Neurodevelopmental programming of adiposity: contributions to obesity risk
We describe the physiological outcomes of perinatal under- and overfeeding and explore potential mechanisms that may mediate the impact of such exposures on the development of feeding circuits within the CNS-including the influences of metabolic hormones and epigenetic changes. The perinatal environment, reflective of maternal nutritional status, contributes to the programming of offspring adiposity. The in utero and early postnatal periods represent critically sensitive developmental windows during which the hormonal and metabolic milieu affects the maturation of the hypothalamus. Maternal hyperglycemia is associated with...
Source: ENDOCR REV - November 16, 2023 Category: Endocrinology Authors: Alicja A Skowronski Rudolph L Leibel Charles A LeDuc Source Type: research
Thyroid cancer and insulin resistance
In conclusion, the association between thyroid cancer and diabetes may be explained by insulin resistance, as shown in observational studies. However, the causal role is yet to be defined. Although the wide use of different antidiabetic agents has been related to thyroid cancer prevalence and progression, future research with drugs such as metformin or GLP-1 RA is still needed.PMID:37957487 | DOI:10.1007/s11154-023-09849-7 (Source: ENDOCR REV)
Source: ENDOCR REV - November 13, 2023 Category: Endocrinology Authors: Gabriela Brenta Fernando Di Fermo Source Type: research
Thyroid cancer and insulin resistance
In conclusion, the association between thyroid cancer and diabetes may be explained by insulin resistance, as shown in observational studies. However, the causal role is yet to be defined. Although the wide use of different antidiabetic agents has been related to thyroid cancer prevalence and progression, future research with drugs such as metformin or GLP-1 RA is still needed.PMID:37957487 | DOI:10.1007/s11154-023-09849-7 (Source: ENDOCR REV)
Source: ENDOCR REV - November 13, 2023 Category: Endocrinology Authors: Gabriela Brenta Fernando Di Fermo Source Type: research
Thyroid cancer and insulin resistance
In conclusion, the association between thyroid cancer and diabetes may be explained by insulin resistance, as shown in observational studies. However, the causal role is yet to be defined. Although the wide use of different antidiabetic agents has been related to thyroid cancer prevalence and progression, future research with drugs such as metformin or GLP-1 RA is still needed.PMID:37957487 | DOI:10.1007/s11154-023-09849-7 (Source: ENDOCR REV)
Source: ENDOCR REV - November 13, 2023 Category: Endocrinology Authors: Gabriela Brenta Fernando Di Fermo Source Type: research
Thyroid ultrasound and its ancillary techniques
Rev Endocr Metab Disord. 2023 Nov 10. doi: 10.1007/s11154-023-09841-1. Online ahead of print.ABSTRACTUltrasound (US) of the thyroid has been used as a diagnostic tool since the late 1960s. US is the most important imaging tool for diagnosing thyroid disease. In the majority of cases a correct diagnosis can already be made in synopsis of the sonographic together with clinical findings and basal thyroid hormone parameters. However, the characterization of thyroid nodules by US remains challenging. The introduction of Thyroid Imaging Reporting and Data Systems (TIRADSs) has improved diagnostic accuracy of thyroid cancer signi...
Source: ENDOCR REV - November 9, 2023 Category: Endocrinology Authors: Joerg Bojunga Pierpaolo Trimboli Source Type: research
Thyroid ultrasound and its ancillary techniques
Rev Endocr Metab Disord. 2023 Nov 10. doi: 10.1007/s11154-023-09841-1. Online ahead of print.ABSTRACTUltrasound (US) of the thyroid has been used as a diagnostic tool since the late 1960s. US is the most important imaging tool for diagnosing thyroid disease. In the majority of cases a correct diagnosis can already be made in synopsis of the sonographic together with clinical findings and basal thyroid hormone parameters. However, the characterization of thyroid nodules by US remains challenging. The introduction of Thyroid Imaging Reporting and Data Systems (TIRADSs) has improved diagnostic accuracy of thyroid cancer signi...
Source: ENDOCR REV - November 9, 2023 Category: Endocrinology Authors: Joerg Bojunga Pierpaolo Trimboli Source Type: research
Thyroid ultrasound and its ancillary techniques
Rev Endocr Metab Disord. 2023 Nov 10. doi: 10.1007/s11154-023-09841-1. Online ahead of print.ABSTRACTUltrasound (US) of the thyroid has been used as a diagnostic tool since the late 1960s. US is the most important imaging tool for diagnosing thyroid disease. In the majority of cases a correct diagnosis can already be made in synopsis of the sonographic together with clinical findings and basal thyroid hormone parameters. However, the characterization of thyroid nodules by US remains challenging. The introduction of Thyroid Imaging Reporting and Data Systems (TIRADSs) has improved diagnostic accuracy of thyroid cancer signi...
Source: ENDOCR REV - November 9, 2023 Category: Endocrinology Authors: Joerg Bojunga Pierpaolo Trimboli Source Type: research
Thyroid ultrasound and its ancillary techniques
Rev Endocr Metab Disord. 2023 Nov 10. doi: 10.1007/s11154-023-09841-1. Online ahead of print.ABSTRACTUltrasound (US) of the thyroid has been used as a diagnostic tool since the late 1960s. US is the most important imaging tool for diagnosing thyroid disease. In the majority of cases a correct diagnosis can already be made in synopsis of the sonographic together with clinical findings and basal thyroid hormone parameters. However, the characterization of thyroid nodules by US remains challenging. The introduction of Thyroid Imaging Reporting and Data Systems (TIRADSs) has improved diagnostic accuracy of thyroid cancer signi...
Source: ENDOCR REV - November 9, 2023 Category: Endocrinology Authors: Joerg Bojunga Pierpaolo Trimboli Source Type: research
Diabetes mellitus, energy metabolism and COVID-19
Endocr Rev. 2023 Nov 2:bnad032. doi: 10.1210/endrev/bnad032. Online ahead of print.ABSTRACTObesity, diabetes mellitus (mostly type 2) and COVID-19 show mutual interactions, as they are not only risk factors for both acute and chronic COVID-19 manifestations, but also because COVID-19 alters energy metabolism. Such metabolic alterations can lead to dysglycemia and long-lasting effects. Thus, the COVID-19 pandemic has the potential for a further rise of the diabetes pandemic. This review outlines how pre-existing metabolic alterations spanning from excess visceral adipose tissue to hyperglycemia and overt diabetes may exacer...
Source: ENDOCR REV - November 7, 2023 Category: Endocrinology Authors: Caterina Conte Elisa Cipponeri Michael Roden Source Type: research
Diabetes mellitus, energy metabolism and COVID-19
Endocr Rev. 2023 Nov 2:bnad032. doi: 10.1210/endrev/bnad032. Online ahead of print.ABSTRACTObesity, diabetes mellitus (mostly type 2) and COVID-19 show mutual interactions, as they are not only risk factors for both acute and chronic COVID-19 manifestations, but also because COVID-19 alters energy metabolism. Such metabolic alterations can lead to dysglycemia and long-lasting effects. Thus, the COVID-19 pandemic has the potential for a further rise of the diabetes pandemic. This review outlines how pre-existing metabolic alterations spanning from excess visceral adipose tissue to hyperglycemia and overt diabetes may exacer...
Source: ENDOCR REV - November 7, 2023 Category: Endocrinology Authors: Caterina Conte Elisa Cipponeri Michael Roden Source Type: research
Molecular testing for thyroid nodules: Where are we now?
Rev Endocr Metab Disord. 2023 Oct 30. doi: 10.1007/s11154-023-09842-0. Online ahead of print.ABSTRACTApproximately 25% of the fine needle aspiration samples (FNAB) of thyroid nodules are classified as "indeterminate samples", that means, Bethesda III and IV categories. Until the last decade, most of these cases underwent diagnostic surgery, although only a minority (13-34%) confirmed malignancy postoperatively. In view of this, with the objective of improving the preoperative diagnosis in these cases, the molecular tests emerged, which are validated from the diagnostic point of view, presenting good performance, with good ...
Source: ENDOCR REV - October 30, 2023 Category: Endocrinology Authors: Carolina Ferraz Source Type: research
Molecular testing for thyroid nodules: Where are we now?
Rev Endocr Metab Disord. 2023 Oct 30. doi: 10.1007/s11154-023-09842-0. Online ahead of print.ABSTRACTApproximately 25% of the fine needle aspiration samples (FNAB) of thyroid nodules are classified as "indeterminate samples", that means, Bethesda III and IV categories. Until the last decade, most of these cases underwent diagnostic surgery, although only a minority (13-34%) confirmed malignancy postoperatively. In view of this, with the objective of improving the preoperative diagnosis in these cases, the molecular tests emerged, which are validated from the diagnostic point of view, presenting good performance, with good ...
Source: ENDOCR REV - October 30, 2023 Category: Endocrinology Authors: Carolina Ferraz Source Type: research
Molecular testing for thyroid nodules: Where are we now?
Rev Endocr Metab Disord. 2023 Oct 30. doi: 10.1007/s11154-023-09842-0. Online ahead of print.ABSTRACTApproximately 25% of the fine needle aspiration samples (FNAB) of thyroid nodules are classified as "indeterminate samples", that means, Bethesda III and IV categories. Until the last decade, most of these cases underwent diagnostic surgery, although only a minority (13-34%) confirmed malignancy postoperatively. In view of this, with the objective of improving the preoperative diagnosis in these cases, the molecular tests emerged, which are validated from the diagnostic point of view, presenting good performance, with good ...
Source: ENDOCR REV - October 30, 2023 Category: Endocrinology Authors: Carolina Ferraz Source Type: research
Molecular testing for thyroid nodules: Where are we now?
Rev Endocr Metab Disord. 2023 Oct 30. doi: 10.1007/s11154-023-09842-0. Online ahead of print.ABSTRACTApproximately 25% of the fine needle aspiration samples (FNAB) of thyroid nodules are classified as "indeterminate samples", that means, Bethesda III and IV categories. Until the last decade, most of these cases underwent diagnostic surgery, although only a minority (13-34%) confirmed malignancy postoperatively. In view of this, with the objective of improving the preoperative diagnosis in these cases, the molecular tests emerged, which are validated from the diagnostic point of view, presenting good performance, with good ...
Source: ENDOCR REV - October 30, 2023 Category: Endocrinology Authors: Carolina Ferraz Source Type: research
Molecular testing for thyroid nodules: Where are we now?
Rev Endocr Metab Disord. 2023 Oct 30. doi: 10.1007/s11154-023-09842-0. Online ahead of print.ABSTRACTApproximately 25% of the fine needle aspiration samples (FNAB) of thyroid nodules are classified as "indeterminate samples", that means, Bethesda III and IV categories. Until the last decade, most of these cases underwent diagnostic surgery, although only a minority (13-34%) confirmed malignancy postoperatively. In view of this, with the objective of improving the preoperative diagnosis in these cases, the molecular tests emerged, which are validated from the diagnostic point of view, presenting good performance, with good ...
Source: ENDOCR REV - October 30, 2023 Category: Endocrinology Authors: Carolina Ferraz Source Type: research
