatment is effective on CM and improves the functional well-being and quality of life of patients.Eur Neurol (Source: European Neurology)
Source: European Neurology - September 23, 2020 Category: Neurology Source Type: research
Axonal Degeneration Independent of Inflammatory Activity: Is It More Intense in the Early Stages of Relapsing-Remitting Multiple Sclerosis Disease?
Conclusion: The axonal degeneration rate is faster in RRMS patients in the first years of the disease than in later years. In addition, axonal degeneration occurs independently of inflammatory activity. Axonal degeneration is correlated with disability progression, but not with inflammatory findings, such as clinical episodes and MRI activity.Eur Neurol (Source: European Neurology)
Source: European Neurology - September 21, 2020 Category: Neurology Source Type: research
Dawson Fingers in Older Adults with Cerebral Small Vessel Disease: A Population Study
Dawson fingers are used to differentiate multiple sclerosis (MS) from other conditions that affect the subcortical white matter. However, there are no studies evaluating the presence of Dawson fingers in subjects with cerebral small vessel disease (cSVD). We aimed to assess prevalence and correlates of Dawson fingers in older adults with cSVD-related moderate-to-severe white matter hyperintensities (WMH). Community-dwelling older adults residing in rural Ecuador – identified by means of door-to-door surveys – underwent a brain MRI. Exams of individuals with cSVD-related moderat e-to-severe WMH were reviewed with atte...
Source: European Neurology - September 17, 2020 Category: Neurology Source Type: research
Therapeutic and Immunoregulatory Effects of Tacrolimus in Patients with Refractory Generalized Myasthenia Gravis
Conclusion: Our study indicated the clinical efficacy of tacrolimus in patients with refractory generalized MG. The underlying immunoregulatory mechanism of tacrolimus may involve alterations in the phenotypes of peripheral blood lymphocytes and Th1/Th2-related cytokine expression of PBMCs.Eur Neurol (Source: European Neurology)
Source: European Neurology - September 15, 2020 Category: Neurology Source Type: research
The Merging Tracks of Anosognosia and Neglect
Anosognosia and hemineglect are among the most startling neurological phenomena identified during the 20th century. Though both are associated with right hemisphere cerebral dysfunction, notably stroke, each disorder had its own distinct literature. Anosognosia, as coined by Babinski in 1914, describes patients who seem to have no idea of their paralysis, despite general cognitive preservation. Certain patients seem more than unaware, with apparent resistance to awareness. More extreme, and qualitatively distinct, is denial of hemiplegia. Various interpretations of pathogenesis are still deliberated. As accounts of its cap...
Source: European Neurology - September 14, 2020 Category: Neurology Source Type: research
Uncovering the Potential Differentially Expressed miRNAs and mRNAs in Ischemic Stroke Based on Integrated Analysis in the Gene Expression Omnibus Database
Conclusions: The identified differentially expressed miRNAs and mRNAs may be associated with the development of ischemic stroke.Eur Neurol (Source: European Neurology)
Source: European Neurology - September 9, 2020 Category: Neurology Source Type: research
Age and Diastolic Blood Pressure Play an Important Role in the Progression of White Matter Lesions: A Meta-Analysis
Conclusion: The relationship between DBP and WMLs is closer than that of SBP. Also, the risk of WML progression in patients aged under 70 years was higher than that in patients aged over 70 years. Furthermore, when DBP is elevated in patients younger than 70 years of age, the risk of WML progression may be higher. Therefore, it is expected that more researchers will attach importance to the change in DBP and identify the range of blood pressure and strategies that control DBP, thus contributing to delay the progression of WMLs.Eur Neurol (Source: European Neurology)
Source: European Neurology - September 9, 2020 Category: Neurology Source Type: research
Cerebral Venous Thrombosis: A Comprehensive Review
Conclusion: CSVT is a potentially fatal neurological condition that is often under-diagnosed due to its nonspecific presentation. Timely diagnosis and treatment can reduce morbidity and mortality, remarkably improving the outcome in affected individuals.Eur Neurol (Source: European Neurology)
Source: European Neurology - September 2, 2020 Category: Neurology Source Type: research
Myelography and the 20th Century Localization of Spinal Cord Lesions
In this article, we commemorate the centenary of myelography, a neuroradiological procedure that, despite certain disadvantages, significantly contributed to the diagnosis and localization of spinal cord lesions during the 20th century. From the start, the use of myelography was characterized by different views regarding the potential dangers associated with the prolonged exposure of a “foreign body” to the central nervous system. Such differences in attitude resulted in divergent myelography practices; its precise indications, technical performance, and adopted contrast material remaining subject to variability until ...
Source: European Neurology - September 1, 2020 Category: Neurology Source Type: research
Worth Their Salt: One Hundred Years of Hyperosmolar Therapy
In this article, we commemorate the centenary of the discovery and clinical implementation of hyperosmolar therapy for the treatment of increased intracranial pressure (ICP). Following the pioneering work of anatomists Weed and McKibben in 1919, the use of hypertonic solutions was soon adopted into clinical practice, even though the preferred hypertonic agent, route of administration, and ideas regarding the physiological mechanism by which it reduced ICP diverged. These divergent conceptions and practices have continued to surround the use of hyperosmolar therapy into present times.Eur Neurol (Source: European Neurology)
Source: European Neurology - August 31, 2020 Category: Neurology Source Type: research
