Commander-in-chief: monocytes rally the troops for defense against aspergillosis
Curr Opin Immunol. 2023 Jul 29;84:102371. doi: 10.1016/j.coi.2023.102371. Online ahead of print.ABSTRACTThe detrimental impact of fungal infections to human health has steadily increased over the past decades. In October of 2022, the World Health Organization published the first ever fungal-pathogen priority list highlighting increased awareness of this problem, and the need for more research in this area. There were four distinct fungal pathogens identified as critical priority groups with Aspergillus fumigatus (Af) being the only mold. Af is a common environmental fungus responsible for over 90% of invasive aspergillosis...
Source: Current Opinion in Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Keyi Wang Vanessa Espinosa Amariliz Rivera Source Type: research
Developments in oral enterotoxigenic Escherichia coli vaccines
Curr Opin Immunol. 2023 Jul 29;84:102372. doi: 10.1016/j.coi.2023.102372. Online ahead of print.ABSTRACTEnterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in children in developing countries and in travelers. WHO has affirmed ETEC as a priority vaccine target, but there is no licensed ETEC vaccine available yet. We here describe recent, promising developments of different live, inactivated, and subunit ETEC candidate vaccines expressing or containing nontoxic enterotoxin and/or colonization factor antigens with a focus on oral vaccines. Many of the ETEC candidate vaccines have been tested in clinical tr...
Source: Current Opinion in Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Ann-Mari Svennerholm Anna Lundgren Source Type: research
Commander-in-chief: monocytes rally the troops for defense against aspergillosis
Curr Opin Immunol. 2023 Jul 29;84:102371. doi: 10.1016/j.coi.2023.102371. Online ahead of print.ABSTRACTThe detrimental impact of fungal infections to human health has steadily increased over the past decades. In October of 2022, the World Health Organization published the first ever fungal-pathogen priority list highlighting increased awareness of this problem, and the need for more research in this area. There were four distinct fungal pathogens identified as critical priority groups with Aspergillus fumigatus (Af) being the only mold. Af is a common environmental fungus responsible for over 90% of invasive aspergillosis...
Source: Current Opinion in Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Keyi Wang Vanessa Espinosa Amariliz Rivera Source Type: research
Viral-vectored respiratory mucosal vaccine strategies
Curr Opin Immunol. 2023 Jul 25;84:102370. doi: 10.1016/j.coi.2023.102370. Online ahead of print.ABSTRACTIncreasing global concerns of pandemic respiratory viruses highlight the importance of developing optimal vaccination strategies that encompass vaccine platform, delivery route, and regimens. The decades-long effort to develop vaccines to combat respiratory infections such as influenza, respiratory syncytial virus, and tuberculosis has met with challenges, including the inability of systemically administered vaccines to induce respiratory mucosal (RM) immunity. In this regard, ample preclinical and available clinical stu...
Source: Current Opinion in Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Mangalakumari Jeyanathan Sam Afkhami Alisha Kang Zhou Xing Source Type: research
Viral-vectored respiratory mucosal vaccine strategies
Curr Opin Immunol. 2023 Jul 25;84:102370. doi: 10.1016/j.coi.2023.102370. Online ahead of print.ABSTRACTIncreasing global concerns of pandemic respiratory viruses highlight the importance of developing optimal vaccination strategies that encompass vaccine platform, delivery route, and regimens. The decades-long effort to develop vaccines to combat respiratory infections such as influenza, respiratory syncytial virus, and tuberculosis has met with challenges, including the inability of systemically administered vaccines to induce respiratory mucosal (RM) immunity. In this regard, ample preclinical and available clinical stu...
Source: Current Opinion in Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Mangalakumari Jeyanathan Sam Afkhami Alisha Kang Zhou Xing Source Type: research
Viral-vectored respiratory mucosal vaccine strategies
Curr Opin Immunol. 2023 Jul 25;84:102370. doi: 10.1016/j.coi.2023.102370. Online ahead of print.ABSTRACTIncreasing global concerns of pandemic respiratory viruses highlight the importance of developing optimal vaccination strategies that encompass vaccine platform, delivery route, and regimens. The decades-long effort to develop vaccines to combat respiratory infections such as influenza, respiratory syncytial virus, and tuberculosis has met with challenges, including the inability of systemically administered vaccines to induce respiratory mucosal (RM) immunity. In this regard, ample preclinical and available clinical stu...
Source: Current Opinion in Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Mangalakumari Jeyanathan Sam Afkhami Alisha Kang Zhou Xing Source Type: research
Viral-vectored respiratory mucosal vaccine strategies
Curr Opin Immunol. 2023 Jul 25;84:102370. doi: 10.1016/j.coi.2023.102370. Online ahead of print.ABSTRACTIncreasing global concerns of pandemic respiratory viruses highlight the importance of developing optimal vaccination strategies that encompass vaccine platform, delivery route, and regimens. The decades-long effort to develop vaccines to combat respiratory infections such as influenza, respiratory syncytial virus, and tuberculosis has met with challenges, including the inability of systemically administered vaccines to induce respiratory mucosal (RM) immunity. In this regard, ample preclinical and available clinical stu...
Source: Current Opinion in Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Mangalakumari Jeyanathan Sam Afkhami Alisha Kang Zhou Xing Source Type: research
Tissue-specific macrophage immunometabolism
Curr Opin Immunol. 2023 Jul 18;84:102369. doi: 10.1016/j.coi.2023.102369. Online ahead of print.ABSTRACTMacrophages are phagocytic cells distributed across tissues that sustain homeostasis by constantly probing their local environment. Upon perturbations, macrophages rewire their energy metabolism to execute their immune programs. Intensive research in the field of immunometabolism highlights cell-intrinsic immunometabolites such as succinate and itaconate as immunomodulatory signals. A role for cell-extrinsic stimuli now emerges with evidence for signals that shape macrophages' metabolism in a tissue-specific manner. In t...
Source: Current Opinion in Immunology - July 20, 2023 Category: Allergy & Immunology Authors: Hadar Ben-Arosh Roi Avraham Source Type: research
Tissue-specific macrophage immunometabolism
Curr Opin Immunol. 2023 Jul 18;84:102369. doi: 10.1016/j.coi.2023.102369. Online ahead of print.ABSTRACTMacrophages are phagocytic cells distributed across tissues that sustain homeostasis by constantly probing their local environment. Upon perturbations, macrophages rewire their energy metabolism to execute their immune programs. Intensive research in the field of immunometabolism highlights cell-intrinsic immunometabolites such as succinate and itaconate as immunomodulatory signals. A role for cell-extrinsic stimuli now emerges with evidence for signals that shape macrophages' metabolism in a tissue-specific manner. In t...
Source: Current Opinion in Immunology - July 20, 2023 Category: Allergy & Immunology Authors: Hadar Ben-Arosh Roi Avraham Source Type: research
Tissue-specific macrophage immunometabolism
Curr Opin Immunol. 2023 Jul 18;84:102369. doi: 10.1016/j.coi.2023.102369. Online ahead of print.ABSTRACTMacrophages are phagocytic cells distributed across tissues that sustain homeostasis by constantly probing their local environment. Upon perturbations, macrophages rewire their energy metabolism to execute their immune programs. Intensive research in the field of immunometabolism highlights cell-intrinsic immunometabolites such as succinate and itaconate as immunomodulatory signals. A role for cell-extrinsic stimuli now emerges with evidence for signals that shape macrophages' metabolism in a tissue-specific manner. In t...
Source: Current Opinion in Immunology - July 20, 2023 Category: Allergy & Immunology Authors: Hadar Ben-Arosh Roi Avraham Source Type: research
Tissue-specific macrophage immunometabolism
Curr Opin Immunol. 2023 Jul 18;84:102369. doi: 10.1016/j.coi.2023.102369. Online ahead of print.ABSTRACTMacrophages are phagocytic cells distributed across tissues that sustain homeostasis by constantly probing their local environment. Upon perturbations, macrophages rewire their energy metabolism to execute their immune programs. Intensive research in the field of immunometabolism highlights cell-intrinsic immunometabolites such as succinate and itaconate as immunomodulatory signals. A role for cell-extrinsic stimuli now emerges with evidence for signals that shape macrophages' metabolism in a tissue-specific manner. In t...
Source: Current Opinion in Immunology - July 20, 2023 Category: Allergy & Immunology Authors: Hadar Ben-Arosh Roi Avraham Source Type: research
Tissue-specific macrophage immunometabolism
Curr Opin Immunol. 2023 Jul 18;84:102369. doi: 10.1016/j.coi.2023.102369. Online ahead of print.ABSTRACTMacrophages are phagocytic cells distributed across tissues that sustain homeostasis by constantly probing their local environment. Upon perturbations, macrophages rewire their energy metabolism to execute their immune programs. Intensive research in the field of immunometabolism highlights cell-intrinsic immunometabolites such as succinate and itaconate as immunomodulatory signals. A role for cell-extrinsic stimuli now emerges with evidence for signals that shape macrophages' metabolism in a tissue-specific manner. In t...
Source: Current Opinion in Immunology - July 20, 2023 Category: Allergy & Immunology Authors: Hadar Ben-Arosh Roi Avraham Source Type: research
Mitochondrial reactive oxygen species: double agents in Mycobacterium tuberculosis infection
Curr Opin Immunol. 2023 Jul 12;84:102366. doi: 10.1016/j.coi.2023.102366. Online ahead of print.ABSTRACTIn addition to housing the major energy-producing pathways in cells, mitochondria are active players in innate immune responses. One critical way mitochondria fulfill this role is by releasing damage-associated molecular patterns (mtDAMPs) that are recognized by innate sensors to activate pathways including, but not limited to, cytokine expression, selective autophagy, and cell death. Mitochondrial reactive oxygen species (mtROS) is a multifunctional mtDAMP linked to pro- and antimicrobial immune outcomes. Formed as a by...
Source: Current Opinion in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Lily M Ellzey Kristin L Patrick Robert O Watson Source Type: research
Mitochondrial reactive oxygen species: double agents in Mycobacterium tuberculosis infection
Curr Opin Immunol. 2023 Jul 12;84:102366. doi: 10.1016/j.coi.2023.102366. Online ahead of print.ABSTRACTIn addition to housing the major energy-producing pathways in cells, mitochondria are active players in innate immune responses. One critical way mitochondria fulfill this role is by releasing damage-associated molecular patterns (mtDAMPs) that are recognized by innate sensors to activate pathways including, but not limited to, cytokine expression, selective autophagy, and cell death. Mitochondrial reactive oxygen species (mtROS) is a multifunctional mtDAMP linked to pro- and antimicrobial immune outcomes. Formed as a by...
Source: Current Opinion in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Lily M Ellzey Kristin L Patrick Robert O Watson Source Type: research
Mitochondrial reactive oxygen species: double agents in Mycobacterium tuberculosis infection
Curr Opin Immunol. 2023 Jul 12;84:102366. doi: 10.1016/j.coi.2023.102366. Online ahead of print.ABSTRACTIn addition to housing the major energy-producing pathways in cells, mitochondria are active players in innate immune responses. One critical way mitochondria fulfill this role is by releasing damage-associated molecular patterns (mtDAMPs) that are recognized by innate sensors to activate pathways including, but not limited to, cytokine expression, selective autophagy, and cell death. Mitochondrial reactive oxygen species (mtROS) is a multifunctional mtDAMP linked to pro- and antimicrobial immune outcomes. Formed as a by...
Source: Current Opinion in Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Lily M Ellzey Kristin L Patrick Robert O Watson Source Type: research
