Exacerbation Rate in Generalized Myasthenia Gravis and Its Predictors
Conclusion: More than half of newly diagnosed AChR + MG cases experience an exacerbation in the first 6 years. Gender, disease severity at onset and prednisone dose reduction are predictors that could inform clinical practice and future research.Eur Neurol (Source: European Neurology)
Source: European Neurology - December 15, 2020 Category: Neurology Source Type: research
Comorbidity of Cervical Spondylogenic Myelopathy and Amyotrophic Lateral Sclerosis: When Electromyography Makes the Difference in Diagnosis
Cervical spondylogenic myelopathy (CSM) represents a common differential diagnosis for spinal onset Amyotrophic Lateral Sclerosis (ALS). Identifying occurrence of ALS in patients with CSM may be challenging. We evaluated the accuracy of Awaji criteria in the diagnosis of ALS in a cohort of patients with CSM. We screened all patients attending Turin ALS Center during the 2006 –2018 period. We selected only patients for whom cervical cord MRI showed radiological signs of CSM. All patients underwent electromyography (EMG), and Awaji criteria were used for diagnosis of clinically probable ALS. All patients were followed up c...
Source: European Neurology - December 9, 2020 Category: Neurology Source Type: research
Role of NLRP3 Inflammasomes in Neuroinflammation Diseases
Background: Inflammasomes are large intracellular multi-protein signaling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1 and pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1 β and proIL-18 to produce active forms. The inflammasome complex consists of a nod-like receptor, the adapter apoptosis-associated speck-like protein, and caspase-1. Dysregulation of NLRP3 inflammasome activation is involved in neuroinf...
Source: European Neurology - November 17, 2020 Category: Neurology Source Type: research
Treatment of Cognitive Impairment and the Role of Demographic Factors in Disease Progression: The Final Results of the Russian Observational Program “DIAMANT”
Conclusions: In the study, we observed the efficacy of Divaza for the treatment of CD: a therapy contributed to an increase in the mean MoCA score and the positive dynamics in the number of patients with cognitive improvement.Eur Neurol (Source: European Neurology)
Source: European Neurology - November 17, 2020 Category: Neurology Source Type: research
PREvention of VENous Thromboembolism in Hemorrhagic Stroke Patients – PREVENTIHS Study: A Randomized Controlled Trial and a Systematic Review and Meta-Analysis
Conclusions: In patients with acute ICH, the use of anticoagulants to prevent VTE was safe but the overall level of evidence was low due to the low number of patients included in randomized clinical trials.Eur Neurol (Source: European Neurology)
Source: European Neurology - November 13, 2020 Category: Neurology Source Type: research
Charcot and His Passion for Dogs: A Historical Note
Jean-Martin Charcot, one of the most brilliant neurologists in history, was a man of few words and few gestures. He had an impenetrable and unmovable face and was described as being austere, reserved, and shy. In contrast, in his personal life, he was a softhearted man who loved animals – especially dogs. In this historical note, we sought to look into the past and learn more about Dr. Charcot’s personal life – which was robustly impacted by his passion for dogs.Eur Neurol (Source: European Neurology)
Source: European Neurology - November 11, 2020 Category: Neurology Source Type: research
Multifocal Motor Neuropathy with Persistent Conduction Block: The Seminal Case
This article provides an insight into the medical history of MMN “patient zero” and the first scientific publication that led to the recognition of MMN by the medical community. Multifocal motor neuropathy is nowadays recognized as a disease that produces asymmetric muscle weakness and cramping, with spontaneous motor unit activity (fasciculations and myokymi a) but without sensory disorder. From an electrophysiological point of view, the neuropathy is characterized by persistent conduction blocks that usually initially affect the proximal upper extremity. The path to recognizing this rare entity was long and winding. ...
Source: European Neurology - November 11, 2020 Category: Neurology Source Type: research
Patients ’ Experiences of Remote Neurology Consultations during the COVID-19 Pandemic
Telemedicine has been widely implemented during the COVID-19 global pandemic to enable continuity of care of chronic illnesses. We modified our general neurology clinic to be conducted using remote audio-only telephone consultations. We included all patients over a 10-week period who agreed to both a telephone consultation and a questionnaire afterwards in order to ascertain the patient ’s perspective of the experience. There were 212 participants consisting of men (43.8%) and women (56.2%). The mean ± standard deviation of age was 47.8 ± 17.0 (range 17–93) years. For the most part, patients found remote consultation...
Source: European Neurology - November 4, 2020 Category: Neurology Source Type: research
Assessment of Patients with Intracerebral Hemorrhage or Hemorrhagic Transformation in the VENOST Study
Conclusion: CVST, an important cause of stroke in the young, should be monitored closely if the patients have additional symptoms of headache, multiple sinus involvement, and CH. Older age and parenchymal lesion, either hemorrhagic infarction or intracerebral hemorrhage, imply poor outcome.Eur Neurol (Source: European Neurology)
Source: European Neurology - October 30, 2020 Category: Neurology Source Type: research
Inhibition of LncRNA MALAT1 Attenuates Cerebral Ischemic Reperfusion Injury via Regulating AQP4 Expression
Stroke is one of the leading causes of mortality and disability worldwide. Long noncoding RNAs (lncRNAs) including MALAT1 have been shown to have critical roles in cerebral ischemia reperfusion injury (CIRI). However, the underlying mechanism of MALAT1 in CIRI has not been elucidated. The present study aimed to investigate the function and potential regulatory mechanism of MALAT1 in cerebral ischemic reperfusion injury. We established the middle cerebral artery occlusion (MCAO) model and oxygen-glucose deprivation/reoxygenation (OGD/RX) model in vivo and in vitro, and then Cell Counting Kit-8 (CCK-8), RT-qPCR, flow cytomet...
Source: European Neurology - October 30, 2020 Category: Neurology Source Type: research
Predictive Value and Correlation of Neuron-Specific Enolase for Prognosis in Patients with Coma: A Systematic Review and Meta-Analysis
Conclusions: The NSE concentration of patients with poor coma prognosis is significantly higher than that of the control group. The high NSE concentration is not necessarily a poor prognosis for coma, but low NSE concentration indicates a high probability of a good prognosis for coma.Eur Neurol (Source: European Neurology)
Source: European Neurology - October 30, 2020 Category: Neurology Source Type: research
Utility and Results from a Patient-Reported Online Survey in Myotonic Dystrophies Types 1 and 2
Discussion: Overall, as our results are consistent with the results of clinical studies and online registries, it can be assumed that this type of systematic gathering of data from patients with rare diseases is useful and provides realistic and appropriate results. Due to the nature of online surveys and the absence of an assessor, some uncertainty remains. Furthermore, survey frauds cannot be completely excluded. An additional clinical assessment could confirm the given information and will improve the utility and validity of reported symptoms participants provide in online surveys. Therefore, we recommend a combination ...
Source: European Neurology - October 29, 2020 Category: Neurology Source Type: research
A Novel Method for Sleep-Stage Classification Based on Sonification of Sleep Electroencephalogram Signals Using Wavelet Transform and Recurrent Neural Network
Conclusion: The present EEG sonification method leads to valid sleep staging by clinicians. The method could be used on various EEG databases for classification, differentiation, diagnosis, and treatment purposes. Real-time EEG sonification can be used as a feedback tool for replanning of neurophysiological functions for the management of many neurological and psychiatric disorders in the future.Eur Neurol (Source: European Neurology)
Source: European Neurology - October 29, 2020 Category: Neurology Source Type: research
Cerebral Hyperperfusion Syndrome and Related Conditions
Cerebral vasoconstriction is a normal physiological response under determined conditions to preserve a normal cerebral blood flow. However, there are several syndromes, with impaired cerebral autoregulation and cerebral vasoconstriction, not related with infection or inflammation, which share the same radiological and clinical presentation. We review here the cerebral hyperperfusion syndrome and related conditions such as hypertensive encephalopathy, posterior reversible encephalopathy syndrome, and reversible cerebral vasoconstriction syndrome. These syndromes might share the same pathophysiological mechanism with endothe...
Source: European Neurology - October 16, 2020 Category: Neurology Source Type: research
Erratum
Eur Neurol (Source: European Neurology)
Source: European Neurology - October 12, 2020 Category: Neurology Source Type: research
