Endocrinology and Metabolism Clinics of North America This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Role of Bone Turnover Markers in Osteoporosis Therapy
Bone turnover markers fill a clinical need that improves comprehensive care of metabolic bone health and osteoporosis. Creating a standard process for drawing them that reduces modifiable variability improves their precision and clinical usefulness. Creating a standard process for interpreting them by applying statistical significance improves their clinical applicability. Understanding what causes them to increase and decrease can help elucidate secondary causes of osteoporosis. Monitoring them can assess patient adherence to therapy for a silent disease that will progressively become louder with an aging global populatio...
Source: Endocrinology and Metabolism Clinics of North America - April 28, 2021 Category: Endocrinology Authors: Sumeet Jain Source Type: research

Assessment of Skeletal Strength
A bone fractures when a force applied to it exceeds its strength. Assessment of bone strength is an important component in determining the risk of fracture and guiding treatment decisions. Dual-energy X-ray absorptiometry is used to diagnosis osteoporosis, estimate fracture risk, and monitor changes in bone density. Fracture risk algorithms provide enhanced fracture risk predictability. Advanced technologies with computed tomography (CT) and MRI can measure parameters of bone microarchitecture. Mathematical modeling using CT data can evaluate the behavior of bone structures in response to external loading. Microindentation...
Source: Endocrinology and Metabolism Clinics of North America - April 28, 2021 Category: Endocrinology Authors: E. Michael Lewiecki Source Type: research

2021  Updates on Osteoporosis Diagnosis and Therapy
In this Special Edition of Endocrinology and Metabolism Clinics of North America, our objective was to focus on the latest updates on the diagnosis and management of osteoporosis from the past decade. Significant progress has been made in the therapeutics of osteoporosis, with the addition of a new agent and significantly longer clinical experience with established agents. As we have gained knowledge about the therapeutic options, many more questions have arisen. What are the latest guidelines on postmenopausal osteoporosis treatment, and how are they similar or different? What is the ideal initial agent based on patients ...
Source: Endocrinology and Metabolism Clinics of North America - April 28, 2021 Category: Endocrinology Authors: Pauline M. Camacho Tags: Preface Source Type: research

Updates on Osteoporosis
The “Updates on Osteoporosis” issue of the Endocrinology and Metabolism Clinics of North America reflects the significant recent progress in management of this highly prevalent condition. The guest editor is Dr Pauline M. Camacho, MD, FACE, Professor of Medicine at Loyola University Medical Center, and Director of the Loyola Osteoporosis and Metabolic Bone Disease Center. Dr Camacho is the first author of the 2020 update to the American Association of Clinical Endocrinologists (AACE)/American College of Endocrinology guidelines on diagnosis and treatment of postmenopausal osteoporosis. (Source: Endocrinology and Metabo...
Source: Endocrinology and Metabolism Clinics of North America - April 28, 2021 Category: Endocrinology Authors: Adriana G. Ioachimescu Tags: Foreword Source Type: research

Diagnosis of Polycystic Ovary Syndrome
This article reviews the rationale for and the limitations of these criteria as well as which criteria to use and when. The insights provided into PCOS pathogenesis by modern genetic analyses and the promise of objective data mining approaches for biologically relevant disease classification are discussed. (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - January 29, 2021 Category: Endocrinology Authors: Sydney Chang, Andrea Dunaif Source Type: research

Genetics of Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a complex genetic disorder with many genetic loci contributing small risk. Large genome-wide association studies identified 21 genetic risk loci for PCOS in European and Han Chinese women. The genetic architecture is similar across PCOS diagnostic categories. The next wave of analysis will incorporate large genotyped datasets linked to medical records, increasing numbers and ethnic subsets. The resulting genetic risk loci can then be used to create robust genetic risk scores enhanced with clinical information, environment and lifestyle data for a precision medicine approach to PCOS diagn...
Source: Endocrinology and Metabolism Clinics of North America - January 29, 2021 Category: Endocrinology Authors: Corrine K. Welt Source Type: research

Sexual Dysfunctions in Women
A critique of the literature that androgen deficit underlies women ’s sexual dysfunctions is provided. Although there is scant evidence that androgens are responsible, many aspects of androgen activity remain to be investigated. Research does link serum levels of dehydroepiandrosterone (DHEA) to women’s sexual desire but apparently not via DHEA’s androgenic a ctivity. Current assessment and management of women’s sexual dysfunction are summarized. (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - January 29, 2021 Category: Endocrinology Authors: Rosemary Basson Source Type: research

Hyperandrogenic Anovulation
Hyperandrogenic anovulation refers to the constellation of disorders that present in women with irregular menses, hirsutism and/or acne across the lifespan. Understanding the clinical signs and symptoms of each diagnosis in the differential and laboratory testing to confirm or exclude a diagnosis allows a clinician to appropriately counsel and treat the patient. (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - January 29, 2021 Category: Endocrinology Authors: Margaret E. Wierman Source Type: research

Androgens in Women: Too Much, Too Little, Just Right
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - January 29, 2021 Category: Endocrinology Authors: Margaret E. Wierman Source Type: research

Copyright
Elsevier (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - January 29, 2021 Category: Endocrinology Source Type: research

Contributors
ADRIANA G. IOACHIMESCU, MD, PhD, FACE (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - January 29, 2021 Category: Endocrinology Source Type: research

Contents
Adriana G. Ioachimescu (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - January 29, 2021 Category: Endocrinology Source Type: research

Forthcoming Issues
Updates on Osteoporosis (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - January 29, 2021 Category: Endocrinology Source Type: research

Polycystic Ovary Syndrome
The pathophysiology of symptomatic polycystic ovary syndrome (PCOS) often unfolds across puberty, but the ontogeny of PCOS is difficult to study because, in general, its pathophysiology is well entrenched before the diagnosis can be confirmed. However, the study of high-risk groups (daughters of women with PCOS, girls with premature pubarche, and girls with obesity) can offer insight in this regard. Available data support the hypothesis that the pubertal development of PCOS involves various combinations of genetic predisposition, intrauterine programming, hyperinsulinism, and numerous other abnormalities that provoke repro...
Source: Endocrinology and Metabolism Clinics of North America - January 11, 2021 Category: Endocrinology Authors: Christine M. Burt Solorzano, Christopher R. McCartney Source Type: research

Management of Women with Polycystic Ovary Syndrome During Pregnancy
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among reproductive age women and is associated with subfertility and adverse perinatal outcomes, which may include early pregnancy loss, gestational diabetes mellitus, hypertensive spectrum disorder, preterm birth, fetal growth disorders, and cesarean deliveries. The phenotypic heterogeneity, different diagnostic criteria, and PCOS-related conditions that women enter pregnancy with have limited evidenced-based studies and guidelines to reduce pregnancy complications among this high-risk population. This review summarizes the available evidence on the approa...
Source: Endocrinology and Metabolism Clinics of North America - January 11, 2021 Category: Endocrinology Authors: Amy M. Valent, Linda A. Barbour Source Type: research