What is the carcinoid syndrome? A critical appraisal of its proposed mediators
Endocr Rev. 2023 Dec 1:bnad035. doi: 10.1210/endrev/bnad035. Online ahead of print.ABSTRACTThe carcinoid syndrome (CS) is a debilitating disease that affects approximately 20% of patients with neuroendocrine neoplasms (NEN). Due to the increasing incidence and improved overall survival of patients with NEN over recent decades, patients are increasingly suffering from chronic and refractory CS symptoms. At present, symptom control is hampered by an incomplete understanding of the pathophysiology of this syndrome. This systematic review is the first to critically appraise the available evidence for the various hormonal media...
Source: ENDOCR REV - December 1, 2023 Category: Endocrinology Authors: Merijn C F Mulders Wouter W de Herder Johannes Hofland Source Type: research
Epigenetic programming for obesity and noncommunicable disease: From womb to tomb
Rev Endocr Metab Disord. 2023 Dec 2. doi: 10.1007/s11154-023-09854-w. Online ahead of print.ABSTRACTSeveral epidemiological, clinical and experimental studies in recent decades have shown the relationship between exposure to stressors during development and health outcomes later in life. The characterization of these susceptible phases, such as preconception, gestation, lactation and adolescence, and the understanding of factors that influence the risk of an adult individual for developing obesity, metabolic and cardiovascular diseases, is the focus of the DOHaD (Developmental Origins of Health and Disease) research line. ...
Source: ENDOCR REV - December 1, 2023 Category: Endocrinology Authors: Lucas Paulo Jacinto Saavedra Silvano Piovan Veridiana Mota Moreira Gessica Dutra Gon çalves Anna Rebeka Oliveira Ferreira Maiara Vanusa Guedes Ribeiro Maria Nat ália Chimirri Peres Douglas Lopes Almeida Scarlett Rodrigues Raposo Mariane Carneiro da Silv Source Type: research
What is the carcinoid syndrome? A critical appraisal of its proposed mediators
Endocr Rev. 2023 Dec 1:bnad035. doi: 10.1210/endrev/bnad035. Online ahead of print.ABSTRACTThe carcinoid syndrome (CS) is a debilitating disease that affects approximately 20% of patients with neuroendocrine neoplasms (NEN). Due to the increasing incidence and improved overall survival of patients with NEN over recent decades, patients are increasingly suffering from chronic and refractory CS symptoms. At present, symptom control is hampered by an incomplete understanding of the pathophysiology of this syndrome. This systematic review is the first to critically appraise the available evidence for the various hormonal media...
Source: ENDOCR REV - December 1, 2023 Category: Endocrinology Authors: Merijn C F Mulders Wouter W de Herder Johannes Hofland Source Type: research
Appetite- and weight-regulating neuroendocrine circuitry in hypothalamic obesity
Endocr Rev. 2023 Nov 29:bnad033. doi: 10.1210/endrev/bnad033. Online ahead of print.ABSTRACTSince hypothalamic obesity (HyOb) was first described over 120 years ago by Joseph Babinski and Alfred Fröhlich, advances in molecular genetic laboratory techniques have allowed us to elucidate various components of the intricate neurocircuitry governing appetite and weight regulation connecting the hypothalamus, pituitary gland, brainstem, adipose tissue, pancreas and gastrointestinal tract. On a background of an increasing prevalence of population-level common obesity, the number of survivors of congenital (e.g. septo-optic dyspl...
Source: ENDOCR REV - November 29, 2023 Category: Endocrinology Authors: Hoong-Wei Gan Manuela Cerbone Mehul Tulsidas Dattani Source Type: research
Appetite- and weight-regulating neuroendocrine circuitry in hypothalamic obesity
Endocr Rev. 2023 Nov 29:bnad033. doi: 10.1210/endrev/bnad033. Online ahead of print.ABSTRACTSince hypothalamic obesity (HyOb) was first described over 120 years ago by Joseph Babinski and Alfred Fröhlich, advances in molecular genetic laboratory techniques have allowed us to elucidate various components of the intricate neurocircuitry governing appetite and weight regulation connecting the hypothalamus, pituitary gland, brainstem, adipose tissue, pancreas and gastrointestinal tract. On a background of an increasing prevalence of population-level common obesity, the number of survivors of congenital (e.g. septo-optic dyspl...
Source: ENDOCR REV - November 29, 2023 Category: Endocrinology Authors: Hoong-Wei Gan Manuela Cerbone Mehul Tulsidas Dattani Source Type: research
Dynamic risk assessment in patients with differentiated thyroid cancer
Rev Endocr Metab Disord. 2023 Nov 28. doi: 10.1007/s11154-023-09857-7. Online ahead of print.ABSTRACTThe current approach for patients with differentiated thyroid carcinoma should be individualized according to the risk of recurrence, and this stratification could be used to identify the risk of persistent/recurrent disease in three scenarios: preoperatively, immediately postoperatively, and during long-term follow-up. The initial risk of recurrence will tailor the management of the patient in the preoperative and immediate postoperative settings, while the dynamic risk, which considers the responses to treatment, could gu...
Source: ENDOCR REV - November 28, 2023 Category: Endocrinology Authors: Erika Abelleira Fernando Jerkovich Source Type: research
Dynamic risk assessment in patients with differentiated thyroid cancer
Rev Endocr Metab Disord. 2023 Nov 28. doi: 10.1007/s11154-023-09857-7. Online ahead of print.ABSTRACTThe current approach for patients with differentiated thyroid carcinoma should be individualized according to the risk of recurrence, and this stratification could be used to identify the risk of persistent/recurrent disease in three scenarios: preoperatively, immediately postoperatively, and during long-term follow-up. The initial risk of recurrence will tailor the management of the patient in the preoperative and immediate postoperative settings, while the dynamic risk, which considers the responses to treatment, could gu...
Source: ENDOCR REV - November 28, 2023 Category: Endocrinology Authors: Erika Abelleira Fernando Jerkovich Source Type: research
Current practice in intermediate risk differentiated thyroid cancer - a review
Rev Endocr Metab Disord. 2023 Nov 23. doi: 10.1007/s11154-023-09852-y. Online ahead of print.ABSTRACTAlthough the overall prognosis for differentiated thyroid cancer (DTC) is excellent, a subset of patients will experience disease recurrence or may not respond to standard treatments. In recent years, DTC management has become more personalized in order to enhance treatment efficacy and avoid unnecessary interventions.In this context, major guidelines recommend post-surgery staging to assess the risk of disease persistence, recurrence, and mortality. Consequently, risk stratification becomes pivotal in determining the neces...
Source: ENDOCR REV - November 23, 2023 Category: Endocrinology Authors: Rosalia do Prado Padovani Fernanda Barbosa Duarte Camila Nascimento Source Type: research
Current practice in intermediate risk differentiated thyroid cancer - a review
Rev Endocr Metab Disord. 2023 Nov 23. doi: 10.1007/s11154-023-09852-y. Online ahead of print.ABSTRACTAlthough the overall prognosis for differentiated thyroid cancer (DTC) is excellent, a subset of patients will experience disease recurrence or may not respond to standard treatments. In recent years, DTC management has become more personalized in order to enhance treatment efficacy and avoid unnecessary interventions.In this context, major guidelines recommend post-surgery staging to assess the risk of disease persistence, recurrence, and mortality. Consequently, risk stratification becomes pivotal in determining the neces...
Source: ENDOCR REV - November 23, 2023 Category: Endocrinology Authors: Rosalia do Prado Padovani Fernanda Barbosa Duarte Camila Nascimento Source Type: research
Current practice in intermediate risk differentiated thyroid cancer - a review
Rev Endocr Metab Disord. 2023 Nov 23. doi: 10.1007/s11154-023-09852-y. Online ahead of print.ABSTRACTAlthough the overall prognosis for differentiated thyroid cancer (DTC) is excellent, a subset of patients will experience disease recurrence or may not respond to standard treatments. In recent years, DTC management has become more personalized in order to enhance treatment efficacy and avoid unnecessary interventions.In this context, major guidelines recommend post-surgery staging to assess the risk of disease persistence, recurrence, and mortality. Consequently, risk stratification becomes pivotal in determining the neces...
Source: ENDOCR REV - November 23, 2023 Category: Endocrinology Authors: Rosalia do Prado Padovani Fernanda Barbosa Duarte Camila Nascimento Source Type: research
Circadian alignment of food intake and glycaemic control by time-restricted eating: A systematic review and meta-analysis
Rev Endocr Metab Disord. 2023 Nov 22. doi: 10.1007/s11154-023-09853-x. Online ahead of print.ABSTRACTDaily rhythms of metabolic function are supported by molecular circadian clock systems that are strongly regulated by feeding and fasting. Intermittent fasting diets have been associated with weight loss and improved metabolism. However, the effects of time-restricted eating (TRE) on glycemic parameters are still under debate. In this review, we aim to systematically analyze the effects of TRE on glycemic parameters. We searched on PubMed, EMBASE, and the Cochrane Library for controlled studies in which subjects followed TR...
Source: ENDOCR REV - November 22, 2023 Category: Endocrinology Authors: Susana Rovira-Llopis Clara Luna-Marco Laura Perea-Galera Celia Ba ñuls Carlos Morillas Victor M Victor Source Type: research
Circadian alignment of food intake and glycaemic control by time-restricted eating: A systematic review and meta-analysis
Rev Endocr Metab Disord. 2023 Nov 22. doi: 10.1007/s11154-023-09853-x. Online ahead of print.ABSTRACTDaily rhythms of metabolic function are supported by molecular circadian clock systems that are strongly regulated by feeding and fasting. Intermittent fasting diets have been associated with weight loss and improved metabolism. However, the effects of time-restricted eating (TRE) on glycemic parameters are still under debate. In this review, we aim to systematically analyze the effects of TRE on glycemic parameters. We searched on PubMed, EMBASE, and the Cochrane Library for controlled studies in which subjects followed TR...
Source: ENDOCR REV - November 22, 2023 Category: Endocrinology Authors: Susana Rovira-Llopis Clara Luna-Marco Laura Perea-Galera Celia Ba ñuls Carlos Morillas Victor M Victor Source Type: research
Correction to: Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis
Rev Endocr Metab Disord. 2023 Nov 18. doi: 10.1007/s11154-023-09851-z. Online ahead of print.NO ABSTRACTPMID:37979073 | DOI:10.1007/s11154-023-09851-z (Source: ENDOCR REV)
Source: ENDOCR REV - November 18, 2023 Category: Endocrinology Authors: Elena Russo Mathilda Guizzardi Luca Canali Francesca Gaino Andrea Costantino Gherardo Mazziotti Andrea Lania Silvia Uccella Luca Di Tommaso Fabio Ferreli Luca Malvezzi Giuseppe Spriano Giuseppe Mercante Source Type: research
Correction to: Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis
Rev Endocr Metab Disord. 2023 Nov 18. doi: 10.1007/s11154-023-09851-z. Online ahead of print.NO ABSTRACTPMID:37979073 | DOI:10.1007/s11154-023-09851-z (Source: ENDOCR REV)
Source: ENDOCR REV - November 18, 2023 Category: Endocrinology Authors: Elena Russo Mathilda Guizzardi Luca Canali Francesca Gaino Andrea Costantino Gherardo Mazziotti Andrea Lania Silvia Uccella Luca Di Tommaso Fabio Ferreli Luca Malvezzi Giuseppe Spriano Giuseppe Mercante Source Type: research
Correction to: Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis
Rev Endocr Metab Disord. 2023 Nov 18. doi: 10.1007/s11154-023-09851-z. Online ahead of print.NO ABSTRACTPMID:37979073 | DOI:10.1007/s11154-023-09851-z (Source: ENDOCR REV)
Source: ENDOCR REV - November 18, 2023 Category: Endocrinology Authors: Elena Russo Mathilda Guizzardi Luca Canali Francesca Gaino Andrea Costantino Gherardo Mazziotti Andrea Lania Silvia Uccella Luca Di Tommaso Fabio Ferreli Luca Malvezzi Giuseppe Spriano Giuseppe Mercante Source Type: research
