The role of the antigen processing machinery in the regulation and trafficking of intracellular -Toll-like receptor molecules

Curr Opin Immunol. 2023 Aug 8;84:102375. doi: 10.1016/j.coi.2023.102375. Online ahead of print.ABSTRACTIntracellular Toll-like receptors (TLRs) are key components of the innate immune system. Their expression in antigen-presenting cells (APCs), and in particular dendritic cells (DCs), makes them critical in the induction of the adaptive immune response. In DCs, they interact with the chaperone UNC93B1 that mediates their trafficking from the endoplasmic reticulum (ER) to endosomes where they are cleaved by proteases and activated. All these different steps are also shared by major histocompatibility complex class-II (MHCII) molecules. Here, we will discuss the tight relationship intracellular TLRs have with the antigen processing machinery in APCs for their trafficking and activation.PMID:37562076 | DOI:10.1016/j.coi.2023.102375

Source: Current Opinion in Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Mo ïse de Lavergne Lucie Maisonneuve Katrina Podsypanina B énédicte Manoury Source Type: research