Histologic and Clinical Effects of Different Topical Corticosteroids for Eosinophilic Esophagitis: Lessons from an Updated Meta-Analysis of Placebo-Controlled Randomized Trials
Conclusions: TS are effective for short-term induction of histological remission in EoE with less impressive clinical response rates. The mode of drug delivery to the esophagus may be a relevant factor for the degree of histologic remission. Further trials should use uniform assessment criteria and long-term patient-centered outcomes.Digestion (Source: Digestion)
Source: Digestion - July 1, 2020 Category: Gastroenterology Source Type: research
Clinical Outcomes of Vonoprazan-Treated Patients after Endoscopic Submucosal Dissection for Gastric Neoplasms: A Prospective Multicenter Observation Study
Conclusions: VPZ therapy showed an efficacy and feasibility in preventing a delayed bleeding after ESD similar to the PPI therapy. VPZ for 6 weeks and PPI for 8 weeks were similarly effective for an artificial ulcer healing after ESD.Digestion (Source: Digestion)
Source: Digestion - June 25, 2020 Category: Gastroenterology Source Type: research
An Update on Eosinophilic Esophagitis: Etiological Factors, Coexisting Diseases, and Complications
This study aimed to provide gastroenterologists with novel insights into the evaluation of esophageal involvement with eosinophils and to pay special attention to the etiological factors, coexisting clinical diseases, and complications.Digestion (Source: Digestion)
Source: Digestion - June 22, 2020 Category: Gastroenterology Source Type: research
Emerging Treatment Options in Inflammatory Bowel Disease: Janus Kinases, Stem Cells, and More
Background: Treatment of inflammatory bowel diseases (IBD) has tremendously improved during the last 20 years; however, a substantial fraction of patients does not respond to available therapies or lose response, and new strategies are needed.Summary: Two pharmacological principles have been successfully used for IBD treatment: inhibition of cellular signaling and interference with leukocyte trafficking. Besides tumor necrosis factor, interleukin (IL)-23 is a promising drug target, and antibodies for the combined inhibition of IL-23 and IL-12 (ustekinumab and briakinumab) or selective IL-23 inhibition (brazikumab, risankiz...
Source: Digestion - June 22, 2020 Category: Gastroenterology Source Type: research
Current Opinion about Hepatocellular Carcinoma & #x3c;10 mm
Background: Early detection of hepatocellular carcinoma (HCC) is important. Advances in liver imaging techniques have facilitated the detection of HCC at an early stage. However, there is a controversial discussion on how to diagnose very small HCC by imaging. The aim of the current review is to present current published data on HCC ≤10 mm and discuss on how to best diagnose and treat such lesions.Summary: It is still challenging, however, to accurately characterize HCC #x3c;10 mm. The accuracy of contrast-enhanced ultrasound may be critical for early treatment decisions for cancer patients, particularly when CECT and/or...
Source: Digestion - June 9, 2020 Category: Gastroenterology Source Type: research
Endoscopic and Clinicopathological Features of Superficial Non-Ampullary Duodenal Tumor Based on the Mucin Phenotypes
Conclusions: SNADETs showed distinct endoscopic/clinicopathological features according to the mucin phenotype. Tumor location, coloration, macroscopic type, and endoscopic findings including M-NBI are useful to distinguish the mucin phenotypes of SNADETs.Digestion (Source: Digestion)
Source: Digestion - June 9, 2020 Category: Gastroenterology Source Type: research
A Prospective Multicenter Study on the Prevalence of Fructose Malabsorption in Patients with Chronic Inflammatory Bowel Disease
Conclusions: Fructose malabsorption is not more common among patients with IBD than healthy subjects. However, the greater prevalence of patient-reported symptoms among patients with IBD may be of pathological and therapeutic relevance.Digestion (Source: Digestion)
Source: Digestion - June 9, 2020 Category: Gastroenterology Source Type: research
How Much Liver Tissue Is Required for Sufficient Histological Staging in Patients with Primary Biliary Cholangitis?
Conclusion: ARFI and MLFS are probably well suited for the assessment of liver fibrosis in patients with PBC. A minimum of 10 portal fields could improve the histological assessment in PBC and can probably be achieved by obtaining two 16G biopsies.Digestion (Source: Digestion)
Source: Digestion - June 3, 2020 Category: Gastroenterology Source Type: research
Erratum
Digestion (Source: Digestion)
Source: Digestion - May 20, 2020 Category: Gastroenterology Source Type: research
Interleukin-1 β as a Predictor of Glucocorticoid Response in Ulcerative Colitis
Conclusions: Mucosally expressed IL-1 β can be used as a predictor of GC response in patients with UC.Digestion (Source: Digestion)
Source: Digestion - May 20, 2020 Category: Gastroenterology Source Type: research
Association between High Levels of Circulating Chemerin and Colorectal Adenoma in Men
Conclusions: Our findings indicated that increased serum chemerin levels are positively associated with the presence of CRA in men. Chemerin may play an important role in the development of CRA.Digestion (Source: Digestion)
Source: Digestion - July 3, 2019 Category: Gastroenterology Source Type: research
Endoscopic Evaluation of Neoadjuvant Chemotherapeutic Efficacy in Gastric Cancer before Gastrectomy Might be as Useful as Histological Assessment after Gastrectomy
Conclusions: Most endoscopic responders showed JCGC histological responses. Evaluation of neoadjuvant chemotherapeutic efficacy by endoscopy in gastric cancer may be useful before gastrectomy. As this was a retrospective study, further investigations are required. The protocol was approved by the ethics review committee at Osaka Medical College (No. 2422) and was registered in the University Hospital Medical Information Network Clinical Trial Registry (UMIN000033088).Digestion (Source: Digestion)
Source: Digestion - June 28, 2019 Category: Gastroenterology Source Type: research
Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis
Conclusions: We found that 4 weeks of IN suppository can be tolerated by UC patients, but its efficacy was limited by the severity of the disease. Further investigation will be needed in order to confirm the optimum dose of IN suppository for patients with UC.Digestion (Source: Digestion)
Source: Digestion - June 25, 2019 Category: Gastroenterology Source Type: research
Risk Factors and Nomogram for Pancreatic Stone Formation in Chronic Pancreatitis over a Long-Term Course: A Cohort of 2,153 Patients
Conclusions: The nomogram achieved an individualized prediction of pancreatic stones development in CP. It may help the management of pancreatic stones.Digestion (Source: Digestion)
Source: Digestion - June 25, 2019 Category: Gastroenterology Source Type: research
Testing of < b > < i > Helicobacter pylori < /i > < /b > by Endoscopic Biopsy: The Clinical Dilemma of Suppressive Conditions
Conclusion: Guidelines recommendH. pylori testing under non-suppressive conditions. However, this does not always meet the clinical practice. Our data show that de facto, many patients undergoing elective EGD are tested forH. pylori under suppressive conditions coming along with a higher risk of potentially false negative results. Particularly, concerning this issue, further research is needed to improve and clarify everyday clinical practice.Digestion (Source: Digestion)
Source: Digestion - June 19, 2019 Category: Gastroenterology Source Type: research
