Animal models of shigellosis: a historical overview
Curr Opin Immunol. 2023 Nov 10;85:102399. doi: 10.1016/j.coi.2023.102399. Online ahead of print.ABSTRACTShigella spp. are major causative agents of bacillary dysentery, a severe enteric disease characterized by destruction and inflammation of the colonic epithelium accompanied by acute diarrhea, fever, and abdominal pain. Although antibiotics have traditionally been effective, the prevalence of multidrug-resistant strains is increasing, stressing the urgent need for a vaccine. The human-specific nature of shigellosis and the absence of a dependable animal model have posed significant obstacles in understanding Shigella pat...
Source: Current Opinion in Immunology - November 12, 2023 Category: Allergy & Immunology Authors: No émie Alphonse Charlotte Odendall Source Type: research
Animal models of shigellosis: a historical overview
Curr Opin Immunol. 2023 Nov 10;85:102399. doi: 10.1016/j.coi.2023.102399. Online ahead of print.ABSTRACTShigella spp. are major causative agents of bacillary dysentery, a severe enteric disease characterized by destruction and inflammation of the colonic epithelium accompanied by acute diarrhea, fever, and abdominal pain. Although antibiotics have traditionally been effective, the prevalence of multidrug-resistant strains is increasing, stressing the urgent need for a vaccine. The human-specific nature of shigellosis and the absence of a dependable animal model have posed significant obstacles in understanding Shigella pat...
Source: Current Opinion in Immunology - November 12, 2023 Category: Allergy & Immunology Authors: No émie Alphonse Charlotte Odendall Source Type: research
Animal models of shigellosis: a historical overview
Curr Opin Immunol. 2023 Nov 10;85:102399. doi: 10.1016/j.coi.2023.102399. Online ahead of print.ABSTRACTShigella spp. are major causative agents of bacillary dysentery, a severe enteric disease characterized by destruction and inflammation of the colonic epithelium accompanied by acute diarrhea, fever, and abdominal pain. Although antibiotics have traditionally been effective, the prevalence of multidrug-resistant strains is increasing, stressing the urgent need for a vaccine. The human-specific nature of shigellosis and the absence of a dependable animal model have posed significant obstacles in understanding Shigella pat...
Source: Current Opinion in Immunology - November 12, 2023 Category: Allergy & Immunology Authors: No émie Alphonse Charlotte Odendall Source Type: research
Animal models of shigellosis: a historical overview
Curr Opin Immunol. 2023 Nov 10;85:102399. doi: 10.1016/j.coi.2023.102399. Online ahead of print.ABSTRACTShigella spp. are major causative agents of bacillary dysentery, a severe enteric disease characterized by destruction and inflammation of the colonic epithelium accompanied by acute diarrhea, fever, and abdominal pain. Although antibiotics have traditionally been effective, the prevalence of multidrug-resistant strains is increasing, stressing the urgent need for a vaccine. The human-specific nature of shigellosis and the absence of a dependable animal model have posed significant obstacles in understanding Shigella pat...
Source: Current Opinion in Immunology - November 12, 2023 Category: Allergy & Immunology Authors: No émie Alphonse Charlotte Odendall Source Type: research
Animal models of shigellosis: a historical overview
Curr Opin Immunol. 2023 Nov 10;85:102399. doi: 10.1016/j.coi.2023.102399. Online ahead of print.ABSTRACTShigella spp. are major causative agents of bacillary dysentery, a severe enteric disease characterized by destruction and inflammation of the colonic epithelium accompanied by acute diarrhea, fever, and abdominal pain. Although antibiotics have traditionally been effective, the prevalence of multidrug-resistant strains is increasing, stressing the urgent need for a vaccine. The human-specific nature of shigellosis and the absence of a dependable animal model have posed significant obstacles in understanding Shigella pat...
Source: Current Opinion in Immunology - November 12, 2023 Category: Allergy & Immunology Authors: No émie Alphonse Charlotte Odendall Source Type: research
AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity
Curr Opin Immunol. 2023 Nov 4;85:102397. doi: 10.1016/j.coi.2023.102397. Online ahead of print.ABSTRACTThe proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cancer-immunity and immunotherapy responses. The differentiation of these cells is controlled by several transcription factors (TFs), including members of the activator protein (AP)-1 family. The activity of AP-1 family members is regulated by various immune signaling pathways, which can be triggered by activating or inhibitory receptors as well as cytokines. The target genes controlled by AP-1 TFs are cent...
Source: Current Opinion in Immunology - November 6, 2023 Category: Allergy & Immunology Authors: Diana Schnoegl Angela Hiesinger Nicholas D Huntington Dagmar Gotthardt Source Type: research
AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity
Curr Opin Immunol. 2023 Nov 4;85:102397. doi: 10.1016/j.coi.2023.102397. Online ahead of print.ABSTRACTThe proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cancer-immunity and immunotherapy responses. The differentiation of these cells is controlled by several transcription factors (TFs), including members of the activator protein (AP)-1 family. The activity of AP-1 family members is regulated by various immune signaling pathways, which can be triggered by activating or inhibitory receptors as well as cytokines. The target genes controlled by AP-1 TFs are cent...
Source: Current Opinion in Immunology - November 6, 2023 Category: Allergy & Immunology Authors: Diana Schnoegl Angela Hiesinger Nicholas D Huntington Dagmar Gotthardt Source Type: research
AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity
Curr Opin Immunol. 2023 Nov 4;85:102397. doi: 10.1016/j.coi.2023.102397. Online ahead of print.ABSTRACTThe proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cancer-immunity and immunotherapy responses. The differentiation of these cells is controlled by several transcription factors (TFs), including members of the activator protein (AP)-1 family. The activity of AP-1 family members is regulated by various immune signaling pathways, which can be triggered by activating or inhibitory receptors as well as cytokines. The target genes controlled by AP-1 TFs are cent...
Source: Current Opinion in Immunology - November 6, 2023 Category: Allergy & Immunology Authors: Diana Schnoegl Angela Hiesinger Nicholas D Huntington Dagmar Gotthardt Source Type: research
AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity
Curr Opin Immunol. 2023 Nov 4;85:102397. doi: 10.1016/j.coi.2023.102397. Online ahead of print.ABSTRACTThe proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cancer-immunity and immunotherapy responses. The differentiation of these cells is controlled by several transcription factors (TFs), including members of the activator protein (AP)-1 family. The activity of AP-1 family members is regulated by various immune signaling pathways, which can be triggered by activating or inhibitory receptors as well as cytokines. The target genes controlled by AP-1 TFs are cent...
Source: Current Opinion in Immunology - November 6, 2023 Category: Allergy & Immunology Authors: Diana Schnoegl Angela Hiesinger Nicholas D Huntington Dagmar Gotthardt Source Type: research
AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity
Curr Opin Immunol. 2023 Nov 4;85:102397. doi: 10.1016/j.coi.2023.102397. Online ahead of print.ABSTRACTThe proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cancer-immunity and immunotherapy responses. The differentiation of these cells is controlled by several transcription factors (TFs), including members of the activator protein (AP)-1 family. The activity of AP-1 family members is regulated by various immune signaling pathways, which can be triggered by activating or inhibitory receptors as well as cytokines. The target genes controlled by AP-1 TFs are cent...
Source: Current Opinion in Immunology - November 6, 2023 Category: Allergy & Immunology Authors: Diana Schnoegl Angela Hiesinger Nicholas D Huntington Dagmar Gotthardt Source Type: research
The future of vaccination in Latin America: learning from the COVID-19 pandemic
Curr Opin Immunol. 2023 Oct 6;85:102390. doi: 10.1016/j.coi.2023.102390. Online ahead of print.ABSTRACTThe SARS-CoV-2 pandemic caused millions of deaths around the world. This dramatic balance requires governments, international organizations, vaccine manufacturers, and the scientific community itself to take stock of what has been done and what could have been done better. In this sense, the tremendous inequity in access to vaccines, the main tool to deal with the pandemic, deserves deep reflection and a set of actions to be carried out by low- and middle-income countries. Among them, the construction of a joint effort to...
Source: Current Opinion in Immunology - October 8, 2023 Category: Allergy & Immunology Authors: Fernando E D íaz Lourdes Arruvito Jorge Geffner Source Type: research
The future of vaccination in Latin America: learning from the COVID-19 pandemic
Curr Opin Immunol. 2023 Oct 6;85:102390. doi: 10.1016/j.coi.2023.102390. Online ahead of print.ABSTRACTThe SARS-CoV-2 pandemic caused millions of deaths around the world. This dramatic balance requires governments, international organizations, vaccine manufacturers, and the scientific community itself to take stock of what has been done and what could have been done better. In this sense, the tremendous inequity in access to vaccines, the main tool to deal with the pandemic, deserves deep reflection and a set of actions to be carried out by low- and middle-income countries. Among them, the construction of a joint effort to...
Source: Current Opinion in Immunology - October 8, 2023 Category: Allergy & Immunology Authors: Fernando E D íaz Lourdes Arruvito Jorge Geffner Source Type: research
The future of vaccination in Latin America: learning from the COVID-19 pandemic
Curr Opin Immunol. 2023 Oct 6;85:102390. doi: 10.1016/j.coi.2023.102390. Online ahead of print.ABSTRACTThe SARS-CoV-2 pandemic caused millions of deaths around the world. This dramatic balance requires governments, international organizations, vaccine manufacturers, and the scientific community itself to take stock of what has been done and what could have been done better. In this sense, the tremendous inequity in access to vaccines, the main tool to deal with the pandemic, deserves deep reflection and a set of actions to be carried out by low- and middle-income countries. Among them, the construction of a joint effort to...
Source: Current Opinion in Immunology - October 8, 2023 Category: Allergy & Immunology Authors: Fernando E D íaz Lourdes Arruvito Jorge Geffner Source Type: research
The future of vaccination in Latin America: learning from the COVID-19 pandemic
Curr Opin Immunol. 2023 Oct 6;85:102390. doi: 10.1016/j.coi.2023.102390. Online ahead of print.ABSTRACTThe SARS-CoV-2 pandemic caused millions of deaths around the world. This dramatic balance requires governments, international organizations, vaccine manufacturers, and the scientific community itself to take stock of what has been done and what could have been done better. In this sense, the tremendous inequity in access to vaccines, the main tool to deal with the pandemic, deserves deep reflection and a set of actions to be carried out by low- and middle-income countries. Among them, the construction of a joint effort to...
Source: Current Opinion in Immunology - October 8, 2023 Category: Allergy & Immunology Authors: Fernando E D íaz Lourdes Arruvito Jorge Geffner Source Type: research
The future of vaccination in Latin America: learning from the COVID-19 pandemic
Curr Opin Immunol. 2023 Oct 6;85:102390. doi: 10.1016/j.coi.2023.102390. Online ahead of print.ABSTRACTThe SARS-CoV-2 pandemic caused millions of deaths around the world. This dramatic balance requires governments, international organizations, vaccine manufacturers, and the scientific community itself to take stock of what has been done and what could have been done better. In this sense, the tremendous inequity in access to vaccines, the main tool to deal with the pandemic, deserves deep reflection and a set of actions to be carried out by low- and middle-income countries. Among them, the construction of a joint effort to...
Source: Current Opinion in Immunology - October 8, 2023 Category: Allergy & Immunology Authors: Fernando E D íaz Lourdes Arruvito Jorge Geffner Source Type: research
