Diagnosis and therapeutic approach to bone health in patients with hypopituitarism
Rev Endocr Metab Disord. 2024 Apr 3. doi: 10.1007/s11154-024-09878-w. Online ahead of print.ABSTRACTThe results of many studies in recent years indicate a significant impact of pituitary function on bone health. The proper function of the pituitary gland has a significant impact on the growth of the skeleton and the appearance of sexual dimorphism. It is also responsible for achieving peak bone mass, which protects against the development of osteoporosis and fractures later in life. It is also liable for the proper remodeling of the skeleton, which is a physiological mechanism managing the proper mechanical resistance of b...
Source: ENDOCR REV - April 2, 2024 Category: Endocrinology Authors: Justyna Kuliczkowska-P łaksej Aleksandra Zdrojowy-We łna Aleksandra Jawiarczyk-Przyby łowska Łukasz Gojny Marek Bolanowski Source Type: research
Diagnosis and therapeutic approach to bone health in patients with hypopituitarism
Rev Endocr Metab Disord. 2024 Apr 3. doi: 10.1007/s11154-024-09878-w. Online ahead of print.ABSTRACTThe results of many studies in recent years indicate a significant impact of pituitary function on bone health. The proper function of the pituitary gland has a significant impact on the growth of the skeleton and the appearance of sexual dimorphism. It is also responsible for achieving peak bone mass, which protects against the development of osteoporosis and fractures later in life. It is also liable for the proper remodeling of the skeleton, which is a physiological mechanism managing the proper mechanical resistance of b...
Source: ENDOCR REV - April 2, 2024 Category: Endocrinology Authors: Justyna Kuliczkowska-P łaksej Aleksandra Zdrojowy-We łna Aleksandra Jawiarczyk-Przyby łowska Łukasz Gojny Marek Bolanowski Source Type: research
Diagnosis and therapeutic approach to bone health in patients with hypopituitarism
Rev Endocr Metab Disord. 2024 Apr 3. doi: 10.1007/s11154-024-09878-w. Online ahead of print.ABSTRACTThe results of many studies in recent years indicate a significant impact of pituitary function on bone health. The proper function of the pituitary gland has a significant impact on the growth of the skeleton and the appearance of sexual dimorphism. It is also responsible for achieving peak bone mass, which protects against the development of osteoporosis and fractures later in life. It is also liable for the proper remodeling of the skeleton, which is a physiological mechanism managing the proper mechanical resistance of b...
Source: ENDOCR REV - April 2, 2024 Category: Endocrinology Authors: Justyna Kuliczkowska-P łaksej Aleksandra Zdrojowy-We łna Aleksandra Jawiarczyk-Przyby łowska Łukasz Gojny Marek Bolanowski Source Type: research
Endocrine involvement in hepatic glycogen storage diseases: pathophysiology and implications for care
Rev Endocr Metab Disord. 2024 Apr 1. doi: 10.1007/s11154-024-09880-2. Online ahead of print.ABSTRACTHepatic glycogen storage diseases constitute a group of disorders due to defects in the enzymes and transporters involved in glycogen breakdown and synthesis in the liver. Although hypoglycemia and hepatomegaly are the primary manifestations of (most of) hepatic GSDs, involvement of the endocrine system has been reported at multiple levels in individuals with hepatic GSDs. While some endocrine abnormalities (e.g., hypothalamic‑pituitary axis dysfunction in GSD I) can be direct consequence of the genetic defect itself, othe...
Source: ENDOCR REV - March 31, 2024 Category: Endocrinology Authors: Alessandro Rossi Chiara Simeoli Rosario Pivonello Mariacarolina Salerno Carmen Rosano Barbara Brunetti Pietro Strisciuglio Annamaria Colao Giancarlo Parenti Daniela Melis Terry G J Derks Source Type: research
Endocrine involvement in hepatic glycogen storage diseases: pathophysiology and implications for care
Rev Endocr Metab Disord. 2024 Apr 1. doi: 10.1007/s11154-024-09880-2. Online ahead of print.ABSTRACTHepatic glycogen storage diseases constitute a group of disorders due to defects in the enzymes and transporters involved in glycogen breakdown and synthesis in the liver. Although hypoglycemia and hepatomegaly are the primary manifestations of (most of) hepatic GSDs, involvement of the endocrine system has been reported at multiple levels in individuals with hepatic GSDs. While some endocrine abnormalities (e.g., hypothalamic‑pituitary axis dysfunction in GSD I) can be direct consequence of the genetic defect itself, othe...
Source: ENDOCR REV - March 31, 2024 Category: Endocrinology Authors: Alessandro Rossi Chiara Simeoli Rosario Pivonello Mariacarolina Salerno Carmen Rosano Barbara Brunetti Pietro Strisciuglio Annamaria Colao Giancarlo Parenti Daniela Melis Terry G J Derks Source Type: research
Endocrine involvement in hepatic glycogen storage diseases: pathophysiology and implications for care
Rev Endocr Metab Disord. 2024 Apr 1. doi: 10.1007/s11154-024-09880-2. Online ahead of print.ABSTRACTHepatic glycogen storage diseases constitute a group of disorders due to defects in the enzymes and transporters involved in glycogen breakdown and synthesis in the liver. Although hypoglycemia and hepatomegaly are the primary manifestations of (most of) hepatic GSDs, involvement of the endocrine system has been reported at multiple levels in individuals with hepatic GSDs. While some endocrine abnormalities (e.g., hypothalamic‑pituitary axis dysfunction in GSD I) can be direct consequence of the genetic defect itself, othe...
Source: ENDOCR REV - March 31, 2024 Category: Endocrinology Authors: Alessandro Rossi Chiara Simeoli Rosario Pivonello Mariacarolina Salerno Carmen Rosano Barbara Brunetti Pietro Strisciuglio Annamaria Colao Giancarlo Parenti Daniela Melis Terry G J Derks Source Type: research
The glucocorticoid receptor: isoforms, functions, and contribution to glucocorticoid sensitivity
Endocr Rev. 2024 Mar 29:bnae008. doi: 10.1210/endrev/bnae008. Online ahead of print.ABSTRACTGlucocorticoids exert pleiotropic effects on all tissues to regulate cellular and metabolic homeostasis. Synthetic forms are used therapeutically in a wide range of conditions for their anti-inflammatory benefits at the cost of dose and duration-dependent side effects. Significant variability occurs between tissues, disease states, and individuals with regard to both the beneficial and deleterious effects. The glucocorticoid receptor is the site of action for these hormones and a vast body of work has been conducted understanding it...
Source: ENDOCR REV - March 29, 2024 Category: Endocrinology Authors: Jack Lockett Warrick J Inder Vicki L Clifton Source Type: research
The glucocorticoid receptor: isoforms, functions, and contribution to glucocorticoid sensitivity
Endocr Rev. 2024 Mar 29:bnae008. doi: 10.1210/endrev/bnae008. Online ahead of print.ABSTRACTGlucocorticoids exert pleiotropic effects on all tissues to regulate cellular and metabolic homeostasis. Synthetic forms are used therapeutically in a wide range of conditions for their anti-inflammatory benefits at the cost of dose and duration-dependent side effects. Significant variability occurs between tissues, disease states, and individuals with regard to both the beneficial and deleterious effects. The glucocorticoid receptor is the site of action for these hormones and a vast body of work has been conducted understanding it...
Source: ENDOCR REV - March 29, 2024 Category: Endocrinology Authors: Jack Lockett Warrick J Inder Vicki L Clifton Source Type: research
The glucocorticoid receptor: isoforms, functions, and contribution to glucocorticoid sensitivity
Endocr Rev. 2024 Mar 29:bnae008. doi: 10.1210/endrev/bnae008. Online ahead of print.ABSTRACTGlucocorticoids exert pleiotropic effects on all tissues to regulate cellular and metabolic homeostasis. Synthetic forms are used therapeutically in a wide range of conditions for their anti-inflammatory benefits at the cost of dose and duration-dependent side effects. Significant variability occurs between tissues, disease states, and individuals with regard to both the beneficial and deleterious effects. The glucocorticoid receptor is the site of action for these hormones and a vast body of work has been conducted understanding it...
Source: ENDOCR REV - March 29, 2024 Category: Endocrinology Authors: Jack Lockett Warrick J Inder Vicki L Clifton Source Type: research
Correction to: "The Basis for Weekly Insulin Therapy: Evolving Evidence With Insulin Icodec and Insulin Efsitora Alfa"
Endocr Rev. 2024 Mar 22:bnae012. doi: 10.1210/endrev/bnae012. Online ahead of print.NO ABSTRACTPMID:38518751 | DOI:10.1210/endrev/bnae012 (Source: ENDOCR REV)
Source: ENDOCR REV - March 22, 2024 Category: Endocrinology Source Type: research
Correction to: "The Basis for Weekly Insulin Therapy: Evolving Evidence With Insulin Icodec and Insulin Efsitora Alfa"
Endocr Rev. 2024 Mar 22:bnae012. doi: 10.1210/endrev/bnae012. Online ahead of print.NO ABSTRACTPMID:38518751 | DOI:10.1210/endrev/bnae012 (Source: ENDOCR REV)
Source: ENDOCR REV - March 22, 2024 Category: Endocrinology Source Type: research
Correction to: "The Basis for Weekly Insulin Therapy: Evolving Evidence With Insulin Icodec and Insulin Efsitora Alfa"
Endocr Rev. 2024 Mar 22:bnae012. doi: 10.1210/endrev/bnae012. Online ahead of print.NO ABSTRACTPMID:38518751 | DOI:10.1210/endrev/bnae012 (Source: ENDOCR REV)
Source: ENDOCR REV - March 22, 2024 Category: Endocrinology Source Type: research
Correction to: "The Basis for Weekly Insulin Therapy: Evolving Evidence With Insulin Icodec and Insulin Efsitora Alfa"
Endocr Rev. 2024 Mar 22:bnae012. doi: 10.1210/endrev/bnae012. Online ahead of print.NO ABSTRACTPMID:38518751 | DOI:10.1210/endrev/bnae012 (Source: ENDOCR REV)
Source: ENDOCR REV - March 22, 2024 Category: Endocrinology Source Type: research
Correction to: "The Basis for Weekly Insulin Therapy: Evolving Evidence With Insulin Icodec and Insulin Efsitora Alfa"
Endocr Rev. 2024 Mar 22:bnae012. doi: 10.1210/endrev/bnae012. Online ahead of print.NO ABSTRACTPMID:38518751 | DOI:10.1210/endrev/bnae012 (Source: ENDOCR REV)
Source: ENDOCR REV - March 22, 2024 Category: Endocrinology Source Type: research
Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction
Endocr Rev. 2024 Mar 19:bnae010. doi: 10.1210/endrev/bnae010. Online ahead of print.ABSTRACTMultiple changes occur in hormonal regulation with aging and across various endocrine organs. These changes are associated with multiple age-related disorders and diseases. A better understanding of responsible underling biological mechanisms could help in the management of multiple endocrine disorders over and above hormone replacement therapy (HRT). Cellular senescence is involved in multiple biological aging processes and pathologies common in elderly individuals. Cellular senescence, which occurs in many older individuals but al...
Source: ENDOCR REV - March 19, 2024 Category: Endocrinology Authors: Masayoshi Suda Karl H Paul Utkarsh Tripathi Tohru Minamino Tamara Tchkonia James L Kirkland Source Type: research
