Serum interleukin-33 and soluble suppression of tumorigenicity 2 in pediatric leukemia with febrile neutropenia
Conclusion: IL-33 and sST2 levels were not found valuable as diagnostic and prognostic markers to predict bacterial sepsis in patients with FN.What is Known:• Neutropenic patients are at high risk of serious bacterial and viral infections, but the admission symptom is often only fever.• Febrile neutropenia has a high mortality rate if not treated effectively.What is New:• Febrile neutropenia is not only caused by bacterial infections. Therefore, new biomarkers should be identified to prevent overuse of antibiotics.• Specific biomarkers are needed to diagnose bacterial sepsis in the early phase of febrile neutropeni...
Source: European Journal of Pediatrics - February 17, 2024 Category: Pediatrics Source Type: research
Trends in Apgar scores and umbilical artery pH: a population-based cohort study on 10,696,831 live births in Germany, 2008 –2022
Conclusion: Rates of low 5-min Apgar scores and UA pH in liveborn infants increased from 2008 to 2022 in Germany.What is Known:• Low Apgar scores at 5 min after birth and umbilical arterial blood pH are associated with adverse perinatal outcomes.• Prospective collection of Apgar scores and arterial blood pH data allows for nationwide quality assurance.What is New:• The rates of liveborn infants with 5-min Apgar scores< 7 rose from 0.97 to 1.30% and that of umbilical arterial blood pH< 7.10 from 1.55 to 2.30% between 2008 –2010 and 2020–2022.• In spontaneously born term singletons in cephalic presentation,...
Source: European Journal of Pediatrics - February 17, 2024 Category: Pediatrics Source Type: research
Minimally invasive surgical approach in children treated for oesophageal atresia is associated with attention problems at school age: a prospective cohort study
Conclusion: Children who undergo minimally invasive surgery for OA correction are at risk for sustained attention problems at school age. Future studies unravelling the effects of perioperative events on neurodevelopment should lead to optimal surgical, anaesthesiological, and intensive care management in the neonatal period.What is Known:• School-aged children born with oesophageal atresia have normal intelligence but problems with sustained attention at eight years.What is New:• Oesophageal atresia patients, who undergo minimally invasive surgery or who have a background of lower socioeconomic status are at serious r...
Source: European Journal of Pediatrics - February 16, 2024 Category: Pediatrics Source Type: research
Long-term safety and tolerability of ambrisentan treatment for pediatric patients with pulmonary arterial hypertension: An open-label extension study
Conclusion: Long-term weight-based ambrisentan dosing, alone or combined with other PAH therapies in children with PAH aged 8– < 18 years, exhibited tolerability and clinical improvements consistent with prior randomized study results. Trial registration: NCT01342952, April 27, 2011.What is Known:•The endothelin receptor antagonist, ambrisentan, is indicated for treatment of pulmonary arterial hypertension (PAH). Previous studies have shown similar efficacy and tolerability in pediatric patients as in adults.What is New:• This open-label extension study assessed the long-term use of ambrisentan in p...
Source: European Journal of Pediatrics - February 16, 2024 Category: Pediatrics Source Type: research
Correlation between early postnatal body weight changes and lung ultrasound scores as predictors of bronchopulmonary dysplasia in preterm infants: A secondary analysis of a prospective study
Conclusion: In a cohort of extreme preterm infants, our study revealed a positive yet weak correlation between LUS and EWC, suggesting that EWC was not the major contributing to the evolving chronic lung disease.What is Known:• Recent evidence links Early Weight-Changes with bronchopulmonary dysplasia in preterm neonates.• Lung ultrasound score has shown promise in early prediction of the subsequent development of bronchopulmonary dysplasia in preterm infants. No studies have examined the correlation between Early Weight-Changes and Lung ultrasound score in preterm infants during first 2 weeks after birth.What is New:...
Source: European Journal of Pediatrics - February 16, 2024 Category: Pediatrics Source Type: research
Cardiomyopathy, carnitine deficiency, and celiac disease
(Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - February 15, 2024 Category: Pediatrics Source Type: research
Neurodevelopmental outcomes of preterm and growth-restricted neonate with congenital heart defect: a systematic review and meta-analysis
Conclusions: Based on a low level of evidence, prematurity and/or growth retardation appear to accentuate specific neurodevelopmental outcomes in certain CHD subgroups. Further evidence is needed to confirm these findings.Trial registration: PROSPERO [CRD42020201414].What is Known:• Children born with CHD, preterm birth, or growth restriction at birth are independently at higher risk for neurodevelopmental impairment.• The additional effect of preterm birth and/or growth restriction on neurodevelopmental outcomes in children with CHD remains unclear.What is New:• Prematurity and/or growth retardation appear to accent...
Source: European Journal of Pediatrics - February 14, 2024 Category: Pediatrics Source Type: research
Association between co-sleeping in the first year of life and preschoolers ´ sleep patterns
Conclusion: Based on the present findings, co-sleeping during the first year of life appears to be associated with poor sleep patterns in young preschoolers.What is Known:• Co-sleeping shows benefits for infants and parents, mainly facilitating successful breastfeeding.• Literature on the effect of co-sleeping in lately sleep quality in children and their parents is very limited.What is New:• Co-sleeping practiced during the first year of life could be associated with a worse sleep pattern measured with BISQ-E tool.• A balance between the correct practice of co-sleeping and the achievement of a healthy sleep routin...
Source: European Journal of Pediatrics - February 14, 2024 Category: Pediatrics Source Type: research
Interplay of the Mediterranean diet and genetic hypertension risk on blood pressure in European adolescents: Findings from the HELENA study
Conclusion: The study suggests that higher adherence to the MedDiet is associated with reduced BP levels in adolescents and provides evidence of a genetic-diet interaction influencing BP in adolescents.What is Known:• Adherence to the Mediterranean diet may reduce BP levels.What is New:• It is the first study to assess the connection between adherence to a Mediterranean diet, a hypertension genetic risk score, and how they interact in influencing blood pressure.• It is conducted within a multicenter cohort of European adolescents. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - February 13, 2024 Category: Pediatrics Source Type: research
Refeeding syndrome and psychopharmacological interventions in children and adolescents with Anorexia Nervosa: a focus on olanzapine-related modifications of electrolyte balance
Conclusion: The present paper describes the occurrence of Refeeding Syndrome and its association with olanzapine prescriptions in children and adolescents with Anorexia Nervosa. Olanzapine was associated with a more positive phosphorus balance, but not with a different occurrence of Refeeding Syndrome. Furthe r, longitudinal studies are required.What is Known:• Refeeding Syndrome (RS) is a critical complication during refeeding in malnourished patients, marked by electrolyte (phosphorus, magnesium, potassium) imbalances.• Olanzapine, an atypical antipsychotic with nutritional and biochemical impacts, is used in Anore...
Source: European Journal of Pediatrics - February 12, 2024 Category: Pediatrics Source Type: research
Risk of atrial fibrillation development in adolescent patients with inflammatory bowel disease
Conclusion: Atrial EMD is increased in pediatric patients with IBD indicating the increased risk of AF development. Measurement of atrial EMD parameters might be used to predict the risk of the development of AF in pediatric patients with IBD.What is Known:• There is increasing evidence linking chronic inflammation to the initiation and continuation of atrial fibrillation (AF).• Inflammatory bowel diseases are chronic systemic inflammatory disorders with both intestinal and extra-intestinal manifestations.• Atrial electromechanical delay (EMD) has been reported as an early marker of AF.What is New:• Atrial EMD is...
Source: European Journal of Pediatrics - February 12, 2024 Category: Pediatrics Source Type: research
Screening for functional gastrointestinal disorders in preterm infants up to 12 months of corrected age: a prospective cohort study
Conclusions: Preterm infants have a higher prevalence of FGIDs compared with term controls. Therefore, especially if they have gastrointestinal complaints, they should be screened for FGIDs. Possibly due to maturational differences, the time of occurrence of FGIDs may differ in preterm infants. Infantile colic incidence decreases with exclusive breastfeeding.What is Known:•The functional gastrointestinal disorders are a very common in infancy.•Data on preterm infants with FGIDs are currently very limited.What is New:•Preterm infants have a higher incidence of infantile colic, rumination syndrome, functional constipat...
Source: European Journal of Pediatrics - February 12, 2024 Category: Pediatrics Source Type: research
Estimated C-reactive protein (CRP) velocity for rapidly distinguishing bacterial from other etiologies in children presenting to emergency department with remarkably elevated CRP levels
Conclusion: Pediatric patients with very high CRP levels and fever mostly have bacterial infections. eCRPv levels, unlike CRP values alone, can serve as the sole independent predictor of bacterial infection > 72 h from symptom onset, warranting further prospective investigations into CRP kinetics in pediatric patients.What is Known:• The use of a single C-reactive protein (CRP) value to differentiate between bacterial and non-bacterial causes is limited.• Estimated CRP velocity (eCRPv) has shown promise in enhancing such discrimination in adults, but data on CRP kinetics in pediatric patients is sparse.What i...
Source: European Journal of Pediatrics - February 12, 2024 Category: Pediatrics Source Type: research
Exploring flatfeet morphology in children aged 6 –12 years: relationships with body mass and body height through footprints and three-dimensional measurements
Conclusion: The main characteristics of flat feet include lower arches and instep heights and ankle heights but higher rearfoot valgus angles. In general, overweight children ’s feet do not have the common features of flat feet. In contrast, short children had similar features of flatfoot except for rearfoot valgus. Assessment of posture, such as rearfoot valgus, can be critical in identifying children with flat feet.What is Known:• The morphology of children's feet is associated with body growth, but the relationship between flatfeet and body mass and height remains controversial.What is New:• Three-dimensional foot...
Source: European Journal of Pediatrics - February 9, 2024 Category: Pediatrics Source Type: research
Our estimates of neonatal radiation exposure fall short of reality
Conclusion: Radiation exposure in these newborns was underestimated, emphasizing the need for awareness regarding associated risks and strict criteria for requesting radiological exams. Lung ultrasound is a radiation-free and effective option in managing respiratory diseases in newborns, reducing the reliance on chest X-rays.What is Known:• Radiation used in diagnostic exams is not risk-free.• Radiation risk is much higher in small Infants due to the exposure area and the prolonged expectance of life.What is New:• Radiation exposure is underestimated in the neonatal population.• The study found a mean radiation exp...
Source: European Journal of Pediatrics - February 9, 2024 Category: Pediatrics Source Type: research
