Game of Omes: ribosome profiling expands the MHC-I immunopeptidome
Curr Opin Immunol. 2023 May 27;83:102342. doi: 10.1016/j.coi.2023.102342. Online ahead of print.ABSTRACTPeptide ligands presented by cell-surface MHC class-I molecules enable T cells to eradicate intracellular pathogens and cancers. The presented peptide repertoire, the class-I immunopeptidome, is generated from each cell's translatome in a highly biased manner to avoid overrepresenting highly abundant translation products. The immunopeptidome can only be defined by mass spectrometry (MS). Here, we review recent advances in immunopeptidomics, focusing on using ribosome profiling as the optimal MS database to optimize the f...
Source: Current Opinion in Immunology - May 29, 2023 Category: Allergy & Immunology Authors: Jaroslav Holly Jonathan W Yewdell Source Type: research
Game of Omes: ribosome profiling expands the MHC-I immunopeptidome
Curr Opin Immunol. 2023 May 27;83:102342. doi: 10.1016/j.coi.2023.102342. Online ahead of print.ABSTRACTPeptide ligands presented by cell-surface MHC class-I molecules enable T cells to eradicate intracellular pathogens and cancers. The presented peptide repertoire, the class-I immunopeptidome, is generated from each cell's translatome in a highly biased manner to avoid overrepresenting highly abundant translation products. The immunopeptidome can only be defined by mass spectrometry (MS). Here, we review recent advances in immunopeptidomics, focusing on using ribosome profiling as the optimal MS database to optimize the f...
Source: Current Opinion in Immunology - May 29, 2023 Category: Allergy & Immunology Authors: Jaroslav Holly Jonathan W Yewdell Source Type: research
CD1 displays its own negative regulators
Curr Opin Immunol. 2023 May 26;83:102339. doi: 10.1016/j.coi.2023.102339. Online ahead of print.ABSTRACTAfter two decades of the study of lipid antigens that activate CD1-restricted T cells, new studies show how autoreactive αβ T-cell receptors (TCRs) can directly recognize the outer surface of CD1 proteins in ways that are lipid-agnostic. Most recently, this lipid agnosticism has turned to negativity, with the discovery of natural CD1 ligands that dominantly negatively block autoreactive αβ TCR binding to CD1a and CD1d. This review highlights the basic differences between positive and negative regulation of cellular s...
Source: Current Opinion in Immunology - May 28, 2023 Category: Allergy & Immunology Authors: Adam Shahine Ildiko Van Rhijn Jamie Rossjohn D Branch Moody Source Type: research
Visualising tapasin- and TAPBPR-assisted editing of major histocompatibility complex class-I immunopeptidomes
Curr Opin Immunol. 2023 May 26;83:102340. doi: 10.1016/j.coi.2023.102340. Online ahead of print.ABSTRACTWhich peptides are selected for presentation by major histocompatibility complex class-I (MHC-I) molecules is a key determinant of successful immune responses. Peptide selection is co-ordinated by the tapasin and TAP Binding PRotein (TAPBPR) proteins, which ensure MHC-I molecules preferentially acquire high-affinity-binding peptides. New structural analyses have offered insight into how tapasin achieves this function within the peptide-loading complex (PLC) (comprising the Transporter associated with Antigen Presentation...
Source: Current Opinion in Immunology - May 28, 2023 Category: Allergy & Immunology Authors: Andy van Hateren Tim Elliott Source Type: research
The multifaceted roles of CD4 < sup > + < /sup > T cells and MHC class II in cancer surveillance
Curr Opin Immunol. 2023 May 26;83:102345. doi: 10.1016/j.coi.2023.102345. Online ahead of print.ABSTRACTCD4+ T cells exhibit diverse functions in cancer surveillance. Concordantly, single-cell transcriptional analyses have revealed several distinct CD4+ T-cell differentiation states in tumours, including cytotoxic and regulatory subsets associated with favourable or unfavourable outcomes, respectively. These transcriptional states are determined and further shaped by dynamic interactions of CD4+ T cells with different types of immune cells, stromal cells and cancer cells. Therefore, we discuss the cellular networks in the ...
Source: Current Opinion in Immunology - May 28, 2023 Category: Allergy & Immunology Authors: Emma Bawden Thomas Gebhardt Source Type: research
Eat, prey, love: Pathogen-mediated subversion of lysosomal biology
Curr Opin Immunol. 2023 May 26;83:102344. doi: 10.1016/j.coi.2023.102344. Online ahead of print.ABSTRACTThe mammalian lysosome is classically considered the 'garbage can' of the cell, contributing to clearance of infection through its primary function as a degradative organelle. Intracellular pathogens have evolved several strategies to evade contact with this harsh environment through subversion of endolysosomal trafficking or escape into the cytosol. Pathogens can also manipulate pathways that lead to lysosomal biogenesis or alter the abundance or activity of lysosomal content. This pathogen-driven subversion of lysosoma...
Source: Current Opinion in Immunology - May 28, 2023 Category: Allergy & Immunology Authors: Lauren E Bird Laura E Edgington-Mitchell Hayley J Newton Source Type: research
Functional flexibility and plasticity in immune control of systemic Salmonella infection
We describe remarkable levels of flexibility with which the host coordinates and adapts these responses. This involves interchangeable cellular sources of IFN-γ regulated by innate and adaptive cues, and the rewiring of PCD pathways in previously unknown ways. We discuss that such plasticity is likely the consequence of host-pathogen coevolution and raise the possibility of further functional overlap between these seemingly distinct processes.PMID:37245415 | DOI:10.1016/j.coi.2023.102343 (Source: Current Opinion in Immunology)
Source: Current Opinion in Immunology - May 28, 2023 Category: Allergy & Immunology Authors: Sven Engel Annabell Bachem Richard A Strugnell Andreas Strasser Marco J Herold Sammy Bedoui Source Type: research
Transcriptomics of Epstein-Barr virus aids to the classification of T-cell evasion in nasopharyngeal carcinoma
Curr Opin Immunol. 2023 May 24;83:102335. doi: 10.1016/j.coi.2023.102335. Online ahead of print.ABSTRACTEpstein-Barr virus (EBV) contributes to oncogenesis and immune evasion in nasopharyngeal carcinoma (NPC). At present, an aggregated, higher-level view on the impact of EBV genes toward the immune microenvironment of NPC is lacking. To this end, we have interrogated tumor-derived RNA sequences of 106 treatment-naive NPC patients for 98 EBV transcripts, and captured the presence of 10 different immune cell populations as well as 23 different modes of T-cell evasion. We discovered 3 clusters of EBV genes that each associate...
Source: Current Opinion in Immunology - May 26, 2023 Category: Allergy & Immunology Authors: Shweta Mahajan Michiel Bongaerts Jose Hardillo Anna Tsang Kwok W Lo Dian Kortleve Brigette Ma Reno Debets Source Type: research
Harnessing dendritic cell diversity in cancer immunotherapy
Curr Opin Immunol. 2023 May 24;82:102341. doi: 10.1016/j.coi.2023.102341. Online ahead of print.ABSTRACTDendritic cells (DCs) are ubiquitous immune cells endowed with a unique capacity to initiate antigen-specific immunity and tolerance. Owing to their unique functional attributes, DCs have long been considered ideal candidates for the induction of effective antitumour responses. At the forefront of the cancer-immunity cycle, attempts to harness DC natural adjuvant properties in the clinic have resulted so far in suboptimal antitumour responses. A better understanding of the heterogeneity of the DC network and its dynamics...
Source: Current Opinion in Immunology - May 26, 2023 Category: Allergy & Immunology Authors: Hae-Young Park Mitra Ashayeripanah Micha ël Chopin Source Type: research
Transcriptomics of Epstein-Barr virus aids to the classification of T-cell evasion in nasopharyngeal carcinoma
Curr Opin Immunol. 2023 May 24;83:102335. doi: 10.1016/j.coi.2023.102335. Online ahead of print.ABSTRACTEpstein-Barr virus (EBV) contributes to oncogenesis and immune evasion in nasopharyngeal carcinoma (NPC). At present, an aggregated, higher-level view on the impact of EBV genes toward the immune microenvironment of NPC is lacking. To this end, we have interrogated tumor-derived RNA sequences of 106 treatment-naive NPC patients for 98 EBV transcripts, and captured the presence of 10 different immune cell populations as well as 23 different modes of T-cell evasion. We discovered 3 clusters of EBV genes that each associate...
Source: Current Opinion in Immunology - May 26, 2023 Category: Allergy & Immunology Authors: Shweta Mahajan Michiel Bongaerts Jose Hardillo Anna Tsang Kwok W Lo Dian Kortleve Brigette Ma Reno Debets Source Type: research
Harnessing dendritic cell diversity in cancer immunotherapy
Curr Opin Immunol. 2023 May 24;82:102341. doi: 10.1016/j.coi.2023.102341. Online ahead of print.ABSTRACTDendritic cells (DCs) are ubiquitous immune cells endowed with a unique capacity to initiate antigen-specific immunity and tolerance. Owing to their unique functional attributes, DCs have long been considered ideal candidates for the induction of effective antitumour responses. At the forefront of the cancer-immunity cycle, attempts to harness DC natural adjuvant properties in the clinic have resulted so far in suboptimal antitumour responses. A better understanding of the heterogeneity of the DC network and its dynamics...
Source: Current Opinion in Immunology - May 26, 2023 Category: Allergy & Immunology Authors: Hae-Young Park Mitra Ashayeripanah Micha ël Chopin Source Type: research
Transcriptomics of Epstein-Barr virus aids to the classification of T-cell evasion in nasopharyngeal carcinoma
Curr Opin Immunol. 2023 May 24;83:102335. doi: 10.1016/j.coi.2023.102335. Online ahead of print.ABSTRACTEpstein-Barr virus (EBV) contributes to oncogenesis and immune evasion in nasopharyngeal carcinoma (NPC). At present, an aggregated, higher-level view on the impact of EBV genes toward the immune microenvironment of NPC is lacking. To this end, we have interrogated tumor-derived RNA sequences of 106 treatment-naive NPC patients for 98 EBV transcripts, and captured the presence of 10 different immune cell populations as well as 23 different modes of T-cell evasion. We discovered 3 clusters of EBV genes that each associate...
Source: Current Opinion in Immunology - May 26, 2023 Category: Allergy & Immunology Authors: Shweta Mahajan Michiel Bongaerts Jose Hardillo Anna Tsang Kwok W Lo Dian Kortleve Brigette Ma Reno Debets Source Type: research
Harnessing dendritic cell diversity in cancer immunotherapy
Curr Opin Immunol. 2023 May 24;82:102341. doi: 10.1016/j.coi.2023.102341. Online ahead of print.ABSTRACTDendritic cells (DCs) are ubiquitous immune cells endowed with a unique capacity to initiate antigen-specific immunity and tolerance. Owing to their unique functional attributes, DCs have long been considered ideal candidates for the induction of effective antitumour responses. At the forefront of the cancer-immunity cycle, attempts to harness DC natural adjuvant properties in the clinic have resulted so far in suboptimal antitumour responses. A better understanding of the heterogeneity of the DC network and its dynamics...
Source: Current Opinion in Immunology - May 26, 2023 Category: Allergy & Immunology Authors: Hae-Young Park Mitra Ashayeripanah Micha ël Chopin Source Type: research
In the right place at the right time: tissue-resident memory T cells in immunity to cancer
Curr Opin Immunol. 2023 May 23;83:102338. doi: 10.1016/j.coi.2023.102338. Online ahead of print.ABSTRACTTissue-resident memory (Trm) cells have recently emerged as essential components of the immune response to cancer. Here, we highlight new studies that demonstrate how CD8+ Trm cells are ideally suited to accumulate in tumors and associated tissues, to recognize a wide range of tumor antigens (Ags), and to persist as durable memory. We discuss compelling evidence that Trm cells maintain potent recall function and serve as principal mediators of immune checkpoint blockade (ICB) therapeutic efficacy in patients. Finally, we...
Source: Current Opinion in Immunology - May 25, 2023 Category: Allergy & Immunology Authors: Delaney E Ramirez Asmaa Mohamed Yina H Huang Mary Jo Turk Source Type: research
In the right place at the right time: tissue-resident memory T cells in immunity to cancer
Curr Opin Immunol. 2023 May 23;83:102338. doi: 10.1016/j.coi.2023.102338. Online ahead of print.ABSTRACTTissue-resident memory (Trm) cells have recently emerged as essential components of the immune response to cancer. Here, we highlight new studies that demonstrate how CD8+ Trm cells are ideally suited to accumulate in tumors and associated tissues, to recognize a wide range of tumor antigens (Ags), and to persist as durable memory. We discuss compelling evidence that Trm cells maintain potent recall function and serve as principal mediators of immune checkpoint blockade (ICB) therapeutic efficacy in patients. Finally, we...
Source: Current Opinion in Immunology - May 25, 2023 Category: Allergy & Immunology Authors: Delaney E Ramirez Asmaa Mohamed Yina H Huang Mary Jo Turk Source Type: research
