The multifaceted roles of CD4 < sup > + < /sup > T cells and MHC class II in cancer surveillance

Curr Opin Immunol. 2023 May 26;83:102345. doi: 10.1016/j.coi.2023.102345. Online ahead of print.ABSTRACTCD4+ T cells exhibit diverse functions in cancer surveillance. Concordantly, single-cell transcriptional analyses have revealed several distinct CD4+ T-cell differentiation states in tumours, including cytotoxic and regulatory subsets associated with favourable or unfavourable outcomes, respectively. These transcriptional states are determined and further shaped by dynamic interactions of CD4+ T cells with different types of immune cells, stromal cells and cancer cells. Therefore, we discuss the cellular networks in the tumour microenvironment (TME) that either promote or impede CD4+ T-cell cancer surveillance. We consider antigen/Major histocompatibility complexclass-II (MHC-II)-dependent interactions of CD4+ T cells with both professional antigen-presenting cells and cancer cells, the latter of which can directly express MHC-II, at least in some tumours. Additionally, we examine recent single-cell RNA sequencing studies that have shed light on the phenotype and functions of cancer-specific CD4+ T cells in human tumours.PMID:37245413 | DOI:10.1016/j.coi.2023.102345
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Source Type: research