Endocrinology and Metabolism Clinics of North America This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Endocrine Aspects of Aging
Age-related changes in medicine are the norm. Age-driven changes in hormones are not only to be expected but also an essential component of normal physiology and pathophysiology. For example, thyroid function changes as an infant matures and becomes a child and through teenage and adult years. Similarly, gonadal function changes before puberty, throughout puberty, and in adulthood. Therefore, it is not surprising that as the mature individual ages concomitant hormonal changes occur. As the global population ages, the current issue on the endocrinology of the aging patient is both welcome and timely, as there is a vast quan...
Source: Endocrinology and Metabolism Clinics of North America - March 21, 2023 Category: Endocrinology Authors: Robert Rapaport Tags: Foreword Source Type: research

Endocrinology of the Aging Patient
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - March 21, 2023 Category: Endocrinology Authors: Rita Rastogi Kalyani Source Type: research

Copyright
Elsevier (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - March 21, 2023 Category: Endocrinology Source Type: research

Contributors
ROBERT RAPAPORT, MD (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - March 21, 2023 Category: Endocrinology Source Type: research

Contents
Robert Rapaport (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - March 21, 2023 Category: Endocrinology Source Type: research

Forthcoming Issues
Metabolic Associated Fatty Liver Disease (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - March 21, 2023 Category: Endocrinology Source Type: research

Management of Metabolic-Associated Fatty Liver Disease
Metabolic-associated fatty liver disease (MAFLD), previously known as nonalcoholic fatty liver disease (NAFLD), is the most common cause of liver disease in the world. Its prevalence is over 30% and is becoming the most common cause of liver transplants. Rates are rising along with obesity-related diseases. Risk factors for MAFLD include adverse lifestyles, genetic variations, advancing age, male sex, and alterations in the gut microbiota. Extrahepatic complications include cardiovascular disease, renal dysfunction, and colorectal cancer. As there are no currently approved medications for MAFLD, management mainly focuses o...
Source: Endocrinology and Metabolism Clinics of North America - March 19, 2023 Category: Endocrinology Authors: Kirthika Venkatesan, Nisha Nigil Haroon Source Type: research

Lean Metabolic-Associated Fatty Liver Disease
This article examines recently published data on lean MAFLD cohorts to highlight the prevalence, pathophysiological characteristics, associated liver fibrosis, genetics, hepatic and extrahepatic complications, prognosis, treatment, and research into this unique subtype of MAFLD. (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - March 19, 2023 Category: Endocrinology Authors: Cameron Gofton, McCawley Clark-Dickson, Jacob George Source Type: research

Metabolic-Associated Fatty Liver Disease in Childhood and Adolescence
Metabolic-associated fatty liver disease (MAFLD) has become the most common cause for chronic liver disease among children and adolescents globally. Although liver biopsy remains the gold standard for diagnosis, emerging technology, like velocity controlled transient elastography, a noninvasive method, is being utilized to evaluate degree of fibrosis in these patients. The discovery of multiple gene polymorphisms has brought new hope for possible treatment targets. However, this research is still ongoing, making lifestyle changes and weight reduction the current mainstay of treatment. This review briefly reviews the most r...
Source: Endocrinology and Metabolism Clinics of North America - March 16, 2023 Category: Endocrinology Authors: Carolyn Vespoli, Anoop Mohamed Iqbal, Mohammad Nasser Kabbany, Kadakkal Radhakrishnan Source Type: research

The Interlink Between Metabolic-Associated Fatty Liver Disease and Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) affects around 10% of women in the reproductive age group and is characterized by ovulatory dysfunction, hyperandrogenism, and/or polycystic ovarian morphology. PCOS is highly associated with metabolic-associated fatty liver disease (MAFLD) as both diseases share common risk factors. At the time of diagnosis of PCOS, screening for MAFLD is necessary because most patients with MAFLD are asymptomatic. The importance of early detection of MAFLD in patients with PCOS is that a timely intervention in patients with steatosis or steatohepatitis can reduce the probability of liver disease progressi...
Source: Endocrinology and Metabolism Clinics of North America - March 15, 2023 Category: Endocrinology Authors: Paulina Vidal-Cevallos, Alejandra Mijangos-Trejo, Misael Uribe, Norberto Ch ávez Tapia Source Type: research

Metabolic-Associated Fatty Liver Disease and Sarcopenia
The current evidence indicates a strong association between sarcopenia, the loss of muscle mass and strength, and metabolic-associated fatty liver disease (MAFLD). The two entities share many common pathophysiologic mechanisms, and their coexistence may result in higher rates of morbidity and mortality. Therefore, given their increasing incidence in the modern world, there is a need for a better understanding of the liver-muscle axis for early identification of sarcopenia in patients with MAFLD and vice versa. This review aims at presenting current data regarding the correlation between sarcopenia and MAFLD, the associated...
Source: Endocrinology and Metabolism Clinics of North America - March 15, 2023 Category: Endocrinology Authors: Triada Bali, Lampros Chrysavgis, Evangelos Cholongitas Source Type: research

Pathobiology of Metabolic-Associated Fatty Liver Disease
Metabolic-associated fatty liver disease (MAFLD), formerly known as nonalcoholic fatty liver disease, is highly associated with the metabolic syndrome. Given its high heterogeneity in patients along with unpredictable clinical outcomes, MAFLD is difficult to diagnose and manage. MAFLD is associated with obesity, diabetes, metabolic derangements, lipid disorders, cardiovascular disorders, sleep apnea, sarcopenia, gut dysbiosis, and sex hormone-related disorders. Identification of risk factors is imperative in understanding disease heterogeneity and clinical presentation to reliably diagnose and manage patients. The complexi...
Source: Endocrinology and Metabolism Clinics of North America - March 8, 2023 Category: Endocrinology Authors: Sherouk Fouda, Mohammed Sadiq Jeeyavudeen, Joseph M. Pappachan, Venkataraman Jayanthi Source Type: research

Cardiovascular Implications of Metabolic Dysfunction-Associated Fatty Liver Disease
Both nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD) have been associated with incident cardiovascular disease (CVD), independent of confounders. Causality has recently been inferred by Mendelian randomization studies. Although these findings have contributed to current guidelines that recommend screening for and treatment of cardiovascular risk factors, it not yet clear how to position NAFLD/MAFLD in cardiovascular risk estimation scores and, consequently, which treatment targets should be used. This review aims to provide practical tools as well as suggestions for...
Source: Endocrinology and Metabolism Clinics of North America - March 8, 2023 Category: Endocrinology Authors: Zhewen Ren, Anke Wesselius, Coen D.A. Stehouwer, Martijn C.G.J. Brouwers Source Type: research

Metabolic-Associated Fatty Liver Disease and the Gut Microbiota
As an important sequela of the burgeoning global obesity problem, metabolic-associated fatty liver disease (MAFLD) has gained increasing prominence recently. The gut –liver axis (GLA) provides a direct conduit to the liver for the gut microbiota and their metabolic by-products (including secondary bile acids, ethanol, and trimethylamine). These GLA-related factors, including the host inflammatory response and integrity of the gut mucosal wall, likely contribut e to the pathogenesis of MAFLD. Accordingly, these GLA-related factors are targets for possible preventive and treatment strategies for MAFLD, and include probioti...
Source: Endocrinology and Metabolism Clinics of North America - March 1, 2023 Category: Endocrinology Authors: Thomas M. Barber, Petra Hanson, Martin O. Weickert Source Type: research

Endocrinology of the Aging Patient
The United Nations projects that by 2050, 1 in 6 people in the world will be over the age of 65 years, up from 1 in 11 in 2019.1 Given these numbers, it is imperative to understand the hormonal changes that occur with aging in order to attain optimal health outcomes for older adults. In this theme issue of Endocrinology and Metabolism Clinics of North America, we focus on endocrinology of the aging patient and explore in-depth the alterations in multiple endocrine axes that occur across the lifespan. (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - February 26, 2023 Category: Endocrinology Authors: Rita Rastogi Kalyani Tags: Preface Source Type: research