Endocrinology and Metabolism Clinics of North America This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Characterizing Multimorbidity from Type 2 Diabetes
Patients with type 2 diabetes mellitus (T2DM) often live with and develop multiple co-occurring conditions, namely multimorbidity, with diffuse impacts on clinical care and patient quality of life. However, literature characterizing T2DM-related multimorbidity patterns is limited. This review summarizes the findings from the emerging literature characterizing and quantifying the association of T2DM with multimorbidity clusters. The authors ’ findings reveal 3 dominant cluster types appearing in patients with T2DM-related multimorbidity, such as cardiometabolic precursor conditions, vascular conditions, and mental health ...
Source: Endocrinology and Metabolism Clinics of North America - August 14, 2021 Category: Endocrinology Authors: Meryem Cicek, James Buckley, Jonathan Pearson-Stuttard, Edward W. Gregg Source Type: research

An Update on the Epidemiology of Type 2 Diabetes
This article highlights global trends in T2D and discusses the role of genes, early-life exposures, and lifestyle risk factors in the cause of T2D, with an emphasis on populations in current hotspots of the epidemic. It also considers potential impacts of the coronavirus disease 2019 pandemic and T2D prevention policies and action. (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - August 14, 2021 Category: Endocrinology Authors: Maria G. Tinajero, Vasanti S. Malik Source Type: research

Untamed Pandemic of Diabetes: 100 years After the Discovery of Insulin
One hundred years ago in 1921, in one of science ’s great breakthroughs, Best, Banting, and Macleod discovered insulin, and it was subsequently purified by James Collip.1 In those days, children with diabetic ketoacidosis (DKA) lay in crowded dark wards, comatose and dying, while family members, helpless in grief, watched the young die before th eir eyes. One dramatic day in 1922, Banting, Best, and Collip walked from bed to bed in one of these wards at the University of Toronto and injected purified insulin into several children dying of DKA. (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - August 14, 2021 Category: Endocrinology Authors: K.M. Venkat Narayan Tags: Preface Source Type: research

A Population-Based Approach to Diabetes and Prediabetes
The “Pandemic of Diabetes and Prediabetes: Prevention and Control” issue of the Endocrinology and Metabolism Clinics of North America is a fascinating journey through the epidemiology, prevention, and therapeutic advances of one of most prevalent and complex health care problems in twenty-first cent ury. Dr K.M. Venkat Narayan, MD, MSc, MBA, Professor of Epidemiology and Medicine at Emory School of Medicine, the Director of Emory Global Diabetes Research Center, and the Ruth and O.C. Hubert Chair of Global Health kindly agreed to serve as our guest editor. (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - August 14, 2021 Category: Endocrinology Authors: Adriana G. Ioachimescu Tags: Foreword Source Type: research

Dedication
This special theme issue on diabetes is dedicated to the 100th anniversary of the discovery of insulin in the hope that it will catalyze the realization of the vision of Best, Banting, and Macleod to deliver best and affordable care to the hundreds of millions worldwide suffering from diabetes, and that it will also catapult global interdisciplinary research to prevent and cure the disease. (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - August 14, 2021 Category: Endocrinology Authors: K.M. Venkat Narayan Source Type: research

Definition and Classification of Diabetes and Prediabetes and Emerging Data on Phenotypes
Diabetes diagnosis has important implications for individuals. Diagnostic criteria for fasting and 2-hour plasma glucose and HbA1c are universally agreed. Intermediate hyperglycemia/prediabetes is a risk factor for diabetes and cardiovascular disease. Because risk is a continuum, determining cut-point is problematic and reflected in significant differences in recommended fasting glucose and HbA1c criteria. Many types of diabetes are recognized. Diabetes classification systems are limited by a lack of understanding of etiopathogenetic pathways leading to diminished β-cell function. The World Health Organization classificat...
Source: Endocrinology and Metabolism Clinics of North America - August 14, 2021 Category: Endocrinology Authors: Stephen Colagiuri Source Type: research

Pandemic of Diabetes and Prediabetes: Prevention and Control
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - August 14, 2021 Category: Endocrinology Authors: K.M. Venkat Narayan Source Type: research

Copyright
Elsevier (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - August 14, 2021 Category: Endocrinology Source Type: research

Contributors
ADRIANA G. IOACHIMESCU, MD, PhD (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - August 14, 2021 Category: Endocrinology Source Type: research

Contents
K.M. Venkat Narayan (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - August 14, 2021 Category: Endocrinology Source Type: research

Forthcoming Issues
Hypercalcemia (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - August 14, 2021 Category: Endocrinology Source Type: research

Diabetes in Youth
This article summarizes the epidemiology, etiology, management, and complications of type 1 and type 2 diabetes in youth, as well as future directions and opportunities. (Source: Endocrinology and Metabolism Clinics of North America)
Source: Endocrinology and Metabolism Clinics of North America - July 13, 2021 Category: Endocrinology Authors: Anna R. Kahkoska, Dana Dabelea Source Type: research

Anticipation of Precision Diabetes and Promise of Integrative Multi-Omics
Precision diabetes is a concept of customizing delivery of health practices based on variability of diabetes. The authors reviewed recent research on type 2 diabetes heterogeneity and -omic biomarkers, including genomic, epigenomic, and metabolomic markers associated with type 2 diabetes. The emerging multiomics approach integrates complementary and interconnected molecular layers to provide systems level understanding of disease mechanisms and subtypes. Although the multiomic approach is not currently ready for routine clinical applications, future studies in the context of precision diabetes, particular in populations fr...
Source: Endocrinology and Metabolism Clinics of North America - July 13, 2021 Category: Endocrinology Authors: Chang Liu, Yan V. Sun Source Type: research

Screening for Diabetes and Prediabetes
Overt type 2 diabetes mellitus (T2DM) is preceded by prediabetes and latent diabetes (lasts 9 –12 years). Key dysglycemia screening tests are fasting plasma glucose and hemoglobin A1C. Screen-detected T2DM benefits from multifactorial management of cardiovascular risk beyond glycemia. Prediabetes is best addressed by lifestyle modification, with the goal of preventing T2DM. Although there is no trial evidence of prediabetes/T2DM screening effectiveness, simulations suggest that clinic-based opportunistic screening of high-risk individuals is cost-effective. The most rigorous extant recommendations are those of the Ameri...
Source: Endocrinology and Metabolism Clinics of North America - July 12, 2021 Category: Endocrinology Authors: Daisy Duan, Andre P. Kengne, Justin B. Echouffo-Tcheugui Source Type: research

Prevention of Type 2 Diabetes
The global diabetes burden is staggering, and prevention efforts are needed to reduce the impact on individuals and populations. There is strong evidence from efficacy trials showing that lifestyle interventions promoting increased physical activity, improvements in diet, and/or weight loss significantly reduce diabetes incidence and improve cardiometabolic risk factors. Implementation research assessing the feasibility, effectiveness, and cost-effectiveness of delivering these proven programs at the community level has shown success, but more research is needed to overcome barriers to implementation in different settings ...
Source: Endocrinology and Metabolism Clinics of North America - July 12, 2021 Category: Endocrinology Authors: Mary Beth Weber, Saria Hassan, Rakale Quarells, Megha Shah Source Type: research