Biomarkers to Guide Medical Therapy in Primary Aldosteronism
Endocr Rev. 2023 Jul 13:bnad024. doi: 10.1210/endrev/bnad024. Online ahead of print.ABSTRACTPrimary aldosteronism (PA) is an endocrinopathy characterized by dysregulated aldosterone production that occurs despite suppression of renin and angiotensin II, and that is non-suppressible by volume and sodium loading. The effectiveness of surgical adrenalectomy for patients with lateralizing PA is characterized by the attenuation of excess aldosterone production leading to blood pressure reduction, correction of hypokalemia, and increases in renin; biomarkers that collectively indicate a reversal of PA pathophysiology and restora...
Source: ENDOCR REV - July 13, 2023 Category: Endocrinology Authors: Gregory L Hundemer Alexander A Leung Gregory A Kline Jenifer M Brown Adina F Turcu Anand Vaidya Source Type: research
Postprandial plasma GLP-1 levels are elevated in individuals with postprandial hypoglycaemia following Roux-en-Y gastric bypass - a systematic review
CONCLUSION: Following RYGB, postprandial peak plasma GLP-1, insulin and C-peptide concentrations are greater in individuals with post-bariatric surgery hypoglycaemia, while HbA1c is less. These observations support the concept that antagonism of GLP-1 would prove beneficial in the management of individuals with hypoglycaemia following RYGB.PROSPERO Registration Number: CRD42021287515.PMID:37439960 | DOI:10.1007/s11154-023-09823-3 (Source: ENDOCR REV)
Source: ENDOCR REV - July 13, 2023 Category: Endocrinology Authors: Ryan Joseph Jalleh Mahesh Michael Umapathysivam Mark Philip Plummer Adam Deane Karen Louise Jones Michael Horowitz Source Type: research
Application of radiomics and machine learning to thyroid diseases in nuclear medicine: a systematic review
CONCLUSION: Despite some intrinsic limitations of radiomics and ML may have affect the results of this review, these technologies seem to have a promising role in the assessment of thyroid diseases. Validation of preliminary findings in multicentric studies is needed to translate radiomics and ML approaches in the clinical setting.PMID:37434097 | DOI:10.1007/s11154-023-09822-4 (Source: ENDOCR REV)
Source: ENDOCR REV - July 11, 2023 Category: Endocrinology Authors: Francesco Dondi Roberto Gatta Giorgio Treglia Arnoldo Piccardo Domenico Albano Luca Camoni Elisa Gatta Maria Cavadini Carlo Cappelli Francesco Bertagna Source Type: research
Ectopic insulinoma: a systematic review
In conclusion, ectopic insulinomas are presented as hypoglycaemia with female preponderance. Functional imaging [68Ga]Ga-DOTA-exedin-4 PET/CT and 68Ga-labelled-DOTA-conjugated somatostatin analogue PET/TC have very high sensitivity. Clinicians should be alert to the possibility of extra-pancreatic insulinomas when classic diagnostic tests and intraoperative pancreas exploration failed to locate the tumour.PMID:37434098 | DOI:10.1007/s11154-023-09824-2 (Source: ENDOCR REV)
Source: ENDOCR REV - July 11, 2023 Category: Endocrinology Authors: Fernando Guerrero-P érez Nuria Vilarrasa Lidia V Hu ánuco Juli Busquets Lluis Secanella Jos é L Vercher-Conejero Noemi Vidal Silvia N äf Cortés Carles Villabona Source Type: research
Application of radiomics and machine learning to thyroid diseases in nuclear medicine: a systematic review
CONCLUSION: Despite some intrinsic limitations of radiomics and ML may have affect the results of this review, these technologies seem to have a promising role in the assessment of thyroid diseases. Validation of preliminary findings in multicentric studies is needed to translate radiomics and ML approaches in the clinical setting.PMID:37434097 | DOI:10.1007/s11154-023-09822-4 (Source: ENDOCR REV)
Source: ENDOCR REV - July 11, 2023 Category: Endocrinology Authors: Francesco Dondi Roberto Gatta Giorgio Treglia Arnoldo Piccardo Domenico Albano Luca Camoni Elisa Gatta Maria Cavadini Carlo Cappelli Francesco Bertagna Source Type: research
Ectopic insulinoma: a systematic review
In conclusion, ectopic insulinomas are presented as hypoglycaemia with female preponderance. Functional imaging [68Ga]Ga-DOTA-exedin-4 PET/CT and 68Ga-labelled-DOTA-conjugated somatostatin analogue PET/TC have very high sensitivity. Clinicians should be alert to the possibility of extra-pancreatic insulinomas when classic diagnostic tests and intraoperative pancreas exploration failed to locate the tumour.PMID:37434098 | DOI:10.1007/s11154-023-09824-2 (Source: ENDOCR REV)
Source: ENDOCR REV - July 11, 2023 Category: Endocrinology Authors: Fernando Guerrero-P érez Nuria Vilarrasa Lidia V Hu ánuco Juli Busquets Lluis Secanella Jos é L Vercher-Conejero Noemi Vidal Silvia N äf Cortés Carles Villabona Source Type: research
Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics
Endocr Rev. 2023 Jul 6:bnad020. doi: 10.1210/endrev/bnad020. Online ahead of print.ABSTRACTEndometriosis is a prevalent gynecological condition associated with pelvic pain and infertility. Despite more than a century of research, the etiology of endometriosis still eludes scientific consensus. This lack of clarity has resulted in suboptimal prevention, diagnosis, and treatment options. Evidence of genetic contributors to endometriosis is interesting but limited; however, significant progress has been made in recent years in identifying epigenetic role in the pathogenesis of endometriosis through clinical studies, in vitro ...
Source: ENDOCR REV - July 6, 2023 Category: Endocrinology Authors: Ryan M Marquardt Dinh Nam Tran Bruce A Lessey Md Saidur Rahman Jae-Wook Jeong Source Type: research
The Hypothalamus-Pituitary-Adrenocortical response to critical illness: a concept in need of revision
Endocr Rev. 2023 Jul 6:bnad021. doi: 10.1210/endrev/bnad021. Online ahead of print.ABSTRACTBased on insights obtained during the last decade, the classical concept of an activated hypothalamus-pituitary-adrenocortical (HPA) axis in response to critical illness is in need of revision. After a brief central HPA axis activation, the vital maintenance of increased systemic cortisol availability and action in response to critical illness is predominantly driven by peripheral adaptations rather than by an ongoing centrally-activated several-fold increased production and secretion of cortisol. Besides the known reduction of corti...
Source: ENDOCR REV - July 6, 2023 Category: Endocrinology Authors: Lies Langouche Arno T éblick Jan Gunst Greet Van den Berghe Source Type: research
Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics
Endocr Rev. 2023 Jul 6:bnad020. doi: 10.1210/endrev/bnad020. Online ahead of print.ABSTRACTEndometriosis is a prevalent gynecological condition associated with pelvic pain and infertility. Despite more than a century of research, the etiology of endometriosis still eludes scientific consensus. This lack of clarity has resulted in suboptimal prevention, diagnosis, and treatment options. Evidence of genetic contributors to endometriosis is interesting but limited; however, significant progress has been made in recent years in identifying epigenetic role in the pathogenesis of endometriosis through clinical studies, in vitro ...
Source: ENDOCR REV - July 6, 2023 Category: Endocrinology Authors: Ryan M Marquardt Dinh Nam Tran Bruce A Lessey Md Saidur Rahman Jae-Wook Jeong Source Type: research
The Hypothalamus-Pituitary-Adrenocortical response to critical illness: a concept in need of revision
Endocr Rev. 2023 Jul 6:bnad021. doi: 10.1210/endrev/bnad021. Online ahead of print.ABSTRACTBased on insights obtained during the last decade, the classical concept of an activated hypothalamus-pituitary-adrenocortical (HPA) axis in response to critical illness is in need of revision. After a brief central HPA axis activation, the vital maintenance of increased systemic cortisol availability and action in response to critical illness is predominantly driven by peripheral adaptations rather than by an ongoing centrally-activated several-fold increased production and secretion of cortisol. Besides the known reduction of corti...
Source: ENDOCR REV - July 6, 2023 Category: Endocrinology Authors: Lies Langouche Arno T éblick Jan Gunst Greet Van den Berghe Source Type: research
Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics
Endocr Rev. 2023 Jul 6:bnad020. doi: 10.1210/endrev/bnad020. Online ahead of print.ABSTRACTEndometriosis is a prevalent gynecological condition associated with pelvic pain and infertility. Despite more than a century of research, the etiology of endometriosis still eludes scientific consensus. This lack of clarity has resulted in suboptimal prevention, diagnosis, and treatment options. Evidence of genetic contributors to endometriosis is interesting but limited; however, significant progress has been made in recent years in identifying epigenetic role in the pathogenesis of endometriosis through clinical studies, in vitro ...
Source: ENDOCR REV - July 6, 2023 Category: Endocrinology Authors: Ryan M Marquardt Dinh Nam Tran Bruce A Lessey Md Saidur Rahman Jae-Wook Jeong Source Type: research
The Hypothalamus-Pituitary-Adrenocortical response to critical illness: a concept in need of revision
Endocr Rev. 2023 Jul 6:bnad021. doi: 10.1210/endrev/bnad021. Online ahead of print.ABSTRACTBased on insights obtained during the last decade, the classical concept of an activated hypothalamus-pituitary-adrenocortical (HPA) axis in response to critical illness is in need of revision. After a brief central HPA axis activation, the vital maintenance of increased systemic cortisol availability and action in response to critical illness is predominantly driven by peripheral adaptations rather than by an ongoing centrally-activated several-fold increased production and secretion of cortisol. Besides the known reduction of corti...
Source: ENDOCR REV - July 6, 2023 Category: Endocrinology Authors: Lies Langouche Arno T éblick Jan Gunst Greet Van den Berghe Source Type: research
Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics
Endocr Rev. 2023 Jul 6:bnad020. doi: 10.1210/endrev/bnad020. Online ahead of print.ABSTRACTEndometriosis is a prevalent gynecological condition associated with pelvic pain and infertility. Despite more than a century of research, the etiology of endometriosis still eludes scientific consensus. This lack of clarity has resulted in suboptimal prevention, diagnosis, and treatment options. Evidence of genetic contributors to endometriosis is interesting but limited; however, significant progress has been made in recent years in identifying epigenetic role in the pathogenesis of endometriosis through clinical studies, in vitro ...
Source: ENDOCR REV - July 6, 2023 Category: Endocrinology Authors: Ryan M Marquardt Dinh Nam Tran Bruce A Lessey Md Saidur Rahman Jae-Wook Jeong Source Type: research
The Hypothalamus-Pituitary-Adrenocortical response to critical illness: a concept in need of revision
Endocr Rev. 2023 Jul 6:bnad021. doi: 10.1210/endrev/bnad021. Online ahead of print.ABSTRACTBased on insights obtained during the last decade, the classical concept of an activated hypothalamus-pituitary-adrenocortical (HPA) axis in response to critical illness is in need of revision. After a brief central HPA axis activation, the vital maintenance of increased systemic cortisol availability and action in response to critical illness is predominantly driven by peripheral adaptations rather than by an ongoing centrally-activated several-fold increased production and secretion of cortisol. Besides the known reduction of corti...
Source: ENDOCR REV - July 6, 2023 Category: Endocrinology Authors: Lies Langouche Arno T éblick Jan Gunst Greet Van den Berghe Source Type: research
Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics
Endocr Rev. 2023 Jul 6:bnad020. doi: 10.1210/endrev/bnad020. Online ahead of print.ABSTRACTEndometriosis is a prevalent gynecological condition associated with pelvic pain and infertility. Despite more than a century of research, the etiology of endometriosis still eludes scientific consensus. This lack of clarity has resulted in suboptimal prevention, diagnosis, and treatment options. Evidence of genetic contributors to endometriosis is interesting but limited; however, significant progress has been made in recent years in identifying epigenetic role in the pathogenesis of endometriosis through clinical studies, in vitro ...
Source: ENDOCR REV - July 6, 2023 Category: Endocrinology Authors: Ryan M Marquardt Dinh Nam Tran Bruce A Lessey Md Saidur Rahman Jae-Wook Jeong Source Type: research
