Functional flexibility and plasticity in immune control of systemic Salmonella infection

We describe remarkable levels of flexibility with which the host coordinates and adapts these responses. This involves interchangeable cellular sources of IFN-γ regulated by innate and adaptive cues, and the rewiring of PCD pathways in previously unknown ways. We discuss that such plasticity is likely the consequence of host-pathogen coevolution and raise the possibility of further functional overlap between these seemingly distinct processes.PMID:37245415 | DOI:10.1016/j.coi.2023.102343

Source: Current Opinion in Immunology - May 28, 2023 Category: Allergy & Immunology Authors: Sven Engel Annabell Bachem Richard A Strugnell Andreas Strasser Marco J Herold Sammy Bedoui Source Type: research