Mini-Puberty, Physiological and Disordered: Consequences, and Potential for Therapeutic Replacement
Endocr Rev. 2024 Mar 4:bnae003. doi: 10.1210/endrev/bnae003. Online ahead of print.ABSTRACTThere are 3 physiological waves of central hypothalamic-pituitary-gonadal (HPG) axis activity over the lifetime. The first occurs during fetal life, the second-termed "mini-puberty"-in the first months after birth, and the third at puberty. After adolescence, the axis remains active all through adulthood. Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disorder characterized by a deficiency in hypothalamic gonadotropin-releasing hormone (GnRH) secretion or action. In cases of severe CHH, all 3 waves of GnRH pulsatili...
Source: ENDOCR REV - March 4, 2024 Category: Endocrinology Authors: Julia Rohayem Emma C Alexander Sabine Heger Anna Nordenstr öm Sasha R Howard Source Type: research
Mini-Puberty, Physiological and Disordered: Consequences, and Potential for Therapeutic Replacement
Endocr Rev. 2024 Mar 4:bnae003. doi: 10.1210/endrev/bnae003. Online ahead of print.ABSTRACTThere are 3 physiological waves of central hypothalamic-pituitary-gonadal (HPG) axis activity over the lifetime. The first occurs during fetal life, the second-termed "mini-puberty"-in the first months after birth, and the third at puberty. After adolescence, the axis remains active all through adulthood. Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disorder characterized by a deficiency in hypothalamic gonadotropin-releasing hormone (GnRH) secretion or action. In cases of severe CHH, all 3 waves of GnRH pulsatili...
Source: ENDOCR REV - March 4, 2024 Category: Endocrinology Authors: Julia Rohayem Emma C Alexander Sabine Heger Anna Nordenstr öm Sasha R Howard Source Type: research
Mini-Puberty, Physiological and Disordered: Consequences, and Potential for Therapeutic Replacement
Endocr Rev. 2024 Mar 4:bnae003. doi: 10.1210/endrev/bnae003. Online ahead of print.ABSTRACTThere are 3 physiological waves of central hypothalamic-pituitary-gonadal (HPG) axis activity over the lifetime. The first occurs during fetal life, the second-termed "mini-puberty"-in the first months after birth, and the third at puberty. After adolescence, the axis remains active all through adulthood. Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disorder characterized by a deficiency in hypothalamic gonadotropin-releasing hormone (GnRH) secretion or action. In cases of severe CHH, all 3 waves of GnRH pulsatili...
Source: ENDOCR REV - March 4, 2024 Category: Endocrinology Authors: Julia Rohayem Emma C Alexander Sabine Heger Anna Nordenstr öm Sasha R Howard Source Type: research
Mini-Puberty, Physiological and Disordered: Consequences, and Potential for Therapeutic Replacement
Endocr Rev. 2024 Mar 4:bnae003. doi: 10.1210/endrev/bnae003. Online ahead of print.ABSTRACTThere are 3 physiological waves of central hypothalamic-pituitary-gonadal (HPG) axis activity over the lifetime. The first occurs during fetal life, the second-termed "mini-puberty"-in the first months after birth, and the third at puberty. After adolescence, the axis remains active all through adulthood. Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disorder characterized by a deficiency in hypothalamic gonadotropin-releasing hormone (GnRH) secretion or action. In cases of severe CHH, all 3 waves of GnRH pulsatili...
Source: ENDOCR REV - March 4, 2024 Category: Endocrinology Authors: Julia Rohayem Emma C Alexander Sabine Heger Anna Nordenstr öm Sasha R Howard Source Type: research
A multifaceted and inclusive methodology for the detection of sarcopenia in patients undergoing bariatric surgery: an in-depth analysis of current evidence
Rev Endocr Metab Disord. 2024 Mar 1. doi: 10.1007/s11154-023-09864-8. Online ahead of print.ABSTRACTBariatric surgery is widely recognized as the most effective intervention for obesity and offers benefits beyond weight loss. However, not all patients achieve satisfactory weight loss, balanced changes in body composition, and resolution of comorbidities. Therefore, thorough pre- and postoperative evaluations are important to predict success and minimize adverse effects. More comprehensive assessments require broadening the focus beyond body weight and fat measurements to consider quantitative and qualitative evaluations of...
Source: ENDOCR REV - March 1, 2024 Category: Endocrinology Authors: Eunhye Seo Yeongkeun Kwon Ahmad ALRomi Mohannad Eledreesi Sungsoo Park Source Type: research
A multifaceted and inclusive methodology for the detection of sarcopenia in patients undergoing bariatric surgery: an in-depth analysis of current evidence
Rev Endocr Metab Disord. 2024 Mar 1. doi: 10.1007/s11154-023-09864-8. Online ahead of print.ABSTRACTBariatric surgery is widely recognized as the most effective intervention for obesity and offers benefits beyond weight loss. However, not all patients achieve satisfactory weight loss, balanced changes in body composition, and resolution of comorbidities. Therefore, thorough pre- and postoperative evaluations are important to predict success and minimize adverse effects. More comprehensive assessments require broadening the focus beyond body weight and fat measurements to consider quantitative and qualitative evaluations of...
Source: ENDOCR REV - March 1, 2024 Category: Endocrinology Authors: Eunhye Seo Yeongkeun Kwon Ahmad ALRomi Mohannad Eledreesi Sungsoo Park Source Type: research
A multifaceted and inclusive methodology for the detection of sarcopenia in patients undergoing bariatric surgery: an in-depth analysis of current evidence
Rev Endocr Metab Disord. 2024 Mar 1. doi: 10.1007/s11154-023-09864-8. Online ahead of print.ABSTRACTBariatric surgery is widely recognized as the most effective intervention for obesity and offers benefits beyond weight loss. However, not all patients achieve satisfactory weight loss, balanced changes in body composition, and resolution of comorbidities. Therefore, thorough pre- and postoperative evaluations are important to predict success and minimize adverse effects. More comprehensive assessments require broadening the focus beyond body weight and fat measurements to consider quantitative and qualitative evaluations of...
Source: ENDOCR REV - March 1, 2024 Category: Endocrinology Authors: Eunhye Seo Yeongkeun Kwon Ahmad ALRomi Mohannad Eledreesi Sungsoo Park Source Type: research
Diagnosis and management of secondary adrenal crisis
Rev Endocr Metab Disord. 2024 Feb 27. doi: 10.1007/s11154-024-09877-x. Online ahead of print.ABSTRACTAdrenal crisis (AC) is a life threatening acute adrenal insufficiency (AI) episode which can occur in patients with primary AI but also secondary AI (SAI), tertiary AI (TAI) and iatrogenic AI (IAI). In SAI, TAI and IAI, AC may develop when the HPA axis is unable to mount an adequate glucocorticoid response to severe stress due to pituitary or hypothalamic disruption. It manifests as an acute deterioration in multi-organ homeostasis that, if untreated, leads to shock and death. Despite the availability of effective preventiv...
Source: ENDOCR REV - February 27, 2024 Category: Endocrinology Authors: Luciana Martel-Duguech Jonathan Poirier Isabelle Bourdeau Andr é Lacroix Source Type: research
Diagnosis and management of secondary adrenal crisis
Rev Endocr Metab Disord. 2024 Feb 27. doi: 10.1007/s11154-024-09877-x. Online ahead of print.ABSTRACTAdrenal crisis (AC) is a life threatening acute adrenal insufficiency (AI) episode which can occur in patients with primary AI but also secondary AI (SAI), tertiary AI (TAI) and iatrogenic AI (IAI). In SAI, TAI and IAI, AC may develop when the HPA axis is unable to mount an adequate glucocorticoid response to severe stress due to pituitary or hypothalamic disruption. It manifests as an acute deterioration in multi-organ homeostasis that, if untreated, leads to shock and death. Despite the availability of effective preventiv...
Source: ENDOCR REV - February 27, 2024 Category: Endocrinology Authors: Luciana Martel-Duguech Jonathan Poirier Isabelle Bourdeau Andr é Lacroix Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
