The Hypothalamus-Pituitary-Adrenocortical response to critical illness: a concept in need of revision
Endocr Rev. 2023 Jul 6:bnad021. doi: 10.1210/endrev/bnad021. Online ahead of print.ABSTRACTBased on insights obtained during the last decade, the classical concept of an activated hypothalamus-pituitary-adrenocortical (HPA) axis in response to critical illness is in need of revision. After a brief central HPA axis activation, the vital maintenance of increased systemic cortisol availability and action in response to critical illness is predominantly driven by peripheral adaptations rather than by an ongoing centrally-activated several-fold increased production and secretion of cortisol. Besides the known reduction of corti...
Source: ENDOCR REV - July 6, 2023 Category: Endocrinology Authors: Lies Langouche Arno T éblick Jan Gunst Greet Van den Berghe Source Type: research
Precision nutrition for targeting pathophysiology of cardiometabolic phenotypes
Rev Endocr Metab Disord. 2023 Jul 5. doi: 10.1007/s11154-023-09821-5. Online ahead of print.ABSTRACTObesity is a heterogenous disease accompanied by a broad spectrum of cardiometabolic risk profiles. Traditional paradigms for dietary weight management do not address biological heterogeneity between individuals and have catastrophically failed to combat the global pandemic of obesity-related diseases. Nutritional strategies that extend beyond basic weight management to instead target patient-specific pathophysiology are warranted. In this narrative review, we provide an overview of the tissue-level pathophysiological proces...
Source: ENDOCR REV - July 4, 2023 Category: Endocrinology Authors: Christopher E Shannon M éabh B Ní Chathail Sin éad M Mullin Andrew Meehan Fiona C McGillicuddy Helen M Roche Source Type: research
Targeting aging with the healthy skeletal system: The endocrine role of bone
Rev Endocr Metab Disord. 2023 Jul 5. doi: 10.1007/s11154-023-09812-6. Online ahead of print.ABSTRACTAging is an inevitable biological process, and longevity may be related to bone health. Maintaining strong bone health can extend one's lifespan, but the exact mechanism is unclear. Bone and extraosseous organs, including the heart and brain, have complex and precise communication mechanisms. In addition to its load bearing capacity, the skeletal system secretes cytokines, which play a role in bone regulation of extraosseous organs. FGF23, OCN, and LCN2 are three representative bone-derived cytokines involved in energy metab...
Source: ENDOCR REV - July 4, 2023 Category: Endocrinology Authors: Xuan-Qi Zheng Jia-Liang Lin Jie Huang Tong Wu Chun-Li Song Source Type: research
Precision nutrition for targeting pathophysiology of cardiometabolic phenotypes
Rev Endocr Metab Disord. 2023 Jul 5. doi: 10.1007/s11154-023-09821-5. Online ahead of print.ABSTRACTObesity is a heterogenous disease accompanied by a broad spectrum of cardiometabolic risk profiles. Traditional paradigms for dietary weight management do not address biological heterogeneity between individuals and have catastrophically failed to combat the global pandemic of obesity-related diseases. Nutritional strategies that extend beyond basic weight management to instead target patient-specific pathophysiology are warranted. In this narrative review, we provide an overview of the tissue-level pathophysiological proces...
Source: ENDOCR REV - July 4, 2023 Category: Endocrinology Authors: Christopher E Shannon M éabh B Ní Chathail Sin éad M Mullin Andrew Meehan Fiona C McGillicuddy Helen M Roche Source Type: research
Targeting aging with the healthy skeletal system: The endocrine role of bone
Rev Endocr Metab Disord. 2023 Jul 5. doi: 10.1007/s11154-023-09812-6. Online ahead of print.ABSTRACTAging is an inevitable biological process, and longevity may be related to bone health. Maintaining strong bone health can extend one's lifespan, but the exact mechanism is unclear. Bone and extraosseous organs, including the heart and brain, have complex and precise communication mechanisms. In addition to its load bearing capacity, the skeletal system secretes cytokines, which play a role in bone regulation of extraosseous organs. FGF23, OCN, and LCN2 are three representative bone-derived cytokines involved in energy metab...
Source: ENDOCR REV - July 4, 2023 Category: Endocrinology Authors: Xuan-Qi Zheng Jia-Liang Lin Jie Huang Tong Wu Chun-Li Song Source Type: research
