New findings on brain actions of growth hormone and potential clinical implications
Rev Endocr Metab Disord. 2023 Dec 7. doi: 10.1007/s11154-023-09861-x. Online ahead of print.ABSTRACTGrowth hormone (GH) is secreted by somatotropic cells of the anterior pituitary gland. The classical effects of GH comprise the stimulation of cell proliferation, tissue and body growth, lipolysis, and insulin resistance. The GH receptor (GHR) is expressed in numerous brain regions. Notably, a growing body of evidence indicates that GH-induced GHR signaling in specific neuronal populations regulates multiple physiological functions, including energy balance, glucose homeostasis, stress response, behavior, and several neurolo...
Source: ENDOCR REV - December 7, 2023 Category: Endocrinology Authors: Jose Donato John J Kopchick Source Type: research
New findings on brain actions of growth hormone and potential clinical implications
Rev Endocr Metab Disord. 2023 Dec 7. doi: 10.1007/s11154-023-09861-x. Online ahead of print.ABSTRACTGrowth hormone (GH) is secreted by somatotropic cells of the anterior pituitary gland. The classical effects of GH comprise the stimulation of cell proliferation, tissue and body growth, lipolysis, and insulin resistance. The GH receptor (GHR) is expressed in numerous brain regions. Notably, a growing body of evidence indicates that GH-induced GHR signaling in specific neuronal populations regulates multiple physiological functions, including energy balance, glucose homeostasis, stress response, behavior, and several neurolo...
Source: ENDOCR REV - December 7, 2023 Category: Endocrinology Authors: Jose Donato John J Kopchick Source Type: research
Potential therapeutic strategies for osteoarthritis via CRISPR/Cas9 mediated gene editing
Rev Endocr Metab Disord. 2023 Dec 6. doi: 10.1007/s11154-023-09860-y. Online ahead of print.ABSTRACTOsteoarthritis (OA) is an incapacitating and one of the most common physically degenerative conditions with an assorted etiology and a highly complicated molecular mechanism that to date lacks an efficient treatment. The capacity to design biological networks and accurately modify existing genomic sites holds an apt potential for applications across medical and biotechnological sciences. One of these highly specific genomes editing technologies is the CRISPR/Cas9 mechanism, referred to as the clustered regularly interspaced ...
Source: ENDOCR REV - December 6, 2023 Category: Endocrinology Authors: Rexhina Vlashi Xingen Zhang Haibo Li Guiqian Chen Source Type: research
Efficacy and tolerability of somatostatin analogues according to gender in patients with neuroendocrine tumors
Rev Endocr Metab Disord. 2023 Dec 5. doi: 10.1007/s11154-023-09858-6. Online ahead of print.ABSTRACTAs the incidence of neuroendocrine tumors has been rising, gender differences in epidemiology and clinical behavior have emerged, and interest into a gender-driven management of these tumors has grown with the aim to improve survival and quality of life of these patients. Somatostatin Analogues represent the first line of systemic treatment of both functional and non-functional neuroendocrine tumors, through the expression of somatostatin receptors (SSTRs) in the tumor cells, and proved effective in controlling hormonal hype...
Source: ENDOCR REV - December 5, 2023 Category: Endocrinology Authors: Rosaria M Ruggeri Irene Aini Stefano Gay Erika Maria Grossrubatscher Camilla Mancini Maria Grazia Tarsitano Virginia Zamponi Andrea M Isidori Annamaria Colao Antongiulio Faggiano NIKE group Source Type: research
An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications
Rev Endocr Metab Disord. 2023 Dec 5. doi: 10.1007/s11154-023-09850-0. Online ahead of print.ABSTRACTAdipose tissue, including white adipose tissue (WAT), brown adipose tissue (BAT), and beige adipose tissue, is vital in modulating whole-body energy metabolism. While WAT primarily stores energy, BAT dissipates energy as heat for thermoregulation. Beige adipose tissue is a hybrid form of adipose tissue that shares characteristics with WAT and BAT. Dysregulation of adipose tissue metabolism is linked to various disorders, including obesity, type 2 diabetes, cardiovascular diseases, cancer, and infertility. Both brown and beig...
Source: ENDOCR REV - December 5, 2023 Category: Endocrinology Authors: Zeinab Ghesmati Mohsen Rashid Shabnam Fayezi Frank Gieseler Effat Alizadeh Masoud Darabi Source Type: research
Efficacy and tolerability of somatostatin analogues according to gender in patients with neuroendocrine tumors
Rev Endocr Metab Disord. 2023 Dec 5. doi: 10.1007/s11154-023-09858-6. Online ahead of print.ABSTRACTAs the incidence of neuroendocrine tumors has been rising, gender differences in epidemiology and clinical behavior have emerged, and interest into a gender-driven management of these tumors has grown with the aim to improve survival and quality of life of these patients. Somatostatin Analogues represent the first line of systemic treatment of both functional and non-functional neuroendocrine tumors, through the expression of somatostatin receptors (SSTRs) in the tumor cells, and proved effective in controlling hormonal hype...
Source: ENDOCR REV - December 5, 2023 Category: Endocrinology Authors: Rosaria M Ruggeri Irene Aini Stefano Gay Erika Maria Grossrubatscher Camilla Mancini Maria Grazia Tarsitano Virginia Zamponi Andrea M Isidori Annamaria Colao Antongiulio Faggiano NIKE group Source Type: research
An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications
Rev Endocr Metab Disord. 2023 Dec 5. doi: 10.1007/s11154-023-09850-0. Online ahead of print.ABSTRACTAdipose tissue, including white adipose tissue (WAT), brown adipose tissue (BAT), and beige adipose tissue, is vital in modulating whole-body energy metabolism. While WAT primarily stores energy, BAT dissipates energy as heat for thermoregulation. Beige adipose tissue is a hybrid form of adipose tissue that shares characteristics with WAT and BAT. Dysregulation of adipose tissue metabolism is linked to various disorders, including obesity, type 2 diabetes, cardiovascular diseases, cancer, and infertility. Both brown and beig...
Source: ENDOCR REV - December 5, 2023 Category: Endocrinology Authors: Zeinab Ghesmati Mohsen Rashid Shabnam Fayezi Frank Gieseler Effat Alizadeh Masoud Darabi Source Type: research
Association between protein undernutrition and diabetes: Molecular implications in the reduction of insulin secretion
Rev Endocr Metab Disord. 2023 Dec 4. doi: 10.1007/s11154-023-09856-8. Online ahead of print.ABSTRACTUndernutrition is still a recurring nutritional problem in low and middle-income countries. It is directly associated with the social and economic sphere, but it can also negatively impact the health of the population. In this sense, it is believed that undernourished individuals may be more susceptible to the development of non-communicable diseases, such as diabetes mellitus, throughout life. This hypothesis was postulated and confirmed until today by several studies that demonstrate that experimental models submitted to p...
Source: ENDOCR REV - December 4, 2023 Category: Endocrinology Authors: Thiago Dos Reis Araujo Bruna Louren çoni Alves Lohanna Monali Barreto Dos Santos Luciana Mateus Gon çalves Everardo Magalh ães Carneiro Source Type: research
Association between protein undernutrition and diabetes: Molecular implications in the reduction of insulin secretion
Rev Endocr Metab Disord. 2023 Dec 4. doi: 10.1007/s11154-023-09856-8. Online ahead of print.ABSTRACTUndernutrition is still a recurring nutritional problem in low and middle-income countries. It is directly associated with the social and economic sphere, but it can also negatively impact the health of the population. In this sense, it is believed that undernourished individuals may be more susceptible to the development of non-communicable diseases, such as diabetes mellitus, throughout life. This hypothesis was postulated and confirmed until today by several studies that demonstrate that experimental models submitted to p...
Source: ENDOCR REV - December 4, 2023 Category: Endocrinology Authors: Thiago Dos Reis Araujo Bruna Louren çoni Alves Lohanna Monali Barreto Dos Santos Luciana Mateus Gon çalves Everardo Magalh ães Carneiro Source Type: research
New insights in thyroid diagnosis and treatment
Rev Endocr Metab Disord. 2023 Dec 2. doi: 10.1007/s11154-023-09859-5. Online ahead of print.ABSTRACTThe prevalence of thyroid disease continues to rise. As a consequence, the research in the thyroid field has significantly increased over time. Thus, clinicians, and endocrinologists first, have to be aware of the important continuous progress achieved, in particular of thyroid cancer, to better manage their patients. This themed issue, titled "New Insights in Thyroid Diagnosis and Treatment," delves deep into contemporary hot topics in thyroid field. These papers included in the present issue are focused on several aspects ...
Source: ENDOCR REV - December 2, 2023 Category: Endocrinology Authors: Fabian Pitoia Pierpaolo Trimboli Source Type: research
New insights in thyroid diagnosis and treatment
Rev Endocr Metab Disord. 2023 Dec 2. doi: 10.1007/s11154-023-09859-5. Online ahead of print.ABSTRACTThe prevalence of thyroid disease continues to rise. As a consequence, the research in the thyroid field has significantly increased over time. Thus, clinicians, and endocrinologists first, have to be aware of the important continuous progress achieved, in particular of thyroid cancer, to better manage their patients. This themed issue, titled "New Insights in Thyroid Diagnosis and Treatment," delves deep into contemporary hot topics in thyroid field. These papers included in the present issue are focused on several aspects ...
Source: ENDOCR REV - December 2, 2023 Category: Endocrinology Authors: Fabian Pitoia Pierpaolo Trimboli Source Type: research
What is the carcinoid syndrome? A critical appraisal of its proposed mediators
Endocr Rev. 2023 Dec 1:bnad035. doi: 10.1210/endrev/bnad035. Online ahead of print.ABSTRACTThe carcinoid syndrome (CS) is a debilitating disease that affects approximately 20% of patients with neuroendocrine neoplasms (NEN). Due to the increasing incidence and improved overall survival of patients with NEN over recent decades, patients are increasingly suffering from chronic and refractory CS symptoms. At present, symptom control is hampered by an incomplete understanding of the pathophysiology of this syndrome. This systematic review is the first to critically appraise the available evidence for the various hormonal media...
Source: ENDOCR REV - December 1, 2023 Category: Endocrinology Authors: Merijn C F Mulders Wouter W de Herder Johannes Hofland Source Type: research
Epigenetic programming for obesity and noncommunicable disease: From womb to tomb
Rev Endocr Metab Disord. 2023 Dec 2. doi: 10.1007/s11154-023-09854-w. Online ahead of print.ABSTRACTSeveral epidemiological, clinical and experimental studies in recent decades have shown the relationship between exposure to stressors during development and health outcomes later in life. The characterization of these susceptible phases, such as preconception, gestation, lactation and adolescence, and the understanding of factors that influence the risk of an adult individual for developing obesity, metabolic and cardiovascular diseases, is the focus of the DOHaD (Developmental Origins of Health and Disease) research line. ...
Source: ENDOCR REV - December 1, 2023 Category: Endocrinology Authors: Lucas Paulo Jacinto Saavedra Silvano Piovan Veridiana Mota Moreira Gessica Dutra Gon çalves Anna Rebeka Oliveira Ferreira Maiara Vanusa Guedes Ribeiro Maria Nat ália Chimirri Peres Douglas Lopes Almeida Scarlett Rodrigues Raposo Mariane Carneiro da Silv Source Type: research
What is the carcinoid syndrome? A critical appraisal of its proposed mediators
Endocr Rev. 2023 Dec 1:bnad035. doi: 10.1210/endrev/bnad035. Online ahead of print.ABSTRACTThe carcinoid syndrome (CS) is a debilitating disease that affects approximately 20% of patients with neuroendocrine neoplasms (NEN). Due to the increasing incidence and improved overall survival of patients with NEN over recent decades, patients are increasingly suffering from chronic and refractory CS symptoms. At present, symptom control is hampered by an incomplete understanding of the pathophysiology of this syndrome. This systematic review is the first to critically appraise the available evidence for the various hormonal media...
Source: ENDOCR REV - December 1, 2023 Category: Endocrinology Authors: Merijn C F Mulders Wouter W de Herder Johannes Hofland Source Type: research
Appetite- and weight-regulating neuroendocrine circuitry in hypothalamic obesity
Endocr Rev. 2023 Nov 29:bnad033. doi: 10.1210/endrev/bnad033. Online ahead of print.ABSTRACTSince hypothalamic obesity (HyOb) was first described over 120 years ago by Joseph Babinski and Alfred Fröhlich, advances in molecular genetic laboratory techniques have allowed us to elucidate various components of the intricate neurocircuitry governing appetite and weight regulation connecting the hypothalamus, pituitary gland, brainstem, adipose tissue, pancreas and gastrointestinal tract. On a background of an increasing prevalence of population-level common obesity, the number of survivors of congenital (e.g. septo-optic dyspl...
Source: ENDOCR REV - November 29, 2023 Category: Endocrinology Authors: Hoong-Wei Gan Manuela Cerbone Mehul Tulsidas Dattani Source Type: research
