Pulling the trigger: Noncoding RNAs in white adipose tissue browning
Rev Endocr Metab Disord. 2023 Dec 29. doi: 10.1007/s11154-023-09866-6. Online ahead of print.ABSTRACTWhite adipose tissue (WAT) serves as the primary site for energy storage and endocrine regulation in mammals, while brown adipose tissue (BAT) is specialized for thermogenesis and energy expenditure. The conversion of white adipocytes to brown-like fat cells, known as browning, has emerged as a promising therapeutic strategy for reversing obesity and its associated co-morbidities. Noncoding RNAs (ncRNAs) are a class of transcripts that do not encode proteins but exert regulatory functions on gene expression at various level...
Source: ENDOCR REV - December 29, 2023 Category: Endocrinology Authors: Dehuan Liang Guoping Li Source Type: research
Pulling the trigger: Noncoding RNAs in white adipose tissue browning
Rev Endocr Metab Disord. 2023 Dec 29. doi: 10.1007/s11154-023-09866-6. Online ahead of print.ABSTRACTWhite adipose tissue (WAT) serves as the primary site for energy storage and endocrine regulation in mammals, while brown adipose tissue (BAT) is specialized for thermogenesis and energy expenditure. The conversion of white adipocytes to brown-like fat cells, known as browning, has emerged as a promising therapeutic strategy for reversing obesity and its associated co-morbidities. Noncoding RNAs (ncRNAs) are a class of transcripts that do not encode proteins but exert regulatory functions on gene expression at various level...
Source: ENDOCR REV - December 29, 2023 Category: Endocrinology Authors: Dehuan Liang Guoping Li Source Type: research
Diagnosing and treating the elderly individual with hypopituitarism
Rev Endocr Metab Disord. 2023 Dec 27. doi: 10.1007/s11154-023-09870-w. Online ahead of print.ABSTRACTHypopituitarism in the elderly is an underestimated condition mainly due to the non-specific presentation that can be attributed to the effects of aging and the presence of comorbidities. Diagnosis and treatment of hypopituitarism often represent a challenging task and this is even more significant in the elderly. Diagnosis can be insidious due to the physiological changes occurring with aging that complicate the interpretation of hormonal investigations, and the need to avoid some provocative tests that carry higher risks ...
Source: ENDOCR REV - December 27, 2023 Category: Endocrinology Authors: Andrea Corsello Rosa Maria Paragliola Roberto Salvatori Source Type: research
Diagnosing and treating the elderly individual with hypopituitarism
Rev Endocr Metab Disord. 2023 Dec 27. doi: 10.1007/s11154-023-09870-w. Online ahead of print.ABSTRACTHypopituitarism in the elderly is an underestimated condition mainly due to the non-specific presentation that can be attributed to the effects of aging and the presence of comorbidities. Diagnosis and treatment of hypopituitarism often represent a challenging task and this is even more significant in the elderly. Diagnosis can be insidious due to the physiological changes occurring with aging that complicate the interpretation of hormonal investigations, and the need to avoid some provocative tests that carry higher risks ...
Source: ENDOCR REV - December 27, 2023 Category: Endocrinology Authors: Andrea Corsello Rosa Maria Paragliola Roberto Salvatori Source Type: research
Diagnosing and treating the elderly individual with hypopituitarism
Rev Endocr Metab Disord. 2023 Dec 27. doi: 10.1007/s11154-023-09870-w. Online ahead of print.ABSTRACTHypopituitarism in the elderly is an underestimated condition mainly due to the non-specific presentation that can be attributed to the effects of aging and the presence of comorbidities. Diagnosis and treatment of hypopituitarism often represent a challenging task and this is even more significant in the elderly. Diagnosis can be insidious due to the physiological changes occurring with aging that complicate the interpretation of hormonal investigations, and the need to avoid some provocative tests that carry higher risks ...
Source: ENDOCR REV - December 27, 2023 Category: Endocrinology Authors: Andrea Corsello Rosa Maria Paragliola Roberto Salvatori Source Type: research
Diagnosing and treating the elderly individual with hypopituitarism
Rev Endocr Metab Disord. 2023 Dec 27. doi: 10.1007/s11154-023-09870-w. Online ahead of print.ABSTRACTHypopituitarism in the elderly is an underestimated condition mainly due to the non-specific presentation that can be attributed to the effects of aging and the presence of comorbidities. Diagnosis and treatment of hypopituitarism often represent a challenging task and this is even more significant in the elderly. Diagnosis can be insidious due to the physiological changes occurring with aging that complicate the interpretation of hormonal investigations, and the need to avoid some provocative tests that carry higher risks ...
Source: ENDOCR REV - December 27, 2023 Category: Endocrinology Authors: Andrea Corsello Rosa Maria Paragliola Roberto Salvatori Source Type: research
Diagnosing and treating the elderly individual with hypopituitarism
Rev Endocr Metab Disord. 2023 Dec 27. doi: 10.1007/s11154-023-09870-w. Online ahead of print.ABSTRACTHypopituitarism in the elderly is an underestimated condition mainly due to the non-specific presentation that can be attributed to the effects of aging and the presence of comorbidities. Diagnosis and treatment of hypopituitarism often represent a challenging task and this is even more significant in the elderly. Diagnosis can be insidious due to the physiological changes occurring with aging that complicate the interpretation of hormonal investigations, and the need to avoid some provocative tests that carry higher risks ...
Source: ENDOCR REV - December 27, 2023 Category: Endocrinology Authors: Andrea Corsello Rosa Maria Paragliola Roberto Salvatori Source Type: research
Diagnosing and treating the elderly individual with hypopituitarism
Rev Endocr Metab Disord. 2023 Dec 27. doi: 10.1007/s11154-023-09870-w. Online ahead of print.ABSTRACTHypopituitarism in the elderly is an underestimated condition mainly due to the non-specific presentation that can be attributed to the effects of aging and the presence of comorbidities. Diagnosis and treatment of hypopituitarism often represent a challenging task and this is even more significant in the elderly. Diagnosis can be insidious due to the physiological changes occurring with aging that complicate the interpretation of hormonal investigations, and the need to avoid some provocative tests that carry higher risks ...
Source: ENDOCR REV - December 27, 2023 Category: Endocrinology Authors: Andrea Corsello Rosa Maria Paragliola Roberto Salvatori Source Type: research
Cognition and psychological wellbeing in hypopituitary patients
Rev Endocr Metab Disord. 2023 Dec 26. doi: 10.1007/s11154-023-09869-3. Online ahead of print.ABSTRACTHypopituitarism (HP) frequently occurs in patients presenting with sellar masses and despite recent advances in therapeutic options, HP patients consistently suffer from impaired quality of life due to psychological distress and cognitive dysfunction. These neurocognitive complications tend to persist in spite of surgical or biochemical remission of the disease making it especially challenging to segregate the effect of HP per se from other comorbidities such as the effect of tumour, surgery, radiation therapy, or complicat...
Source: ENDOCR REV - December 25, 2023 Category: Endocrinology Authors: Syed Ali Imran Michael Wilkinson Source Type: research
Cognition and psychological wellbeing in hypopituitary patients
Rev Endocr Metab Disord. 2023 Dec 26. doi: 10.1007/s11154-023-09869-3. Online ahead of print.ABSTRACTHypopituitarism (HP) frequently occurs in patients presenting with sellar masses and despite recent advances in therapeutic options, HP patients consistently suffer from impaired quality of life due to psychological distress and cognitive dysfunction. These neurocognitive complications tend to persist in spite of surgical or biochemical remission of the disease making it especially challenging to segregate the effect of HP per se from other comorbidities such as the effect of tumour, surgery, radiation therapy, or complicat...
Source: ENDOCR REV - December 25, 2023 Category: Endocrinology Authors: Syed Ali Imran Michael Wilkinson Source Type: research
Correction to: Potential therapeutic strategies for osteoarthritis via CRISPR/Cas9 mediated gene editing
Rev Endocr Metab Disord. 2023 Dec 22. doi: 10.1007/s11154-023-09867-5. Online ahead of print.NO ABSTRACTPMID:38135809 | DOI:10.1007/s11154-023-09867-5 (Source: ENDOCR REV)
Source: ENDOCR REV - December 22, 2023 Category: Endocrinology Authors: Rexhina Vlashi Xingen Zhang Haibo Li Guiqian Chen Source Type: research
Correction to: Potential therapeutic strategies for osteoarthritis via CRISPR/Cas9 mediated gene editing
Rev Endocr Metab Disord. 2023 Dec 22. doi: 10.1007/s11154-023-09867-5. Online ahead of print.NO ABSTRACTPMID:38135809 | DOI:10.1007/s11154-023-09867-5 (Source: ENDOCR REV)
Source: ENDOCR REV - December 22, 2023 Category: Endocrinology Authors: Rexhina Vlashi Xingen Zhang Haibo Li Guiqian Chen Source Type: research
The molecular biology of midgut neuroendocrine neoplasms
Endocr Rev. 2023 Dec 20:bnad034. doi: 10.1210/endrev/bnad034. Online ahead of print.ABSTRACTMidgut neuroendocrine neoplasms (NENs) are one of the most common subtypes of NEN, and their incidence is rising globally. Despite being the most frequently diagnosed malignancy of the small intestine, little is known about their underlying molecular biology. Their unusually low mutational burden compared to other solid tumours, and the unexplained occurrence of multi-focal tumours makes the molecular biology of midgut NENs a particularly fascinating field of research. This review provides an overview of recent advances in the under...
Source: ENDOCR REV - December 20, 2023 Category: Endocrinology Authors: Amy P Webster Chrissie Thirlwell Source Type: research
The molecular biology of midgut neuroendocrine neoplasms
Endocr Rev. 2023 Dec 20:bnad034. doi: 10.1210/endrev/bnad034. Online ahead of print.ABSTRACTMidgut neuroendocrine neoplasms (NENs) are one of the most common subtypes of NEN, and their incidence is rising globally. Despite being the most frequently diagnosed malignancy of the small intestine, little is known about their underlying molecular biology. Their unusually low mutational burden compared to other solid tumours, and the unexplained occurrence of multi-focal tumours makes the molecular biology of midgut NENs a particularly fascinating field of research. This review provides an overview of recent advances in the under...
Source: ENDOCR REV - December 20, 2023 Category: Endocrinology Authors: Amy P Webster Chrissie Thirlwell Source Type: research
The molecular biology of midgut neuroendocrine neoplasms
Endocr Rev. 2023 Dec 20:bnad034. doi: 10.1210/endrev/bnad034. Online ahead of print.ABSTRACTMidgut neuroendocrine neoplasms (NENs) are one of the most common subtypes of NEN, and their incidence is rising globally. Despite being the most frequently diagnosed malignancy of the small intestine, little is known about their underlying molecular biology. Their unusually low mutational burden compared to other solid tumours, and the unexplained occurrence of multi-focal tumours makes the molecular biology of midgut NENs a particularly fascinating field of research. This review provides an overview of recent advances in the under...
Source: ENDOCR REV - December 20, 2023 Category: Endocrinology Authors: Amy P Webster Chrissie Thirlwell Source Type: research
