Unsupervised identification of cardiometabolic profiles among adolescents: findings from the PARIS birth cohort study
Conclusion: The two profiles identified, based on cardiometabolic health, were associated with early indicators and handgrip strength. Results suggest that the waist-to-height ratio is a useful clinical tool for screening individuals at cardiometabolic risk and who therefore require clinical follow-up.What is Known:• Although there is a need for tools to assess cardiometabolic health during adolescence, there is no consensus on the definition of metabolic syndrome for this age group.What is Knew:• The findings suggest that waist-to-height ratio can serve as a simple and valuable clinical tool for screening individuals ...
Source: European Journal of Pediatrics - November 18, 2023 Category: Pediatrics Source Type: research
Congenital diaphragmatic hernia: quality improvement using a maximal lung protection strategy and early surgery-improved survival
Conclusion: MLP with early surgery significantly improved survival and additional adverse outcomes of neonates with CDH. Prospective randomized studies are necessary to confirm the findings of the current study.What is Known:• Ventilator-induced lung injury was reported as the main cause of mortality in neonates with congenital diaphragmatic hernia (CDH).• Conventional ventilation is recommended by the European CDH consortium as the first-line ventilation modality; timing of surgery is controversial.What is New:• A maximal lung protection strategy based on 15-Hz high-frequency oscillatory ventilation with low dist...
Source: European Journal of Pediatrics - November 17, 2023 Category: Pediatrics Source Type: research
Availability of psychological resources for parents receiving communication of positivity at newborn screening for metabolic diseases in Italy
Conclusion: There is a need for harmonization among the Italian ENBS centers concerning the availability of psychological resources and how these resources are provided to families. Parents ’ needs remained only partially fulfilled.What is Known:• Receiving communication of positivity at the ENBS can be highly stressful for parents and requires adequate psychological support.• The guidelines recommend psychological support for parents during the ENBS process.What is New:• Only 14/23 (60.9%) of Italian ENBS centers have a clinical psychologist within the team.• In half of the consultations with parents receiving c...
Source: European Journal of Pediatrics - November 17, 2023 Category: Pediatrics Source Type: research
Continuous renal replacement therapy in neonates and children: what does the pediatrician need to know? An overview from the Critical Care Nephrology Section of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC)
Conclusion: In this review, from the Critical Care Nephrology section of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC), we summarize the key aspects of CRRT delivery and highlight the importance of adequate follow up among AKI survivors which might be of relevance for the general ped iatric community.What is Known:• CRRT is the preferred method of renal support in critically ill and hemodynamically unstable children in the PICU as it allows for gentle removal of fluids and solutes.• Although CRRT has become an important and integral part of modern pediatric critical care, wide practice varia...
Source: European Journal of Pediatrics - November 17, 2023 Category: Pediatrics Source Type: research
Cow ’s Milk-related Symptom Score (CoMiSS) values in presumed healthy European infants aged 6–12 months: a cross-sectional study
Conclusions: This study provided CoMiSS values in presumed healthy infants aged 6–12 months. Additional studies should be conducted to establish the use of CoMiSS to assess cow’s milk-related symptoms in infants 6 months and older.What is Known:• The Cow’s Milk-related Symptom Score (CoMiSS) is an awareness tool for evaluating symptoms related to cow’s milk.• CoMiSS values for presumed healthy infants aged 0-6 months infants are already available.What is New:• CoMiSS values in European infants aged 6-12 months are provided.• These CoMiSS values differed across various age groups but not across groups ...
Source: European Journal of Pediatrics - November 17, 2023 Category: Pediatrics Source Type: research
COVID-19 in hospitalized infants aged under 3 months: multi-center experiences across Turkey
Conclusions: Our study discloses the clinical observations and accompanying bacterial infections found in infants aged under 3 months with COVID-19. These findings can shed light on COVID-19 in infancy for physicians because there is limited clinical evidence available.What is Known:• COVID-19 in infants and older children has been seen more mildly than in adults.• The most common symptoms of COVID-19 in infants are fever and cough, as in older children and adults. COVID-19 should be one of the differential diagnoses in infants with fever.What is New:• Although most infants under three months had fever, the clinic...
Source: European Journal of Pediatrics - November 16, 2023 Category: Pediatrics Source Type: research
The efficacy and safety of continuous blood purification in neonates with septic shock and acute kidney injury: a two-center retrospective study
Conclusion: CBP can efficiently maintain hemodynamic stability, improve renal function, and has good safety in neonates with septic shock and AKI. However, the mortality rate remains high, and whether CBP improves the prognosis of neonates with septic shock and AKI remains unclear.What is Known:• Over 50% of children with septic shock have severe AKI, of which 21.6% required CBP.• The clinical application of CBP in septic shock has attracted increasing attention.What is New:• CBP can efficiently maintain hemodynamic stability, improve renal function, and has good safety in neonates with septic shock and AKI.• The m...
Source: European Journal of Pediatrics - November 16, 2023 Category: Pediatrics Source Type: research
Dental caries in children and vitamin D deficiency: a narrative review
Conclusion: In conclusion, vitamin D deficiency would increase the risk of caries in the primary and/or permanent dentition. Relationship between vitamin D deficiency and dental caries is evident enough for vitamin D deficiency to be considered as a risk factor for dental caries in children. Optimal levels of vitamin D throughout pregnancy and childhood may be considered an additional preventive measure for dental caries in the primary and permanent dentition. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - November 15, 2023 Category: Pediatrics Source Type: research
Correction to: Investigation of endothelial dysfunction and arterial stiffness in multisystem inflammatory syndrome in children
(Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - November 15, 2023 Category: Pediatrics Source Type: research
High-flow nasal cannula use in pediatric patients for other indications than acute bronchiolitis —a scoping review of randomized controlled trials
Conclusion: This systematic scoping review provides an overview of current evidence for HFNC use in pediatric patients. Future studies should aim for better quality and include economic evaluation with cost-effectiveness analysis.Protocol registration: Protocol has been publishedhttps://osf.io/a3y46/.What is Known:• High flow nasal cannula has been effective in acute bronchiolitis and neonatal respiratory care.• The use of HFNC on other conditions is also common and increasing, but the evidence supporting this has not been previously summarized.What is New:• We found that HFNC has been studies in relatively few studi...
Source: European Journal of Pediatrics - November 14, 2023 Category: Pediatrics Source Type: research
Exploratory assessment of parental physical disease categories as predictors of documented physical child abuse
Conclusion: Most parental physical disease categories did not show statistically significant associations, but some showed predictive ability. Further research is needed to explore preventive potential.What is Known:• Few and broad categories of parental physical disease have been examined as risk factors for severe physical child abuse; no prior study has used several categories as predictors.What is New:• Unspecific symptoms, ischemic heart disease, peripheral artery occlusive disease, stroke, chronic pulmonary disease, stomach ulcer/chronic gastritis, painful condition, and epilepsy all showed to be potential predic...
Source: European Journal of Pediatrics - November 13, 2023 Category: Pediatrics Source Type: research
Neurodevelopment at 24 months corrected age in extremely preterm infants treated with dexamethasone alternatives during the late postnatal period: a cohort study
Conclusions: Betamethasone or hydrocortisone hemisuccinate treatment was not an independent risk for suboptimal neurological development, growth and respiratory outcomes assessed at 24 months corrected age in extremely premature infants. Registration number: The study was registered on the ClinicalTrials.gov register: NCT05055193.What is Known:• Late postnatal steroids are used to treat bronchopulmonary dysplasia• Meta-analyses warned against the neurological risk of dexamethasone use during neonatal period. Early or late hydrocortisone hemisuccinate has been evaluated in multiple studies, none of which have rep...
Source: European Journal of Pediatrics - November 13, 2023 Category: Pediatrics Source Type: research
Early weight measures and long-term neuropsychological outcome of critically ill neonates and infants: a secondary analysis of the PEPaNIC trial
Conclusion: Growth in weight during hospital stay of young survivors of critical illness is impaired. Worse early growth in weight is associated with lower weight and height but not with neuropsychological outcomes at 4-year follow-up.What is Known:• Critically ill neonates and infants show impaired early growth during admission and are at risk for later neuropsychological impairments.• Unraveling the association between early growth and later neuropsychological impairments is crucial since the first year of life is critical for brain development.What is New:• Critically ill neonates and infants had age appropriate w...
Source: European Journal of Pediatrics - November 11, 2023 Category: Pediatrics Source Type: research
Barriers to the spiritual care of parents taking care of their child with a life-limiting condition at home
Conclusion: Parents of children with life-limiting conditions face existential challenges. However, care needs are often not identified, and existing support is not recognized as such. The main challenge is to provide care professionals and parents with the tools and terminology that suit existing care needs.What is Known:• Spiritual care needs are an important aspect of pediatric palliative care.• Parents of children with life-limiting conditions feel unsupported when dealing with spiritual questions.What is New:• Parents and professionals mention barriers that hinder spiritual support for parents.• There is a d...
Source: European Journal of Pediatrics - November 11, 2023 Category: Pediatrics Source Type: research
Sports despite masks: no negative effects of FFP2 face masks on cardiopulmonary exercise capacity in children
Conclusion: In this study, no significant differences in the cardiorespiratory function at peak exercise could be discerned when wearing an FFP2/N95 face mask. While the end-tidal values for CO2 increased significantly and the end-tidal values for O2 decreased significantly, these values did never reach levels of hypercapnia or hypoxia. Furthermore, the children terminated the exercise at a lower RER and heart rate (HR) suggesting a subconscious awareness of the higher strain. Since the detrimental effects of limiting sports during the pandemic are well documented, stopping PE lessons altogether because of the minor phys...
Source: European Journal of Pediatrics - November 11, 2023 Category: Pediatrics Source Type: research
