The role of the antigen processing machinery in the regulation and trafficking of intracellular -Toll-like receptor molecules
Curr Opin Immunol. 2023 Aug 8;84:102375. doi: 10.1016/j.coi.2023.102375. Online ahead of print.ABSTRACTIntracellular Toll-like receptors (TLRs) are key components of the innate immune system. Their expression in antigen-presenting cells (APCs), and in particular dendritic cells (DCs), makes them critical in the induction of the adaptive immune response. In DCs, they interact with the chaperone UNC93B1 that mediates their trafficking from the endoplasmic reticulum (ER) to endosomes where they are cleaved by proteases and activated. All these different steps are also shared by major histocompatibility complex class-II (MHCII...
Source: Current Opinion in Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Mo ïse de Lavergne Lucie Maisonneuve Katrina Podsypanina B énédicte Manoury Source Type: research
An easy pill to swallow: oral recombinant vaccines for the 21st century
Curr Opin Immunol. 2023 Aug 8;84:102374. doi: 10.1016/j.coi.2023.102374. Online ahead of print.ABSTRACTOral vaccines have a distinctive advantage of stimulating immune responses in the mucosa, where numerous pathogens gain entry and cause disease. Although various efforts have been attempted to create recombinant mucosal vaccines that provoke strong immunogenicity, the outcomes in clinical trials have been weak or inconsistent. Therefore, next-generation mucosal vaccines are needed that are more immunogenic. Here, we discuss oral vaccines with an emphasis on a next-generation mucosal vaccine that utilizes a nonreplicating ...
Source: Current Opinion in Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Molly R Braun Becca A Flitter William Sun Sean N Tucker Source Type: research
The role of the antigen processing machinery in the regulation and trafficking of intracellular -Toll-like receptor molecules
Curr Opin Immunol. 2023 Aug 8;84:102375. doi: 10.1016/j.coi.2023.102375. Online ahead of print.ABSTRACTIntracellular Toll-like receptors (TLRs) are key components of the innate immune system. Their expression in antigen-presenting cells (APCs), and in particular dendritic cells (DCs), makes them critical in the induction of the adaptive immune response. In DCs, they interact with the chaperone UNC93B1 that mediates their trafficking from the endoplasmic reticulum (ER) to endosomes where they are cleaved by proteases and activated. All these different steps are also shared by major histocompatibility complex class-II (MHCII...
Source: Current Opinion in Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Mo ïse de Lavergne Lucie Maisonneuve Katrina Podsypanina B énédicte Manoury Source Type: research
An easy pill to swallow: oral recombinant vaccines for the 21st century
Curr Opin Immunol. 2023 Aug 8;84:102374. doi: 10.1016/j.coi.2023.102374. Online ahead of print.ABSTRACTOral vaccines have a distinctive advantage of stimulating immune responses in the mucosa, where numerous pathogens gain entry and cause disease. Although various efforts have been attempted to create recombinant mucosal vaccines that provoke strong immunogenicity, the outcomes in clinical trials have been weak or inconsistent. Therefore, next-generation mucosal vaccines are needed that are more immunogenic. Here, we discuss oral vaccines with an emphasis on a next-generation mucosal vaccine that utilizes a nonreplicating ...
Source: Current Opinion in Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Molly R Braun Becca A Flitter William Sun Sean N Tucker Source Type: research
The role of the antigen processing machinery in the regulation and trafficking of intracellular -Toll-like receptor molecules
Curr Opin Immunol. 2023 Aug 8;84:102375. doi: 10.1016/j.coi.2023.102375. Online ahead of print.ABSTRACTIntracellular Toll-like receptors (TLRs) are key components of the innate immune system. Their expression in antigen-presenting cells (APCs), and in particular dendritic cells (DCs), makes them critical in the induction of the adaptive immune response. In DCs, they interact with the chaperone UNC93B1 that mediates their trafficking from the endoplasmic reticulum (ER) to endosomes where they are cleaved by proteases and activated. All these different steps are also shared by major histocompatibility complex class-II (MHCII...
Source: Current Opinion in Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Mo ïse de Lavergne Lucie Maisonneuve Katrina Podsypanina B énédicte Manoury Source Type: research
Human guanylate-binding proteins in intracellular pathogen detection, destruction, and host cell death induction
Curr Opin Immunol. 2023 Aug 1;84:102373. doi: 10.1016/j.coi.2023.102373. Online ahead of print.ABSTRACTCell-intrinsic defense is an essential part of the immune response against intracellular pathogens regulated by cytokine-induced proteins and pathways. One of the most upregulated families of proteins in this defense system are the guanylate-binding proteins (GBPs), large GTPases of the dynamin family, induced in response to interferon gamma. Human GBPs (hGBPs) exert their antimicrobial activity through detection of pathogen-associated molecular patterns and/or damage-associated molecular patterns to execute control mecha...
Source: Current Opinion in Immunology - August 3, 2023 Category: Allergy & Immunology Authors: Yolanda Rivera-Cuevas Barbara Clough Eva-Maria Frickel Source Type: research
Human guanylate-binding proteins in intracellular pathogen detection, destruction, and host cell death induction
Curr Opin Immunol. 2023 Aug 1;84:102373. doi: 10.1016/j.coi.2023.102373. Online ahead of print.ABSTRACTCell-intrinsic defense is an essential part of the immune response against intracellular pathogens regulated by cytokine-induced proteins and pathways. One of the most upregulated families of proteins in this defense system are the guanylate-binding proteins (GBPs), large GTPases of the dynamin family, induced in response to interferon gamma. Human GBPs (hGBPs) exert their antimicrobial activity through detection of pathogen-associated molecular patterns and/or damage-associated molecular patterns to execute control mecha...
Source: Current Opinion in Immunology - August 3, 2023 Category: Allergy & Immunology Authors: Yolanda Rivera-Cuevas Barbara Clough Eva-Maria Frickel Source Type: research
Human guanylate-binding proteins in intracellular pathogen detection, destruction, and host cell death induction
Curr Opin Immunol. 2023 Aug 1;84:102373. doi: 10.1016/j.coi.2023.102373. Online ahead of print.ABSTRACTCell-intrinsic defense is an essential part of the immune response against intracellular pathogens regulated by cytokine-induced proteins and pathways. One of the most upregulated families of proteins in this defense system are the guanylate-binding proteins (GBPs), large GTPases of the dynamin family, induced in response to interferon gamma. Human GBPs (hGBPs) exert their antimicrobial activity through detection of pathogen-associated molecular patterns and/or damage-associated molecular patterns to execute control mecha...
Source: Current Opinion in Immunology - August 3, 2023 Category: Allergy & Immunology Authors: Yolanda Rivera-Cuevas Barbara Clough Eva-Maria Frickel Source Type: research
Human guanylate-binding proteins in intracellular pathogen detection, destruction, and host cell death induction
Curr Opin Immunol. 2023 Aug 1;84:102373. doi: 10.1016/j.coi.2023.102373. Online ahead of print.ABSTRACTCell-intrinsic defense is an essential part of the immune response against intracellular pathogens regulated by cytokine-induced proteins and pathways. One of the most upregulated families of proteins in this defense system are the guanylate-binding proteins (GBPs), large GTPases of the dynamin family, induced in response to interferon gamma. Human GBPs (hGBPs) exert their antimicrobial activity through detection of pathogen-associated molecular patterns and/or damage-associated molecular patterns to execute control mecha...
Source: Current Opinion in Immunology - August 3, 2023 Category: Allergy & Immunology Authors: Yolanda Rivera-Cuevas Barbara Clough Eva-Maria Frickel Source Type: research
Human guanylate-binding proteins in intracellular pathogen detection, destruction, and host cell death induction
Curr Opin Immunol. 2023 Aug 1;84:102373. doi: 10.1016/j.coi.2023.102373. Online ahead of print.ABSTRACTCell-intrinsic defense is an essential part of the immune response against intracellular pathogens regulated by cytokine-induced proteins and pathways. One of the most upregulated families of proteins in this defense system are the guanylate-binding proteins (GBPs), large GTPases of the dynamin family, induced in response to interferon gamma. Human GBPs (hGBPs) exert their antimicrobial activity through detection of pathogen-associated molecular patterns and/or damage-associated molecular patterns to execute control mecha...
Source: Current Opinion in Immunology - August 3, 2023 Category: Allergy & Immunology Authors: Yolanda Rivera-Cuevas Barbara Clough Eva-Maria Frickel Source Type: research
Developments in oral enterotoxigenic Escherichia coli vaccines
Curr Opin Immunol. 2023 Jul 29;84:102372. doi: 10.1016/j.coi.2023.102372. Online ahead of print.ABSTRACTEnterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in children in developing countries and in travelers. WHO has affirmed ETEC as a priority vaccine target, but there is no licensed ETEC vaccine available yet. We here describe recent, promising developments of different live, inactivated, and subunit ETEC candidate vaccines expressing or containing nontoxic enterotoxin and/or colonization factor antigens with a focus on oral vaccines. Many of the ETEC candidate vaccines have been tested in clinical tr...
Source: Current Opinion in Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Ann-Mari Svennerholm Anna Lundgren Source Type: research
Commander-in-chief: monocytes rally the troops for defense against aspergillosis
Curr Opin Immunol. 2023 Jul 29;84:102371. doi: 10.1016/j.coi.2023.102371. Online ahead of print.ABSTRACTThe detrimental impact of fungal infections to human health has steadily increased over the past decades. In October of 2022, the World Health Organization published the first ever fungal-pathogen priority list highlighting increased awareness of this problem, and the need for more research in this area. There were four distinct fungal pathogens identified as critical priority groups with Aspergillus fumigatus (Af) being the only mold. Af is a common environmental fungus responsible for over 90% of invasive aspergillosis...
Source: Current Opinion in Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Keyi Wang Vanessa Espinosa Amariliz Rivera Source Type: research
Developments in oral enterotoxigenic Escherichia coli vaccines
Curr Opin Immunol. 2023 Jul 29;84:102372. doi: 10.1016/j.coi.2023.102372. Online ahead of print.ABSTRACTEnterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in children in developing countries and in travelers. WHO has affirmed ETEC as a priority vaccine target, but there is no licensed ETEC vaccine available yet. We here describe recent, promising developments of different live, inactivated, and subunit ETEC candidate vaccines expressing or containing nontoxic enterotoxin and/or colonization factor antigens with a focus on oral vaccines. Many of the ETEC candidate vaccines have been tested in clinical tr...
Source: Current Opinion in Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Ann-Mari Svennerholm Anna Lundgren Source Type: research
Commander-in-chief: monocytes rally the troops for defense against aspergillosis
Curr Opin Immunol. 2023 Jul 29;84:102371. doi: 10.1016/j.coi.2023.102371. Online ahead of print.ABSTRACTThe detrimental impact of fungal infections to human health has steadily increased over the past decades. In October of 2022, the World Health Organization published the first ever fungal-pathogen priority list highlighting increased awareness of this problem, and the need for more research in this area. There were four distinct fungal pathogens identified as critical priority groups with Aspergillus fumigatus (Af) being the only mold. Af is a common environmental fungus responsible for over 90% of invasive aspergillosis...
Source: Current Opinion in Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Keyi Wang Vanessa Espinosa Amariliz Rivera Source Type: research
Developments in oral enterotoxigenic Escherichia coli vaccines
Curr Opin Immunol. 2023 Jul 29;84:102372. doi: 10.1016/j.coi.2023.102372. Online ahead of print.ABSTRACTEnterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in children in developing countries and in travelers. WHO has affirmed ETEC as a priority vaccine target, but there is no licensed ETEC vaccine available yet. We here describe recent, promising developments of different live, inactivated, and subunit ETEC candidate vaccines expressing or containing nontoxic enterotoxin and/or colonization factor antigens with a focus on oral vaccines. Many of the ETEC candidate vaccines have been tested in clinical tr...
Source: Current Opinion in Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Ann-Mari Svennerholm Anna Lundgren Source Type: research
