Usefulness of Magnifying Endoscopy with Narrow-Band Imaging for Diagnosing Mixed Poorly Differentiated Gastric Cancers
Conclusion: Combining biopsy and ME-NBI improved the accuracy of pretreatment diagnosis before ESD in undifferentiated-type cancer.Digestion (Source: Digestion)
Source: Digestion - August 17, 2021 Category: Gastroenterology Source Type: research
Ustekinumab Improves Active Crohn ’s Disease by Suppressing the T Helper 17 Pathway
Conclusion: In patients with active CD, UST therapy suppressed Th17 cell differentiation both in the peripheral blood and colonic tissues.Digestion (Source: Digestion)
Source: Digestion - July 22, 2021 Category: Gastroenterology Source Type: research
Leucine-Rich Alpha-2 Glycoprotein May Be Predictive of the Adalimumab Trough Level and Antidrug Antibody Development for Patients with Inflammatory Bowel Disease: A Sub-Analysis of the PLANET Study
Conclusion: LRG, rather than CRP or fCAL, may be a marker for predicting the trough level of ADA for patients with CD and UC treated with ADA.Digestion (Source: Digestion)
Source: Digestion - July 16, 2021 Category: Gastroenterology Source Type: research
Small Neuroendocrine Tumors of the Whole Gastrointestinal Tract Performed Endoscopic or Surgical Resections Also Show Positive for Lymphovascular Invasion
Conclusions: GI-NETs ≤10 mm had a lymphovascular invasion prevalence exceeding 10%. The lymphovascular invasion impact in GI-NET development is incompletely understood, but careful follow-up, including consideration of additional surgical resection, is crucial in cases with lymphovascular invasion.Digestion (Source: Digestion)
Source: Digestion - July 15, 2021 Category: Gastroenterology Source Type: research
Prognostic Impact and Clinicopathological Features of Multiple Colorectal Cancers and Extracolorectal Malignancies: A Nationwide Retrospective Study
Conclusion: SEMs were a strong poor prognostic factor for patients with stage I –III CRC. Patients with CRC, particularly those with SCRCs, should be surveyed for SEMs, especially for stomach and lung cancers.Digestion (Source: Digestion)
Source: Digestion - July 14, 2021 Category: Gastroenterology Source Type: research
Clue of Diagnosis for Autoimmune Gastritis
Conclusion: Endoscopists frequently overlooked AIG, especially in posteradication cases. Pathological assessment using the updated Sydney system afterH. pylori eradication might be a promising strategy to detect AIG better.Digestion (Source: Digestion)
Source: Digestion - July 1, 2021 Category: Gastroenterology Source Type: research
Endocytoscopy Is Useful for the Diagnosis of Superficial Nonampullary Duodenal Epithelial Tumors
Conclusions: ECS diagnosis with methylene blue provides a high accuracy rate and good interobserver agreement to predict histology of SNADETs.Digestion (Source: Digestion)
Source: Digestion - June 7, 2021 Category: Gastroenterology Source Type: research
Risk of Vaccine-Preventable Infections in Swiss Adults with Inflammatory Bowel Disease
Conclusions: Although many guidelines recommend the vaccination of IBD patients, disease prevention through immunization is still often overlooked, including in Switzerland, increasing their risk of vaccine-preventable diseases. Serological testing should be standardized to monitor patients ’ protection during follow-up as immunity may wane faster in this population.Digestion (Source: Digestion)
Source: Digestion - May 10, 2021 Category: Gastroenterology Source Type: research
Gastric Adenoma: A High Incidence Rate of Developing Carcinoma and Risk of Metachronous Gastric Cancer according to Long-Term Follow-Up
Conclusion: Given the high rate of carcinoma development in patients with risk factors, resection of gastric adenoma should be considered during the initial examination. Careful observation and follow-up should also be conducted to detect not only changes in the primary adenoma but also the occurrence of metachronous carcinoma, especially in cases of adenoma progressing to carcinoma.Digestion (Source: Digestion)
Source: Digestion - April 9, 2021 Category: Gastroenterology Source Type: research
Relationship between Immunophenotype and Clinicopathological Findings for Superficial Nonampullary Duodenal Epithelial Tumor
Conclusion: Pathological intestinal character was correlated with the presence of WOS, and CD10 loss was associated with malignant potential of SNADETs.Digestion (Source: Digestion)
Source: Digestion - April 1, 2021 Category: Gastroenterology Source Type: research
Analysis of Ascites-Challenged Blood in Patients with Liver Cirrhosis Using Rotational Thromboelastometry: How Robust Is the Evidence on Ascites-Attributed Fibrinolysis?
Conclusions: ROTEM provided new evidence that ascites may not primarily induce fibrinolysis in cirrhotic patients. This finding seems to be of significant importance for the clinical management of cirrhotic patients experiencing complications, for example, abdominal hemorrhage after liver biopsy or paracentesis; here, replacement of prothrombin complex concentrates and/or fibrinogen concentrates may prove more beneficial than the use of fresh frozen plasma or antifibrinolytic drugs.Digestion (Source: Digestion)
Source: Digestion - March 18, 2021 Category: Gastroenterology Source Type: research
Comprehensive Analysis of microRNA Profiles in Organoids Derived from Human Colorectal Adenoma and Cancer
Conclusions: We report for the first time the miRNA profiles of exosomes in CRA- and CRC-derived organoids. The upregulation of miR-1246 might play a role in increased cell proliferation in the process of CRA-carcinoma transition.Digestion (Source: Digestion)
Source: Digestion - March 1, 2021 Category: Gastroenterology Source Type: research
Diagnostic Accuracy and Therapeutic Efficacy of Digital Single-Operator Cholangioscopy for Biliary Lesions and Stenosis
Conclusions: Our study demonstrates that dSOC has a high diagnostic accuracy as well as a favorable safety profile. Therefore, dSOC should be discussed as standard of care during endoscopic retrograde cholangiography for indeterminate biliary lesions.Digestion (Source: Digestion)
Source: Digestion - February 25, 2021 Category: Gastroenterology Source Type: research
Efficacy of Sodium Carboxymethylcellulose Compared to Sodium Hyaluronate as Submucosal Injectant for Gastric Endoscopic Submucosal Dissection: A Randomized Controlled Trial
Conclusion: SCMC was comparable to SH in terms of procedure time, treatment outcome, and ease and safety of treatment in gastric ESD. Further studies are needed to demonstrate the differences between the 2 injectants.Digestion (Source: Digestion)
Source: Digestion - February 19, 2021 Category: Gastroenterology Source Type: research
International Observational Survey of the Effectiveness of Personal Protective Equipment during Endoscopic Procedures Performed in Patients with COVID-19
Conclusions: The risk of COVID-19 transmission during any endoscopic procedure was low in clinical practice.Digestion (Source: Digestion)
Source: Digestion - February 16, 2021 Category: Gastroenterology Source Type: research
