Phase angle as a marker of outcome in hospitalized pediatric patients. A systematic review of the evidence (GRADE) with meta-analysis
Rev Endocr Metab Disord. 2023 Jul 24. doi: 10.1007/s11154-023-09817-1. Online ahead of print.ABSTRACTPhase angle (PhA) is a valuable tool for evaluating the nutritional and inflammatory status, which can accompany acute and severe disorders. PhA is a cellular health biomarker, whose value is particularly substantial due to the negative consequences of these situations in the pediatric population. Relevant literature was collected with the aim of comprehensively analysing the evidence on the association between an altered PhA can serve as a predictive-marker for mortality and poor-outcomes in at-risk-pediatric patients. Und...
Source: ENDOCR REV - July 24, 2023 Category: Endocrinology Authors: Roc ío Fernández-Jiménez Rafael Mart ín-Masot Isabel Cornejo-Pareja Isabel M Vegas-Aguilar Marta Herrador-L ópez Francisco J Tinahones V íctor Manuel Navas-López Diego Bellido-Guerrero Jos é Manuel García-Almeida Source Type: research
Phase angle as a marker of outcome in hospitalized pediatric patients. A systematic review of the evidence (GRADE) with meta-analysis
Rev Endocr Metab Disord. 2023 Jul 24. doi: 10.1007/s11154-023-09817-1. Online ahead of print.ABSTRACTPhase angle (PhA) is a valuable tool for evaluating the nutritional and inflammatory status, which can accompany acute and severe disorders. PhA is a cellular health biomarker, whose value is particularly substantial due to the negative consequences of these situations in the pediatric population. Relevant literature was collected with the aim of comprehensively analysing the evidence on the association between an altered PhA can serve as a predictive-marker for mortality and poor-outcomes in at-risk-pediatric patients. Und...
Source: ENDOCR REV - July 24, 2023 Category: Endocrinology Authors: Roc ío Fernández-Jiménez Rafael Mart ín-Masot Isabel Cornejo-Pareja Isabel M Vegas-Aguilar Marta Herrador-L ópez Francisco J Tinahones V íctor Manuel Navas-López Diego Bellido-Guerrero Jos é Manuel García-Almeida Source Type: research
Towards precision medicine in non-alcoholic fatty liver disease
Rev Endocr Metab Disord. 2023 Jul 21. doi: 10.1007/s11154-023-09820-6. Online ahead of print.ABSTRACTNon-Alcoholic Fatty Liver Disease (NAFLD) refers to the accumulation of lipid laden vacuoles in hepatocytes, occurring in the context of visceral adiposity, insulin resistance and other features of the metabolic syndrome. Its more severe form (NASH, Non-Alcoholic Steatohepatitis) is becoming the leading aetiology of end-stage liver disease and hepatocellular carcinoma, and also contributes to cardiovascular disease, diabetes and extrahepatic malignancy. Management is currently limited to lifestyle modification and optimisat...
Source: ENDOCR REV - July 21, 2023 Category: Endocrinology Authors: Sven M Francque Source Type: research
Towards precision medicine in non-alcoholic fatty liver disease
Rev Endocr Metab Disord. 2023 Jul 21. doi: 10.1007/s11154-023-09820-6. Online ahead of print.ABSTRACTNon-Alcoholic Fatty Liver Disease (NAFLD) refers to the accumulation of lipid laden vacuoles in hepatocytes, occurring in the context of visceral adiposity, insulin resistance and other features of the metabolic syndrome. Its more severe form (NASH, Non-Alcoholic Steatohepatitis) is becoming the leading aetiology of end-stage liver disease and hepatocellular carcinoma, and also contributes to cardiovascular disease, diabetes and extrahepatic malignancy. Management is currently limited to lifestyle modification and optimisat...
Source: ENDOCR REV - July 21, 2023 Category: Endocrinology Authors: Sven M Francque Source Type: research
Towards precision medicine in non-alcoholic fatty liver disease
Rev Endocr Metab Disord. 2023 Jul 21. doi: 10.1007/s11154-023-09820-6. Online ahead of print.ABSTRACTNon-Alcoholic Fatty Liver Disease (NAFLD) refers to the accumulation of lipid laden vacuoles in hepatocytes, occurring in the context of visceral adiposity, insulin resistance and other features of the metabolic syndrome. Its more severe form (NASH, Non-Alcoholic Steatohepatitis) is becoming the leading aetiology of end-stage liver disease and hepatocellular carcinoma, and also contributes to cardiovascular disease, diabetes and extrahepatic malignancy. Management is currently limited to lifestyle modification and optimisat...
Source: ENDOCR REV - July 21, 2023 Category: Endocrinology Authors: Sven M Francque Source Type: research
The emerging therapeutic potential of kisspeptin and neurokinin B
Endocr Rev. 2023 Jul 20:bnad023. doi: 10.1210/endrev/bnad023. Online ahead of print.ABSTRACTKisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) neuronal activity and pulsatile GnRH secretion. Their critical role in reproductive health was first identified after inactivating variants in genes encoding for KP or NKB signaling were shown to result in congenital hypogonadotropic hypogonadism (CHH) and a failure of pubertal development. Over the past two decades since their discovery, a wealth of evidence from ...
Source: ENDOCR REV - July 19, 2023 Category: Endocrinology Authors: Bijal Patel Kanyada Koysombat Edouard G Mills Jovanna Tsoutsouki Alexander N Comninos Ali Abbara Waljit S Dhillo Source Type: research
The emerging therapeutic potential of kisspeptin and neurokinin B
Endocr Rev. 2023 Jul 20:bnad023. doi: 10.1210/endrev/bnad023. Online ahead of print.ABSTRACTKisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) neuronal activity and pulsatile GnRH secretion. Their critical role in reproductive health was first identified after inactivating variants in genes encoding for KP or NKB signaling were shown to result in congenital hypogonadotropic hypogonadism (CHH) and a failure of pubertal development. Over the past two decades since their discovery, a wealth of evidence from ...
Source: ENDOCR REV - July 19, 2023 Category: Endocrinology Authors: Bijal Patel Kanyada Koysombat Edouard G Mills Jovanna Tsoutsouki Alexander N Comninos Ali Abbara Waljit S Dhillo Source Type: research
Crosstalk between the neuroendocrine system and bone homeostasis
Endocr Rev. 2023 Jul 17:bnad025. doi: 10.1210/endrev/bnad025. Online ahead of print.ABSTRACTThe homeostasis of bone microenvironment is the foundation of bone health and comprises two concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In the early 21st century, leptin, an adipocytes-derived hormone was found to affect bone homeostasis through hypothalamic relay and sympathetic nervous system, involving neurotransmitters like serotonin and norepinephrine. This discovery has provided a new perspective regarding the synergistic effects of endocrine and nervous systems on skeletal homeostasis. ...
Source: ENDOCR REV - July 17, 2023 Category: Endocrinology Authors: Yuhu Zhao Xiaole Peng Qing Wang Zhiyu Zhang Liangliang Wang Yaozeng Xu Huilin Yang Jiaxiang Bai Dechun Geng Source Type: research
Crosstalk between the neuroendocrine system and bone homeostasis
Endocr Rev. 2023 Jul 17:bnad025. doi: 10.1210/endrev/bnad025. Online ahead of print.ABSTRACTThe homeostasis of bone microenvironment is the foundation of bone health and comprises two concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In the early 21st century, leptin, an adipocytes-derived hormone was found to affect bone homeostasis through hypothalamic relay and sympathetic nervous system, involving neurotransmitters like serotonin and norepinephrine. This discovery has provided a new perspective regarding the synergistic effects of endocrine and nervous systems on skeletal homeostasis. ...
Source: ENDOCR REV - July 17, 2023 Category: Endocrinology Authors: Yuhu Zhao Xiaole Peng Qing Wang Zhiyu Zhang Liangliang Wang Yaozeng Xu Huilin Yang Jiaxiang Bai Dechun Geng Source Type: research
Crosstalk between the neuroendocrine system and bone homeostasis
Endocr Rev. 2023 Jul 17:bnad025. doi: 10.1210/endrev/bnad025. Online ahead of print.ABSTRACTThe homeostasis of bone microenvironment is the foundation of bone health and comprises two concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In the early 21st century, leptin, an adipocytes-derived hormone was found to affect bone homeostasis through hypothalamic relay and sympathetic nervous system, involving neurotransmitters like serotonin and norepinephrine. This discovery has provided a new perspective regarding the synergistic effects of endocrine and nervous systems on skeletal homeostasis. ...
Source: ENDOCR REV - July 17, 2023 Category: Endocrinology Authors: Yuhu Zhao Xiaole Peng Qing Wang Zhiyu Zhang Liangliang Wang Yaozeng Xu Huilin Yang Jiaxiang Bai Dechun Geng Source Type: research
Radiation-Related Thyroid Cancer
This article reviews radiation doses to the thyroid and corresponding cancer risks due to planned, existing, and emergency exposure situations, and medical, public, and occupational categories of exposures. Any exposure scenario may deliver a range of doses to the thyroid, and the risk for cancer is addressed along with modifying factors. The consequences of the Chornobyl and Fukushima nuclear power plants accidents are described, summarizing the information on thyroid cancer epidemiology, treatment and prognosis, clinicopathological characteristics, and genetic alterations. The Chornobyl thyroid cancers evolve in time: be...
Source: ENDOCR REV - July 14, 2023 Category: Endocrinology Authors: Vladimir Saenko Norisato Mitsutake Source Type: research
Radiation-Related Thyroid Cancer
This article reviews radiation doses to the thyroid and corresponding cancer risks due to planned, existing, and emergency exposure situations, and medical, public, and occupational categories of exposures. Any exposure scenario may deliver a range of doses to the thyroid, and the risk for cancer is addressed along with modifying factors. The consequences of the Chornobyl and Fukushima nuclear power plants accidents are described, summarizing the information on thyroid cancer epidemiology, treatment and prognosis, clinicopathological characteristics, and genetic alterations. The Chornobyl thyroid cancers evolve in time: be...
Source: ENDOCR REV - July 14, 2023 Category: Endocrinology Authors: Vladimir Saenko Norisato Mitsutake Source Type: research
Radiation-Related Thyroid Cancer
This article reviews radiation doses to the thyroid and corresponding cancer risks due to planned, existing, and emergency exposure situations, and medical, public, and occupational categories of exposures. Any exposure scenario may deliver a range of doses to the thyroid, and the risk for cancer is addressed along with modifying factors. The consequences of the Chornobyl and Fukushima nuclear power plants accidents are described, summarizing the information on thyroid cancer epidemiology, treatment and prognosis, clinicopathological characteristics, and genetic alterations. The Chornobyl thyroid cancers evolve in time: be...
Source: ENDOCR REV - July 14, 2023 Category: Endocrinology Authors: Vladimir Saenko Norisato Mitsutake Source Type: research
Biomarkers to Guide Medical Therapy in Primary Aldosteronism
Endocr Rev. 2023 Jul 13:bnad024. doi: 10.1210/endrev/bnad024. Online ahead of print.ABSTRACTPrimary aldosteronism (PA) is an endocrinopathy characterized by dysregulated aldosterone production that occurs despite suppression of renin and angiotensin II, and that is non-suppressible by volume and sodium loading. The effectiveness of surgical adrenalectomy for patients with lateralizing PA is characterized by the attenuation of excess aldosterone production leading to blood pressure reduction, correction of hypokalemia, and increases in renin; biomarkers that collectively indicate a reversal of PA pathophysiology and restora...
Source: ENDOCR REV - July 13, 2023 Category: Endocrinology Authors: Gregory L Hundemer Alexander A Leung Gregory A Kline Jenifer M Brown Adina F Turcu Anand Vaidya Source Type: research
Postprandial plasma GLP-1 levels are elevated in individuals with postprandial hypoglycaemia following Roux-en-Y gastric bypass - a systematic review
CONCLUSION: Following RYGB, postprandial peak plasma GLP-1, insulin and C-peptide concentrations are greater in individuals with post-bariatric surgery hypoglycaemia, while HbA1c is less. These observations support the concept that antagonism of GLP-1 would prove beneficial in the management of individuals with hypoglycaemia following RYGB.PROSPERO Registration Number: CRD42021287515.PMID:37439960 | DOI:10.1007/s11154-023-09823-3 (Source: ENDOCR REV)
Source: ENDOCR REV - July 13, 2023 Category: Endocrinology Authors: Ryan Joseph Jalleh Mahesh Michael Umapathysivam Mark Philip Plummer Adam Deane Karen Louise Jones Michael Horowitz Source Type: research
