Expert Opinions on the Current Therapeutic Management of Inflammatory Bowel Disease during the COVID-19 Pandemic: Japan IBD COVID-19 Taskforce, Intractable Diseases, the Health and Labor Sciences Research
Background: The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as a dramatic challenge for all healthcare systems worldwide. This outbreak immediately affected gastroenterologists as well as global physicians worldwide because COVID-19 can be associated with not only triggering respiratory inflammation but also gastrointestinal (GI) inflammation based on the mechanism by which SARS-CoV-2 enters cells via its receptor the angiotensin-converting enzyme 2, which is expressed on GI cells. However, the comorbidity spectrum of digestive system in patients with COVID-19 rema...
Source: Digestion - September 4, 2020 Category: Gastroenterology Source Type: research
Factors Associated with Fibrosis during Colorectal Endoscopic Submucosal Dissection: Does Pretreatment Biopsy Potentially Elicit Submucosal Fibrosis and Affect Endoscopic Submucosal Dissection Outcomes?
Conclusions: Pretreatment biopsy causes submucosal fibrosis resulting in prolonged procedure times and incomplete resection. These findings suggest important benefits of avoiding biopsy before ESD.Digestion (Source: Digestion)
Source: Digestion - August 31, 2020 Category: Gastroenterology Source Type: research
Efficacy of Magnifying Narrow Band Imaging with Acetic Acid Spray in Diagnosing Superficial Non-Ampullary Duodenal Epithelial Tumors
Conclusion: MA-NBI may be useful in differentiating between category 3 and category 4/5 lesions of SNADETs.Digestion (Source: Digestion)
Source: Digestion - August 26, 2020 Category: Gastroenterology Source Type: research
Repeated Lusutrombopag Treatment for Thrombocytopenia in Patients with Chronic Liver Disease
Conclusions: Repeated use of lusutrombopag might be safe and effective against thrombocytopenia in patients with CLD undergoing multi-cycle invasive procedures, although long-term data from more patients are required.Digestion (Source: Digestion)
Source: Digestion - August 25, 2020 Category: Gastroenterology Source Type: research
Publisher's Note
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Source: Digestion - August 24, 2020 Category: Gastroenterology Source Type: research
Malignancies in Inflammatory Bowel Disease
Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, primarily of, but not restricted to, the gut. Association between IBD and cancer has been clearly established and is uniformly accepted.Summary: IBD patients are at particular risk for intestinal and extraintestinal cancers. There are 2 underlying mechanisms: (1) IBD-related inflammation triggers initiation and progression of tumor formation. This particularly results in the development of colorectal cancer, small bowel adenocarcinoma, intestinal lymphoma, anal cancer, and cholangiocarcinoma. (2) Immunosuppressive drugs exhibit carcinogenic pr...
Source: Digestion - August 14, 2020 Category: Gastroenterology Source Type: research
Clinical Characteristics of Intramucosal Gastric Cancers with Lymphovascular Invasion Resected by Endoscopic Submucosal Dissection
Conclusion: Careful follow-up may be appropriate for MGCs with LVI due to the low risk of LNM. Additionally, the pap component is a significant factor in MGCs with LVI.Digestion (Source: Digestion)
Source: Digestion - August 13, 2020 Category: Gastroenterology Source Type: research
Impaired Mucosal Integrity in Proximal Esophagus Is Involved in Development of Proton Pump Inhibitor-Refractory Nonerosive Reflux Disease
Conclusions: The reflux perception is related to an impairment of the proximal esophageal mucosal integrity in patients with nonerosive reflux disease despite PPI.Digestion (Source: Digestion)
Source: Digestion - August 12, 2020 Category: Gastroenterology Source Type: research
Special Issue of Digestion: Inflammatory Bowel Disease
Digestion (Source: Digestion)
Source: Digestion - August 5, 2020 Category: Gastroenterology Source Type: research
Role of Ulcerative Colitis Endoscopic Index of Severity (UCEIS) versus Mayo Endoscopic Subscore (MES) in Predicting Patients ′ Response to Biological Therapy and the Need for Colectomy
Conclusion: UCEIS may be superior to MES because of its accuracy and predictive role. Therefore, UCEIS should be considered for use in daily clinical practice.Digestion (Source: Digestion)
Source: Digestion - July 31, 2020 Category: Gastroenterology Source Type: research
TNF-Alpha Blockers in Inflammatory Bowel Diseases: Practical Recommendations and a User ’s Guide: An Update
Background: Anti-tumour necrosis factor-alpha (anti-TNF) antagonists have been the mainstay in the treatment of inflammatory bowel diseases (IBDs) for over 20 years.Summary: This review article aimed to provide an update on recent advances in TNF antagonist therapy for IBDs.Key Messages: Their position in the treatment algorithm has evolved to “rapid step-up therapy” or “top-down therapy” according to disease severity and patients’ characteristics. Limitations of anti-TNF antagonists include loss of response in up to 30–50% of patients with or without the development of antibodies. Therapeutic drug monitoring s...
Source: Digestion - July 31, 2020 Category: Gastroenterology Source Type: research
Contribution of Serotonin 3A Receptor to Motor Function and Its Expression in the Gastrointestinal Tract
Conclusions: These results show that 5-HT3AR is highly expressed in the stomach and large intestine and that the activation of 5-HT3AR accelerates gastric emptying and large intestine transit. Additionally, 5-HT3AR is highly expressed in cholinergic neurons and some interstitial cells, such as PDGFR α+ cells.Digestion (Source: Digestion)
Source: Digestion - July 29, 2020 Category: Gastroenterology Source Type: research
Role of a Rare Variant in < b > < i > APC < /i > < /b > Gene Promoter 1B Region in Classic Familial Adenomatous Polyposis
Conclusions: The variant (c.-190G#x3e;A) in theAPC promoter 1B region is able to cause FAP with a classic phenotype, but this kind of variant in the noncoding region could be missed by conventional genetic testing. Thus, utilizing sequencing technologies covering a larger area can help us to further explore the pathogenesis in variant-negative FAP cases.Digestion (Source: Digestion)
Source: Digestion - July 23, 2020 Category: Gastroenterology Source Type: research
Covering Post-Endoscopic Submucosal Dissection Ulcers in Miniature Swine with Hexanoyl (Hx:C6) Group-Modified Alkaline-Treated Gelatin Porous Film (HAG) Induces Proper Healing by Decreasing Inflammation and Fibrosis
Conclusions: HAG sheets induced post-ESD ulcer healing with less submucosal inflammation and muscularis propria injury and have the potential to decrease excess scarring.Digestion (Source: Digestion)
Source: Digestion - July 22, 2020 Category: Gastroenterology Source Type: research
Monocyte-Derived Hepatocyte-Like Cell Test: A Novel Tool for in vitro Identification of Drug-Induced Liver Injury in Patients with Herbal or Dietary Supplements
Conclusions: Our data provide evidence that the MH cell test can be a useful tool to identify the role of HDS in causing DILI and therefore support causality assessment in patients consuming HDS.Digestion (Source: Digestion)
Source: Digestion - July 20, 2020 Category: Gastroenterology Source Type: research
