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Diabetes Remission
The “Diabetes Remission” issue of the Endocrinology and Metabolism Clinics of North America presents our current understanding of the mechanisms and implications of attaining significantly improved glycemia in patients who no longer require pharmacologic treatment. The guest editor is Dr Betul Hatip oglu, Professor of Medicine at Case Western Reserve University School of Medicine. Dr Hatipoglu has done extensive work in the field of diabetes and pancreatic islet cell transplantation. (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - February 7, 2023 Category: Endocrinology Authors: Adriana G. Ioachimescu Tags: Foreword Source Type: research

Diabetes Remission
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - February 7, 2023 Category: Endocrinology Authors: Betul A. Hatipoglu Source Type: research

Copyright
Elsevier (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - February 7, 2023 Category: Endocrinology Source Type: research

Contributors
ADRIANA G. IOACHIMESCU, MD, PHD, FACE (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - February 7, 2023 Category: Endocrinology Source Type: research

Contents
Adriana G. Ioachimescu (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - February 7, 2023 Category: Endocrinology Source Type: research

Forthcoming Issues
Endocrinology of the Aging Patient (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - February 7, 2023 Category: Endocrinology Source Type: research

Nagging Pain and Foot Ulcers Can be Treated into Remission
Lower extremity ulcerations are very common in patients with diabetes. These wounds lead to amputation in a surprisingly large percentage of patients with diabetes. The mortality rate following amputation in a patient with diabetes is alarmingly high. Preventive treatment is pivotal to avoid the numerous complications associated with diabetic ulcerations. However, at the onset of ulceration, early treatment under the supervision and guidance of a specialist can result in remission. Diabetic peripheral neuropathy is also a life-altering and debilitating disease. Although some patients experience numbness, some experience pa...
Source: Endocrinology and Metabolism Clinics of North America - December 16, 2022 Category: Endocrinology Authors: Craig B. Frey, Richard Park, Rachel Robinson, Courtney Yoder Source Type: research

Diabetic Kidney Care Redefined with a New Way into Remission
Diabetic kidney disease has been a leading cause for end-stage kidney disease. Traditional methods to slow progression include tight glycemic control, blood pressure control, and use of renin –angiotensin axis inhibitors. Finerenone and sodium glucose co-transporters have shown proven benefit in diabetic kidney disease regression recently. Other potential targets for slowing the decline in diabetic kidney disease are transforming growth factor beta, endothelin antagonist, protein kinas e C inhibitors, advanced glycation end product inhibition, Janus kinase-signal transducer and activator of transcription pathway inhibiti...
Source: Endocrinology and Metabolism Clinics of North America - December 6, 2022 Category: Endocrinology Authors: Nour Hammad, Mohamed Hassanein, Mahboob Rahman Source Type: research

Root Cause for Metabolic Syndrome and Type 2 Diabetes
Obesity and its association with metabolic syndrome are implicated in many disease states. Research has focused on the role of diet and lifestyle modifications in the evolution of prediabetes to diabetes seeking ways to intervene and improve outcomes. Proven nutritional include leaner proteins, an abundance of vegetables, extra-virgin olive oil, and controlled portioning of carbs and starches. The transition from a sedentary state to an exercise routine of moderate intensity has shown efficacy in lowering metabolic risks. The synergy of dietary and physical activity modifications are the building blocks for lifestyle modif...
Source: Endocrinology and Metabolism Clinics of North America - December 6, 2022 Category: Endocrinology Authors: Revital Gorodeski Baskin, Dima Alfakara Source Type: research

Can the Future be Bright with Advances in Diabetic Eye Care?
The prevalence of diabetic retinopathy is steadily increasing as the population of patients with diabetes grows. In the past decade, the development of anti-VEGF agents has dramatically changed the treatment landscape for diabetic retinopathy and diabetic macular edema (DME). Newer agents in development aim to reduce the treatment burden of diabetic retinopathy (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - November 17, 2022 Category: Endocrinology Authors: Samantha Paul, Christian Kim, Mohamed Kamel Soliman, Warren Sobol, Jose J. Echegaray, Shree Kurup Source Type: research

Rekindling Hope for Remission
The individual and societal burdens of living with a chronic disease are a global issue. Diabetes directly increases health care costs to manage the disease and the associated complications and indirectly increases the economic burden through long-term complications that hinder the productivity of humans worldwide. Thus, it is crucial to have accurate information on diabetes-related costs and the geographic and global economic impact when planning interventions and future strategies. Health care systems must work with government agencies to plan national-level pre diabetes and diabetes strategies and policies. Public healt...
Source: Endocrinology and Metabolism Clinics of North America - November 17, 2022 Category: Endocrinology Authors: Betul Hatipoglu Source Type: research

Nonalcoholic Fatty Liver Disease
Management of nonalcoholic fatty liver disease (NAFLD) is crucial for type 2 diabetes (T2D) remission because they are linked through the common pathophysiology of insulin resistance and lipotoxicity. One in three patients with T2D has nonalcoholic steatohepatitis leading to fibrosis, cirrhosis, and hepatocellular carcinoma. Noninvasive testing with imaging and/or serum biomarkers can assess the risk for advanced liver disease. A liver biopsy is only necessary in select patients where there is diagnostic doubt. Treatments for NAFLD parallel T2D remission strategies focusing on weight loss and managing comorbid conditions t...
Source: Endocrinology and Metabolism Clinics of North America - November 17, 2022 Category: Endocrinology Authors: Scott Isaacs Source Type: research

Ameliorating Cardiovascular Risk in Patients with Type 2 Diabetes
Patients with type 2 diabetes (T2D) are at an increased risk of cardiovascular disease (CVD), which constitutes the most common cause of morbidity and mortality in these patients. Intensive CVD risk factor control can ameliorate the elevated CVD associated with T2D. In this review, we provide an overview of CVD risk factor control, including traditional (blood pressure, glycemia, lipid, thrombosis, and lifestyle modifications) and nontraditional (social and environmental determinants of health) in patients with T2D, including evidence on management and outcomes. (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - November 17, 2022 Category: Endocrinology Authors: Issam Motairek, Sadeer Al-Kindi Source Type: research

Intervention with Therapeutic Agents, Understanding the Path to Remission to Type 2 Diabetes
Type 2 diabetes is characterized by progressive decline in pancreatic β-cell function. Newer agents, such as glucagon-like peptide-1 receptor agonist (GLP-1RA) and dual incretin agonists, can augment β-cell function and delay the need for additional antihyperglycemics. However, the effect on β-cell function ceases after stopping the medications. When combined with intensive lifestyle modifications, higher doses of GLP-1RA than those used for diabetes treatment can be used to induce weight loss. More research is needed on whether the weight loss achieved with GLP1-RA can be sustained after stopping medication and in turn...
Source: Endocrinology and Metabolism Clinics of North America - November 17, 2022 Category: Endocrinology Authors: Shuai Hao, Guillermo E. Umpierrez, Priyathama Vellanki Source Type: research

What Is a Honeymoon in Type 1, Can It Go into Remission?
Type 1 diabetes is a chronic autoimmune disorder that results in destruction of insulin-producing cells in the pancreas. The autoimmune process is thought to be waxing and waning resulting in variable endogenous insulin secretion ability. An example of this is the honeymoon phase or partial remission phase of type 1 diabetes, during which optimal control of blood glucoses can be maintained with significantly reduced exogenous insulin, and occasionally exogenous insulin can be temporarily discontinued altogether. Understanding this phase is important because even fairly small amounts of endogenous insulin secretion is assoc...
Source: Endocrinology and Metabolism Clinics of North America - November 17, 2022 Category: Endocrinology Authors: Anuradha Viswanathan, Jamie R. Wood, Betul Hatipoglu Source Type: research