AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity

Curr Opin Immunol. 2023 Nov 4;85:102397. doi: 10.1016/j.coi.2023.102397. Online ahead of print.ABSTRACTThe proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cancer-immunity and immunotherapy responses. The differentiation of these cells is controlled by several transcription factors (TFs), including members of the activator protein (AP)-1 family. The activity of AP-1 family members is regulated by various immune signaling pathways, which can be triggered by activating or inhibitory receptors as well as cytokines. The target genes controlled by AP-1 TFs are central to generate immunity to pathogens or malignancies. Here, we provide an overview of the current understanding of how AP-1 TFs regulate cytotoxic lymphocytes.PMID:37931499 | DOI:10.1016/j.coi.2023.102397
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Source Type: research