The future of vaccination in Latin America: learning from the COVID-19 pandemic
Curr Opin Immunol. 2023 Oct 6;85:102390. doi: 10.1016/j.coi.2023.102390. Online ahead of print.ABSTRACTThe SARS-CoV-2 pandemic caused millions of deaths around the world. This dramatic balance requires governments, international organizations, vaccine manufacturers, and the scientific community itself to take stock of what has been done and what could have been done better. In this sense, the tremendous inequity in access to vaccines, the main tool to deal with the pandemic, deserves deep reflection and a set of actions to be carried out by low- and middle-income countries. Among them, the construction of a joint effort to...
Source: Current Opinion in Immunology - October 8, 2023 Category: Allergy & Immunology Authors: Fernando E D íaz Lourdes Arruvito Jorge Geffner Source Type: research
Challenges and opportunities in the development of mucosal mRNA vaccines
Curr Opin Immunol. 2023 Sep 28;85:102388. doi: 10.1016/j.coi.2023.102388. Online ahead of print.ABSTRACTmRNA vaccines have played a critical role in controlling the SARS-CoV-2 pandemic, and are being actively studied for use in other diseases. There is a growing interest in applying mRNA vaccines at mucosal surfaces as it enables access to a unique immune reservoir in a less-invasive manner. However, mucosal surfaces present several barriers to mRNA uptake, including degrading enzymes, mucus, and clearance mechanisms. In this mini-review, we discuss our understanding of the immune response to mucosal mRNA vaccines as it co...
Source: Current Opinion in Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Ameya R Kirtane Chaoyang Tang Dylan Freitas Joshua D Bernstock Giovanni Traverso Source Type: research
Challenges and opportunities in the development of mucosal mRNA vaccines
Curr Opin Immunol. 2023 Sep 28;85:102388. doi: 10.1016/j.coi.2023.102388. Online ahead of print.ABSTRACTmRNA vaccines have played a critical role in controlling the SARS-CoV-2 pandemic, and are being actively studied for use in other diseases. There is a growing interest in applying mRNA vaccines at mucosal surfaces as it enables access to a unique immune reservoir in a less-invasive manner. However, mucosal surfaces present several barriers to mRNA uptake, including degrading enzymes, mucus, and clearance mechanisms. In this mini-review, we discuss our understanding of the immune response to mucosal mRNA vaccines as it co...
Source: Current Opinion in Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Ameya R Kirtane Chaoyang Tang Dylan Freitas Joshua D Bernstock Giovanni Traverso Source Type: research
Challenges and opportunities in the development of mucosal mRNA vaccines
Curr Opin Immunol. 2023 Sep 28;85:102388. doi: 10.1016/j.coi.2023.102388. Online ahead of print.ABSTRACTmRNA vaccines have played a critical role in controlling the SARS-CoV-2 pandemic, and are being actively studied for use in other diseases. There is a growing interest in applying mRNA vaccines at mucosal surfaces as it enables access to a unique immune reservoir in a less-invasive manner. However, mucosal surfaces present several barriers to mRNA uptake, including degrading enzymes, mucus, and clearance mechanisms. In this mini-review, we discuss our understanding of the immune response to mucosal mRNA vaccines as it co...
Source: Current Opinion in Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Ameya R Kirtane Chaoyang Tang Dylan Freitas Joshua D Bernstock Giovanni Traverso Source Type: research
Challenges and opportunities in the development of mucosal mRNA vaccines
Curr Opin Immunol. 2023 Sep 28;85:102388. doi: 10.1016/j.coi.2023.102388. Online ahead of print.ABSTRACTmRNA vaccines have played a critical role in controlling the SARS-CoV-2 pandemic, and are being actively studied for use in other diseases. There is a growing interest in applying mRNA vaccines at mucosal surfaces as it enables access to a unique immune reservoir in a less-invasive manner. However, mucosal surfaces present several barriers to mRNA uptake, including degrading enzymes, mucus, and clearance mechanisms. In this mini-review, we discuss our understanding of the immune response to mucosal mRNA vaccines as it co...
Source: Current Opinion in Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Ameya R Kirtane Chaoyang Tang Dylan Freitas Joshua D Bernstock Giovanni Traverso Source Type: research
Challenges and opportunities in the development of mucosal mRNA vaccines
Curr Opin Immunol. 2023 Sep 28;85:102388. doi: 10.1016/j.coi.2023.102388. Online ahead of print.ABSTRACTmRNA vaccines have played a critical role in controlling the SARS-CoV-2 pandemic, and are being actively studied for use in other diseases. There is a growing interest in applying mRNA vaccines at mucosal surfaces as it enables access to a unique immune reservoir in a less-invasive manner. However, mucosal surfaces present several barriers to mRNA uptake, including degrading enzymes, mucus, and clearance mechanisms. In this mini-review, we discuss our understanding of the immune response to mucosal mRNA vaccines as it co...
Source: Current Opinion in Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Ameya R Kirtane Chaoyang Tang Dylan Freitas Joshua D Bernstock Giovanni Traverso Source Type: research
Challenges and opportunities in the development of mucosal mRNA vaccines
Curr Opin Immunol. 2023 Sep 28;85:102388. doi: 10.1016/j.coi.2023.102388. Online ahead of print.ABSTRACTmRNA vaccines have played a critical role in controlling the SARS-CoV-2 pandemic, and are being actively studied for use in other diseases. There is a growing interest in applying mRNA vaccines at mucosal surfaces as it enables access to a unique immune reservoir in a less-invasive manner. However, mucosal surfaces present several barriers to mRNA uptake, including degrading enzymes, mucus, and clearance mechanisms. In this mini-review, we discuss our understanding of the immune response to mucosal mRNA vaccines as it co...
Source: Current Opinion in Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Ameya R Kirtane Chaoyang Tang Dylan Freitas Joshua D Bernstock Giovanni Traverso Source Type: research
Challenges and opportunities in the development of mucosal mRNA vaccines
Curr Opin Immunol. 2023 Sep 28;85:102388. doi: 10.1016/j.coi.2023.102388. Online ahead of print.ABSTRACTmRNA vaccines have played a critical role in controlling the SARS-CoV-2 pandemic, and are being actively studied for use in other diseases. There is a growing interest in applying mRNA vaccines at mucosal surfaces as it enables access to a unique immune reservoir in a less-invasive manner. However, mucosal surfaces present several barriers to mRNA uptake, including degrading enzymes, mucus, and clearance mechanisms. In this mini-review, we discuss our understanding of the immune response to mucosal mRNA vaccines as it co...
Source: Current Opinion in Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Ameya R Kirtane Chaoyang Tang Dylan Freitas Joshua D Bernstock Giovanni Traverso Source Type: research
The role of interferon in the thymus
Curr Opin Immunol. 2023 Oct;84:102389. doi: 10.1016/j.coi.2023.102389. Epub 2023 Sep 20.ABSTRACTInterferons (IFNs) are a family of proteins that are generated in response to viral infection and induce an antiviral response in many cell types. The COVID-19 pandemic revealed that patients with inborn errors of type-I IFN immunity were more prone to severe infections, but also found that many patients with severe COVID-19 had anti-IFN autoantibodies that led to acquired defects in type-I IFN immunity. These findings revealed the previously unappreciated finding that central immune tolerance to IFN is essential to immune healt...
Source: Current Opinion in Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Ryan J Martinez Kristin A Hogquist Source Type: research
The role of interferon in the thymus
Curr Opin Immunol. 2023 Sep 20;84:102389. doi: 10.1016/j.coi.2023.102389. Online ahead of print.ABSTRACTInterferons (IFNs) are a family of proteins that are generated in response to viral infection and induce an antiviral response in many cell types. The COVID-19 pandemic revealed that patients with inborn errors of type-I IFN immunity were more prone to severe infections, but also found that many patients with severe COVID-19 had anti-IFN autoantibodies that led to acquired defects in type-I IFN immunity. These findings revealed the previously unappreciated finding that central immune tolerance to IFN is essential to immu...
Source: Current Opinion in Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Ryan J Martinez Kristin A Hogquist Source Type: research
The role of interferon in the thymus
Curr Opin Immunol. 2023 Sep 20;84:102389. doi: 10.1016/j.coi.2023.102389. Online ahead of print.ABSTRACTInterferons (IFNs) are a family of proteins that are generated in response to viral infection and induce an antiviral response in many cell types. The COVID-19 pandemic revealed that patients with inborn errors of type-I IFN immunity were more prone to severe infections, but also found that many patients with severe COVID-19 had anti-IFN autoantibodies that led to acquired defects in type-I IFN immunity. These findings revealed the previously unappreciated finding that central immune tolerance to IFN is essential to immu...
Source: Current Opinion in Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Ryan J Martinez Kristin A Hogquist Source Type: research
The role of interferon in the thymus
Curr Opin Immunol. 2023 Sep 20;84:102389. doi: 10.1016/j.coi.2023.102389. Online ahead of print.ABSTRACTInterferons (IFNs) are a family of proteins that are generated in response to viral infection and induce an antiviral response in many cell types. The COVID-19 pandemic revealed that patients with inborn errors of type-I IFN immunity were more prone to severe infections, but also found that many patients with severe COVID-19 had anti-IFN autoantibodies that led to acquired defects in type-I IFN immunity. These findings revealed the previously unappreciated finding that central immune tolerance to IFN is essential to immu...
Source: Current Opinion in Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Ryan J Martinez Kristin A Hogquist Source Type: research
The role of interferon in the thymus
Curr Opin Immunol. 2023 Sep 20;84:102389. doi: 10.1016/j.coi.2023.102389. Online ahead of print.ABSTRACTInterferons (IFNs) are a family of proteins that are generated in response to viral infection and induce an antiviral response in many cell types. The COVID-19 pandemic revealed that patients with inborn errors of type-I IFN immunity were more prone to severe infections, but also found that many patients with severe COVID-19 had anti-IFN autoantibodies that led to acquired defects in type-I IFN immunity. These findings revealed the previously unappreciated finding that central immune tolerance to IFN is essential to immu...
Source: Current Opinion in Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Ryan J Martinez Kristin A Hogquist Source Type: research
The role of interferon in the thymus
Curr Opin Immunol. 2023 Sep 20;84:102389. doi: 10.1016/j.coi.2023.102389. Online ahead of print.ABSTRACTInterferons (IFNs) are a family of proteins that are generated in response to viral infection and induce an antiviral response in many cell types. The COVID-19 pandemic revealed that patients with inborn errors of type-I IFN immunity were more prone to severe infections, but also found that many patients with severe COVID-19 had anti-IFN autoantibodies that led to acquired defects in type-I IFN immunity. These findings revealed the previously unappreciated finding that central immune tolerance to IFN is essential to immu...
Source: Current Opinion in Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Ryan J Martinez Kristin A Hogquist Source Type: research
Pharma - manufacturing: the unappreciated and overlooked indispensable skill
Curr Opin Immunol. 2023 Sep 11;84:102385. doi: 10.1016/j.coi.2023.102385. Online ahead of print.ABSTRACTThe process of vaccine production, manufacturing, is time-intensive, complex, expensive, and highly technical, requiring close coordination and collaboration among multiple companies with different inputs, from active pharmaceutical ingredients to glass, and specializations, and with the supply chains spread across many countries. Covid-19 pandemic highlighted that neglecting and ignoring the need for a global effort in vaccine manufacturing and delivery can have alarming, and devastating, repercussions, especially when ...
Source: Current Opinion in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Jenik Radon Grace Pan Source Type: research
