Editorial overview: The march of mucosal vaccines
Curr Opin Immunol. 2023 Dec 20;86:102408. doi: 10.1016/j.coi.2023.102408. Online ahead of print.NO ABSTRACTPMID:38128438 | DOI:10.1016/j.coi.2023.102408 (Source: Current Opinion in Immunology)
Source: Current Opinion in Immunology - December 21, 2023 Category: Allergy & Immunology Authors: E C Lavelle Meritxell Genesc à Source Type: research
Differential signaling by type-I and type-III interferons in mucosa
Curr Opin Immunol. 2023 Dec 19;86:102400. doi: 10.1016/j.coi.2023.102400. Online ahead of print.ABSTRACTMucosal surfaces are barrier sites that protect the body from the outside environment. They have developed mechanisms to handle microbiota-associated triggers while remaining responsive to pathogens. Cells at mucosal surfaces rely on both the type-I and -III interferons (IFNs) as key cytokines to protect the epithelium itself and to prevent systemic spread of viral infections. Type-I and -III IFNs have been shown to use distinct receptors but similar JAK/STAT signaling cascades to elicit the induction of IFN-stimulated g...
Source: Current Opinion in Immunology - December 20, 2023 Category: Allergy & Immunology Authors: Megan L Stanifer Steeve Boulant Source Type: research
Differential signaling by type-I and type-III interferons in mucosa
Curr Opin Immunol. 2023 Dec 19;86:102400. doi: 10.1016/j.coi.2023.102400. Online ahead of print.ABSTRACTMucosal surfaces are barrier sites that protect the body from the outside environment. They have developed mechanisms to handle microbiota-associated triggers while remaining responsive to pathogens. Cells at mucosal surfaces rely on both the type-I and -III interferons (IFNs) as key cytokines to protect the epithelium itself and to prevent systemic spread of viral infections. Type-I and -III IFNs have been shown to use distinct receptors but similar JAK/STAT signaling cascades to elicit the induction of IFN-stimulated g...
Source: Current Opinion in Immunology - December 20, 2023 Category: Allergy & Immunology Authors: Megan L Stanifer Steeve Boulant Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Dec;85:102398. doi: 10.1016/j.coi.2023.102398. Epub 2023 Nov 16.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or direct muc...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Dec;85:102398. doi: 10.1016/j.coi.2023.102398. Epub 2023 Nov 16.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or direct muc...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Dec;85:102398. doi: 10.1016/j.coi.2023.102398. Epub 2023 Nov 16.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or direct muc...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Dec;85:102398. doi: 10.1016/j.coi.2023.102398. Epub 2023 Nov 16.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or direct muc...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Dec;85:102398. doi: 10.1016/j.coi.2023.102398. Epub 2023 Nov 16.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or direct muc...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Dec;85:102398. doi: 10.1016/j.coi.2023.102398. Epub 2023 Nov 16.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or direct muc...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Dec;85:102398. doi: 10.1016/j.coi.2023.102398. Epub 2023 Nov 16.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or direct muc...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Dec;85:102398. doi: 10.1016/j.coi.2023.102398. Epub 2023 Nov 16.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or direct muc...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Dec;85:102398. doi: 10.1016/j.coi.2023.102398. Epub 2023 Nov 16.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or direct muc...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Dec;85:102398. doi: 10.1016/j.coi.2023.102398. Epub 2023 Nov 16.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or direct muc...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Dec;85:102398. doi: 10.1016/j.coi.2023.102398. Epub 2023 Nov 16.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or direct muc...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research
Recent advances in enterotoxin vaccine adjuvants
Curr Opin Immunol. 2023 Dec;85:102398. doi: 10.1016/j.coi.2023.102398. Epub 2023 Nov 16.ABSTRACTEnterotoxin adjuvants have been researched for their ability to promote immunity to co-delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be included in any currently licensed vaccines. They include molecules derived from the bacterial toxins of Vibrio cholerae, cholera toxin, or Escherichia coli, heat-labile toxin, such as detoxified mutants or subunits. This class of adjuvants is distinguished by their delivery possibilities, which include parenteral injection, skin applications, or direct muc...
Source: Current Opinion in Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Jessica W Crothers Elizabeth B Norton Source Type: research