Treatment Patterns in Newly Diagnosed Patients with Crohn ’s Disease Who Received Biologics Following Diagnosis: A Nationwide, Retrospective, Longitudinal, Observational Study Using a Medical Claims Database in Japan
Conclusions: In this study, we discovered the typical treatment pattern of patients with CD who received biologics and are registered in the JMDC database in Japan. Biologics were commonly used in the early phase of CD treatment. Treatment with traditional approaches such as steroids and nutritional therapy with evaluation for small intestine lesions, before turning to the use of biologics, may be prudent for achieving optimal outcomes.Digestion (Source: Digestion)
Source: Digestion - November 30, 2022 Category: Gastroenterology Source Type: research
A Close Follow-Up Strategy in the Short Period of Time after < b > < i > Helicobacter pylori < /i > < /b > Eradication Contributes to Earlier Detection of Gastric Cancer
Conclusions: Frequent surveillance after HP eradication is efficient for the early detection of EGC during the first 65 months.Digestion (Source: Digestion)
Source: Digestion - November 24, 2022 Category: Gastroenterology Source Type: research
Possible Role of Image-Enhanced Endoscopy in the Evaluation of Mucosal Healing of Ulcerative Colitis
Background: Mucosal healing (MH) is recognized as a therapeutic target in ulcerative colitis (UC) because of evidence that it is associated with favorable clinical outcomes. Current endoscopic assessment of MH by conventional white-light endoscopy is subject to several important clinical issues including the subjective nature of assessment, intra- and interobserver variability, and persistent microscopic inflammation, even in mucosa it was observed as quiescent on conventional endoscopy.Summary: Advances in image-enhancement technologies enable the provision of high-contrast images that emphasize the mucosal structures, bl...
Source: Digestion - November 23, 2022 Category: Gastroenterology Source Type: research
Positioning and Usefulness of Biomarkers in Inflammatory Bowel Disease
Background: Mucosal healing (MH) was proposed to be an ideal treatment goal for patients with inflammatory bowel disease (IBD). Instead of endoscopy to confirm MH, biomarkers are frequently used and have become an indispensable modality for the clinical examination of patients with IBD.Summary: Common biomarkers of IBD include C-reactive protein (CRP), erythrocyte sedimentation rate, antineutrophil cytoplasmic antibodies, anti-Saccharomyces cerevisiae antibodies, leucine-rich α2 glycoprotein, fecal calprotectin (FCP), and the fecal immunochemical test. Biomarkers play five major roles in the management of IBD: (1) diagnos...
Source: Digestion - November 18, 2022 Category: Gastroenterology Source Type: research
Targeted Metabolomic Profiling of Plasma Samples in Gastric Cancer by Liquid Chromatography-Mass Spectrometry
Conclusion: We analyzed plasma metabolomics, and a combination of the quantified metabolites showed high sensitivity for the detection of GC. The independence of the RBF-SVM from tumor markers suggested that their complementary use would be helpful for GC screening.Digestion (Source: Digestion)
Source: Digestion - November 18, 2022 Category: Gastroenterology Source Type: research
Being Elderly Is Associated with Infectious and Fatal Postoperative Complications in Ulcerative Colitis Patients
Conclusion: Age ≥65 years was identified as a risk factor for infectious and fatal complications. It is important to avoid urgent/emergent surgery in elderly patients with an ASA score #x3e;3 by emphasizing surgical and medical collaboration and optimizing the timing of surgery.Digestion (Source: Digestion)
Source: Digestion - November 16, 2022 Category: Gastroenterology Source Type: research
Predicting Inadequate Bowel Preparation When Using Sodium Picosulfate plus Magnesium Citrate for Colonoscopy: Development and Validation of a Prediction Score
This study aimed to identify the risk factors for inadequate bowel preparation when using sodium picosulfate plus magnesium citrate for colonoscopy and to develop a scoring model to predict which patients will have inadequate bowel preparation.Methods: A total of 350 Japanese patients were enrolled from June 2021 to April 2022. Data on patient background, details of colonoscopy, and satisfaction assessment questionnaire results were prospectively collected. The scoring model for inadequate bowel preparation was developed based on multiple logistic regression analyses, and its performance was internally validated using boot...
Source: Digestion - November 15, 2022 Category: Gastroenterology Source Type: research
Clinical Impact of Endoscopic Evaluation of the Small Bowel in Crohn ’s Disease
Background: The STRIDE-II position statement has established endoscopic healing as the long-term target of treatment for inflammatory bowel disease, and ileocolonoscopy is considered the gold standard for assessment of endoscopic healing. However, precise assessment of endoscopic healing cannot be achieved by ileocolonoscopy alone in patients with Crohn ’s disease (CD).Summary: Approximately 70 –80% of patients with CD have small bowel disease, and intestinal complications develop more frequently in the small bowel than in the colorectum. The recent advent of small bowel capsule endoscopy and balloon-assisted enterosco...
Source: Digestion - November 10, 2022 Category: Gastroenterology Source Type: research
New and Emerging Treatments for Inflammatory Bowel Disease
Background: The specific etiopathogenesis of inflammatory bowel disease (IBD) is still unknown. Although the conventional anti-inflammatory or immunomodulatory drugs relatively nonspecific to pathogenesis have been quite useful in many cases, elucidating the pathogenesis has gradually facilitated developments of disease-specific therapies for refractory cases in the last 2 decades.Summary: With a greater understanding of the multiple overactive signaling pathways of the gut mucosal immune response and enhanced leukocyte trafficking, several biological agents or small molecule drugs following the first novel biologic, anti-...
Source: Digestion - November 10, 2022 Category: Gastroenterology Source Type: research
Significance of 5-Aminosalicylic Acid Intolerance in the Clinical Management of Ulcerative Colitis
Background: Two major types of 5-aminosalicylic acid (5-ASA)-containing preparations, namely, mesalazine/5-ASA and sulfasalazine (SASP), are currently used as first-line therapy for ulcerative colitis. Recent reports show that optimization of 5-ASA therapy is beneficial for both patient outcomes and healthcare costs. Although 5-ASA and SASP have good efficacy and safety profiles, clinicians occasionally encounter patients who develop 5-ASA intolerance.Summary: The most common symptoms of acute 5-ASA intolerance syndrome are exacerbation of diarrhea, fever, and abdominal pain. Patients who discontinue 5-ASA therapy because ...
Source: Digestion - November 10, 2022 Category: Gastroenterology Source Type: research
Development and Application of Regenerative Medicine in Inflammatory Bowel Disease
Background: Inflammatory bowel disease (IBD) is characterized by idiopathic and chronic inflammation arising elsewhere within the gastrointestinal tract. Consequently, the mucosal tissue is destroyed during the active phase of the disease, and therefore, spontaneous repair of damaged tissue is required to restore the function and long-term homeostasis of the intestinal mucosa. Also, in patients with refractory Crohn ’s disease, loss of massive intestinal function can lead to short bowel syndrome or may lead to fatal intestinal failure.Summary: The concept of mucosal healing shares the idea that both regulation of mucosal...
Source: Digestion - November 9, 2022 Category: Gastroenterology Source Type: research
Network Analysis of Gut Microbiota Including < b > < i > Fusobacterium < /i > < /b > and Oral Origin Bacteria and Their Distribution on Tumor Surface, Normal Mucosa, and in Feces in Patients with Colorectal Cancer
Conclusion: In patients with CRC, many bacteria were correlated with each other, andFusobacterium and oral origin bacteria formed a positively correlated network on tumor surface.Fusobacterium was equally distributed on tumor surface and throughout the lumen and mucus in the colon. In the colon whereFusobacterium is widely distributed,Fusobacterium would adhere to the tumor surface and be correlated with oral origin bacteria to make a microenvironment that is favorable for CRC.Digestion (Source: Digestion)
Source: Digestion - November 7, 2022 Category: Gastroenterology Source Type: research
Current Status and Future Prospects of Inflammatory Bowel Disease Genetics
Background: The genetic background of inflammatory bowel diseases (IBDs) has been explored using genetic analysis techniques, such as genome-wide association studies for the population and whole-exome sequencing analyses of family lineages in cases of very early onset.Summary: The results of genetic analysis for IBD indicated the involvement of innate and adaptive immune system variations and epithelial abnormalities in the pathogenesis of IBD. Several associated genes were also reported, indicating that IBD occurs in a heterogeneous population with an extremely diverse background. The genetic background of IBDs is current...
Source: Digestion - November 2, 2022 Category: Gastroenterology Source Type: research
Clinical Significance and Properties of IFN- γ < sup > + < /sup > IL-17 < sup > + < /sup > Th17 Cells in Liver Injury Associated with Chronic Hepatitis B Virus Infection
Conclusions: IFN- γ+IL-17+ Th17 cells have Th17 cell-like properties in the progression of chronic HBV infection. CCR5 and CXCR3 facilitated the recruitment of IFN- γ+IL-17+ Th17 cells and Tregs to the liver. Importantly, the ratio of IFN- γ+IL-17+ Th17 cells to Tregs might be an effective assessment indicator of the severity of liver injury.Digestion (Source: Digestion)
Source: Digestion - October 20, 2022 Category: Gastroenterology Source Type: research
Magnifying Narrow-Band Imaging with Acetic Acid Spray for Superficial Non-Ampullary Duodenal Epithelial Tumors Based on the Mucin Phenotype
Conclusion: MA-NBI can distinguish the mucin phenotypes of SNADETs and may facilitate histological grade diagnosis.Digestion (Source: Digestion)
Source: Digestion - October 20, 2022 Category: Gastroenterology Source Type: research
