Symptomatic corpus luteum hemorrhage in adolescent females with ITP
Conclusion: CLH could potentially pose a significant complication in the context of adolescent females with ITP, requiring a strong index of suspicion to direct expedient therapy.What is Known:• Immune thrombocytopenia is typically associated with minor bleeding tendency.• Corpus luteum hemorrhage is generally asymptomatic; however, in women with bleeding disorders, it has the potential to result in substantial intra-abdominal bleeding.What is New:• Corpus luteum hemorrhage leading to intra-abdominal bleeding is a potential severe complication of immune thrombocytopenia in adolescent females. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - April 11, 2024 Category: Pediatrics Source Type: research
Why all newborn hip screening programs have same results —a mini review
Conclusion: It seems that DDH screening strategies have strengths and limitations without notable differences in the most severe outcomes (late-detected cases requiring operative treatment). Thus, it is important to acknowledge that the used screening policy is a combination of values and available resources rather than a decision based on clear evidence. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - April 9, 2024 Category: Pediatrics Source Type: research
Prospective case series study on the use of a novel analgosedation protocol for ultrasound-guided catheterization in Neonatal Intensive Care Unit
Conclusion: Our study represents the very first step towards the design of a validated protocol for analgosedation during ultrasound-guided CICC insertion in NICU.What is Known:• Critically ill newborns admitted to Neonatal Intensive Care Unit often require a centrally inserted central catheter.• Achieving an appropriate level of sedation and analgesia is paramount for procedure success and patient safety, avoiding the potential risks associated with excessive deep sedation.What is New:• The use of this new protocol for analgosedation is able to achieve a good level of sedation and pain control without significant ad...
Source: European Journal of Pediatrics - April 9, 2024 Category: Pediatrics Source Type: research
Changing trends in the global, regional, and national burden of iodine deficiency among adolescents and young adults: population-based study
Conclusion: Globally, the iodine deficiency burden among adolescents has substantially decreased since 1990; however, low-SDI countries still bear a great burden. Implementation measures and monitoring systems should be strengthened to reduce the iodine deficiency burden, especially among adolescents.What is Known:• Iodine deficiency can cause severe or irreversible developmental disorders, particularly in adolescents and young adults.• Universal Salt Iodization was implemented for ensuring appropriate iodine intake.What is New:• We found substantial declines in the prevalence rates of iodine deficiency among adolesc...
Source: European Journal of Pediatrics - April 9, 2024 Category: Pediatrics Source Type: research
Perspectives of refugee parents and unaccompanied minors on initial health assessment and access to care
Conclusion: The perspectives of refugee parents and unaccompanied minors revealed opportunities to improve the experience of and access to health care of refugees entering the Netherlands, especially risk-specific screening and more adequate education about health, diseases, and the Dutch health care system.What is Known:• Refugees have specific health needs due to pre-flight, flight, and resettlement conditions. Health assessment upon entry was non-obligatory in the Netherlands, except for the tuberculosis screening. Health needs were not always met, and refugees experienced barriers in access to care.What is New:• ...
Source: European Journal of Pediatrics - April 9, 2024 Category: Pediatrics Source Type: research
Pulse oximetry signal loss during hypoxic episodes in preterm infants receiving automated oxygen control
Conclusion: SL is common during pHE and must hence be considered in AOC-algorithm designs. Administering a “backup FiO2” (which reflects FiO2-requirements during normoxemia) during SL may prolong pHE with SL. Trial registration: The study was registered atwww.clinicaltrials.gov under the registration no. NCT03785899.What is Known:• Previous studies examined SpO2 signal loss (SL) during routine manual oxygen control being rare, but pronounced in lower SpO2 states.• Oxygen titration during SL is unlikely to be beneficial as SpO2 may recover to a normoxic range.What is New:• Periods of low signal quality of SpO2 a...
Source: European Journal of Pediatrics - April 9, 2024 Category: Pediatrics Source Type: research
Effectiveness of self-financed rotavirus vaccines on acute gastroenteritis primary care episodes using real-world data in Spain: a propensity score –matched analysis of cohort study
Conclusion: Considering that RV is the causative agent in 20% of AGE cases, a direct effectiveness of 82% preventing AGE-PC episodes due to RV could be deduced using a novel spatiotemporal approach. A reduction of 17% of AGE-PC episodes in unvaccinated was observed in areas with VC over 70% because of indirect protection.What is Known:• The effectiveness of RV vaccines preventing hospitalizations due to RV-acute gastroenteritis (RV-AGE) has been extensively studied. However, RV also burdens the primary care (PC) setting, and data on vaccine effectiveness (VE) in preventing AGE-PC visits are scarce.• The RV vaccine dis...
Source: European Journal of Pediatrics - April 7, 2024 Category: Pediatrics Source Type: research
A randomised controlled trial comparing umbilical cord milking to delayed cord clamping at birth in preterm infants 28 –36 weeks gestational age
Conclusion: UCM may be a feasible alternative to DCC especially in settings where the latter is not achievable, without increasing the risk of adverse effects to the preterm infants, this finding needing further confirmation with larger sample.Trial registration: CTRI (Clinical Trial Registry —India) registration number: CTRI/2020/04/024566 (registered prospectively on 13/04/2020).What is Known:• Delayed cord clamping (DCC) is recommended as a standard of care for all the stable term and preterm newborn babies at birth.What is New:• Intact umbilical cord milking may be a reasonable choice of cord management when DCC ...
Source: European Journal of Pediatrics - April 6, 2024 Category: Pediatrics Source Type: research
Total face mask with neurally adjusted ventilatory assist as a rescue therapy in infants with severe bronchiolitis
Conclusion: In infants with severe RSV-induced bronchiolitis, respiratory support with TFM-NIV-NAVA seems to be feasible as a rescue therapy and might be considered in selected patients.What is Known:• Bronchiolitic patients with NIV support failure may require invasive mechanical ventilation.• Interface related complications, especially facial sores, can be a cause of NIV failure.What is New:• Total face mask with non-invasive neurally adjusted ventilatory assist (TFM-NIV-NAVA) seems feasible as a rescue therapy in deteriorating patients with CPAP or NIV failure.• TFM-NIV-NAVA can improve oxygenation rapidly i...
Source: European Journal of Pediatrics - April 6, 2024 Category: Pediatrics Source Type: research
Transcutaneous bilirubin reliability during and after phototherapy depending on skin color
Conclusions: Our study supports the reliability of cTcB to assess SB during and after phototherapy, with differences among skin tones after the treatment. The use of cTcB and Neomar ’s scale during and mainly after phototherapy may help reduce the number of blood samples required.What is Known:• Controversies exist on the reliability of jaundice meters during and after phototherapy in covered skin. Only a few studies have analyzed their accuracy in multiethnic populations, but none has used a validated neonatal skin color scale.What is New:• We verified correlation between serum and transcutaneous bilirubin in covere...
Source: European Journal of Pediatrics - April 6, 2024 Category: Pediatrics Source Type: research
Arterial hypertension in infants with congenital diaphragmatic hernia following surgical repair
Conclusion: This study demonstrates a moderately high incidence of arterial hypertension in CDH infants at discharge and an independent association of creatinine values with arterial hypertension. Physicians should be aware of this risk and include regular BP measurements and test of renal function in CDH car e and follow-up.What is Known:• Due to decreasing mortality, morbidity is increasing in surviving CDH patients.• Pulmonary hypertension and cardiac dysfunction are well-known cardiovascular comorbidities of CDH.What is New:• There is a moderately high incidence of arterial hypertension in CDH infants at discha...
Source: European Journal of Pediatrics - April 6, 2024 Category: Pediatrics Source Type: research
Devices for securing and administering pediatric compounded oral liquids: survey results from French university hospitals
Conclusion: The study highlighted diversity in the practices of French university hospitals regarding dosing delivery devices associated with compounding oral liquid forms for pediatric patients. The findings underscored the need for standardized guidelines to streamline practices and enhance safety and precision in compounded medication administration for children.What is Known:• Administration devices are important to ensure the correct administration of the required dose of oral liquids in pediatrics.• For compounded oral liquid forms, the selection and supply of administration devices are managed by compounding pha...
Source: European Journal of Pediatrics - April 4, 2024 Category: Pediatrics Source Type: research
L-carnitine decreases myocardial injury in children undergoing open-heart surgery: A randomized controlled trial
Conclusion: L-carnitine can reduce myocardial injury, improve post-operative left ventricular cardiac function, and may provide myocardium protection in children with CHD who underwent open-heart surgery. Trial registration: The clinical trial was registered atwww.pactr.org with registration number PACTR202010570607420 at 29/10/2020 before recruiting the patients.What is Known:• Myocardial injury in open-heart surgery is related to several factors including ischemia–reperfusion injury, generation of reactive oxygen species, increased production of inflammatory mediators, and enhancement of apoptosis of cardiomyocyt...
Source: European Journal of Pediatrics - April 3, 2024 Category: Pediatrics Source Type: research
Maternal antenatal mental health and its associations with perinatal outcomes and the use of healthcare services in children from the NINFEA birth cohort study
Conclusion: Antenatal maternal mental health is a potential risk factor for child-health outcomes and healthcare use. Early maternal mental health interventions may help to promote child health and reduce healthcare costs.What is Known:• Poor maternal mental health affects pregnancy outcomes and child health, and children of mothers with mental health conditions tend to have increased healtcare utilization.• Parents with poor mental health often face challenges in caring for their children and have less parenting self-efficacy, which could potentially lead to frequent medical consultations for minor health issues.What ...
Source: European Journal of Pediatrics - April 2, 2024 Category: Pediatrics Source Type: research
Impact of catheterized ductal closure on renal and cerebral oximetry in premature neonates
Conclusion: An improvement in cerebral and renal oximetry following hsPDA closure was observed. However, we did not identify differences in this pattern based on the type of interventional procedure for PDA, whether surgery or catheterization.What is Known:• The presence of a significant ductus is common in premature patients. Studies have shown that it affects cerebral and renal hemodynamics negatively, leading to decreased oximetry values in these areas. It has been reported that closure of the ductus, either pharmacologically or surgically, resu lts in improved oximetry values.What is New:• This study assess the i...
Source: European Journal of Pediatrics - April 1, 2024 Category: Pediatrics Source Type: research
